MicroRNAs in the hypothalamus

Neuroendocrinology

Volumn 98, Issue 4, 2014, Pages 243-253

  Meister, Björn ^a   Herzer, Silke ^a,b   Silahtaroglu, Asli ^c  

^a KAROLINSKA INSTITUTE   (Sweden)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Dicer; Locked nucleic acid; miRNA; Neuroendocrine; Non coding RNA

Indexed keywords

MICRORNA; RNA BINDING PROTEIN;

3' UNTRANSLATED REGION; ARTICLE; BIRTH; CENTRAL NERVOUS SYSTEM; CIRCADIAN RHYTHM; GENE EXPRESSION; HUMAN; HYPOTHALAMUS; LACTATION; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RNA DEGRADATION; SLEEP; WATER METABOLISM; ANIMAL; METABOLISM; 5' UNTRANSLATED REGION; ARCUATE NUCLEUS; BODY WEIGHT; DORSOMEDIAL HYPOTHALAMIC NUCLEUS; FOOD INTAKE; HIPPOCAMPUS; HYPOTHALAMUS VENTROMEDIAL NUCLEUS; INTRON; PHENOTYPE; RNA PROCESSING; RNA SYNTHESIS;

ANIMALS; HUMANS; HYPOTHALAMUS; MICRORNAS; NEURONS;

EID: 84896488362     PISSN: 00283835     EISSN: 14230194     Source Type: Journal    
DOI: 10.1159/000355619     Document Type: Article

References (71)

1. Lee RC, Feinbaum RL, Ambros V: The C. el-egans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 1993; 75:843-854.
2. Reinhart BJ, Slack FJ, Basson M, Pasquinelli AE, Bettinger JC, Rougvie AE, Horvitz HR, Ruvkun G: The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabdi-tis elegans. Nature 2000; 403:901-906.
3. Griffiths-Jones S, Grocock RJ, van Dongen S, Bateman A, Enright AJ: miRBase: microRNA sequences, targets, and gene nomenclature. Nucleic Acids Res 2006; 34:D140-D144.
4. Bartel DP: MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004; 116: 281-297.
5. Kloosterman WP, Plasterk RH: The diverse functions of microRNAs in animal development and disease. Dev Cell 2006; 11:441-450.
6. Wienholds E, Plasterk RH: MicroRNA function in animal development. FEBS Lett 2005; 579:5911-5922.
7. Krützfeldt J, Stoffel M: MicroRNAs: a new class of regulatory genes affecting metabolism. Cell Metab 2006; 4:9-12.
8. Hwang HW, Mendell JT: MicroRNAs in cell proliferation, cell death, and tumorigenesis. Br J Cancer 2007; 96(suppl):R40-R44.
9. Schickel R, Boyerinas B, Park SM, Peter ME: MicroRNAs: key players in the immune system, differentiation, tumorigenesis and cell death. Oncogene 2008; 27:5959-5974.
10. Heneghan HM, Miller N, Kerin MJ: Role of microRNAs in obesity and the metabolic syndrome. Obes Rev 2010; 11:354-361.
11. Czech MP: MicroRNAs as therapeutic targets. N Engl J Med 2006; 354:1194-1195.
12. McDermott AM, Heneghan HM, Miller N, Kerin MJ: The therapeutic potential of mi-croRNAs: disease modulators and drug targets. Pharm Res 2011; 28:3016-3029.
13. Krol J, Loedige I, Filipowicz W: The widespread regulation of microRNA biogenesis, function and decay. Nat Rev Genet 2010; 11: 597-610.
14. Han J, Lee Y, Yeom KH, Kim YK, Jin H, Kim VN: The Drosha-DGCR8 complex in primary microRNA processing. Genes Dev 2004; 18: 3016-3027.
15. Kim VN: MicroRNA precursors in motion: Exportin-5 mediates their nuclear export. Trends Cell Biol 2004; 14:156-159.
16. Fabian MR, Sundermeier TR, Sonenberg N: Understanding how miRNAs post-transcrip-tionally regulate gene expression. Prog Mol Subcell Biol 2010; 50:1-20.
17. Rhoades MW, Reinhart BJ, Lim LP, Burge CB, Bartel B, Bartel DP: Prediction of plant mi-croRNA targets. Cell 2002; 110:513-520.
18. Bartel DP: MicroRNAs: target recognition and regulatory functions. Cell 2009; 136:215-233.
19. Hohjoh H, Fukushima T: Expression profile analysis of microRNA (miRNA) in mouse central nervous system using a new miRNA detection system that examines hybridization signals at every step of washing. Gene 2007; 391:39-44.
20. Bak M, Silahtaroglu A, Møller M, Christensen M, Rath MF, Skryabin B, Tommerup N, Kauppinen S: MicroRNA expression in the adult mouse central nervous system. RNA 2008; 14:432-444.
21. Olsen L, Klausen M, Helboe L, Nielsen FC, Werge T: MicroRNAs show mutually exclusive expression patterns in the brain of adult male rats. PLoS One 2009; 4:e7225.
22. Wienholds E, Kloosterman WP, Miska E, Al-varez-Saavedra E, Berezikov E, de Bruijn E, Horvitz HR, Kauppinen S, Plasterk RH: Mi-croRNA expression in zebrafish embryonic development. Science 2005; 309:310-311.
23. Ason B, Darnell DK, Wittbrodt B, Berezikov E, Kloosterman WP, Wittbrodt J, Antin PB, Plasterk RH: Differences in vertebrate mi-croRNA expression. Proc Natl Acad Sci USA 2006; 103:14385-14389.
24. Kaur H, Arora A, Wengel J, Maiti S: Thermo-dynamic, counterion, and hydration effects for the incorporation of locked nucleic acid nucleotides into DNA duplexes. Biochemistry 2006; 45:7347-7355.
25. Silahtaroglu A, Pfundheller H, Koshkin A, Tommerup N, Kauppinen S: LNA-modified oligonucleotides are highly efficient as FISH probes. Cytogenet Genome Res 2004; 107:32-37.
26. Silahtaroglu AN, Nolting D, Dyrskjøt L, Berezikov E, Møller M, Tommerup N, Kauppinen S: Detection of microRNAs in frozen tissue sections by fluorescence in situ hybridization using locked nucleic acid probes and tyramide signal amplification. Nat Protoc 2007; 2:2520-2528.
27. Herzer S, Silahtaroglu A, Meister B: Locked nucleic acid-based in situ hybridization reveals miR-7a as a hypothalamus-enriched mi-croRNA with a distinct expression pattern. J Neuroendocrinol 2012; 24:1492-1504.
28. Sempere LF, Freemantle S, Pitha-Rowe I, Moss E, Dmitrovsky E, Ambros V: Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation. Genome Biol 2004; 5:R13.
29. Nelson PT, Baldwin DA, Kloosterman WP, Kauppinen S, Plasterk RH, Mourelatos Z: RAKE and LNA-ISH reveal microRNA expression and localization in archival human brain. RNA 2006; 12:187-191.
30. Krichevsky AM, Sonntag KC, Isacson O, Kosik KS: Specific microRNAs modulate embryonic stem cell-derived neurogenesis. Stem Cells 2006; 24:857-864.
31. Makeyev EV, Zhang J, Carrasco MA, Mania-tis T: The microRNA miR-124 promotes neu-ronal differentiation by triggering brain-specific alternative pre-mRNA splicing. Mol Cell 2007; 27:435-448.
32. Visvanathan J, Lee S, Lee B, Lee JW, Lee SK: The microRNA miR-124 antagonizes the anti-neural REST/SCP1 pathway during embryonic CNS development. Genes Dev 2007; 21: 744-749.
33. De Pietri Tonelli D, Pulvers JN, Haffner C, Murchison EP, Hannon GJ, Huttner WB: miRNAs are essential for survival and differentiation of newborn neurons but not for expansion of neural progenitors during early neurogenesis in the mouse embryonic neo-cortex. Development 2008; 135:3911-3912.
34. Meza-Sosa KF, Valle-García D, Pedraza-Alva G, Pérez- Martínez L: Role of microRNAs in central nervous system development and pathology. J Neurosci Res 2012; 90:1-12.
35. Giraldez AJ, Cinalli RM, Glasner ME, Enright AJ, Thomson JM, Baskerville S, Hammond SM, Bartel DP, Schier AF: MicroRNAs regulate brain morphogenesis in zebrafish. Science 2005; 308:833-838.
36. Schaefer A, O'Carroll D, Tan CL, Hillman D, Sugimori M, Llinas R, Greengard P: Cerebel-lar neurodegeneration in the absence of mi-croRNAs. J Exp Med 2007; 204:1553-1558.
37. Damiani D, Alexander JJ, O'Rourke JR, Mc-Manus M, Jadhav AP, Cepko CL, Hauswirth WW, Harfe BD, Strettoi E: Dicer inactivation leads to progressive functional and structural degeneration of the mouse retina. J Neurosci 2008; 28:4878-4887.
38. Kim J, Krichevsky A, Grad Y, Hayes GD, Kosik KS, Church GM, Ruvkun G: Identification of many microRNAs that copurify with polyribosomes in mammalian neurons. Proc Natl Acad Sci USA 2004; 101:360-365.
39. Schratt GM, Tuebing F, Nigh EA, Kane CG, Sabatini ME, Kiebler M, Greenberg ME: A brain-specific microRNA regulates dendritic spine development. Nature 2006; 439:283-289.
40. Liu CM, Wang RY, Saijilafu, Jiao ZX, Zhang BY, Zhou FQ: MicroRNA-138 and SIRT1 form a mutual negative feedback loop to regulate mammalian axon regeneration. Genes Dev 2013; 27:1473-1483.
41. Li B, Sun H: miR-26a promotes neurite outgrowth by repressing PTEN expression. Mol Med Rep 2013; 8:676-680.
42. Mouillet-Richard S, Baudry A, Launay JM, Kellermann O: MicroRNAs and depression. Neurobiol Dis 2012; 46:272-278.
43. Bhalala OG, Srikanth M, Kessler JA: The emerging roles of microRNAs in CNS injuries. Nat Rev Neurol 2013; 9:328-339.
44. Salta E, De Strooper B: Non-coding RNAs with essential roles in neurodegenerative disorders. Lancet Neurol 2012; 11:189-200.
45. Farh KK, Grimson A, Jan C, Lewis BP, Johnston WK, Lim LP, Burge CB, Bartel DP: The widespread impact of mammalian mi-croRNAs on mRNA repression and evolution. Science 2005; 310:1817-1821.
46. Amar L, Benoit C, Beaumont G, Vacher CM, Crepin D, Taouis M, Baroin-Tourancheau A: MicroRNA expression profiling of hypotha-lamic arcuate and paraventricular nuclei from single rats using Illumina sequencing technology. J Neurosci Methods 2012; 209:134-143.
47. Tessmar-Raible K, Raible F, Christodoulou F, Guy K, Rembold M, Hausen H, Arendt D: Conserved sensory-neurosecretory cell types in annelid and fish forebrain: insights into hy-pothalamus evolution. Cell 2007; 129:1389-1400.
48. Sun GR, Li M, Li GX, Tian YD, Han RL, Kang XT: Identification and abundance of miRNA in chicken hypothalamus tissue determined by Solexa sequencing. Genet Mol Res. 2012; 11:4682-4694.
49. Nogueiras R, Tschöp MH, Zigman JM: Central nervous system regulation of energy metabolism: ghrelin versus leptin. Ann NY Acad Sci 2008; 1126:14-19.
50. Meister B: Neurotransmitters in key neurons of the hypothalamus that regulate feeding behavior and body weight. Physiol Behav 2007; 92:263-271.
51. Schneeberger M, Jordi Altirriba J, García A, Esteban Y, Castaño C, García-Lavandeira M, Alvarez CV, Gomis R, Claret M: Deletion of miRNA processing enzyme Dicer in POMC-expressing cells leads to pituitary dysfunction, neurodegeneration and development of obesity. Mol Metab 2013; 2:74-85.
52. Greenman Y, Kuperman Y, Drori Y, Asa SL, Navon I, Forkosh O, Gil S, Stern N, Chen A: Postnatal ablation of POMC neurons induces an obese phenotype characterized by decreased food intake and enhanced anxietylike behavior. Mol Endocrinol 2013; 27:1091-1102.
53. Cansell C, Luquet S: Hypothalamic regulation of energy balance: a key role for Dicer miRNA processing in arcuate POMC neurons. Mol Metab 2013; 2;55-57.
54. Benoit C, Ould-Hamouda H, Crepin D, Gertler A, Amar L, Taouis MJ: Early leptin blockade predisposes fat-fed rats to overweight and modifies hypothalamic mi-croRNAs. J Endocrinol 2013; 218:35-47.
55. Maltais LJ, Lane PW, Beamer WG: Anorexia, a recessive mutation causing starvation in preweanling mice. J Hered 1984; 75:468-472.
56. Mercader JM, González JR, Lozano JJ, Bak M, Kauppinen S, Sumoy L, Dierssen M, Fernán-dez-Aranda F, Visa J, Gratacòs M, Estivill X: Aberrant brain microRNA target and miRISC gene expression in the anx/anx anorexia mouse model. Gene 2012; 497:181-190.
57. Burbach JP, Luckman SM, Murphy D, Gainer H: Gene regulation in the magnocellular hy-pothalamo-neurohypophysial system. Physi-ol Rev 2001; 81:1197-1267.
58. Lee HJ, Palkovits M, Young WS III: miR-7b, a microRNA up-regulated in the hypothala-mus after chronic hyperosmolar stimulation, inhibits Fos translation. Proc Natl Acad Sci USA 2006; 103:15669-15674.
59. Uney JB, Lightman SL: MicroRNAs and osmotic regulation. Proc Natl Acad Sci USA 2006; 103:15278-15279.
60. Miyata S, Tsujioka H, Itoh M, Matsunaga W, Kuramoto H, Kiyohara T: Time course of Fos and Fras expression in the hypothalamic su-praoptic neurons during chronic osmotic stimulation. Mol Brain Res 2001; 90:39-47.
61. Choi JW, Kang SM, Lee Y, Hong SH, Sanek NA, Young WS, Lee HJ: MicroRNA profiling in the mouse hypothalamus reveals oxytocin-regulating microRNA. J Neurochem 2013; 126:331-337.
62. Cheng HY, Obrietan K: Revealing a role of microRNAs in the regulation of the biological clock. Cell Cycle 2007; 6:3034-3035.
63. Mehta N, Cheng HY: Micro-managing the circadian clock: the role of microRNAs in biological timekeeping. J Mol Biol 2013; 425: 3609-3624.
64. Chu C, Zhao Z: MicroRNA in the molecular mechanism of the circadian clock in mammals. Front Biosci 2013; 18:441-446.
65. Cheng HY, Papp JW, Varlamova O, Dziema H, Russell B, Curfman JP, Nakazawa T, Shi-mizu K, Okamura H, Impey S, Obrietan K: MicroRNA modulation of circadian-clock period and entrainment. Neuron 2007; 54: 813-829.
66. Alvarez-Saavedra M, Antoun G, Yanagiya A, Oliva-Hernandez R, Cornejo-Palma D, Perez-Iratxeta C, Sonenberg N, Cheng HY: miRNA-132 orchestrates chromatin remodeling and translational control of the circadi-an clock. Hum Mol Genet 2011; 20:731-751.
67. Davis CJ, Bohnet SG, Meyerson JM, Krueger JM: Sleep loss changes microRNA levels in the brain: a possible mechanism for state-dependent translational regulation. Neurosci Lett 2007; 422:68-73.
68. Davis CJ, Clinton JM, Taishi P, Bohnet SG, Honn KA, Krueger JM: MicroRNA-132 alters sleep and varies with time in brain. J Appl Physiol 2011; 111:665-672.
69. Mongrain V, Hernandez SA, Pradervand S, Dorsaz S, Curie T, Hagiwara G, Gip P, Heller HC, Franken P: Separating the contribution of glucocorticoids and wakefulness to the molecular and electrophysiological correlates of sleep homeostasis. Sleep 2010; 33:1147-1157.
70. Davis CJ, Clinton JM, Krueger JM: Mi-croRNA-138, let-7b, and 125a inhibitors differentially alter sleep and EEG delta-wave activity in rats. J Appl Physiol 2012; 113:1756-1762.
71. Sangiao-Alvarellos S, Manfredi-Lozano M, Ruiz-Pino F, Navarro VM, Sánchez-Garrido MA, Leon S, Dieguez C, Cordido F, Matagne V, Dissen GA, Ojeda SR, Pinilla L, Tena-Sempere M: Changes in hypothalamic expression of the Lin28/let-7 system and related mi-croRNAs during postnatal maturation and after experimental manipulations of puberty. Endocrinology 2013; 154:942-955.