Hypothalamic regulation of energy balance: A key role for DICER miRNA processing in arcuate POMC neurons

Molecular Metabolism

Volumn 2, Issue 2, 2013, Pages 55-57

  Cansell, Celine ^a   Luquet, Serge ^a,b  

^a UNIVERSITÉ PARIS DESCARTES   (France)

^b CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

DICER; MICRORNA; PROOPIOMELANOCORTIN; SMALL INTERFERING RNA;

ARCUATE NUCLEUS; CELL SURVIVAL; DEGENERATIVE DISEASE; ENERGY BALANCE; ENZYME INACTIVATION; HYPOPHYSIS; HYPOTHALAMUS; METABOLIC SYNDROME X; MOLECULAR MECHANICS; NONHUMAN; NOTE; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RNA PROCESSING; RNA TRANSPORT;

EID: 84877674919     PISSN: 22128778     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molmet.2012.12.001     Document Type: Note

References (10)

1. Morton G.J., Cummings D.E., Baskin D.G., Barsh G.S., Schwartz M.W. Central nervous system control of food intake and body weight. Nature 2006, 443:289-295.
2. Broberger C., Johansen J., Johansson C., Schalling M., Hokfelt T. The neuropeptide Y/agouti gene-related protein (AGRP) brain circuitry in normal, anorectic, and monosodium glutamate-treated mice. Proceedings of the National Academy of Sciences of the United States of America 1998, 95:15043-15048.
3. Bouret S.G., Draper S.J., Simerly R.B. Trophic action of leptin on hypothalamic neurons that regulate feeding. Science 2004, 304:108-110.
4. Pinto S., Roseberry A.G., Liu H., Diano S., Shanabrough M., Cai X., et al. Rapid rewiring of arcuate nucleus feeding circuits by leptin. Science 2004, 304:110-115.
5. Thaler J.P., Yi C.X., Schur E.A., Guyenet S.J., Hwang B.H., Dietrich M.O., et al. Obesity is associated with hypothalamic injury in rodents and humans. The Journal of Clinical Investigation 2012, 122:153-162.
6. Coupe B., Ishii Y., Dietrich M.O., Komatsu M., Horvath T.L., Bouret S.G. Loss of autophagy in pro-opiomelanocortin neurons perturbs axon growth and causes metabolic dysregulation. Cell Metabolism 2012, 15:247-255.
7. Benani A., Hryhorczuk C., Gouaze A., Fioramonti X., Brenachot X., Guissard C., et al. Food intake adaptation to dietary fat involves PSA-dependent rewiring of the arcuate melanocortin system in mice. The Journal of Neuroscience 2012, 32:11970-11979.
8. Mcnay D.E., Briancon N., Kokoeva M.V., Maratos-Flier E., Flier J.S. Remodeling of the arcuate nucleus energy-balance circuit is inhibited in obese mice. The Journal of Clinical Investigation 2012, 122:142-152.
9. Schneeberger M, Jordi A, Garcia A, Esteban Y, Castaño C, Garcia-Lavandeira M, et al.. Deletion of miRNA processing enzyme dicer in POMC-expressing cells leads to pituitary dysfunction, neurodegeneration and development of obesity. Molecular Metabolism2. ; in this issue. http://www.dx.doi.org/10.1016/j.molmet.2012.10.001.
10. Krol J., Loedige I., Filipowicz W. The widespread regulation of microRNA biogenesis, function and decay. Nature Reviews Genetics 2010, 11:597-610.