메뉴 건너뛰기




Volumn 1126, Issue , 2008, Pages 14-19

Central nervous system regulation of energy metabolism: Ghrelin versus leptin

Author keywords

Central nervous system; Energy balance equation; Energy partitioning; Ghrelin; Leptin; Melanocortin

Indexed keywords

GHRELIN; GLUCOSE; HORMONE; LEPTIN; LIPID;

EID: 42549165949     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1433.054     Document Type: Conference Paper
Times cited : (103)

References (40)
  • 1
    • 0033540056 scopus 로고    scopus 로고
    • Ghrelin is a growth‐hormone‐releasing acylated peptide from stomach
    • 1 Kojima, M., H. Hosoda, Y. Date, et al. 1999. Ghrelin is a growth‐hormone‐releasing acylated peptide from stomach. Nature 402: 656–660.
    • (1999) Nature , vol.402 , pp. 656-660
    • Kojima, M.1    Hosoda, H.2    Date, Y.3
  • 2
    • 2942528459 scopus 로고    scopus 로고
    • Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin
    • 2 Van Der Lely, A.J., M. Tschop, M.L. Heiman & E. Ghigo. 2004. Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin. Endocr. Rev. 25: 426–457.
    • (2004) Endocr. Rev. , vol.25 , pp. 426-457
    • Van Der Lely, A.J.1    Tschop, M.2    Heiman, M.L.3    Ghigo, E.4
  • 3
    • 9444264700 scopus 로고    scopus 로고
    • Endogenous ghrelin in pancreatic islets restricts insulin release by attenuating Ca2+ signaling in beta‐cells: implication in the glycemic control in rodents
    • 3 Dezaki, K., H. Hosoda, M. Kakei, et al. 2004. Endogenous ghrelin in pancreatic islets restricts insulin release by attenuating Ca2+ signaling in beta‐cells: implication in the glycemic control in rodents. Diabetes 53: 3142–3151.
    • (2004) Diabetes , vol.53 , pp. 3142-3151
    • Dezaki, K.1    Hosoda, H.2    Kakei, M.3
  • 4
    • 33646141847 scopus 로고    scopus 로고
    • Ablation of ghrelin improves the diabetic but not obese phenotype of ob/ob mice
    • 4 Sun, Y., M. Asnicar, P.K. Saha, et al. 2006. Ablation of ghrelin improves the diabetic but not obese phenotype of ob/ob mice. Cell Metab. 3: 379–386.
    • (2006) Cell Metab. , vol.3 , pp. 379-386
    • Sun, Y.1    Asnicar, M.2    Saha, P.K.3
  • 5
    • 0035843183 scopus 로고    scopus 로고
    • A role for ghrelin in the central regulation of feeding
    • 5 Nakazato, M., N. Murakami, Y. Date, et al. 2001. A role for ghrelin in the central regulation of feeding. Nature 409: 194–198.
    • (2001) Nature , vol.409 , pp. 194-198
    • Nakazato, M.1    Murakami, N.2    Date, Y.3
  • 6
    • 0035133586 scopus 로고    scopus 로고
    • Ghrelin is an appetite‐stimulatory signal from stomach with structural resemblance to motilin
    • 6 Asakawa, A., A. Inui, T. Kaga, et al. 2001. Ghrelin is an appetite‐stimulatory signal from stomach with structural resemblance to motilin. Gastroenterology 120: 337–345.
    • (2001) Gastroenterology , vol.120 , pp. 337-345
    • Asakawa, A.1    Inui, A.2    Kaga, T.3
  • 7
    • 0034687376 scopus 로고    scopus 로고
    • Ghrelin induces adiposity in rodents
    • 7 Tschop, M., D.L. Smiley & M.L. Heiman. 2000. Ghrelin induces adiposity in rodents. Nature 407: 908–913.
    • (2000) Nature , vol.407 , pp. 908-913
    • Tschop, M.1    Smiley, D.L.2    Heiman, M.L.3
  • 9
    • 5644249507 scopus 로고    scopus 로고
    • Central administration of ghrelin preferentially enhances fat ingestion
    • 9 Shimbara, T., M.S. Mondal, T. Kawagoe, et al. 2004. Central administration of ghrelin preferentially enhances fat ingestion. Neurosci. Lett. 369: 75–79.
    • (2004) Neurosci. Lett. , vol.369 , pp. 75-79
    • Shimbara, T.1    Mondal, M.S.2    Kawagoe, T.3
  • 10
    • 0035433977 scopus 로고    scopus 로고
    • A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans
    • 10 Cummings, D.E., J.Q. Purnell, R.S. Frayo, et al. 2001. A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes 50: 1714–1719.
    • (2001) Diabetes , vol.50 , pp. 1714-1719
    • Cummings, D.E.1    Purnell, J.Q.2    Frayo, R.S.3
  • 11
    • 1842480284 scopus 로고    scopus 로고
    • Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor
    • 11 Sun, Y., P. Wang, H. Zheng & R.G. Smith. 2004. Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor. Proc. Natl. Acad. Sci. USA 101: 4679–4684.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 4679-4684
    • Sun, Y.1    Wang, P.2    Zheng, H.3    Smith, R.G.4
  • 12
    • 31044451759 scopus 로고    scopus 로고
    • Mice lacking ghrelin receptors resist the development of diet‐induced obesity
    • 12 Zigman, J.M., Y. Nakano, R. Coppari, et al. 2005. Mice lacking ghrelin receptors resist the development of diet‐induced obesity. J. Clin. Invest. 115: 3564–3572.
    • (2005) J. Clin. Invest. , vol.115 , pp. 3564-3572
    • Zigman, J.M.1    Nakano, Y.2    Coppari, R.3
  • 13
    • 0242580169 scopus 로고    scopus 로고
    • Deletion of ghrelin impairs neither growth nor appetite
    • 13 Sun, Y., S. Ahmed & R.G. Smith. 2003. Deletion of ghrelin impairs neither growth nor appetite. Mol Cell Biol. 23: 7973–7981.
    • (2003) Mol Cell Biol. , vol.23 , pp. 7973-7981
    • Sun, Y.1    Ahmed, S.2    Smith, R.G.3
  • 14
    • 31044452189 scopus 로고    scopus 로고
    • Absence of ghrelin protects against early‐onset obesity
    • 14 Wortley, K.E., J.P. Del Rincon, J.D. Murray, et al. 2005. Absence of ghrelin protects against early‐onset obesity. J. Clin. Invest. 115: 3573–3578.
    • (2005) J. Clin. Invest. , vol.115 , pp. 3573-3578
    • Wortley, K.E.1    Del Rincon, J.P.2    Murray, J.D.3
  • 15
    • 32644448802 scopus 로고    scopus 로고
    • Ghrelin neutralization by a ribonucleic acid‐SPM ameliorates obesity in diet‐induced obese mice
    • 15 Shearman, L.P., S.P. Wang, S. Helmling, et al. 2006. Ghrelin neutralization by a ribonucleic acid‐SPM ameliorates obesity in diet‐induced obese mice. Endocrinology 147: 1517–1526.
    • (2006) Endocrinology , vol.147 , pp. 1517-1526
    • Shearman, L.P.1    Wang, S.P.2    Helmling, S.3
  • 17
    • 35548949948 scopus 로고    scopus 로고
    • Small‐molecule ghrelin receptor antagonists improve glucose tolerance, suppress appetite, and promote weight loss
    • 17 Esler, W.P., J. Rudolph, T.H. Claus, et al. 2007. Small‐molecule ghrelin receptor antagonists improve glucose tolerance, suppress appetite, and promote weight loss. Endocrinology 148: 5175–5185.
    • (2007) Endocrinology , vol.148 , pp. 5175-5185
    • Esler, W.P.1    Rudolph, J.2    Claus, T.H.3
  • 18
    • 0035082265 scopus 로고    scopus 로고
    • Circulating ghrelin levels are decreased in human obesity
    • 18 Tschop, M., C. Weyer, P.A. Tataranni, et al. 2001. Circulating ghrelin levels are decreased in human obesity. Diabetes 50: 707–709.
    • (2001) Diabetes , vol.50 , pp. 707-709
    • Tschop, M.1    Weyer, C.2    Tataranni, P.A.3
  • 19
    • 0034853507 scopus 로고    scopus 로고
    • Plasma ghrelin concentration and energy balance: overfeeding and negative energy balance studies in twins
    • 19 Ravussin, E., M. Tschop, S. Morales, et al. 2001. Plasma ghrelin concentration and energy balance: overfeeding and negative energy balance studies in twins. J. Clin. Endocrinol. Metab. 86: 4547–4551.
    • (2001) J. Clin. Endocrinol. Metab. , vol.86 , pp. 4547-4551
    • Ravussin, E.1    Tschop, M.2    Morales, S.3
  • 20
    • 0036126471 scopus 로고    scopus 로고
    • Weight loss increases circulating levels of ghrelin in human obesity
    • 20 Hansen, T.K., R. Dall, H. Hosoda, et al. 2002. Weight loss increases circulating levels of ghrelin in human obesity. Clin. Endocrinol. (Oxf.) 56: 203–206.
    • (2002) Clin. Endocrinol. (Oxf.) , vol.56 , pp. 203-206
    • Hansen, T.K.1    Dall, R.2    Hosoda, H.3
  • 21
    • 13444265857 scopus 로고    scopus 로고
    • Weight gain decreases elevated plasma ghrelin concentrations of patients with anorexia nervosa
    • 21 Otto, B., U. Cuntz, E. Fruehauf, et al. 2001. Weight gain decreases elevated plasma ghrelin concentrations of patients with anorexia nervosa. Eur. J. Endocrinol. 145: 669–673.
    • (2001) Eur. J. Endocrinol. , vol.145 , pp. 669-673
    • Otto, B.1    Cuntz, U.2    Fruehauf, E.3
  • 22
    • 0036061558 scopus 로고    scopus 로고
    • Elevated plasma ghrelin levels in Prader Willi syndrome
    • 22 Cummings, D.E., K. Clement, J.Q. Purnell, et al. 2002. Elevated plasma ghrelin levels in Prader Willi syndrome. Nat. Med. 8: 643–644.
    • (2002) Nat. Med. , vol.8 , pp. 643-644
    • Cummings, D.E.1    Clement, K.2    Purnell, J.Q.3
  • 23
    • 1042267409 scopus 로고    scopus 로고
    • Prader‐Willi syndrome: advances in genetics, pathophysiology and treatment
    • 23 Goldstone, A.P. 2004. Prader‐Willi syndrome: advances in genetics, pathophysiology and treatment. Trends Endocrinol. Metab. 15: 12–20.
    • (2004) Trends Endocrinol. Metab. , vol.15 , pp. 12-20
    • Goldstone, A.P.1
  • 24
    • 33748371601 scopus 로고    scopus 로고
    • Neural mechanisms of addiction: the role of reward‐related learning and memory
    • 24 Hyman, S.E., R.C. Malenka & E.J. Nestler. 2006. Neural mechanisms of addiction: the role of reward‐related learning and memory. Annu. Rev. Neurosci. 29: 565–598.
    • (2006) Annu. Rev. Neurosci. , vol.29 , pp. 565-598
    • Hyman, S.E.1    Malenka, R.C.2    Nestler, E.J.3
  • 25
    • 29044434688 scopus 로고    scopus 로고
    • Expression of ghrelin receptor mRNA in the rat and the mouse brain
    • 25 Zigman, J.M., J.E. Jones, C.E. Lee, et al. 2006. Expression of ghrelin receptor mRNA in the rat and the mouse brain. J. Comp. Neurol. 494: 528–548.
    • (2006) J. Comp. Neurol. , vol.494 , pp. 528-548
    • Zigman, J.M.1    Jones, J.E.2    Lee, C.E.3
  • 26
    • 27744593324 scopus 로고    scopus 로고
    • Ghrelin induces feeding in the mesolimbic reward pathway between the ventral tegmental area and the nucleus accumbens
    • 26 Naleid, A.M., M.K. Grace, D.E. Cummings & A.S. Levine. 2005. Ghrelin induces feeding in the mesolimbic reward pathway between the ventral tegmental area and the nucleus accumbens. Peptides 26: 2274–2279.
    • (2005) Peptides , vol.26 , pp. 2274-2279
    • Naleid, A.M.1    Grace, M.K.2    Cummings, D.E.3    Levine, A.S.4
  • 27
    • 33748560432 scopus 로고    scopus 로고
    • Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite
    • 27 Abizaid, A., Z.W. Liu, Z.B. Andrews, et al. 2006. Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite. J. Clin. Invest. 116: 3229–3239.
    • (2006) J. Clin. Invest. , vol.116 , pp. 3229-3239
    • Abizaid, A.1    Liu, Z.W.2    Andrews, Z.B.3
  • 28
    • 33748362868 scopus 로고    scopus 로고
    • Ghrelin stimulates locomotor activity and accumbal dopamine‐overflow via central cholinergic systems in mice: implications for its involvement in brain reward
    • 28 Jerlhag, E., E. Egecioglu, S.L. Dickson, et al. 2006. Ghrelin stimulates locomotor activity and accumbal dopamine‐overflow via central cholinergic systems in mice: implications for its involvement in brain reward. Addict. Biol. 11: 45–54.
    • (2006) Addict. Biol. , vol.11 , pp. 45-54
    • Jerlhag, E.1    Egecioglu, E.2    Dickson, S.L.3
  • 29
    • 0043030280 scopus 로고    scopus 로고
    • Minireview: from anorexia to obesity–the yin and yang of body weight control
    • 29 Zigman, J.M. & J.K. Elmquist. 2003. Minireview: from anorexia to obesity–the yin and yang of body weight control. Endocrinology 144: 3749–3756.
    • (2003) Endocrinology , vol.144 , pp. 3749-3756
    • Zigman, J.M.1    Elmquist, J.K.2
  • 30
    • 33748931457 scopus 로고    scopus 로고
    • Central nervous system control of food intake and body weight
    • 30 Morton, G.J., D.E. Cummings, D.G. Baskin, et al. 2006. Central nervous system control of food intake and body weight. Nature 443: 289–295.
    • (2006) Nature , vol.443 , pp. 289-295
    • Morton, G.J.1    Cummings, D.E.2    Baskin, D.G.3
  • 31
    • 0015792424 scopus 로고
    • Effects of parabiosis of obese with diabetes and normal mice
    • 31 Coleman, D.L. 1973. Effects of parabiosis of obese with diabetes and normal mice. Diabetologia 9: 294–298.
    • (1973) Diabetologia , vol.9 , pp. 294-298
    • Coleman, D.L.1
  • 32
    • 0028139089 scopus 로고
    • Positional cloning of the mouse obese gene and its human homologue
    • 32 Zhang, Y., R. Proenca, M. Maffei, et al. 1994. Positional cloning of the mouse obese gene and its human homologue. Nature 372: 425–432.
    • (1994) Nature , vol.372 , pp. 425-432
    • Zhang, Y.1    Proenca, R.2    Maffei, M.3
  • 33
    • 2442654859 scopus 로고
    • Identification and expression cloning of a leptin receptor, OB‐R
    • 33 Tartaglia, L.A., M. Dembski, X. Weng, et al. 1995. Identification and expression cloning of a leptin receptor, OB‐R. Cell 83: 1263–1271.
    • (1995) Cell , vol.83 , pp. 1263-1271
    • Tartaglia, L.A.1    Dembski, M.2    Weng, X.3
  • 34
    • 0034789909 scopus 로고    scopus 로고
    • Central melanocortin receptors regulate insulin action
    • 34 Obici, S., Z. Feng, J. Tan, et al. 2001. Central melanocortin receptors regulate insulin action. J. Clin. Invest. 108: 1079–1085.
    • (2001) J. Clin. Invest. , vol.108 , pp. 1079-1085
    • Obici, S.1    Feng, Z.2    Tan, J.3
  • 35
    • 17844389670 scopus 로고    scopus 로고
    • The hypothalamic arcuate nucleus: a key site for mediating leptin's effects on glucose homeostasis and locomotor activity
    • 35 Coppari, R., M. Ichinose, C.E. Lee, et al. 2005. The hypothalamic arcuate nucleus: a key site for mediating leptin's effects on glucose homeostasis and locomotor activity. Cell Metab. 1: 63–72.
    • (2005) Cell Metab. , vol.1 , pp. 63-72
    • Coppari, R.1    Ichinose, M.2    Lee, C.E.3
  • 36
    • 0030878110 scopus 로고    scopus 로고
    • Congenital leptin deficiency is associated with severe early‐onset obesity in humans
    • 36 Montague, C.T., I.S. Farooqi, J.P. Whitehead, et al. 1997. Congenital leptin deficiency is associated with severe early‐onset obesity in humans. Nature 387: 903–908.
    • (1997) Nature , vol.387 , pp. 903-908
    • Montague, C.T.1    Farooqi, I.S.2    Whitehead, J.P.3
  • 37
    • 0033575993 scopus 로고    scopus 로고
    • Effects of recombinant leptin therapy in a child with congenital leptin deficiency
    • 37 Farooqi, I.S., S.A. Jebb, G. Langmack, et al. 1999. Effects of recombinant leptin therapy in a child with congenital leptin deficiency. N. Engl. J. Med. 341: 879–884.
    • (1999) N. Engl. J. Med. , vol.341 , pp. 879-884
    • Farooqi, I.S.1    Jebb, S.A.2    Langmack, G.3
  • 38
    • 34548675339 scopus 로고    scopus 로고
    • Leptin regulates striatal regions and human eating behavior
    • 38 Farooqi, I.S., E. Bullmore, J. Keogh, et al. 2007. Leptin regulates striatal regions and human eating behavior. Science 317: 1355.
    • (2007) Science , vol.317 , pp. 1355
    • Farooqi, I.S.1    Bullmore, E.2    Keogh, J.3
  • 39
    • 0344450708 scopus 로고    scopus 로고
    • A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction
    • 39 Clement, K., C. Vaisse, N. Lahlou, et al. 1998. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature 392: 398–401.
    • (1998) Nature , vol.392 , pp. 398-401
    • Clement, K.1    Vaisse, C.2    Lahlou, N.3
  • 40
    • 0037456768 scopus 로고    scopus 로고
    • Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene
    • 40 Farooqi, I.S., J.M. Keogh, G.S. Yeo, et al. 2003. Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene. N. Engl. J. Med. 348: 1085–1095.
    • (2003) N. Engl. J. Med. , vol.348 , pp. 1085-1095
    • Farooqi, I.S.1    Keogh, J.M.2    Yeo, G.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.