Current progress in bioactive ceramic scaffolds for bone repair and regeneration

International Journal of Molecular Sciences

Volumn 15, Issue 3, 2014, Pages 4714-4732

  Gao, Chengde ^a   Deng, Youwen ^b   Feng, Pei ^a   Mao, Zhongzheng ^a   Li, Pengjian ^a   Yang, Bo ^a   Deng, Junjie ^a   Cao, Yiyuan ^a   Shuai, Cijun ^a,c   Peng, Shuping ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b CENTRAL SOUTH UNIVERSITY   (China)

^c MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Bioactive ceramic; Bone repair; Nanostructure; Pore architecture; Preparation technique

Indexed keywords

BIOACTIVE CERAMIC SCAFFOLD; NANOCERAMICS; NANOCOMPOSITE; NANOMATERIAL; TISSUE SCAFFOLD; UNCLASSIFIED DRUG; BIOMATERIAL; CERAMICS;

BIOCOMPATIBILITY; BONE DEVELOPMENT; BONE REGENERATION; BONE REMODELING; CELL DIFFERENTIATION; CELL PROLIFERATION; FIBER TOUGHNESS; FRACTURE TOUGHNESS; GENE EXPRESSION; HUMAN; MATERIALS; NANOCERAMIC ARTIFICIAL BONE; NONHUMAN; PARTICLE TOUGHNESS; PHYSICAL PARAMETERS; POROSITY; REVIEW; STRENGTH; SYSTEMATIC REVIEW; WHISKER TOUGHNESS; BONE; CERAMICS; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; PHARMACOLOGY; PHYSIOLOGY; PROCEDURES; TISSUE ENGINEERING; TISSUE SCAFFOLD; TRENDS;

BIOCOMPATIBLE MATERIALS; BONE AND BONES; BONE REGENERATION; CELL DIFFERENTIATION; CERAMICS; HUMANS; NANOSTRUCTURES; POROSITY; TISSUE ENGINEERING; TISSUE SCAFFOLDS;

EID: 84896483417     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms15034714     Document Type: Review

References (110)

1. Carrington, J. L. Aging bone and cartilage: Cross-cutting issues. Biochem. Biophys. Res. Commun. 2005, 328, 700-708.
2. Olshansky, S. J.; Passaro, D. J.; Hershow, R. C.; Layden, J.; Carnes, B. A.; Brody, J.; Hayflick, L.; Butler, R. N.; Allison, D. B.; Ludwig, D. S. A potential decline in life expectancy in the United States in the 21st century. N. Engl. J. Med. 2005, 352, 1138-1145.
3. Ebnezar, J. Textbook of Orthopaedics; JP Medical Ltd.: London, UK, 2010.
4. Cancedda, R.; Dozin, B.; Giannoni, P.; Quarto, R. Tissue engineering and cell therapy of cartilage and bone. Matrix Biol. 2003, 22, 81-91.
5. Sun, K.; Tian, S.; Zhang, J.; Xia, C.; Zhang, C.; Yu, T. Anterior cruciate ligament reconstruction with BPTB autograft, irradiated versus non-irradiated allograft: A prospective randomized clinical study. Knee Surg. Sports Traumatol. Arthrosc. 2009, 17, 464-474.
6. Shafiei, Z.; Bigham, A. S.; Dehghani, S. N.; Nezhad, S. T. Fresh cortical autograft versus fresh cortical allograft effects on experimental bone healing in rabbits: Radiological, Histopathological and Biomechanical evaluation. Cell Tissue Bank 2009, 10, 19-26.
7. Younger, E. M.; Chapman, M. W. Morbidity at bone graft donor sites. J. Orthop. Trauma 1989, 3, 192-195.
8. Braddock, M.; Houston, P.; Campbell, C.; Ashcroft, P. Born again bone: Tissue engineering for bone repair. Physiology 2001, 16, 208-213.
9. Hench, L. L.; Polak, J. M. Third-generation biomedical materials. Science 2002, 295, 1014-1017.
10. Hutmacher, D. W. Scaffolds in tissue engineering bone and cartilage. Biomaterials 2000, 21, 2529-2543.
11. Swetha, M.; Sahithi, K.; Moorthi, A.; Srinivasan, N.; Ramasamy, K.; Selvamurugan, N. Biocomposites containing natural polymers and hydroxyapatite for bone tissue engineering. Int. J. Biol. Macromol. 2010, 47, 1-4.
12. Tu, J. W.; Wang, H. J.; Li, H. W.; Dai, K. R.; Wang, J. Y.; Zhang, X. L. The in vivo bone formation by mesenchymal stem cells in zein scaffolds. Biomaterials 2009, 30, 4369-4376.
13. Liu, F. H. Synthesis of bioceramic scaffolds for bone tissue engineering by rapid prototyping technique. J. Sol-Gel Sci. Technol. 2012, 64, 704-710.
14. Zhou, H.; Lee, J. Nanoscale hydroxyapatite particles for bone tissue engineering. Acta Biomater. 2011, 7, 2769-2781.
15. Mirtchi, A. A.; Lemaitre, J.; Terao, N. Calcium phosphate cements: Study of the β-tricalcium phosphate-monocalcium phosphate system. Biomaterials 1989, 10, 475-480.
16. Hench, L. L. The story of Bioglass®. J. Mater. Sci. 2006, 17, 967-978.
17. Liu, X.; Morra, M.; Carpi, A.; Li, B. Bioactive calcium silicate ceramics and coatings. Biomed. Pharmacother. 2008, 62, 526-529.
18. Sultana, N. Biodegradable Polymer-Based Scaffolds for Bone Tissue Engineering; Springer: Berlin, Germany, 2013.
19. Xu, H. H.; Quinn, J. B.; Takagi, S.; Chow, L. C. Synergistic reinforcement of in situ hardening calcium phosphate composite scaffold for bone tissue engineering. Biomaterials 2004, 25, 1029-1037.
20. Rahaman, M. N. Ceramic Processing; CRC Press: Boca Raton, FL, USA, 2007.
21. Kim, S. S.; Park, M. S.; Jeon, O.; Choi, C. Y.; Kim, B. S. Poly(lactide-co-glycolide)/hydroxyapatite composite scaffolds for bone tissue engineering. Biomaterials 2006, 27, 1399-1409.
22. Thompson, I.; Hench, L. Mechanical properties of bioactive glasses, glass-ceramics and composites. Proc. Inst. Mech. Eng. Part H 1998, 212, 127-136.
23. Wu, C. Methods of improving mechanical and biomedical properties of Ca-Si-based ceramics and scaffolds. Expert Rev. Med. Devices 2009, 6, 237-241.
24. Wang, J.; Shaw, L. L. Nanocrystalline hydroxyapatite with simultaneous enhancements in hardness and toughness. Biomaterials 2009, 30, 6565-6572.
25. Fielding, G. A.; Bandyopadhyay, A.; Bose, S. Effects of silica and zinc oxide doping on mechanical and biological properties of 3D printed tricalcium phosphate tissue engineering scaffolds. Dent. Mater. 2012, 28, 113-122.
26. Ramesh, S.; Tan, C.; Sopyan, I.; Hamdi, M.; Teng, W. Consolidation of nanocrystalline hydroxyapatite powder. Sci. Technol. Adv. Mater. 2007, 8, 124-130.
27. Gerhardt, L.-C.; Boccaccini, A. R. Bioactive glass and glass-ceramic scaffolds for bone tissue engineering. Materials 2010, 3, 3867-3910.
28. Becher, P. F. Microstructural design of toughened ceramics. J. Am. Ceram. Soc. 1991, 74, 255-269.
29. Losquadro, W. D.; Tatum, S. A.; Allen, M. J.; Mann, K. A. Polylactide-co-glycolide fiber-reinforced calcium phosphate bone cement. Arch. Facial Plast. Surg. 2009, 11, 104-109.
30. Zhang, Y.; Xu, H. H. Effects of synergistic reinforcement and absorbable fiber strength on hydroxyapatite bone cement. J. Biomed. Mater. Res. Part A 2005, 75, 832-840.
31. Suping, H.; Baiyun, H.; Kechao, Z.; Zhiyou, L. Effects of coatings on the mechanical properties of carbon fiber reinforced HAP composites. Mater. Lett. 2004, 58, 3582-3585.
32. Becher, P. F.; HSUEH, C. H.; Angelini, P.; Tiegs, T. N. Toughening Behavior in Whisker-Reinforced Ceramic Matrix Composites. J. Am. Ceram. Soc. 1988, 71, 1050-1061.
33. Müller, F. A.; Gbureck, U.; Kasuga, T.; Mizutani, Y.; Barralet, J. E.; Lohbauer, U. Whisker-reinforced calcium phosphate cements. J. Am. Ceram. Soc. 2007, 90, 3694-3697.
34. Bose, S.; Banerjee, A.; Dasgupta, S.; Bandyopadhyay, A. Synthesis, processing, mechanical, and biological property characterization of hydroxyapatite whisker-reinforced hydroxyapatite composites. J. Am. Ceram. Soc. 2009, 92, 323-330.
35. Wang, F.; Zhao, S.; Zhao, P.; Zhao, T. R.; Ren, X. H.; Chen, X. N. Hydroxyapatite whisker effect on strength of calcium phosphate bone cement. Adv. Mater. Res. 2012, 534, 30-33.
36. Ahn, E. S.; Gleason, N. J.; Ying, J. Y. The effect of zirconia reinforcing agents on the microstructure and mechanical properties of hydroxyapatite-based nanocomposites. J. Am. Ceram. Soc. 2005, 88, 3374-3379.
37. Wei, G.; Ma, P. X. Structure and properties of nano-hydroxyapatite/polymer composite scaffolds for bone tissue engineering. Biomaterials 2004, 25, 4749-4757.
38. Gentile, P.; Chiono, V.; Boccafoschi, F.; Baino, F.; Vitale-Brovarone, C.; Vernè, E.; Barbani, N.; Ciardelli, G. Composite films of gelatin and hydroxyapatite/bioactive glass for tissue-engineering applications. J. Biomater. Sci. Polym. Ed. 2010, 21, 1207-1226.
39. Gentile, P.; Mattioli-Belmonte, M.; Chiono, V.; Ferretti, C.; Baino, F.; Tonda-Turo, C.; Vitale-Brovarone, C.; Pashkuleva, I.; Reis, R. L.; Ciardelli, G. Bioactive glass/polymer composite scaffolds mimicking bone tissue. J. Biomed. Mater. Res. Part A 2012, 100, 2654-2667.
40. Zhu, Y.-F.; Shi, L.; Liang, J.; Hui, D.; Lau, K.-T. Synthesis of zirconia nanoparticles on carbon nanotubes and their potential for enhancing the fracture toughness of alumina ceramics. Compos. Part B 2008, 39, 1136-1141.
41. Burg, K. J.; Porter, S.; Kellam, J. F. Biomaterial developments for bone tissue engineering. Biomaterials 2000, 21, 2347-2359.
42. Nel, A.; Xia, T.; Mädler, L.; Li, N. Toxic potential of materials at the nanolevel. Science 2006, 311, 622-627.
43. Roco, M. C.; Williams, R.; Alivisatos, P. Nanotechnology Research Directions: IWGN Workshop Report. Vision for Nanotechnology R&D in the Next Decade; National Science and Technology Council: Washington, DC, USA, 1999.
44. Meyers, M. A.; Mishra, A.; Benson, D. J. Mechanical properties of nanocrystalline materials. Prog. Mater. Sci. 2006, 51, 427-556.
45. Chokshi, A. An evaluation of the grain-boundary sliding contribution to creep deformation in polycrystalline alumina. J. Mater. Sci. 1990, 25, 3221-3228.
46. Thomas, S.; Chan, C. H.; Pothen, L. A.; Joy, J.; Maria, H. Natural Rubber Materials: Volume 2: Composites and Nanocomposites; Royal Society of Chemistry: London, UK, 2014; Volume 8.
47. Liu, T.; Yan, Y.; Li, S. Comparative study on lattice parameters of HAP nanoparticles with those of HAP whiskers. J. Wuhan Univ. Technol.-Mater. Sci. Ed. 2008, 23, 395-398.
48. Puzari, A.; Borah, J. P. Ionic self-assembly and hierarchies of polymeric structures generating nanoscale architecture: Opportunities ahead from industrial perspective. Rev. Adv. Mater. Sci. 2013, 34, 88-106.
49. Chun, Y. W.; Crowder, S. W.; Mehl, S. C.; Wang, X.; Bae, H.; Sung, H.-J. Therapeutic application of nanotechnology in cardiovascular and pulmonary regeneration. Comput. Struct. Biotechnol. J. 2013, 7, doi: 10. 5936/csbj. 201304005.
50. Pereira, A. L.; Veras, S. S.; Silveira, É. J.; Seabra, F. R.; Pinto, L. P.; Souza, L. B.; Freitas, R. A. The role of matrix extracellular proteins and metalloproteinases in head and neck carcinomas: An updated review. Revista Brasileira de Otorrinolaringologia 2005, 71, 81-86.
51. Ding, L.; Davidchack, R. L.; Pan, J. A molecular dynamics study of sintering between nanoparticles. Comput. Mater. Sci. 2009, 45, 247-256.
52. Mazaheri, M.; Zahedi, A.; Haghighatzadeh, M.; Sadrnezhaad, S. Sintering of titania nanoceramic: Densification and grain growth. Ceram. Int. 2009, 35, 685-691.
53. Sanosh, K.; Chu, M.-C.; Balakrishnan, A.; Kim, T.; Cho, S.-J. Pressureless sintering of nanocrystalline hydroxyapatite at different temperatures. Met. Mater. Int. 2010, 16, 605-611.
54. Sprio, S.; Tampieri, A.; Celotti, G.; Landi, E. Development of hydroxyapatite/calcium silicate composites addressed to the design of load-bearing bone scaffolds. J. Mech. Behav. Biomed. Mater. 2009, 2, 147-155.
55. Gay, S.; Arostegui, S.; Lemaitre, J. Preparation and characterization of dense nanohydroxyapatite/PLLA composites. Mater. Sci. Eng. C 2009, 29, 172-177.
56. Costa Oliveira, F. A.; Pascaud, P.; Domingues, J.; Marcelo, T.; Cruz Fernandes, J.; Guerra Rosa, L. Elastic properties of microwave sintered hydroxyapatite. Mater. Sci. Forum 2008, 587-588, 17-21.
57. Seo, D. S.; Hwang, K. H.; Lee, J. K. Nanostructured hydroxyapatite by microwave sintering. J. Nanosci. Nanotechnol. 2008, 8, 944-948.
58. Li, S.; Izui, H.; Okano, M. Densification, microstructure, and behavior of hydroxyapatite ceramics sintered by using spark plasma sintering. J. Eng. Mater. Technol. 2008, 130, doi: 10. 1115/1. 2931153.
59. Zhang, J.; Cao, L.; Yang, Y.; Diao, Y.; Shen, X. Step sintering of microwave heating and microwave plasma heating for alumina ceramics. J. Mater. Sci. Technol. Shenyang 1999, 15, 419-422.
60. Liu, Z.; Huang, H.; Gao, X.; Yu, H.; Zhong, X.; Zhu, J.; Zeng, D. Microstructure and property evolution of isotropic and anisotropic NdFeB magnets fabricated from nanocrystalline ribbons by spark plasma sintering and hot deformation. J. Phys. D 2011, 44, 025003.
61. Yang, J.; Ouyang, H.; Wang, Y. Direct metal laser fabrication: Machine development and experimental work. Int. J. Adv. Manuf. Technol. 2010, 46, 1133-1143.
62. Vinet, A.; Caine, M. Development of traction features in sprint spikes using SLS nylon sole units. Procedia Eng. 2010, 2, 2769-2774.
63. Järvenpää, A.; Mäntyjärvi, K.; Merklein, M.; Hietala, M.; Karjalainen, J. Mechanical properties of laser heat treated 6 mm thick UHSS-steel. AIP Conf. Proc. 2011, 1353, 1319.
64. Williams, J. M.; Adewunmi, A.; Schek, R. M.; Flanagan, C. L.; Krebsbach, P. H.; Feinberg, S. E.; Hollister, S. J.; Das, S. Bone tissue engineering using polycaprolactone scaffolds fabricated via selective laser sintering. Biomaterials 2005, 26, 4817-4827.
65. Liao, H. T.; Lee, M. Y.; Tsai, W. W.; Wang, H. C.; Lu, W. C. Osteogenesis of adipose-derived stem cells on polycaprolactone-β-tricalcium phosphate scaffold fabricated via selective laser sintering and surface coating with collagen type I. J. Tissue Eng. Regen. Med. 2013, doi: 10. 1002/term. 1811.
66. Huyghe, J. M.; Raats, P. A.; Cowin, S. C. IUTAM Symposium on Physicochemical and Electromechanical, Interactions in Porous Media; Springer: Dordrecht, The Netherlands, 2005; Volume 125.
67. x gas sensors at room temperature. Nanoscale 2013, 5, 8569-8576.
68. Ryan, G.; Pandit, A.; Apatsidis, D. P. Fabrication methods of porous metals for use in orthopaedic applications. Biomaterials 2006, 27, 2651-2670.
69. Li, N.; Wang, R. Macroporous sol-gel bioglasses scaffold with high compressive strength, porosity and specific surface area. Ceram. Int. 2012, 38, 6889-6893.
70. Lv, Q.; Nair, L.; Laurencin, C. T. Fabrication, characterization, and in vitro evaluation of poly (lactic acid glycolic acid)/nano-hydroxyapatite composite microsphere-based scaffolds for bone tissue engineering in rotating bioreactors. J. Biomed. Mater. Res. Part A 2009, 91, 679-691.
71. Krauss Juillerat, F.; Gonzenbach, U. T.; Elser, P.; Studart, A. R.; Gauckler, L. J. Microstructural Control of Self-Setting Particle-Stabilized Ceramic Foams. J. Am. Ceram. Soc. 2011, 94, 77-83.
72. Espalin, D.; Arcaute, K.; Rodriguez, D.; Medina, F.; Posner, M.; Wicker, R. Fused deposition modeling of patient-specific polymethylmethacrylate implants. Rapid Prototyp. J. 2010, 16, 164-173.
73. Simon, J. L.; Rekow, E. D.; Thompson, V. P.; Beam, H.; Ricci, J. L.; Parsons, J. R. MicroCT analysis of hydroxyapatite bone repair scaffolds created via three-dimensional printing for evaluating the effects of scaffold architecture on bone ingrowth. J. Biomed. Mater. Res. Part A 2008, 85, 371-377.
74. Maeda, C.; Tasaki, S.; Kirihara, S. Accurate fabrication of hydroxyapatite bone models with porous scaffold structures by using stereolithography. In IOP Conference Series: Materials Science and Engineering, 2011; IOP Publishing: Bristol, UK, 2011; p. 072017.
75. Simpson, R. L.; Wiria, F. E.; Amis, A. A.; Chua, C. K.; Leong, K. F.; Hansen, U. N.; Chandrasekaran, M.; Lee, M. W. Development of a 95/5 poly (L-lactide-co-glycolide)/hydroxylapatite and β-tricalcium phosphate scaffold as bone replacement material via selective laser sintering. J. Biomed. Mater. Res. Part B 2008, 84, 17-25.
76. 3 ceramic scaffolds: Preparation, characterization and in vivo osteogenesis. J. Mater. Chem. 2012, 22, 12288-12295.
77. Bian, W.; Li, D.; Lian, Q.; Zhang, W.; Zhu, L.; Li, X.; Jin, Z. Design and fabrication of a novel porous implant with pre-set channels based on ceramic stereolithography for vascular implantation. Biofabrication 2011, 3, 034103.
78. Lin, L.; Ju, S.; Cen, L.; Zhang, H.; Hu, Q. Fabrication of porous β-TCP scaffolds by combination of rapid prototyping and freeze drying technology; In Proceedings of the 7th Asian-Pacific Conference on Medical and Biological Engineering, 2008, Beijing, China, 22-25 April 2008; Springer: Berlin, Germany, 2008; pp. 88-91.
79. Duan, B.; Cheung, W. L.; Wang, M. Optimized fabrication of Ca-P/PHBV nanocomposite scaffolds via selective laser sintering for bone tissue engineering. Biofabrication 2011, 3, 015001.
80. Meng, J.; Xiao, B.; Zhang, Y.; Liu, J.; Xue, H.; Lei, J.; Kong, H.; Huang, Y.; Jin, Z.; Gu, N. Super-paramagnetic responsive nanofibrous scaffolds under static magnetic field enhance osteogenesis for bone repair in vivo. Sci. Rep. 2013, 3, doi: 10. 1038/srep02655.
81. Aderinto, J.; Blunn, G. The evaluation of a bone marrow stromal stem cell-hydroxyapatite composite graft for spinal fusion. A rabbit model. J. Bone Jt. Surg. Br. Vol. 2006, 88, 368-368.
82. Yeung, H.; Qin, L.; Hu, Y. Y.; Lee, K.; Cheng, J. C.; Chan, C. W.; Wong, K.; Yip, R. Bio-engineered mesenchymal stem cell-tricalcium phosphate ceramics composite augmented bone regeneration in posterior spinal fusion. Key Eng. Mater. 2007, 334, 1201-1204.
83. Jo, J. H.; Lee, E. J.; Shin, D. S.; Kim, H. E.; Kim, H. W.; Koh, Y. H.; Jang, J. H. In vitro/in vivo biocompatibility and mechanical properties of bioactive glass nanofiber and poly (ε-caprolactone) composite materials. J. Biomed. Mater. Res. Part B 2009, 91, 213-220.
84. Xu, S.; Lin, K.; Wang, Z.; Chang, J.; Wang, L.; Lu, J.; Ning, C. Reconstruction of calvarial defect of rabbits using porous calcium silicate bioactive ceramics. Biomaterials 2008, 29, 2588-2596.
85. Silva, T. S. N.; Primo, B. T.; Júnior, S.; Novaes, A.; Machado, D. C.; Viezzer, C.; Santos, L. A. Use of calcium phosphate cement scaffolds for bone tissue engineering: In vitro study. Acta Cir. Bras. 2011, 26, 7-11.
86. McCullen, S.; Zhu, Y.; Bernacki, S.; Narayan, R.; Pourdeyhimi, B.; Gorga, R.; Loboa, E. Electrospun composite poly (L-lactic acid)/tricalcium phosphate scaffolds induce proliferation and osteogenic differentiation of human adipose-derived stem cells. Biomed. Mater. 2009, 4, 035002.
87. Xu, C.; Su, P.; Wang, Y.; Chen, X.; Meng, Y.; Liu, C.; Yu, X.; Yang, X.; Yu, W.; Zhang, X. A novel biomimetic composite scaffold hybridized with mesenchymal stem cells in repair of rat bone defects models. J. Biomed. Mater. Res. Part A 2010, 95, 495-503.
88. Ni, S.; Chang, J. In vitro degradation, bioactivity, and cytocompatibility of calcium silicate, dimagnesium silicate, and tricalcium phosphate bioceramics. J. Biomater. Appl. 2009, 24, 139-158.
89. Chiara, G.; Letizia, F.; Lorenzo, F.; Edoardo, S.; Diego, S.; Stefano, S.; Eriberto, B.; Barbara, Z. Nanostructured biomaterials for tissue engineered bone tissue reconstruction. Int. J. Mol. Sci. 2012, 13, 737-757.
90. Schieker, M.; Seitz, H.; Drosse, I.; Seitz, S.; Mutschler, W. Biomaterials as scaffold for bone tissue engineering. Eur. J. Trauma 2006, 32, 114-124.
91. Yoon, S. Y.; Park, H. C.; Jin, H. H.; Lee, W. K. Microstructural and mechanical properties of polymer-based scaffolds reinforced by hydroxyapatite. Mater. Sci. Forum 2007, 765-768.
92. Xu, C.-Z.; Yang, W.-G.; He, X.-F.; Zhou, L.-T.; Han, X.-K.; Xu, X.-F. Vascular endothelial growth factor and nano-hydroxyapatite/collagen composite in the repair of femoral defect in rats. J. Clin. Rehabil. Tissue Eng. Res. 2011, 15, doi: 10. 3969/j. issn. 1673-8225. 2011. 38. 020.
93. Jingushi, S.; Urabe, K.; Okazaki, K.; Hirata, G.; Sakai, A.; Ikenoue, T.; Iwamoto, Y. Intramuscular bone induction by human recombinant bone morphogenetic protein-2 with beta-tricalcium phosphate as a carrier: In vivo bone banking for muscle-pedicle autograft. J. Orthop. Sci. 2002, 7, 490-494.
94. Alvarez, K.; Nakajima, H. Metallic scaffolds for bone regeneration. Materials 2009, 2, 790-832.
95. Wang, X.; Li, Y.; Hodgson, P. D.; Wen, C. E. Biomimetic modification of porous TiNbZr alloy scaffold for bone tissue engineering. Tissue Eng. Part A 2009, 16, 309-316.
96. Xiong, J.; Li, Y.; Hodgson, P. D.; Wen, C. E. In vitro osteoblast-like cell proliferation on nano-hydroxyapatite coatings with different morphologies on a titanium-niobium shape memory alloy. J. Biomed. Mater. Res. Part A 2010, 95, 766-773.
97. Ge, Z.; Jin, Z.; Cao, T. Manufacture of degradable polymeric scaffolds for bone regeneration. Biomed. Mater. 2008, 3, 022001.
98. Zavan, B.; Vindigni, V.; Vezzù, K.; Zorzato, G.; Luni, C.; Abatangelo, G.; Elvassore, N.; Cortivo, R. Hyaluronan based porous nano-particles enriched with growth factors for the treatment of ulcers: A placebo-controlled study. J. Mater. Sci. 2009, 20, 235-247.
99. Vasanthan, K. S.; Subramanian, A.; Krishnan, U. M.; Sethuraman, S. Role of biomaterials, therapeutic molecules and cells for hepatic tissue engineering. Biotechnol. Adv. 2012, 30, 742-752.
100. Cao, H.; Kuboyama, N. A biodegradable porous composite scaffold of PGA/β-TCP for bone tissue engineering. Bone 2010, 46, 386-395.
101. Huang, Y.; Ren, J.; Chen, C.; Ren, T.; Zhou, X. Preparation and properties of poly (lactide-co-glycolide)(PLGA)/nano-hydroxyapatite (NHA) scaffolds by thermally induced phase separation and rabbit MSCs culture on scaffolds. J. Biomater. Appl. 2008, 22, 409-432.
102. Ghomi, H.; Fathi, M.; Edris, H. Effect of the composition of hydroxyapatite/bioactive glass nanocomposite foams on their bioactivity and mechanical properties. Mater. Res. Bull. 2012, 47, 3523-3532.
103. Lee, J. H.; Ryu, M. Y.; Baek, H.-R.; Lee, K. M.; Seo, J.-H.; Lee, H.-K. Fabrication and evaluation of porous beta-tricalcium phosphate/hydroxyapatite (60/40) composite as a bone graft extender using rat calvarial bone defect model. Sci. World J. 2013, 2013, doi: 10. 1155/2013/481789.
104. Lin, K.; Zhang, M.; Zhai, W.; Qu, H.; Chang, J. Fabrication and characterization of hydroxyapatite/wollastonite composite bioceramics with controllable properties for hard tissue repair. J. Am. Ceram. Soc. 2011, 94, 99-105.
105. Hesaraki, S.; Safari, M.; Shokrgozar, M. A. Development of β-tricalcium phosphate/sol-gel derived bioactive glass composites: Physical, mechanical, and in vitro biological evaluations. J. Biomed. Mater. Res. Part B 2009, 91, 459-469.
106. Shuai, C.; Gao, C.; Nie, Y.; Hu, H.; Zhou, Y.; Peng, S. Structure and properties of nano-hydroxypatite scaffolds for bone tissue engineering with a selective laser sintering system. Nanotechnology 2011, 22, 285703.
107. Shuai, C.; Gao, C.; Nie, Y.; Hu, H.; Qu, H.; Peng, S. Structural design and experimental analysis of a selective laser sintering system with nano-hydroxyapatite powder. J. Biomed. Nanotechnol. 2010, 6, 370-374.
108. Shuai, C.; Zhuang, J.; Hu, H.; Peng, S.; Liu, D.; Liu, J. In vitro bioactivity and degradability of β-tricalcium phosphate porous scaffold fabricated via selective laser sintering. Biotechnol. Appl. Biochem. 2013, 60, 266-273.
109. Shuai, C.; Feng, P.; Zhang, L.; Gao, C.; Hu, H.; Peng, S.; Min, A. Correlation between properties and microstructure of laser sintered porous β-tricalcium phosphate bone scaffolds. Sci. Technol. Adv. Mater. 2013, 14, 055002.
110. Shuai, C.; Li, P.; Liu, J.; Peng, S. Optimization of TCP/HAP ratio for better properties of calcium phosphate scaffold via selective laser sintering. Mater. Charact. 2013, 77, 23-31.