Pau d'arco activates Nrf2-dependent gene expression via the MEK/ERK-pathway

Journal of Toxicological Sciences

Volumn 39, Issue 2, 2014, Pages 353-361

  Richter, Michelle ^a   Winkel, Angelika F ^a   Schummer, Dietmar ^a   Gerlitz, Martin ^a   de Hoop, Meltsje ^a   Brunner, Bodo ^a   Glien, Maike ^a   Schmoll, Dieter ^a  

^a SANOFI AVENTIS DEUTSCHLAND GMBH   (Germany)

Author keywords

ERK; Keap1; Nrf2; Phytomedicine; Red lapacho

Indexed keywords

1, 4 DIAMINO 1, 4 BIS (2 AMINOPHENYLTHIO) 2, 3 DICYANOBUTADIENE; 2 (2 CHLORO 4 IODOANILINO) N CYCLOPROPYLMETHOXY 3,4 DIFLUOROBENZAMIDE; BENZENE TETRAOLE; BENZENE TRIOLE; GLYCOGEN SYNTHASE KINASE; HEME OXYGENASE 1; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PAU D ARCO EXTRACT; PHOSPHATIDYLINOSITOL 3 KINASE; PLANT EXTRACT; PLANT MEDICINAL PRODUCT; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SMALL INTERFERING RNA; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; BINDING AFFINITY; CELL STRAIN HEPG2; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; FEMALE; GENE ACTIVATION; GENE EXPRESSION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IN VITRO GENE TRANSFER; MASS SPECTROMETRY; MOUSE; NONHUMAN; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; FEMALE; GENE EXPRESSION; HEME OXYGENASE-1; HEP G2 CELLS; HUMANS; INTESTINES; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MAP KINASE SIGNALING SYSTEM; MEDICINE, TRADITIONAL; MICE; MICE, INBRED C57BL; MOLECULAR TARGETED THERAPY; NAD(P)H DEHYDROGENASE (QUINONE); NF-E2-RELATED FACTOR 2; PHYTOTHERAPY; PLANT EXTRACTS; STIMULATION, CHEMICAL; TABEBUIA; WATER;

EID: 84896474163     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.39.353     Document Type: Article

References (25)

1. Bain, J., Plater, L., Elliott, M., Shpiro, N., Hastie, C.J., McLauchlan, H., Klevernic, I., Arthur, J.S., Alessi, D.R. and Cohen, P. (2007): The selectivity of protein kinase inhibitors: a further update. Biochem. J., 408, 297-315.
2. Buckingham, J. (ed.) (2010): Dictionary of Natural Products on DVD, Version 19.1, CRC Press, Boca Raton, FL, USA.
3. Copple, I.M. (2012): The Keap1-Nrf2 cell defense pathway--a promising therapeutic target? Adv. Pharmacol., 63, 43-79.
4. Cornblatt, B.S., Ye, L., Dinkova-Kostova, A.T., Erb, M., Fahey, J.W., Singh, N.K., Chen, M.S., Stierer, T., Garrett-Mayer, E., Argani, P., Davidson, N.E., Talalay, P., Kensler, T.W. and Visvanathan, K. (2007): Preclinical and clinical evaluation of sulforaphane for chemoprevention in the breast. Carcinogenesis, 28, 1485-1490.
5. Dinkova-Kostova, A.T. and Talalay, P. (2010): NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1), a multifunctional antioxidant enzyme and exceptionally versatile cytoprotector. Arch. Biochem. Biophys., 501, 116-123.
6. Dinkova-Kostova, A.T. and Kostov, R.V. (2012): Glucosinolates and isothiocyanates in health and disease. Trends Mol. Med., 18, 337-347.
7. Feng, J., Zhang, P., Chen, X. and He, G. (2011): PI3K and ERK/ Nrf2 pathways are involved in oleanolic acid-induced heme oxygenase- 1 expression in rat vascular smooth muscle cells. Cell Biochem., 112, 1524-1531.
8. Gómez Castellanos, J.R., Prieto, J.M. and Heinrich, M. (2009): Red Lapacho (Tabebuia impetiginosa)--a global ethnopharmacological commodity? J. Ethnopharmacol., 121, 1-13.
9. Hur, W., Sun, Z., Jiang, T., Mason, D.E., Peters, E.C., Zhang, D.D., Luesch, H., Schultz, P.G. and Gray, N.S. (2010): A small-molecule inducer of the antioxidant response element. Chem. Biol., 17, 537-547.
10. Khor, T.O., Huang, M.T., Kwon, K.H., Chan, J.Y., Reddy, B.S. and Kong, A.N. (2006): Nrf2-deficient mice have an increased susceptibility to dextran sulfate sodium-induced colitis, Cancer Res., 66, 11580-11584.
11. Kim, H., Kim, W., Yum, S., Hong, S., Oh, J.E., Lee, J.W., Kwak, M.K., Park, E.J., Na, D.H. and Jung, Y. (2013): Caffeic acid phenethyl ester activation of Nrf2 pathway is enhanced under oxidative state: structural analysis and potential as a pathologically targeted therapeutic agent in treatment of colonic inflammation. Free Radic. Biol. Med., 65, 552-562.
12. Li, C.J., Averboukh, L. and Pardee, A.B. (1993): beta-Lapachone, a novel DNA topoisomerase I inhibitor with a mode of action different from camptothecin. J. Biol. Chem., 268, 22463-82246.
13. Na, H.K., Kim, E.H., Jung, J.H., Lee, H.H., Hyun, J.W. and Surh, Y.J. (2008): (-)-Epigallocatechin gallate induces Nrf2-mediated antioxidant enzyme expression via activation of PI3K and ERK in human mammary epithelial cells. Arch. Biochem. Biophys., 476, 171-177.
14. Owuor, E.D. and Kong, A.N. (2002): Antioxidants and oxidants regulated signal transduction pathways. Biochem. Pharmacol., 64, 765-770.
15. Pergola, P.E., Raskin, P., Toto, R.D., Meyer, C.J., Huff, J.W., Grossman, E.B., Krauth, M., Ruiz, S., Audhya, P., Christ-Schmidt, H., Wittes, J. and Warnock D.G. (2011): BEAM Study Investigators: Bardoxolone methyl and kidney function in CKD with type 2 diabetes. N. Engl. J. Med., 365, 327-336.
16. Rahman, I., Biswas, S.K. and Kirkham, P.A. (2006): Regulation of inflammation and redox signaling by dietary polyphenols. Biochem. Pharmacol., 72, 1439-1452.
17. Runchel, C., Matsuzawa, A. and Ichijo, H. (2011): Mitogen-activated protein kinases in mammalian oxidative stress responses. Antioxid. Redox. Signal., 15, 205-218.
18. Schmoll, D., Wasner, C., Hinds, C.J., Allan, B.B., Walther, R. and Burchell, A. (1999): Identification of a cAMP response element within the glucose- 6-phosphatase hydrolytic subunit gene promoter which is involved in the transcriptional regulation by cAMP and glucocorticoids in H4IIE hepatoma cells. Biochem. J., 338, 457-463.
19. Schmoll, D., Grempler, R., Barthel, A., Joost, H.G. and Walther, R. (2001): Phorbol ester-induced activation of mitogen-activated protein kinase/extracellular-signal-regulated kinase kinase and extracellular-signal-regulated protein kinase decreases glucose-6 -phosphatase gene expression. Biochem. J., 357, 867-873.
20. Sun, Z., Huang, Z. and Zhang, D.D. (2009): Phosphorylation of Nrf2 at multiple sites by MAP kinases has a limited contribution in modulating the Nrf2-dependent antioxidant response. PLoS One, 4, e6588.
21. Wagner, A.E., Will, O., Sturm, C., Lipinski, S., Rosenstiel, P. and Rimbach, G. (2013): DSS-induced acute colitis in C57BL/6 mice is mitigated by sulforaphane pre-treatment. J. Nutr. Biochem. 24, 2085-2091.
22. Wang, X.J., Hayes, J.D. and Wolf, C.R. (2006): Generation of a stable antioxidant response element-driven reporter gene cell line and its use to show redox-dependent activation of nrf2 by cancer chemotherapeutic agents. Cancer Res., 66, 10983-10994.
23. Yamamoto, T., Suzuki, T., Kobayashi, A., Wakabayashi, J., Maher, J., Motohashi, H. and Yamamoto, M. (2008): Physiological Significance of Reactive Cysteine Residues of Keap1 in Determining Nrf2 Activity. Mol. Cell Biol., 28, 2758-2770.
24. Yang, Y.C., Lii, C.K., Lin, A.H., Yeh, Y.W., Yao, H.T., Li, C.C., Liu, K.L. and Chen, H.W. (2001): Induction of glutathione synthesis and heme oxygenase 1 by the flavonoids butein and phloretin is mediated through the ERK/Nrf2 pathway and protects against oxidative stress. Free Radic. Biol. Med., 51, 2073-2081.
25. Yates, M.S., Tauchi, M., Katsuoka, F., Flanders, K.C., Liby, K.T., Honda, T., Gribble, G.W., Johnson, D.A., Johnson, J.A., Burton, N.C., Guilarte, T.R., Yamamoto, M., Sporn, M.B. and Kensler, T.W. (2007): Pharmacodynamic characterization of chemopreventive triterpenoids as exceptionally potent inducers of Nrf2- regulated genes. Mol. Cancer Ther., 6, 154-162.