-
1
-
-
0029353809
-
The proteasome: A protein-degrading organelle?
-
Rubin DM, Finley D. The proteasome: a protein-degrading organelle? Curr Biol 1995;5:854-4
-
(1995)
Curr Biol
, vol.5
, pp. 854-864
-
-
Rubin, D.M.1
Finley, D.2
-
2
-
-
0032488846
-
The proteasome: Compartmentalizing protease
-
Baumeister W, Walz J, Proteolysis C. The proteasome: compartmentalizing protease. Cell 1998;92:367-80
-
(1998)
Cell
, vol.92
, pp. 367-380
-
-
Baumeister, W.1
Walz, J.2
Proteolysis, C.3
-
3
-
-
0030897031
-
Structure of 20S proteasome from yeast at 2.4 A resolution
-
Groll M, Ditzel L, Lowe J, et al. Structure of 20S proteasome from yeast at 2.4 A resolution. Nature 1997;386(6624):463-71
-
(1997)
Nature
, vol.386
, Issue.6624
, pp. 463-471
-
-
Groll, M.1
Ditzel, L.2
Lowe, J.3
-
4
-
-
0036713383
-
Proteasome subunit Rpn1 binds ubiquitin-like protein domains
-
Elsasser S, Gali RR, Schwickart M, et al. Proteasome subunit Rpn1 binds ubiquitin-like protein domains. Nat Cell Biol 2002;4:725-30
-
(2002)
Nat Cell Biol
, vol.4
, pp. 725-730
-
-
Elsasser, S.1
Gali, R.R.2
Schwickart, M.3
-
5
-
-
1542344435
-
Proteasomes and their kin: Proteases in the machine age
-
Pickart CM, Cohen RE. Proteasomes and their kin: proteases in the machine age. Nat Rev Mol Cell Biol 2004;5:177-87
-
(2004)
Nat Rev Mol Cell Biol
, vol.5
, pp. 177-187
-
-
Pickart, C.M.1
Cohen, R.E.2
-
6
-
-
1542344946
-
Phosphorylation of 20S proteasome alpha subunit C8 (alpha7) stabilizes the 26S proteasome and plays a role in the regulation of proteasome complexes by gamma-interferon
-
Bose S, Stratford F, Broadfoot K, et al. Phosphorylation of 20S proteasome alpha subunit C8 (alpha7) stabilizes the 26S proteasome and plays a role in the regulation of proteasome complexes by gamma-interferon. Biochem J 2004;378:177-84
-
(2004)
Biochem J
, vol.378
, pp. 177-184
-
-
Bose, S.1
Stratford, F.2
Broadfoot, K.3
-
7
-
-
84896487374
-
20S proteasome and its inhibitors: Crystallographic knowledge for drug development
-
Borissenko L, Groll M. 20S proteasome and its inhibitors: crystallographic knowledge for drug development. Chem Inform 2007;38:687-717
-
(2007)
Chem Inform
, vol.38
, pp. 687-717
-
-
Borissenko, L.1
Groll, M.2
-
8
-
-
78649350792
-
The ubiquitin-proteasome system and assays to determine responses to inhibitors
-
Tsvetkov L, Nanjundan M, Domino M, et al. The ubiquitin-proteasome system and assays to determine responses to inhibitors. Expert Opin Drug Discov 2010;5:1221-36
-
(2010)
Expert Opin Drug Discov
, vol.5
, pp. 1221-1236
-
-
Tsvetkov, L.1
Nanjundan, M.2
Domino, M.3
-
9
-
-
84856373151
-
Proteasome inhibitors: An expanding army attacking a unique target
-
Kisselev AF, van der Linden WA, Overkleeft HS. Proteasome inhibitors: an expanding army attacking a unique target. Chem Biol 2012;19:99-115
-
(2012)
Chem Biol
, vol.19
, pp. 99-115
-
-
Kisselev, A.F.1
Van Der Linden, W.A.2
Overkleeft, H.S.3
-
10
-
-
1042278905
-
Proteasome and peptidase function in MHC-class-I-mediated antigen presentation
-
Kloetzel PM, Ossendorp F. Proteasome and peptidase function in MHC-class-I-mediated antigen presentation. Curr Opin Immunol 2004;16:76-81
-
(2004)
Curr Opin Immunol
, vol.16
, pp. 76-81
-
-
Kloetzel, P.M.1
Ossendorp, F.2
-
11
-
-
44749085669
-
Thymoproteasome: Probable role in generating positively selecting peptides
-
Murata S, Takahama Y, Tanaka K. Thymoproteasome: probable role in generating positively selecting peptides. Curr Opin Immunol 2008;20:192-6
-
(2008)
Curr Opin Immunol
, vol.20
, pp. 192-196
-
-
Murata, S.1
Takahama, Y.2
Tanaka, K.3
-
12
-
-
0033920566
-
Protease inhibitor-induced apoptosis: Accumulation of wt p53, p21WAF1/CIP1, and induction of apoptosis are independent markers of proteasome inhibition
-
An W, Hwang S, Trepel J, et al. Protease inhibitor-induced apoptosis: accumulation of wt p53, p21WAF1/CIP1, and induction of apoptosis are independent markers of proteasome inhibition. Leukemia 2000; 14: 1276
-
(2000)
Leukemia
, vol.14
, pp. 1276
-
-
An, W.1
Hwang, S.2
Trepel, J.3
-
13
-
-
14544303662
-
Proteasome inhibition as a novel therapeutic target in human cancer
-
Rajkumar SV, Richardson PG, Hideshima T, et al. Proteasome inhibition as a novel therapeutic target in human cancer. J Clin Oncol 2005;23:630-9
-
(2005)
J Clin Oncol
, vol.23
, pp. 630-639
-
-
Rajkumar, S.V.1
Richardson, P.G.2
Hideshima, T.3
-
14
-
-
0036240701
-
The proteasome: A novel target for cancer chemotherapy
-
Almond J, Cohen G. The proteasome: a novel target for cancer chemotherapy. Leukemia 2002;16:433
-
(2002)
Leukemia
, vol.16
, pp. 433
-
-
Almond, J.1
Cohen, G.2
-
15
-
-
58149159907
-
Dysfunction of the ubiquitin-proteasome system in multiple disease conditions: Therapeutic approaches
-
Paul S. Dysfunction of the ubiquitin-proteasome system in multiple disease conditions: therapeutic approaches. Bioessays 2008;30:1172-84
-
(2008)
Bioessays
, vol.30
, pp. 1172-1184
-
-
Paul, S.1
-
16
-
-
77649162855
-
Sent to destroy: The ubiquitin proteasome system regulates cell signaling and protein quality control in cardiovascular development and disease
-
Willis MS, Townley-Tilson WD, Kang EY, et al. Sent to destroy: the ubiquitin proteasome system regulates cell signaling and protein quality control in cardiovascular development and disease. Circ Res 2010;106:463-78
-
(2010)
Circ Res
, vol.106
, pp. 463-478
-
-
Willis, M.S.1
Townley-Tilson, W.D.2
Kang, E.Y.3
-
17
-
-
72949089694
-
Proteasome inhibition during myocardial infarction
-
Yu X, Kem DC. Proteasome inhibition during myocardial infarction. Cardiovasc Res 2010;85:312-20
-
(2010)
Cardiovasc Res
, vol.85
, pp. 312-320
-
-
Yu, X.1
Kem, D.C.2
-
18
-
-
78650840827
-
The role of proteasome inhibition with bortezomib in the treatment of antibody-mediated rejection after kidney-only or kidney-combined organ transplantation
-
Flechner SM, Fatica R, Askar M, et al. The role of proteasome inhibition with bortezomib in the treatment of antibody-mediated rejection after kidney-only or kidney-combined organ transplantation. Transplantation 2010;90:1486-92
-
(2010)
Transplantation
, vol.90
, pp. 1486-1492
-
-
Flechner, S.M.1
Fatica, R.2
Askar, M.3
-
20
-
-
0034864799
-
Proteasome inhibitors: From research tools to drug candidates
-
Kisselev AF, Goldberg AL. Proteasome inhibitors: from research tools to drug candidates. Chem Biol 2001;8:739-58
-
(2001)
Chem Biol
, vol.8
, pp. 739-758
-
-
Kisselev, A.F.1
Goldberg, A.L.2
-
21
-
-
0037376230
-
Potential for proteasome inhibition in the treatment of cancer
-
Adams J. Potential for proteasome inhibition in the treatment of cancer. Drug Discov Today 2003;8(7):307-15
-
(2003)
Drug Discov Today
, vol.8
, Issue.7
, pp. 307-315
-
-
Adams, J.1
-
22
-
-
67650754085
-
Design, synthesis, biological evaluation, and structure-activity relationship (SAR) discussion of dipeptidyl boronate proteasome inhibitors, part I: Comprehensive understanding of the SAR of alpha-amino acid boronates
-
Zhu Y, Zhao X, Zhu X, et al. Design, synthesis, biological evaluation, and structure-activity relationship (SAR) discussion of dipeptidyl boronate proteasome inhibitors, part I: comprehensive understanding of the SAR of alpha-amino acid boronates. J Med Chem 2009;52:4192-9
-
(2009)
J Med Chem
, vol.52
, pp. 4192-4199
-
-
Zhu, Y.1
Zhao, X.2
Zhu, X.3
-
23
-
-
84860436602
-
Advances in the understanding of mechanisms and therapeutic use of bortezomib
-
Mujtaba T, Dou Q. Advances in the understanding of mechanisms and therapeutic use of bortezomib. Discov Med 2011;12:471-80
-
(2011)
Discov Med
, vol.12
, pp. 471-480
-
-
Mujtaba, T.1
Dou, Q.2
-
24
-
-
4644248931
-
Phase II study of the proteasome inhibitor bortezomib (PS-341) in patients with metastatic neuroendocrine tumors
-
Shah MH, Young D, Kindler HL, et al. Phase II study of the proteasome inhibitor bortezomib (PS-341) in patients with metastatic neuroendocrine tumors. Clin Cancer Res 2004;10:6111-18
-
(2004)
Clin Cancer Res
, vol.10
, pp. 6111-6118
-
-
Shah, M.H.1
Young, D.2
Kindler, H.L.3
-
25
-
-
4644304196
-
Phase II trial of bortezomib for patients with advanced renal cell carcinoma
-
Kondagunta GV, Drucker B, Schwartz L, et al. Phase II trial of bortezomib for patients with advanced renal cell carcinoma. J Clin Oncol 2004;22:3720-5
-
(2004)
J Clin Oncol
, vol.22
, pp. 3720-3725
-
-
Kondagunta, G.V.1
Drucker, B.2
Schwartz, L.3
-
26
-
-
20444364475
-
A phase II study of bortezomib in the treatment of metastatic malignant melanoma
-
Markovic SN, Geyer SM, Dawkins F, et al. A phase II study of bortezomib in the treatment of metastatic malignant melanoma. Cancer 2005;103:2584-9
-
(2005)
Cancer
, vol.103
, pp. 2584-2589
-
-
Markovic, S.N.1
Geyer, S.M.2
Dawkins, F.3
-
32
-
-
84873893188
-
Carfilzomib: A novel treatment in relapsed and refractory multiple myeloma
-
Fostier K, De Becker A, Schots R. Carfilzomib: a novel treatment in relapsed and refractory multiple myeloma. Oncol Targets Ther 2012;5:237
-
(2012)
Oncol Targets Ther
, vol.5
, pp. 237
-
-
Fostier, K.1
De Becker, A.2
Schots, R.3
-
33
-
-
36148944490
-
Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, against preclinical models of multiple myeloma
-
Kuhn DJ, Chen Q, Voorhees PM, et al. Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, against preclinical models of multiple myeloma. Blood 2007;110:3281-90
-
(2007)
Blood
, vol.110
, pp. 3281-3290
-
-
Kuhn, D.J.1
Chen, Q.2
Voorhees, P.M.3
-
34
-
-
34447116376
-
Antitumor activity of PR-171, a novel irreversible inhibitor of the proteasome
-
Demo SD, Kirk CJ, Aujay MA, et al. Antitumor activity of PR-171, a novel irreversible inhibitor of the proteasome. Cancer Res 2007;67:6383-91
-
(2007)
Cancer Res
, vol.67
, pp. 6383-6391
-
-
Demo, S.D.1
Kirk, C.J.2
Aujay, M.A.3
-
41
-
-
84896459114
-
-
US Food and Drug Administration
-
US Food and Drug Administration. Approved Drugs-Carfilzomib. 2012. Available from: http://www.fda. gov/Drugs/InformationOnDrugs/ApprovedDrugs/ ucm312945.htm
-
(2012)
Approved Drugs-Carfilzomib.
-
-
-
42
-
-
33744924884
-
Microarray-assisted pathway analysis identifies mitogen-activated protein kinase signaling as a mediator of resistance to the green tea polyphenol epigallocatechin 3-gallate in her-2/neu-overexpressing breast cancer cells
-
Guo S, Lu J, Subramanian A, et al. Microarray-assisted pathway analysis identifies mitogen-activated protein kinase signaling as a mediator of resistance to the green tea polyphenol epigallocatechin 3-gallate in her-2/neu-overexpressing breast cancer cells. Cancer Res 2006;66:5322-9
-
(2006)
Cancer Res
, vol.66
, pp. 5322-5329
-
-
Guo, S.1
Lu, J.2
Subramanian, A.3
-
43
-
-
33745627071
-
Green tea, black tea and breast cancer risk: A meta-analysis of epidemiological studies
-
Sun CL, Yuan JM, Koh WP, et al. Green tea, black tea and breast cancer risk: a meta-analysis of epidemiological studies. Carcinogenesis 2006;27:1310-15
-
(2006)
Carcinogenesis
, vol.27
, pp. 1310-1315
-
-
Sun, C.L.1
Yuan, J.M.2
Koh, W.P.3
-
44
-
-
0035731418
-
Green tea and its catechins inhibit breast cancer xenografts
-
Sartippour MR, Heber D, Ma J, et al. Green tea and its catechins inhibit breast cancer xenografts. Nutr Cancer 2001;40:149-56
-
(2001)
Nutr Cancer
, vol.40
, pp. 149-156
-
-
Sartippour, M.R.1
Heber, D.2
Ma, J.3
-
45
-
-
0031878494
-
Inhibition of spontaneous formation of lung tumors and rhabdomyosarcomas in A/J mice by black and green tea
-
Landau JM, Wang ZY, Yang GY, et al. Inhibition of spontaneous formation of lung tumors and rhabdomyosarcomas in A/J mice by black and green tea. Carcinogenesis 1998;19:501-7
-
(1998)
Carcinogenesis
, vol.19
, pp. 501-507
-
-
Landau, J.M.1
Wang, Z.Y.2
Yang, G.Y.3
-
46
-
-
21144458334
-
Synergistic effect ofgreen tea catechins on cell growth and apoptosis induction in gastric carcinoma cells
-
Horie N, Hirabayashi N, Takahashi Y, et al. Synergistic effect ofgreen tea catechins on cell growth and apoptosis induction in gastric carcinoma cells. Biol Pharm Bull 2005;28:574-9
-
(2005)
Biol Pharm Bull
, vol.28
, pp. 574-579
-
-
Horie, N.1
Hirabayashi, N.2
Takahashi, Y.3
-
47
-
-
31544473720
-
Chemoprevention of human prostate cancer by oral administration of green tea catechins in volunteers with high-grade prostate intraepithelial neoplasia: A preliminary report from a one-year proof-of-principle study
-
Bettuzzi S, Brausi M, Rizzi F, et al. Chemoprevention of human prostate cancer by oral administration of green tea catechins in volunteers with high-grade prostate intraepithelial neoplasia: a preliminary report from a one-year proof-of-principle study. Cancer Res 2006;66:1234-40
-
(2006)
Cancer Res
, vol.66
, pp. 1234-1240
-
-
Bettuzzi, S.1
Brausi, M.2
Rizzi, F.3
-
48
-
-
0042738859
-
Inhibition of bladder tumor growth by the green tea derivative epigallocatechin-3-gallate
-
Kemberling J, Hampton JA, Keck RW, et al. Inhibition of bladder tumor growth by the green tea derivative epigallocatechin-3-gallate. J Urol 2003;170:773-6
-
(2003)
J Urol
, vol.170
, pp. 773-776
-
-
Kemberling, J.1
Hampton, J.A.2
Keck, R.W.3
-
49
-
-
0347417005
-
Docking studies and model development of tea polyphenol proteasome inhibitors: Applications to rational drug design
-
Smith DM, Daniel KG, Wang Z, et al. Docking studies and model development of tea polyphenol proteasome inhibitors: applications to rational drug design. Proteins 2003;54:58-70
-
(2003)
Proteins
, vol.54
, pp. 58-70
-
-
Smith, D.M.1
Daniel, K.G.2
Wang, Z.3
-
50
-
-
0035918278
-
Ester bond-containing tea polyphenols potently inhibit proteasome activity in vitro and in vivo
-
Nam S, Smith DM, Dou QP. Ester bond-containing tea polyphenols potently inhibit proteasome activity in vitro and in vivo. J Biol Chem 2001;276:13322-30
-
(2001)
J Biol Chem
, vol.276
, pp. 13322-13330
-
-
Nam, S.1
Smith, D.M.2
Dou, Q.P.3
-
51
-
-
54849417391
-
Natural polyphenols as proteasome modulators and their role as anti-cancer compounds
-
Bonfili L, Cecarini V, Amici M, et al. Natural polyphenols as proteasome modulators and their role as anti-cancer compounds. FEBS J 2008;275:5512-26
-
(2008)
FEBS J
, vol.275
, pp. 5512-5526
-
-
Bonfili, L.1
Cecarini, V.2
Amici, M.3
-
55
-
-
33751275548
-
A novel anticancer gold(III) dithiocarbamate compound inhibits the activity of a purified 20S proteasome and 26S proteasome in human breast cancer cell cultures and xenografts
-
Milacic V, Chen D, Ronconi L, et al. A novel anticancer gold(III) dithiocarbamate compound inhibits the activity of a purified 20S proteasome and 26S proteasome in human breast cancer cell cultures and xenografts. Cancer Res 2006;66:10478-86
-
(2006)
Cancer Res
, vol.66
, pp. 10478-10486
-
-
Milacic, V.1
Chen, D.2
Ronconi, L.3
-
56
-
-
64449085700
-
The tumor proteasome as a novel target for gold (III) complexes: Implications for breast cancer therapy
-
Milacic V, Dou QP. The tumor proteasome as a novel target for gold (III) complexes: implications for breast cancer therapy. Coord Chem Rev 2009;253:1649-60
-
(2009)
Coord Chem Rev
, vol.253
, pp. 1649-1660
-
-
Milacic, V.1
Dou, Q.P.2
-
57
-
-
54549114503
-
Ni (II), Cu (II), and Zn (II) diethyldithiocarbamate complexes show various activities against the proteasome in breast cancer cells
-
Cvek B, Milacic V, Taraba J, et al. Ni (II), Cu (II), and Zn (II) diethyldithiocarbamate complexes show various activities against the proteasome in breast cancer cells. J Med Chem 2008;51:6256-8
-
(2008)
J Med Chem
, vol.51
, pp. 6256-6258
-
-
Cvek, B.1
Milacic, V.2
Taraba, J.3
-
58
-
-
67649969204
-
Comparative activities of nickel (II) and zinc (II) complexes of asymmetric [NN O] ligands as 26S proteasome inhibitors
-
Frezza M, Hindo SS, Tomco D, et al. Comparative activities of nickel (II) and zinc (II) complexes of asymmetric [NN O] ligands as 26S proteasome inhibitors. Inorg Chem 2009;48:5928-37
-
(2009)
Inorg Chem
, vol.48
, pp. 5928-5937
-
-
Frezza, M.1
Hindo, S.S.2
Tomco, D.3
-
59
-
-
1542270307
-
Organic copper complexes as a new class of proteasome inhibitors and apoptosis inducers in human cancer cells
-
Daniel KG, Gupta P, Harbach RH, et al. Organic copper complexes as a new class of proteasome inhibitors and apoptosis inducers in human cancer cells. Biochem Pharmacol 2004;67:1139-51
-
(2004)
Biochem Pharmacol
, vol.67
, pp. 1139-1151
-
-
Daniel, K.G.1
Gupta, P.2
Harbach, R.H.3
-
60
-
-
84901648175
-
Clioquinol and pyrrolidine dithiocarbamate complex with copper to form proteasome inhibitors and apoptosis inducers in human breast cancer cells
-
Daniel KG, Chen D, Orlu S, et al. Clioquinol and pyrrolidine dithiocarbamate complex with copper to form proteasome inhibitors and apoptosis inducers in human breast cancer cells. Breast Cancer Res 2005;7:R897-908
-
(2005)
Breast Cancer Res
, vol.7
-
-
Daniel, K.G.1
Chen, D.2
Orlu, S.3
-
61
-
-
73949101373
-
Novel 8-hydroxylquinoline analogs induce copper-dependent proteasome inhibition and cell death in human breast cancer cells
-
Milacic V, Jiao P, Zhang B, et al. Novel 8-hydroxylquinoline analogs induce copper-dependent proteasome inhibition and cell death in human breast cancer cells. Int J Oncol 2009;35:1481-91
-
(2009)
Int J Oncol
, vol.35
, pp. 1481-1491
-
-
Milacic, V.1
Jiao, P.2
Zhang, B.3
-
62
-
-
70349911835
-
Metals in anticancer therapy: Copper (II) complexes as inhibitors of the 20S proteasome
-
Hindo SS, Frezza M, Tomco D, et al. Metals in anticancer therapy: copper (II) complexes as inhibitors of the 20S proteasome. Eur J Med Chem 2009;44:4353-61
-
(2009)
Eur J Med Chem
, vol.44
, pp. 4353-4361
-
-
Hindo, S.S.1
Frezza, M.2
Tomco, D.3
-
63
-
-
84868486281
-
Cellular and computational studies of proteasome inhibition and apoptosis induction in human cancer cells by amino acid schiff base-copper complexes
-
Zuo J, Bi C, Fan Y, et al. Cellular and computational studies of proteasome inhibition and apoptosis induction in human cancer cells by amino acid schiff base-copper complexes. J Inorg Biochem 2013;118:83-93
-
(2013)
J Inorg Biochem
, vol.118
, pp. 83-93
-
-
Zuo, J.1
Bi, C.2
Fan, Y.3
-
64
-
-
24544480850
-
Studies on derivatives of 8-hydroxyquinoline (oxine). The sensitivity and selectivity of 5-nitroso-oxine and 2-methyl-5-nitroso-oxine towards the group IIIB metals
-
Hollingshead RGW. Studies on derivatives of 8-hydroxyquinoline (oxine). The sensitivity and selectivity of 5-nitroso-oxine and 2-methyl-5-nitroso-oxine towards the group IIIB metals. Anal Chim Acta 1955;12:401-7
-
(1955)
Anal Chim Acta
, vol.12
, pp. 401-407
-
-
Hollingshead, R.G.W.1
-
67
-
-
0037455147
-
Salinosporamide A: A highly cytotoxic proteasome inhibitor from a novel microbial source, a marine bacterium of the new genus Salinospora
-
Feling RH, Buchanan GO, Mincer TJ, et al. Salinosporamide A: a highly cytotoxic proteasome inhibitor from a novel microbial source, a marine bacterium of the new genus Salinospora. Angew Chem Int Ed 2003;42:355-7
-
(2003)
Angew Chem Int Ed
, vol.42
, pp. 355-357
-
-
Feling, R.H.1
Buchanan, G.O.2
Mincer, T.J.3
-
68
-
-
62149103377
-
Discovery and development of the anticancer agent salinosporamide A (NPI-0052)
-
Fenical W, Jensen PR, Palladino MA, et al. Discovery and development of the anticancer agent salinosporamide A (NPI-0052). Bioorg Med Chem 2009;17:2175-80
-
(2009)
Bioorg Med Chem
, vol.17
, pp. 2175-2180
-
-
Fenical, W.1
Jensen, P.R.2
Palladino, M.A.3
-
69
-
-
77952564354
-
From natural product to clinical trials: NPI-0052 (salinosporamide A), a marine actinomycete-derived anticancer agent. Chapter 12
-
Lam KS, Lloyd GK, Neuteboom STC, et al. From natural product to clinical trials: NPI-0052 (salinosporamide A), a marine actinomycete-derived anticancer agent. Chapter 12. Nat Prod Chem Drug Discov 2010;355-73
-
(2010)
Nat Prod Chem Drug Discov
, pp. 355-373
-
-
Lam, K.S.1
Lloyd, G.K.2
Stc, N.3
-
73
-
-
38949125853
-
Combination of proteasome inhibitors bortezomib and NPI-0052 trigger in vivo synergistic cytotoxicity in multiple myeloma
-
Chauhan D, Singh A, Brahmandam M, et al. Combination of proteasome inhibitors bortezomib and NPI-0052 trigger in vivo synergistic cytotoxicity in multiple myeloma. Blood 2008;111:1654-64
-
(2008)
Blood
, vol.111
, pp. 1654-1664
-
-
Chauhan, D.1
Singh, A.2
Brahmandam, M.3
-
74
-
-
33748300908
-
The proteasome inhibitor NPI-0052 is a more effective inducer of apoptosis than bortezomib in lymphocytes from patients with chronic lymphocytic leukemia
-
Ruiz S, Krupnik Y, Keating M, et al. The proteasome inhibitor NPI-0052 is a more effective inducer of apoptosis than bortezomib in lymphocytes from patients with chronic lymphocytic leukemia. Mol Cancer Ther 2006;5:1836-43
-
(2006)
Mol Cancer Ther
, vol.5
, pp. 1836-1843
-
-
Ruiz, S.1
Krupnik, Y.2
Keating, M.3
-
75
-
-
34347375499
-
NPI-0052, a novel proteasome inhibitor, induces caspase-8 and ROS-dependent apoptosis alone and in combination with HDAC inhibitors in leukemia cells
-
Miller CP, Ban K, Dujka ME, et al. NPI-0052, a novel proteasome inhibitor, induces caspase-8 and ROS-dependent apoptosis alone and in combination with HDAC inhibitors in leukemia cells. Blood 2007;110:267-77
-
(2007)
Blood
, vol.110
, pp. 267-277
-
-
Miller, C.P.1
Ban, K.2
Dujka, M.E.3
-
76
-
-
66149121016
-
Caspase-8 dependent histone acetylation by a novel proteasome inhibitor, NPI-0052: A mechanism for synergy in leukemia cells
-
Miller CP, Rudra S, Keating MJ, et al. Caspase-8 dependent histone acetylation by a novel proteasome inhibitor, NPI-0052: a mechanism for synergy in leukemia cells. Blood 2009;113:4289-99
-
(2009)
Blood
, vol.113
, pp. 4289-4299
-
-
Miller, C.P.1
Rudra, S.2
Keating, M.J.3
-
77
-
-
77957991639
-
Design synthesis and biological evaluation of dibromotyrosine analogues inspired by marine natural products as inhibitors of human prostate cancer proliferation, invasion, and migration
-
Sallam AA, Ramasahayam S, Meyer SA, et al. Design, synthesis, and biological evaluation of dibromotyrosine analogues inspired by marine natural products as inhibitors of human prostate cancer proliferation, invasion, and migration. Bioorg Med Chem 2010;18:7446-57
-
(2010)
Bioorg Med Chem
, vol.18
, pp. 7446-7457
-
-
Sallam, A.A.1
Ramasahayam, S.2
Meyer, S.A.3
-
78
-
-
60049083840
-
Discovery, design, and synthesis of anti-metastatic lead phenylmethylene hydantoins inspired by marine natural products
-
Mudit M, Khanfar M, Muralidharan A, et al. Discovery, design, and synthesis of anti-metastatic lead phenylmethylene hydantoins inspired by marine natural products. Bioorg Med Chem 2009;17:1731-8
-
(2009)
Bioorg Med Chem
, vol.17
, pp. 1731-1738
-
-
Mudit, M.1
Khanfar, M.2
Muralidharan, A.3
-
82
-
-
0028286026
-
Molecular cloning of fibroblast activation protein alpha, a member of the serine protease family selectively expressed in stromal fibroblasts of epithelial cancers
-
Scanlan MJ, Raj B, Calvo B, et al. Molecular cloning of fibroblast activation protein alpha, a member of the serine protease family selectively expressed in stromal fibroblasts of epithelial cancers. Proc Natl Acad Sci 1994;91:5657-61
-
(1994)
Proc Natl Acad Sci
, vol.91
, pp. 5657-5661
-
-
Scanlan, M.J.1
Raj, B.2
Calvo, B.3
-
83
-
-
0037199968
-
Hierarchical organization of modularaity in metabolic networks
-
Ravasz E, Somera AL, Mongru DA, et al. Hierarchical organization of modularaity in metabolic networks. Science 2002;297:1551-5
-
(2002)
Science
, vol.297
, pp. 1551-1555
-
-
Ravasz, E.1
Somera, A.L.2
Mongru, D.A.3
-
84
-
-
0034609791
-
The large-scale organization of metabolic networks
-
Jeong H, Tombor B, Albert R, et al. The large-scale organization of metabolic networks. Nature 2000;407:651-4
-
(2000)
Nature
, vol.407
, pp. 651-654
-
-
Jeong, H.1
Tombor, B.2
Albert, R.3
-
85
-
-
0742305866
-
Network biology: Understanding the cell's functional organization
-
Barabasi AL, Oltvai ZN. Network biology: understanding the cell's functional organization. Nat Rev Genet 2004;5:101-13
-
(2004)
Nat Rev Genet
, vol.5
, pp. 101-113
-
-
Barabasi, A.L.1
Oltvai, Z.N.2
-
86
-
-
0037316239
-
Reconstruction of metabolic networks from genome data and analysis of their global structure for various organisms
-
Ma H, Zeng AP. Reconstruction of metabolic networks from genome data and analysis of their global structure for various organisms. Bioinformatics 2003;19:270-7
-
(2003)
Bioinformatics
, vol.19
, pp. 270-277
-
-
Ma, H.1
Zeng, A.P.2
-
88
-
-
0036176510
-
Mechanisms of cancer drug resistance
-
Gottesman MM. Mechanisms of cancer drug resistance. Annu Rev Med 2002;53:615-27
-
(2002)
Annu Rev Med
, vol.53
, pp. 615-627
-
-
Gottesman, M.M.1
-
89
-
-
16844368698
-
Annual review of medicine. Tumour stem cells and drug resistance
-
Dean M, Fojo T, Bates S. Annual review of medicine. Tumour stem cells and drug resistance. Nat Rev Cancer 2005;5:275-84
-
(2005)
Nat Rev Cancer
, vol.5
, pp. 275-284
-
-
Dean, M.1
Fojo, T.2
Bates, S.3
-
92
-
-
41949110089
-
CEP-18770: A novel, orally active proteasome inhibitor with a tumor-selective pharmacologic profile competitive with bortezomib
-
Piva R, Ruggeri B, Williams M, et al. CEP-18770: a novel, orally active proteasome inhibitor with a tumor-selective pharmacologic profile competitive with bortezomib. Blood 2008;111:2765-75
-
(2008)
Blood
, vol.111
, pp. 2765-2775
-
-
Piva, R.1
Ruggeri, B.2
Williams, M.3
-
93
-
-
84872109533
-
A first in human phase i study of the proteasome inhibitor CEP-18770 in patients with advanced solid tumours and multiple myeloma
-
Gallerani E, Zucchetti M, Brunelli D, et al. A first in human phase I study of the proteasome inhibitor CEP-18770 in patients with advanced solid tumours and multiple myeloma. Eur J Cancer 2013;49(2):290-6
-
(2013)
Eur J Cancer
, vol.49
, Issue.2
, pp. 290-296
-
-
Gallerani, E.1
Zucchetti, M.2
Brunelli, D.3
-
95
-
-
35548979078
-
Inhibition of Jak/STAT signaling ameliorates mice experimental nephrotic syndrome
-
Li R, Yang N, Zhang L, et al. Inhibition of Jak/STAT signaling ameliorates mice experimental nephrotic syndrome. Am J Nephrol 2007;27:580-9
-
(2007)
Am J Nephrol
, vol.27
, pp. 580-589
-
-
Li, R.1
Yang, N.2
Zhang, L.3
-
96
-
-
15944387964
-
The proteasome inhibitor bortezomib sensitizes cells to killing by death receptor ligand TRAIL via BH3-only proteins Bik and Bim
-
Nikrad M, Johnson T, Puthalalath H, et al. The proteasome inhibitor bortezomib sensitizes cells to killing by death receptor ligand TRAIL via BH3-only proteins Bik and Bim. Mol Cancer Ther 2005;4:443-9
-
(2005)
Mol Cancer Ther
, vol.4
, pp. 443-449
-
-
Nikrad, M.1
Johnson, T.2
Puthalalath, H.3
-
97
-
-
0642349188
-
Differential effects of the proteasome inhibitor bortezomib on apoptosis and angiogenesis in human prostate tumor xenografts
-
Williams S, Pettaway C, Song R, et al. Differential effects of the proteasome inhibitor bortezomib on apoptosis and angiogenesis in human prostate tumor xenografts. Mol Cancer Ther 2003;2:835-43
-
(2003)
Mol Cancer Ther
, vol.2
, pp. 835-843
-
-
Williams, S.1
Pettaway, C.2
Song, R.3
-
98
-
-
78049528598
-
Mechanisms of peripheral neuropathy associated with bortezomib and vincristine in patients with newly diagnosed multiple myeloma: A prospective analysis of data from the HOVON-65/GMMG-HD4 trial
-
Broyl A, Corthals SL, Jongen JL, et al. Mechanisms of peripheral neuropathy associated with bortezomib and vincristine in patients with newly diagnosed multiple myeloma: a prospective analysis of data from the HOVON-65/GMMG-HD4 trial. Lancet Oncol 2010;11:1057-65
-
(2010)
Lancet Oncol
, vol.11
, pp. 1057-1065
-
-
Broyl, A.1
Corthals, S.L.2
Jongen, J.L.3
-
99
-
-
29244454269
-
Bortezomib sensitizes pancreatic cancer cells to endoplasmic reticulum stress-mediated apoptosis
-
Nawrocki ST, Carew JS, Pino MS, et al. Bortezomib sensitizes pancreatic cancer cells to endoplasmic reticulum stress-mediated apoptosis. Cancer Res 2005;65:11658-66
-
(2005)
Cancer Res
, vol.65
, pp. 11658-11666
-
-
Nawrocki, S.T.1
Carew, J.S.2
Pino, M.S.3
-
100
-
-
28444436266
-
Risk factors and kinetics of thrombocytopenia associated with bortezomib for relapsed, refractory multiple myeloma
-
Lonial S, Waller EK, Richardson PG, et al. Risk factors and kinetics of thrombocytopenia associated with bortezomib for relapsed, refractory multiple myeloma. Blood 2005;106:3777-84
-
(2005)
Blood
, vol.106
, pp. 3777-3784
-
-
Lonial, S.1
Waller, E.K.2
Richardson, P.G.3
-
101
-
-
33750197980
-
Response to bortezomib and activation of osteoblasts in multiple myeloma
-
Zangari M, Yaccoby S, Cavallo F, et al. Response to bortezomib and activation of osteoblasts in multiple myeloma. Clin Lymphoma Myeloma 2006;7:109-14
-
(2006)
Clin Lymphoma Myeloma
, vol.7
, pp. 109-114
-
-
Zangari, M.1
Yaccoby, S.2
Cavallo, F.3
-
102
-
-
79960105001
-
Identification of genes affecting the toxicity of anti-cancer drug bortezomib by genome-wide screening in S. Pombe
-
Takeda K, Mori A, Yanagida M. Identification of genes affecting the toxicity of anti-cancer drug bortezomib by genome-wide screening in S. pombe. PloS One 2011;6:e22021
-
(2011)
PloS One
, vol.6
-
-
Takeda, K.1
Mori, A.2
Yanagida, M.3
-
103
-
-
45849152092
-
A novel role for a familiar protein in apoptosis induced by proteasome inhibition
-
McConkey DJ. A novel role for a familiar protein in apoptosis induced by proteasome inhibition. Cancer Cell 2008;14:1-2
-
(2008)
Cancer Cell
, vol.14
, pp. 1-2
-
-
McConkey, D.J.1
-
104
-
-
42949125866
-
Target specificity and off-target effects as determinants of cancer drug efficacy
-
Shoshan MC, Linder S. Target specificity and off-target effects as determinants of cancer drug efficacy. Expert Opin Drug Metab Toxicol 2008;4(3):273-80
-
(2008)
Expert Opin Drug Metab Toxicol
, vol.4
, Issue.3
, pp. 273-280
-
-
Shoshan, M.C.1
Linder, S.2
-
105
-
-
77649237033
-
Building on bortezomib: Second-generation proteasome inhibitors as anti-cancer therapy
-
Dick LR, Fleming PE. Building on bortezomib: second-generation proteasome inhibitors as anti-cancer therapy. Drug Discov Today 2010;15:243-9
-
(2010)
Drug Discov Today
, vol.15
, pp. 243-249
-
-
Dick, L.R.1
Fleming, P.E.2
-
106
-
-
79955498420
-
Nonproteasomal targets of the proteasome inhibitors bortezomib and carfilzomib: A link to clinical adverse events
-
Arastu-Kapur S, Anderl JL, Kraus M, et al. Nonproteasomal targets of the proteasome inhibitors bortezomib and carfilzomib: a link to clinical adverse events. Clin Cancer Res 2011;17:2734-43
-
(2011)
Clin Cancer Res
, vol.17
, pp. 2734-2743
-
-
Arastu-Kapur, S.1
Anderl, J.L.2
Kraus, M.3
-
107
-
-
77953163141
-
Genome-wide siRNA screen for modulators of cell death induced by proteasome inhibitor bortezomib
-
Chen S, Blank JL, Peters T, et al. Genome-wide siRNA screen for modulators of cell death induced by proteasome inhibitor bortezomib. Cancer Res 2010;70:4318-26
-
(2010)
Cancer Res
, vol.70
, pp. 4318-4326
-
-
Chen, S.1
Blank, J.L.2
Peters, T.3
-
108
-
-
45849099115
-
Argyrin A reveals a critical role for the tumor suppressor protein p27 in mediating antitumor activities in response to proteasome inhibition
-
Nickeleit I, Zender S, Sasse F, et al. Argyrin A reveals a critical role for the tumor suppressor protein p27 in mediating antitumor activities in response to proteasome inhibition. Cancer Cell 2008;14:23-35
-
(2008)
Cancer Cell
, vol.14
, pp. 23-35
-
-
Nickeleit, I.1
Zender, S.2
Sasse, F.3
|