Involvement of the osteoinductive factors, Tmem119 and BMP-2, and the ER stress response PERK-eIF2α-ATF4 pathway in the commitment of myoblastic into osteoblastic cells

Calcified Tissue International

Volumn 94, Issue 4, 2014, Pages 454-464

  Tanaka, Ken Ichiro ^a   Kaji, Hiroshi ^b   Yamaguchi, Toru ^a   Kanazawa, Ippei ^a   Canaff, Lucie ^c,d   Hendy, Geoffrey N ^c,d   Sugimoto, Toshitsugu ^a  

^a SHIMANE UNIVERSITY FACULTY OF MEDICINE   (Japan)

^b KINKI UNIVERSITY   (Japan)

^c MCGILL UNIVERSITY   (Canada)

^d ROYAL VICTORIA HOSPITAL   (Canada)

Author keywords

Bone morphogenetic protein; Endoplasmic reticulum stress; Myoblast; Osteoblast; PERK eIF2 ATF4; Tmem119

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; ALP PROTEIN; ANTIBIOTIC G 418; BONE MORPHOGENETIC PROTEIN 2; COLLAGEN TYPE 1; INITIATION FACTOR 2ALPHA; LIPOFECTAMINE; MEMBRANE PROTEIN; MEMBRANE PROTEIN 119; OSTEOCALCIN; SALUBRINAL; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR OSTERIX; TRANSCRIPTION FACTOR RUNX2; UNCLASSIFIED DRUG; ATF4 PROTEIN, MOUSE; BMP2 PROTEIN, HUMAN; BMP2 PROTEIN, MOUSE; CINNAMIC ACID DERIVATIVE; EIF2ALPHA KINASE, MOUSE; OBIF PROTEIN, MOUSE; PERK KINASE; PROTEIN KINASE R; PROTEIN SERINE THREONINE KINASE; RECOMBINANT PROTEIN; THIOUREA;

ANIMAL CELL; ARTICLE; BIOSYNTHESIS; BONE DEVELOPMENT; CELL DIFFERENTIATION; CONTROLLED STUDY; DEPHOSPHORYLATION; ENDOPLASMIC RETICULUM STRESS; HUMAN; MINERALIZATION; MOUSE; MYOBLAST; NONHUMAN; OSTEOBLAST; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN INDUCTION; RADIOIMMUNOPRECIPITATION; REAL TIME POLYMERASE CHAIN REACTION; RNA EXTRACTION; STABLE TRANSFECTION; TRANSIENT TRANSFECTION; 3T3 CELL LINE; ANALOGS AND DERIVATIVES; ANIMAL; CELL LINE; CHEMISTRY; CYTOLOGY; ENDOPLASMIC RETICULUM; GENE EXPRESSION REGULATION; METABOLISM; SIGNAL TRANSDUCTION;

3T3 CELLS; ACTIVATING TRANSCRIPTION FACTOR 4; ANIMALS; BONE MORPHOGENETIC PROTEIN 2; CELL DIFFERENTIATION; CELL LINE; CINNAMATES; EIF-2 KINASE; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; GENE EXPRESSION REGULATION; HUMANS; MEMBRANE PROTEINS; MICE; MYOBLASTS; OSTEOBLASTS; PROTEIN-SERINE-THREONINE KINASES; RECOMBINANT PROTEINS; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; THIOUREA;

EID: 84896455034     PISSN: 0171967X     EISSN: 14320827     Source Type: Journal    
DOI: 10.1007/s00223-013-9828-1     Document Type: Article

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