Interaction of Tmem119 and the bone morphogenetic protein pathway in the commitment of myoblastic into osteoblastic cells

Bone

Volumn 51, Issue 1, 2012, Pages 158-167

  Tanaka, Ken Ichiro ^a,b   Inoue, Yoshifumi ^a   Hendy, Geoffrey N ^a,c,g,h   Canaff, Lucie ^a,c,g,h   Katagiri, Takenobu ^d   Kitazawa, Riko ^d   Komori, Toshihisa ^e   Sugimoto, Toshitsugu ^b   Seino, Susumu ^a,f   Kaji, Hiroshi ^a,f  

^a KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b SHIMANE UNIVERSITY FACULTY OF MEDICINE   (Japan)

^c Department of Medicine ^*  (Canada)

^d MCGILL UNIVERSITY   (Canada)

^e ROYAL VICTORIA HOSPITAL   (Canada)

^f SAITAMA MEDICAL UNIVERSITY   (Japan)

^g NAGASAKI UNIVERSITY GRADUATE SCHOOL OF BIOMEDICAL SCIENCES   (Japan)

^h KINKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Bone morphogenetic protein; Fibrodysplasia ossificans progressiva; Muscle ossification; Myoblast; Osteoblast; Tmem119

Indexed keywords

ACTIVIN LIKE KINASE 2; ALKALINE PHOSPHATASE; BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN 4; CELL PROTEIN; DORSOMORPHIN; ENZYME INHIBITOR; NEUTRALIZING ANTIBODY; OSTEOCALCIN; PHOSPHOTRANSFERASE; SMAD1 PROTEIN; SMAD5 PROTEIN; SMALL INTERFERING RNA; TMEM119 PROTEIN; TRANSCRIPTION FACTOR OSTERIX; TRANSCRIPTION FACTOR RUNX2; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BONE MINERALIZATION; CARTILAGE CELL; CELL DIFFERENTIATION; CONTROLLED STUDY; DNA MICROARRAY; DNA SEQUENCE; DOWN REGULATION; GENE EXPRESSION REGULATION; GENE IDENTIFICATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MICROARRAY ANALYSIS; MOLECULAR CLONING; MOUSE; MUSCLE CELL; MYOBLAST; NONHUMAN; NUCLEOTIDE SEQUENCE; OSSIFICATION; OSTEOBLAST; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; REAL TIME POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN 4; BONE MORPHOGENETIC PROTEINS; CELL DIFFERENTIATION; CELL LINE; HUMANS; MEMBRANE PROTEINS; MICE; MYOBLASTS; OSTEOBLASTS; OSTEOCALCIN; REAL-TIME POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION;

EID: 84861806427     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2012.04.017     Document Type: Article

References (34)

1. Shore E.M., Kaplan F.S. Insights from a rare genetic disorder of extra-skeletal bone formation, fibrodysplasia ossificans progressiva (FOP). Bone 2008, 43:427-433.
2. Shore E.M., Xu M., Feldman G.J., Fenstermacher D.A., Cho T.J., Choi I.H., et al. A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva. Nat Genet 2006, 38:525-527.
3. Fukuda T., Kohda M., Kanomata K., Nojima J., Nakamura A., Kamizono J., et al. Constitutively activated ALK2 and increased SMAD1/5 cooperatively induce bone morphogenetic protein signaling in fibrodysplasia ossificans progressiva. J Biol Chem 2009, 284:7149-7156.
4. Song G.A., Kim H.J., Woo K.M., Baek J.H., Kim G.S., Choi J.Y., et al. Molecular consequences of the ACVR1(R206H) mutation of fibrodysplasia ossificans progressiva. J Biol Chem 2010, 285:22542-22553.
5. van Dinther M., Visser N., de Gorter D.J., Doorn J., Goumans M.J., de Boer J., et al. ALK2 R206H mutation linked to fibrodysplasia ossificans progressiva confers constitutive activity to the BMP type I receptor and sensitizes mesenchymal cells to BMP-induced osteoblast differentiation and bone formation. J Bone Miner Res 2010, 25:1208-1215.
6. Yu P.B., Deng D.Y., Lai C.S., Hong C.C., Cuny G.D., Bouxsein M.L., et al. BMP type I receptor inhibition reduces heterotopic ossification. Nat Med 2008, 14:1363-1369.
7. Wang E.A., Rosen V., Cordes P., Hewick R.M., Kriz M.J., Luxenberg D.P., et al. Purification and characterization of other distinct bone-inducing factors. Proc Natl Acad Sci U S A 1988, 85:9484-9488.
8. Wozney J.M., Rosen V., Celeste A.J., Mitsock L.M., Whitters M.J., Kriz R.W., et al. Novel regulators of bone formation: molecular clones and activities. Science 1988, 242:1528-1534.
9. Fujii M., Takeda K., Imamura T., Aoki H., Sampath T.K., Enomoto S., et al. Roles of bone morphogenetic protein type I receptors and Smad proteins in osteoblast and chondroblast differentiation. Mol Biol Cell 1999, 10:3801-3813.
10. Nishimura R., Kato Y., Chen D., Harris S.E., Mundy G.R., Yoneda T. Smad5 and DPC4 are key molecules in mediating BMP-2-induced osteoblastic differentiation of the pluripotent mesenchymal precursor cell line C2C12. J Biol Chem 1998, 273:1872-1879.
11. Yamaguchi A., Katagiri T., Ikeda T., Wozney J.M., Rosen V., Wang E.A., et al. Recombinant human bone morphogenetic protein-2 stimulates osteoblastic maturation and inhibits myogenic differentiation in vitro. J Cell Biol 1991, 113:681-687.
12. Bragdon B., Moseychuk O., Saldanha S., King D., Julian J., Nohe A. Bone morphogenetic proteins: a critical review. Cell Signal 2011, 23:609-620.
13. Hecht J., Seitz V., Urban M., Wagner F., Robinson P.N., Stiege A., et al. Detection of novel skeletogenesis target genes by comprehensive analysis of a Runx2(-/-) mouse model. Gene Expr Patterns 2007, 7:102-112.
14. Sowa H., Kaji H., Yamaguchi T., Sugimoto T., Chihara K. Activations of ERK1/2 and JNK by transforming growth factor beta negatively regulate Smad3-induced alkaline phosphatase activity and mineralization in mouse osteoblastic cells. J Biol Chem 2002, 277:36024-36031.
15. Hisa I., Inoue Y., Hendy G.N., Canaff L., Kitazawa R., Kitazawa S., et al. Parathyroid hormone-responsive Smad3-related factor, Tmem119, promotes osteoblast differentiation and interacts with the bone morphogenetic protein-Runx2 pathway. J Biol Chem 2011, 286:9787-9796.
16. Kanamoto T., Mizuhashi K., Terada K., Minami T., Yoshikawa H., Furukawa T. Isolation and characterization of a novel plasma membrane protein, osteoblast induction factor (obif), associated with osteoblast differentiation. BMC Dev Biol 2009, 9:70.
17. Sowa H., Kaji H., Hendy G.N., Canaff L., Komori T., Sugimoto T., et al. Menin is required for bone morphogenetic protein 2- and transforming growth factor beta-regulated osteoblastic differentiation through interaction with Smads and Runx2. J Biol Chem 2004, 279:40267-40275.
18. Sowa H., Kaji H., Canaff L., Hendy G.N., Tsukamoto T., Yamaguchi T., et al. Inactivation of menin, the product of the multiple endocrine neoplasia type 1 gene, inhibits the commitment of multipotential mesenchymal stem cells into the osteoblast lineage. J Biol Chem 2003, 278:21058-21069.
19. Harada H., Tagashira S., Fujiwara M., Ogawa S., Katsumata T., Yamaguchi A., et al. Cbfa1 isoforms exert functional differences in osteoblast differentiation. J Biol Chem 1999, 274:6972-6978.
20. Shikano S., Bonkobara M., Zukas P.K., Ariizumi K. Molecular cloning of a dendritic cell-associated transmembrane protein, DC-HIL, that promotes RGD-dependent adhesion of endothelial cells through recognition of heparan sulfate proteoglycans. J Biol Chem 2001, 276:8125-8134.
21. Wodarz A., Nusse R. Mechanisms of Wnt signaling in development. Annu Rev Cell Dev Biol 1998, 14:59-88.
22. Lee K.S., Kim H.J., Li Q.L., Chi X.Z., Ueta C., Komori T., et al. Runx2 is a common target of transforming growth factor β1 and bone morphogenetic protein 2, and cooperation between Runx2 and Smad5 induces osteoblast-specific gene expression in the pluripotent mesenchymal precursor cell line C2C12. Mol Cell Biol 2000, 20:8783-8792.
23. Fang J., Hall B.K. Chondrogenic cell differentiation from membrane bone periostea. Anat Embryol 1997, 196:349-362.
24. Komori T. Runx2, a multifunctional transcription factor in skeletal development. J Cell Biochem 2002, 87:1-8.
25. Stein G.S., Lian J.B., van Wijnen A.J., Stein J.L., Montecino M., Javed A., et al. Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression. Oncogene 2004, 23:4315-4329.
26. Nojima J., Kanomata K., Takada Y., Fukuda T., Kokabu S., Ohte S., et al. Dual roles of smad proteins in the conversion from myoblasts to osteoblastic cells by bone morphogenetic proteins. J Biol Chem 2010, 285:15577-15586.
27. Aziz A., Miyake T., Engleka K.A., Epstein J.A., McDermott J.C. Menin expression modulates mesenchymal cell commitment to the myogenic and osteogenic lineages. Dev Biol 2009, 332:116-130.
28. Nakashima A., Katagiri T., Tamura M. Cross-talk between Wnt and bone morphogenetic protein-2 (BMP-2) signaling in differentiation pathway of C2C12 myoblasts. J Biol Chem 2005, 280:37660-37668.
29. Chen Y., Whetstone H.C., Youn A., Nadesan P., Chow E.C., Lin A.C., et al. β-Catenin signaling pathway is crucial for bone morphogenetic protein 2 to induce new bone formation. J Biol Chem 2007, 282:526-533.
30. Pizette S., Niswander L. BMPs are required at two steps of limb chondrogenesis: formation of prechondrogenic condensations and their differentiation into chondrocytes. Dev Biol 2000, 219:237-249.
31. Sun J., Kamei C.N., Layne M.D., Jain M.K., Liao J.K., Lee M.E., et al. Regulation of myogenic terminal differentiation by the hairy-related transcription factor CHF2. J Biol Chem 2001, 276:18591-18596.
32. Balint E., Lapointe D., Drissi H., va der Meijden C., Young D.W., van Wijnen A.J., et al. Phenotype discovery by gene expression profiling: mapping of biological processes linked to BMP-2-mediated osteoblast differentiation. J Cell Biochem 2003, 89:401-426.
33. Kugimiya F., Kawaguchi H., Kamekura S., Chikuda H., Ohba S., Yano F., et al. Involvement of endogenous bone morphogenetic protein (BMP) 2 and BMP6 in bone formation. J Biol Chem 2005, 280:35704-35712.
34. Tsuji K., Bandyopadhyay A., Harfe B.D., Cox K., Kakar S., Gerstenfeld L., et al. BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing. Nat Genet 2006, 38:1424-1429.