Osteoporosis regulation by salubrinal through eIF2α mediated differentiation of osteoclast and osteoblast

Cellular Signalling

Volumn 25, Issue 2, 2013, Pages 552-560

  He, Long ^a   Lee, Junwon ^b   Jang, Jae Hyuk ^a   Sakchaisri, Krisada ^a   Hwang, Joonsung ^a   Cha Molstad, Hyun Joo ^a   Kim, Kyung A ^a   Ryoo, In Ja ^a   Lee, Hee Gu ^a   Kim, Sun Ok ^a   Soung, Nak Kyun ^a   Lee, Kyung Sang ^c   Kwon, Yong Tae ^d,e   Erikson, Raymond Leo ^f   Ahn, Jong Seog ^a   Kim, Bo Yeon ^a  

^a Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^b PaiChai University   (South Korea)

^c NATIONAL CANCER INSTITUTE   (United States)

^d UNIVERSITY OF PITTSBURGH   (United States)

^e Seoul National University   (South Korea)

^f HARVARD UNIVERSITY   (United States)

Author keywords

EIF2 ; NFATc1; Osteoblast; Osteoclast; Salubrinal

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; ALKALINE PHOSPHATASE; INITIATION FACTOR 2ALPHA; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN C FOS; SALUBRINAL; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR NFAT; TRANSCRIPTION FACTOR NFATC1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE DENSITY; CELL DIFFERENTIATION; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GENE EXPRESSION; MOUSE; NONHUMAN; OSTEOBLAST; OSTEOCLASTOGENESIS; OSTEOPOROSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; PROTEIN SYNTHESIS;

ACTIVATING TRANSCRIPTION FACTOR 4; ANIMALS; BONE MARROW CELLS; CALCIUM; CELL DIFFERENTIATION; CELLS, CULTURED; CINNAMATES; COCULTURE TECHNIQUES; DISEASE MODELS, ANIMAL; EUKARYOTIC INITIATION FACTOR-2; FEMUR; MICE; NFATC TRANSCRIPTION FACTORS; OSTEOBLASTS; OSTEOCLASTS; OSTEOPOROSIS; PHOSPHORYLATION; RANK LIGAND; RNA INTERFERENCE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; THIOUREA; TIBIA;

MUS;

EID: 84870802028     PISSN: 08986568     EISSN: 18733913     Source Type: Journal    
DOI: 10.1016/j.cellsig.2012.11.015     Document Type: Article

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