Cryptotanshinone induces G1 cell cycle arrest and autophagic cell death by activating the AMP-activated protein kinase signal pathway in HepG2 hepatoma

Apoptosis

Volumn 19, Issue 4, 2014, Pages 615-628

  Park, In Ja ^a   Yang, Woo Kyeom ^a   Nam, Sang Hee ^a   Hong, Jongki ^b   Yang, Ki Ryeol ^b   Kim, Joungmok ^b   Kim, Sung Soo ^a   Choe, Wonchae ^a   Kang, Insug ^a   Ha, Joohun ^a  

^a Kyung Hee University Hospital   (South Korea)

^b Kyung Hee University   (South Korea)

Author keywords

AMPK; Autophagy; Cell cycle arrest; Cryptotanshinone; HepG2 hepatoma

Indexed keywords

CRYPTOTANSHINONE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; METFORMIN; PROTEIN KINASE LKB1; PROTEIN P53; TUBERIN; ANTINEOPLASTIC AGENT; PHENANTHRENE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGY; CANCER CELL; CELL DEATH; CELL STRAIN HEPG2; CONTROLLED STUDY; DRUG MECHANISM; G1 PHASE CELL CYCLE CHECKPOINT; HEPATOMA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SALVIA MILTIORRHIZA; SIGNAL TRANSDUCTION; TUMOR GROWTH; TUMOR XENOGRAFT; ANIMAL; CANCER TRANSPLANTATION; DRUG EFFECTS; ENZYME ACTIVATION; HEPG2 CELL LINE; METABOLISM; NUDE MOUSE; XENOGRAFT;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; AUTOPHAGY; ENZYME ACTIVATION; G1 PHASE CELL CYCLE CHECKPOINTS; HEP G2 CELLS; HETEROGRAFTS; HUMANS; MALE; METFORMIN; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; PHENANTHRENES; SIGNAL TRANSDUCTION;

EID: 84896400209     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-013-0929-0     Document Type: Article

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