Upregulation of HIF-2α induced by sorafenib contributes to the resistance by activating the TGF-α/EGFR pathway in hepatocellular carcinoma cells

Cellular Signalling

Volumn 26, Issue 5, 2014, Pages 1030-1039

  Zhao, Dali ^a   Zhai, Bo ^a   He, Changjun ^b   Tan, Gang ^a   Jiang, Xian ^a   Pan, Shangha ^a   Dong, Xuesong ^a   Wei, Zheng ^a   Ma, Lixin ^a   Qiao, Haiquan ^a   Jiang, Hongchi ^a   Sun, Xueying ^a  

^a THE FIRST AFFILIATED HOSPITAL OF HARBIN MEDICAL UNIVERSITY   (China)

^b HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

Epidermal growth factor receptor ; Hepatocellular carcinoma; Hypoxia; Hypoxia inducible factor 2 ; Sorafenib; Transforming growth factor

Indexed keywords

CYCLIN D1; EPIDERMAL GROWTH FACTOR RECEPTOR; GEFITINIB; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; SMALL INTERFERING RNA; SORAFENIB; STAT3 PROTEIN; TRANSFORMING GROWTH FACTOR ALPHA; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CANCER RESISTANCE; CELL HYPOXIA; CONTROLLED STUDY; DNA SEQUENCE; DOWN REGULATION; DRUG EFFICACY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INTRACELLULAR SIGNALING; LIVER CELL CARCINOMA; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TARGETING; UPREGULATION; CANCER CELL; CELL PROLIFERATION; DRUG POTENTIATION; DRUG PROTEIN BINDING; ENZYME PHOSPHORYLATION; GENETIC TRANSFECTION; IC50; PROTEIN STABILITY; SIGNAL TRANSDUCTION;

EPIDERMAL GROWTH FACTOR RECEPTOR-Α; HEPATOCELLULAR CARCINOMA; HYPOXIA; HYPOXIA-INDUCIBLE FACTOR-2 Α; SORAFENIB; TRANSFORMING GROWTH FACTOR-Α;

ANIMALS; ANTINEOPLASTIC AGENTS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; DRUG RESISTANCE, NEOPLASM; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LIVER NEOPLASMS; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; NIACINAMIDE; PHENYLUREA COMPOUNDS; QUINAZOLINES; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR ALPHA; UP-REGULATION;

EID: 84896377628     PISSN: 08986568     EISSN: 18733913     Source Type: Journal    
DOI: 10.1016/j.cellsig.2014.01.026     Document Type: Article

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