miR-224 promotion of cell migration and invasion by targeting Homeobox D 10 gene in human hepatocellular carcinoma

Journal of Gastroenterology and Hepatology (Australia)

Volumn 29, Issue 4, 2014, Pages 835-842

  Li, Qiong ^a   Ding, Chenchen ^b   Chen, Chuan ^b   Zhang, Zhimin ^b   Xiao, He ^b   Xie, Fei ^b   Lei, Lin ^b   Chen, Yuanyuan ^b   Mao, Bijing ^b   Jiang, Mei ^b   Li, Jian ^b   Wang, Dong ^b   Wang, Ge ^b  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

^b THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

HOXD10; Human hepatocellular carcinoma (HCC); Invasion; Migration; MiR 224

Indexed keywords

GELATINASE B; HOMEOBOX D 10; HOMEODOMAIN PROTEIN; MICRORNA; MICRORNA 224; P21 ACTIVATED KINASE 4; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; CANCER TISSUE; CELL INVASION; CELL MIGRATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER CELL CARCINOMA; LUCIFERASE ASSAY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING; QUANTITATIVE ANALYSIS; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR GENE; TUMOR INVASION; UPREGULATION; WESTERN BLOTTING;

HOXD10; HUMAN HEPATOCELLULAR CARCINOMA (HCC); INVASION; MIGRATION; MIR-224;

CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CELL MOVEMENT; GENE EXPRESSION; GENE EXPRESSION REGULATION, NEOPLASTIC; HOMEODOMAIN PROTEINS; HUMANS; LIVER NEOPLASMS; MATRIX METALLOPROTEINASE 9; MICRORNAS; NEOPLASM INVASIVENESS; P21-ACTIVATED KINASES; TRANSCRIPTION FACTORS;

EID: 84896359372     PISSN: 08159319     EISSN: 14401746     Source Type: Journal    
DOI: 10.1111/jgh.12429     Document Type: Article

References (42)

1. Lai ECH, Lau WY. The continuing challenge of hepatic cancer in Asia. Surgeon 2005; 3: 210-215.
2. Calin GA, Croce CM. MicroRNA signatures in human cancers. Nat. Rev. Cancer 2006; 6: 857-866.
3. Zhang B, Pan X, Cobb GP, Anderson TA. MicroRNAs as oncogenes and tumor suppressors. Dev. Biol. 2007; 302: 1-12.
4. Gramantieri L, Fornari F, Callegari E etal. MicroRNA involvement in hepatocellular carcinoma. J. Cell. Mol. Med. 2008; 12: 2189-2204.
5. Coulouarn C, Factor VM, Andersen JB, Durkin ME, Thorgeirsson SS. Loss of miR-122 expression in liver cancer correlates with suppression of the hepatic phenotype and gain of metastatic properties. Oncogene 2009; 28: 3526-3536.
6. Li N, Fu H, Tie Y etal. miR-34a inhibits migration and invasion by down-regulation of c-Met expression in human hepatocellular carcinoma cells. Cancer Lett. 2009; 275: 44-53.
7. Meng F, Henson R, Wehbe-Janek H, Ghoshal K, Jacob ST, Patel T. MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer. Gastroenterology 2007; 133: 647-658.
8. Lin S-L, Miller JD, Ying S-Y. Intronic MicroRNA (mi RNA). BioMed Res. Int. 2006; 2006: 26818.
9. Zhang Y, He B-S, Pan Y-Q, Xu Y-Q, Wang S-K. Association of OGG1 Ser326Cys polymorphism with colorectal cancer risk: a meta-analysis. Int. J Colorectal Dis. 2011; 26: 1525-1530.
10. Zhang Y, Takahashi S, Tasaka A, Yoshima T, Ochi H, Chayama K. Involvement of microRNA-224 in cell proliferation, migration, invasion and anti-apoptosis in hepatocellular carcinoma. J. Gastroenterol. Hepatol. 2013; 28: 565-575.
11. Wang Y, Lee ATC, Ma JZI etal. Profiling microRNA expression in hepatocellular carcinoma reveals microRNA-224 up-regulation and apoptosis inhibitor-5 as a microRNA-224-specific target. J. Biol. Chem. 2008; 283: 13205-13215.
12. Yao G, Yin M, Lian J etal. MicroRNA-224 is involved in transforming growth factor-β-mediated mouse granulosa cell proliferation and granulosa cell function by targeting Smad4. Mol. Endocrinol. 2010; 24: 540-551.
13. Li Q, Wang G, Shan JL etal. MicroRNA-224 is upregulated in HepG2 cells and involved in cellular migration and invasion. J. Gastroenterol. Hepatol. 2009; 25: 164-171.
14. Paliouras GN, Naujokas MA, Park M. Pak4, a novel Gab1 binding partner, modulates cell migration and invasion by the Met receptor. Mol. Cell. Biol. 2009; 29: 3018-3032.
15. Mak GW-Y, Chan MM-L, Leong VY-L etal. Overexpression of a novel activator of PAK4, the CDK5 kinase-associated protein CDK5RAP3, promotes hepatocellular carcinoma metastasis. Cancer Res. 2011; 71: 2949-2958.
16. Turpeenniemi-Hujanen T. Gelatinases (MMP-2 and-9) and their natural inhibitors as prognostic indicators in solid cancers. Biochimie 2005; 87: 287-297.
17. Makiyama K, Hamada J-I, Takada M etal. Aberrant expression of HOX genes in human invasive breast carcinoma. Oncol. Rep. 2005; 13: 673-679.
18. Cho M, Yashar P, Kim SK etal. HoxD10 gene delivery using adenovirus/adeno-associate hybrid virus inhibits the proliferation and tumorigenicity of GH4 pituitary lactotrope tumor cells. Biochem. Biophys. Res. Commun. 2008; 371: 371-374.
19. Sun L, Yan W, Wang Y etal. MicroRNA-10b induces glioma cell invasion by modulating MMP-14 and uPAR expression via HOXD10. Brain Res. 2011; 1389: 9-18.
20. Wang L, Chen S, Xue M etal. Homeobox D10 gene, a candidate tumor suppressor, is downregulated through promoter hypermethylation and associated with gastric carcinogenesis. Mol. Med. 2012; 18: 389-400.
21. Tian J, Tang ZY, Ye SL etal. New human hepatocellular carcinoma (HCC) cell line with highly metastatic potential (MHCC97) and its expressions of the factors associated with metastasis. Br. J. Cancer 1999; 81: 814-821.
22. Li Y, Tang Z-Y, Ye S-L etal. Establishment of cell clones with different metastatic potential from the metastatic hepatocellular carcinoma cell line MHCC97. World J. Gastroenterol. 2001; 7: 630-636.
23. Wu Q-f, Liu C, Tai M-h etal. Knockdown of FoxM1 by siRNA interference decreases cell proliferation, induces cell cycle arrest and inhibits cell invasion in MHCC-97H cells in vitro. Acta Pharmacol. Sin. 2010; 31: 361-366.
24. Mencia N, Selga E, Noé V. Underexpression of miR-224 in methotrexate resistant human colon cancer cells. Biochem. Pharmacol. 2011; 82: 1572-1582.
25. Mees ST, Mardin WA, Sielker S etal. Involvement of CD40 targeting miR-224 and miR-486 on the progression of pancreatic ductal adenocarcinomas. Ann. Surg. Oncol. 2009; 16: 2339-2350.
26. Prueitt RL, Yi M, Hudson RS etal. Expression of microRNAs and protein-coding genes associated with perineural invasion in prostate cancer. Prostate 2008; 68: 1152-1164.
27. Nikiforova MN, Tseng GC, Steward D, Diorio D, Nikiforov YE. MicroRNA expression profiling of thyroid tumors: biological significance and diagnostic utility. J. Clin. Endocrinol. Metab. 2008; 93: 1600-1608.
28. Barber BA, Rastegar M. Epigenetic control of Hox genes during neurogenesis, development, and disease. Ann. Anat. 2010; 192: 261-274.
29. Bitu CC, Destro MFSS, Carrera M etal. HOXA1 is overexpressed in oral squamous cell carcinomas and its expression is correlated with poor prognosis. BMC Cancer 2012; 12: 146-156.
30. Di Vinci A, Brigati C, Casciano I etal. HOXA7, 9, and 10 are methylation targets associated with aggressive behavior in meningiomas. Transl. Res. 2012; 160: 355-362.
31. Shah CA, Bei L, Wang H, Platanias LC, Eklund EA. HoxA10 protein regulates transcription of gene encoding fibroblast growth factor 2 (FGF2) in myeloid cells. J. Biol. Chem. 2012; 287: 18230-18248.
32. Yekta S, Tabin CJ, Bartel DP. MicroRNAs in the Hox network: an apparent link to posterior prevalence. Nat. Rev. Genet. 2008; 9: 789-796.
33. Yekta S, Shih I, Bartel DP. MicroRNA-directed cleavage of HOXB8 mRNA. Sci. Signal. 2004; 304: 594-596.
34. Li Q, Zhu F, Chen P. miR-7 and miR-218 epigenetically control tumor suppressor genes RASSF1A and Claudin-6 by targeting HoxB3 in breast cancer. Biochem. Biophys. Res. Commun. 2012; 424: 28-33.
35. Carrio M, Arderiu G, Myers C, Boudreau NJ. Homeobox D10 induces phenotypic reversion of breast tumor cells in a three-dimensional culture model. Cancer Res. 2005; 65: 7177-7185.
36. Liu Z, Zhu J, Cao H, Ren H, Fang X. miR-10b promotes cell invasion through RhoC-AKT signaling pathway by targeting HOXD10 in gastric cancer. Int. J. Oncol. 2012; 40: 1560-1567.
37. Steeg PS. Cancer: micromanagement of metastasis. Nature 2007; 449: 671-673.
38. Clark EA, Golub TR, Lander ES, Hynes RO. Genomic analysis of metastasis reveals an essential role for RhoC. Nature 2000; 406: 532-535.
39. Zha Y, Ding E, Yang L etal. Functional dissection of HOXD cluster genes in regulation of neuroblastoma cell proliferation and differentiation. PloS ONE 2012; 7: e40728.
40. Ye DZ, Field J. PAK signaling in cancer. Cell. Logistics 2012; 2: 105-116.
41. Zhang H-J, Siu MKY, Yeung MCW etal. Overexpressed PAK4 promotes proliferation, migration and invasion of choriocarcinoma. Carcinogenesis 2011; 32: 765-771.
42. Kaneyoshi T, Nakatsukasa H, Higashi T etal. Actual invasive potential of human hepatocellular carcinoma revealed by in situ gelatin zymography. Clin. Cancer Res. 2001; 7: 4027-4032.