Functional dissection of HOXD cluster genes in regulation of neuroblastoma cell proliferation and differentiation

PLoS ONE

Volumn 7, Issue 8, 2012, Pages

  Zha, Yunhong ^a,c   Ding, Emily ^b   Yang, Liqun ^a   Mao, Ling ^a,d   Wang, Xiangwei ^a,e   McCarthy, Brian A ^a   Huang, Shuang ^a   Ding, Han Fei ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

^b Lakeside High School   (United States)

^c Three Gorges University College of Medicine   (China)

^d HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^e THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

HOX PROTEIN; PROTEIN HOXD8; PROTEIN HOXD9; RETINOIC ACID; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; 5' UNTRANSLATED REGION; ARTICLE; CANCER INHIBITION; CELL CYCLE PROGRESSION; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; GENE; GENE ACTIVATION; GENE CONTROL; GENE FUNCTION; GENE INDUCTION; GENE LOCATION; HOXD GENE; HOXD1 GENE; HOXD10 GENE; HOXD11 GENE; HOXD12 GENE; HOXD13 GENE; HOXD3 GENE; HOXD4 GENE; HOXD8 GENE; HOXD9 GENE; HUMAN; HUMAN CELL; NERVE CELL DIFFERENTIATION; NEUROBLASTOMA CELL; PROTEIN EXPRESSION; TRANSCRIPTION INITIATION; UPREGULATION;

CELL CYCLE; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASES; CYCLINS; DOWN-REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, NEOPLASM; HOMEODOMAIN PROTEINS; HUMANS; MULTIGENE FAMILY; NEUROBLASTOMA; SIGNAL TRANSDUCTION; TRETINOIN;

EID: 84864714031     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0040728     Document Type: Article

References (50)

1. Alexander T, Nolte C, Krumlauf R, (2009) Hox genes and segmentation of the hindbrain and axial skeleton. Annu Rev Cell Dev Biol 25: 431-456.
2. Maden M, (2007) Retinoic acid in the development, regeneration and maintenance of the nervous system. Nat Rev Neurosci 8: 755-765.
3. Pearson JC, Lemons D, McGinnis W, (2005) Modulating Hox gene functions during animal body patterning. Nat Rev Genet 6: 893-904.
4. Moens CB, Selleri L, (2006) Hox cofactors in vertebrate development. Dev Biol 291: 193-206.
5. Shah N, Sukumar S, (2010) The Hox genes and their roles in oncogenesis. Nat Rev Cancer 10: 361-371.
6. Jones-Villeneuve EM, McBurney MW, Rogers KA, Kalnins VI, (1982) Retinoic acid induces embryonal carcinoma cells to differentiate into neurons and glial cells. J Cell Biol 94: 253-262.
7. McBurney MW, Jones-Villeneuve EM, Edwards MK, Anderson PJ, (1982) Control of muscle and neuronal differentiation in a cultured embryonal carcinoma cell line. Nature 299: 165-167.
8. Strubing C, Ahnert-Hilger G, Shan J, Wiedenmann B, Hescheler J, et al. (1995) Differentiation of pluripotent embryonic stem cells into the neuronal lineage in vitro gives rise to mature inhibitory and excitatory neurons. Mech Dev 53: 275-287.
9. Sidell N, (1982) Retinoic acid-induced growth inhibition and morphologic differentiation of human neuroblastoma cells in vitro. J Natl Cancer Inst 68: 589-596.
10. Mavilio F, Simeone A, Boncinelli E, Andrews PW, (1988) Activation of four homeobox gene clusters in human embryonal carcinoma cells induced to differentiate by retinoic acid. Differentiation 37: 73-79.
11. Simeone A, Acampora D, Arcioni L, Andrews PW, Boncinelli E, et al. (1990) Sequential activation of HOX2 homeobox genes by retinoic acid in human embryonal carcinoma cells. Nature 346: 763-766.
12. Simeone A, Acampora D, Nigro V, Faiella A, D'Esposito M, et al. (1991) Differential regulation by retinoic acid of the homeobox genes of the four HOX loci in human embryonal carcinoma cells. Mech Dev 33: 215-227.
13. Peverali FA, D'Esposito M, Acampora D, Bunone G, Negri M, et al. (1990) Expression of HOX homeogenes in human neuroblastoma cell culture lines. Differentiation 45: 61-69.
14. Manohar CF, Furtado MR, Salwen HR, Cohn SL, (1993) Hox gene expression in differentiating human neuroblastoma cells. Biochem Mol Biol Int 30: 733-741.
15. Manohar CF, Salwen HR, Furtado MR, Cohn SL, (1996) Up-regulation of HOXC6, HOXD1, and HOXD8 homeobox gene expression in human neuroblastoma cells following chemical induction of differentiation. Tumour Biol 17: 34-47.
16. Brodeur GM, (2003) Neuroblastoma: biological insights into a clinical enigma. Nat Rev Cancer 3: 203-216.
17. Maris JM, (2010) Recent Advances in Neuroblastoma. New England Journal of Medicine 362: 2202-2211.
18. Beckwith JB, Martin RF, (1968) Observations on the histopathology of neuroblastomas. J Pediatr Surg 3: 106-110.
19. Hughes M, Marsden HB, Palmer MK, (1974) Histologic patterns of neuroblastoma related to prognosis and clinical staging. Cancer 34: 1706-1711.
20. Shimada H, Chatten J, Newton WA Jr, Sachs N, Hamoudi AB, et al. (1984) Histopathologic prognostic factors in neuroblastic tumors: definition of subtypes of ganglioneuroblastoma and an age-linked classification of neuroblastomas. J Natl Cancer Inst 73: 405-416.
21. Ambros IM, Hata J, Joshi VV, Roald B, Dehner LP, et al. (2002) Morphologic features of neuroblastoma (Schwannian stroma-poor tumors) in clinically favorable and unfavorable groups. Cancer 94: 1574-1583.
22. Cohn SL, Pearson ADJ, London WB, Monclair T, Ambros PF, et al. (2009) The International Neuroblastoma Risk Group (INRG) Classification System: An INRG Task Force Report. Journal of Clinical Oncology 27: 289-297.
23. Reynolds CP, Matthay KK, Villablanca JG, Maurer BJ, (2003) Retinoid therapy of high-risk neuroblastoma. Cancer Lett 197: 185-192.
24. Volchenboum SL, Cohn SL, (2009) Progress in defining and treating high-risk neuroblastoma: lessons from the bench and bedside. J Clin Oncol 27: 1003-1004.
25. Mao L, Ding J, Zha Y, Yang L, McCarthy BA, et al. (2011) HOXC9 Links Cell-Cycle Exit and Neuronal Differentiation and Is a Prognostic Marker in Neuroblastoma. Cancer Res 71: 4314-4324.
26. Ross RA, Spengler BA, Domenech C, Porubcin M, Rettig WJ, et al. (1995) Human neuroblastoma I-type cells are malignant neural crest stem cells. Cell Growth Differ 6: 449-456.
27. Cui H, Ma J, Ding J, Li T, Alam G, et al. (2006) Bmi-1 regulates the differentiation and clonogenic self-renewal of I-type neuroblastoma cells in a concentration-dependent manner. J Biol Chem 281: 34696-34704.
28. Boncinelli E, Simeone A, Acampora D, Mavilio F, (1991) HOX gene activation by retinoic acid. Trends Genet 7: 329-334.
29. Lufkin T, (1996) Transcriptional control of Hox genes in the vertebrate nervous system. Curr Opin Genet Dev 6: 575-580.
30. Sawhney N, Hall PA, (1992) Ki67-structure, function, and new antibodies. J Pathol 168: 161-162.
31. Murray AW, (2004) Recycling the cell cycle: cyclins revisited. Cell 116: 221-234.
32. Satyanarayana A, Kaldis P, (2009) Mammalian cell-cycle regulation: several Cdks, numerous cyclins and diverse compensatory mechanisms. Oncogene 28: 2925-2939.
33. Gaetano C, Matsumoto K, Thiele CJ, (1991) Retinoic acid negatively regulates p34cdc2 expression during human neuroblastoma differentiation. Cell Growth Differ 2: 487-493.
34. Matsuo T, Thiele CJ, (1998) p27Kip1: a key mediator of retinoic acid induced growth arrest in the SMS-KCNR human neuroblastoma cell line. Oncogene 16: 3337-3343.
35. Alam G, Cui H, Shi H, Yang L, Ding J, et al. (2009) MYCN promotes the expansion of Phox2B-positive neuronal progenitors to drive neuroblastoma development. Am J Pathol 175: 856-866.
36. Hahn CK, Ross KN, Warrington IM, Mazitschek R, Kanegai CM, et al. (2008) Expression-based screening identifies the combination of histone deacetylase inhibitors and retinoids for neuroblastoma differentiation. Proc Natl Acad Sci U S A 105: 9751-9756.
37. Svingen T, Tonissen KF, (2006) Hox transcription factors and their elusive mammalian gene targets. Heredity 97: 88-96.
38. Schuettengruber B, Chourrout D, Vervoort M, Leblanc B, Cavalli G, (2007) Genome regulation by polycomb and trithorax proteins. Cell 128: 735-745.
39. Matthay KK, Villablanca JG, Seeger RC, Stram DO, Harris RE, et al. (1999) Treatment of high-risk neuroblastoma with intensive chemotherapy, radiotherapy, autologous bone marrow transplantation, and 13-cis-retinoic acid. Children's Cancer Group. N Engl J Med 341: 1165-1173.
40. Matthay KK, Reynolds CP, Seeger RC, Shimada H, Adkins ES, et al. (2009) Long-term results for children with high-risk neuroblastoma treated on a randomized trial of myeloablative therapy followed by 13-cis-retinoic acid: a children's oncology group study. J Clin Oncol 27: 1007-1013.
41. Marshall H, Morrison A, Studer M, Popperl H, Krumlauf R, (1996) Retinoids and Hox genes. FASEB J 10: 969-978.
42. Soshnikova N, Duboule D, (2009) Epigenetic temporal control of mouse Hox genes in vivo. Science 324: 1320-1323.
43. Lawrence PA, Morata G, (1994) Homeobox genes: their function in Drosophila segmentation and pattern formation. Cell 78: 181-189.
44. Chisaka O, Capecchi MR, (1991) Regionally restricted developmental defects resulting from targeted disruption of the mouse homeobox gene hox-1.5. Nature 350: 473-479.
45. Greer JM, Puetz J, Thomas KR, Capecchi MR, (2000) Maintenance of functional equivalence during paralogous Hox gene evolution. Nature 403: 661-665.
46. Zhao Y, Potter SS, (2002) Functional comparison of the Hoxa 4, Hoxa 10, and Hoxa 11 homeoboxes. Dev Biol 244: 21-36.
47. Duboule D, (2007) The rise and fall of Hox gene clusters. Development 134: 2549-2560.
48. Yahagi N, Kosaki R, Ito T, Mitsuhashi T, Shimada H, et al. (2004) Position-specific expression of Hox genes along the gastrointestinal tract. Congenit Anom (Kyoto) 44: 18-26.
49. Pattyn A, Morin X, Cremer H, Goridis C, Brunet JF, (1997) Expression and interactions of the two closely related homeobox genes Phox2a and Phox2b during neurogenesis. Development 124: 4065-4075.
50. Silva JM, Marran K, Parker JS, Silva J, Golding M, et al. (2008) Profiling essential genes in human mammary cells by multiplex RNAi screening. Science 319: 617-620.