Drd2 expression in the high alcohol-preferring and low alcohol-preferring mice

Mammalian Genome

Volumn 19, Issue 2, 2008, Pages 69-76

  Bice, Paula J ^a   Liang, Tiebing ^a   Zhang, Lili ^a   Strother, Wendy N ^a   Carr, Lucinda G ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; COMPLEMENTARY DNA; MESSENGER RNA;

3' UNTRANSLATED REGION; ALCOHOL CONSUMPTION; AMYGDALOID NUCLEUS; ANIMAL TISSUE; ARTICLE; BRAIN REGION; CONTROLLED STUDY; DOPAMINE RECEPTOR 2 GENE; DOPAMINERGIC SYSTEM; GENE; GENE EXPRESSION; HIPPOCAMPUS; HUMAN; HUMAN CELL; IN VITRO STUDY; MALE; MOUSE; NEUROBLASTOMA CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; NUCLEUS ACCUMBENS; QUANTITATIVE TRAIT LOCUS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEPTUM PELLUCIDUM; SINGLE NUCLEOTIDE POLYMORPHISM;

3' UNTRANSLATED REGIONS; ALCOHOL DRINKING; ANIMALS; CELL LINE, TUMOR; GENE EXPRESSION REGULATION; HUMANS; LUCIFERASES; MICE; POLYMORPHISM, GENETIC; RECEPTORS, DOPAMINE D2; RNA, MESSENGER;

MUS;

EID: 39149105264     PISSN: 09388990     EISSN: 14321777     Source Type: Journal    
DOI: 10.1007/s00335-007-9089-2     Document Type: Article

References (68)

1. Arinami T, Itokawa M, Komiyama T, Mitsushio H, Mori H, et al. (1993) Association between severity of alcoholism and the A1 allele of the dopamine D2 receptor gene TaqI A RFLP in Japanese. Biol Psychiatry 33:108-114
2. Bau CH, Almeida S, Hutz MH (2000) The TaqI A1 allele of the dopamine D2 receptor gene and alcoholism in Brazil: association and interaction with stress and harm avoidance on severity prediction. Am J Med Genet 96:302-306
3. Belknap JK, Atkins AL (2001) The replicability of QTLs for murine alcohol preference drinking behavior across eight independent studies. Mamm Genome 12:893-899
4. Bice PJ, Foroud T, Carr LG, Zhang L, Liu L, et al. (2006) Identification of QTLs influencing alcohol preference in the High Alcohol Preferring (HAP) and Low Alcohol Preferring (LAP) mouse lines. Behav Genet 36:248-260
5. Blum K, Noble EP, Sheridan PJ, Montgomery A, Ritchie T, et al. (1990) Allelic association of human dopamine D2 receptor gene in alcoholism. JAMA 263:2055-2060
6. Blum K, Noble EP, Sheridan PJ, Finley O, Montgomery A, et al. (1991) Association of the A1 allele of the D2 dopamine receptor gene with severe alcoholism. Alcohol 8:409-416
7. Blum K, Noble EP, Sheridan PJ, Montgomery A, Ritchie T, et al. (1993) Genetic predisposition in alcoholism: association of the D2 dopamine receptor TaqI B1 RFLP with severe alcoholics. Alcohol 10:59-67
8. Blum K, Sheridan PJ, Wood RC, Braverman ER, Chen TJ, et al. (1996) The D2 dopamine receptor gene as a determinant of reward deficiency syndrome. J R Soc Med 89:396-400
9. Bolos AM, Dean M, Lucas-Derse S, Ramsburg M, Brown GL, et al. (1990) Population and pedigree studies reveal a lack of association between the dopamine D2 receptor gene and alcoholism. JAMA 264:3156-3160
10. Bowirrat A, Oscar-Berman M (2005) Relationship between dopaminergic neurotransmission, alcoholism, and Reward Deficiency syndrome. Am J Med Genet B Neuropsychiatr Genet 132:29-37
11. Comings DE, Comings BG, Muhleman D, Dietz G, Shahbahrami B, et al. (1991) The dopamine D2 receptor locus as a modifying gene in neuropsychiatric disorders. JAMA 266:1793-1800
12. Cook BL, Wang ZW, Crowe RR, Hauser R, Freimer M (1992) Alcoholism and the D2 receptor gene. Alcohol Clin Exp Res 16:806-809
13. Cunningham CL (1995) Localization of genes influencing ethanol-induced conditioned place preference and locomotor activity in BXD recombinant inbred mice. Psychopharmacology 120:28-41
14. Dyr W, McBride WJ, Lumeng L, Li TK, Murphy JM (1993) Effects of D1 and D2 dopamine receptor agents on ethanol consumption in the high-alcohol-drinking (HAD) line of rats. Alcohol 10:207-212
15. Edenberg HJ, Foroud T, Koller DL, Goate A, Rice J, et al. (1998) A family-based analysis of the association of the dopamine D2 receptor (DRD2) with alcoholism. Alcohol Clin Exp Res 22:505-512
16. Gelernter J, O'Malley S, Risch N, Kranzler HR, Krystal J, et al. (1991) No association between an allele at the D2 dopamine receptor gene (DRD2) and alcoholism. JAMA 266:1801-1807
17. Goldman D (1993) The DRD2 dopamine receptor and the candidate gene approach in alcoholism. Alcohol Alcohol Suppl 2:27-29
18. Goldman D, Dean M, Brown GL, Bolos AM, Tokola R, et al. (1992) D2 dopamine receptor genotype and cerebrospinal fluid homovanillic acid, 5-hydroxyindoleacetic acid and 3-methoxy-4-hydroxyphenylglycol in alcoholics in Finland and the United States. Acta Psychiatr Scand 86:351-357
19. Goldman D, Urbanek M, Guenther D, Robin R, Long JC (1997) Linkage and association of functional DRD2 variant [Ser311Cys] and DRD2 markers to alcoholism, substance abuse and schizophrenia in Southwestern American Indians. Am J Med Genet 74:386-394
20. Gongwer MA, Murphy JM, McBride WJ, Lumeng L, Li TK (1989) Regional brain contents of serotonin, dopamine and their metabolites in the selectively bred high- and low-alcohol drinking lines of rats. Alcohol 6:317-320
21. Goodwin FL, Koechling UM, Smith BR, Amit Z (1996) Lack of effect of dopamine D2 blockade on ethanol intake in selected and unselected strains of rats. Alcohol 13:273-279
22. Grahame NJ, Li TK, Lumeng L (1999) Selective breeding for high and low alcohol preference in mice. Behav Genet 29:47-57
23. Guardia J, Catafau AM, Batlle F, Martin JC, Segura L, et al. (2000) Striatal dopaminergic D(2) receptor density measured by [(123)I]iodobenzamide SPECT in the prediction of treatment outcome of alcohol-dependent patients. Am J Psychiatry 157:127-129
24. Hitzemann RJ (1998) The regulation of D2 dopamine receptor expression. Mol Psychiatry 3:198-203
25. Hodge CW, Chappelle AM, Samson HH (1996) Dopamine receptors in the medial prefrontal cortex influence ethanol and sucrose-reinforced responding. Alcohol Clin Exp Res 20:1631-1638
26. Hodge CW, Samson HH, Chappelle AM (1997) Alcohol self-administration: further examination of the role of dopamine receptors in the nucleus accumbens. Alcohol Clin Exp Res 21:1083-1091
27. Horvitz JC (2000) Mesolimbocortical and nigrostriatal dopamine responses to salient non-reward events. Neuroscience 96:651-656
28. Kanes S, Dains K, Cipp L, Gatley J, Hitzemann B, et al. (1996) Mapping the genes for haloperidol-induced catalepsy. J Pharmacol Exp Ther 277:1016-1025
29. Kimpel MW, Strother WN, McClintick JN, Carr LG, Liang T, Edenberg HJ, McBride WJ (2007) Functional gene expression differences between inbred alcohol-preferring (iP) and non-preferring (iNP) rats in five brain regions. Alcohol 41:95-132
30. Koob GF Vaccarino FJ, Amalric M, Bloom FE (1987) Positive reinforcement properties of drugs: search for neural substrates. In: J Engel et al. (eds.) Brain Reward Systems and Abuse, Seventh International Berzelius Symposium sponsored by the Swedish Society of Medicine. New York: Raven Press, pp 70-83
31. Levy AD, Murphy JM, McBride WJ, Lumeng L, Li TK (1991) Microinjection of sulpiride into the nucleus accumbens increases ethanol drinking in alcohol-preferring (P) rats. Alcohol Alcohol 1:417-420
32. Liang T, Spence J, Liu L, Strother WN, Chang HW, Ellison JA, Lumeng L, Li TK, Foroud T, Carr LG (2003) Alpha-Synuclein maps to a quantitative trait locus for alcohol preference and is differentially expressed in alcoholpreferring and -nonpreferring rats. Proc Natl Acad Sci 100(8):4690-4695
33. Lu RB, Ko HC, Chang FM, Castiglione CM, Schoolfield G, et al. (1996) No association between alcoholism and multiple polymorphisms at the dopamine D2 receptor gene (DRD2) in three distinct Taiwanese populations. Biol Psychiatry 39:419-429
34. Lu RB, Lee JF, Ko HC, Lin WW (2001) Dopamine D2 receptor gene (DRD2) is associated with alcoholism with conduct disorder. Alcohol Clin Exp Res 25:177-184
35. Matsumoto I, Wilce PA, Buckley T, Dodd P, Puzke J, et al. (2001) Ethanol and gene expression in brain. Alcohol Clin Exp Res 25:82S-86S
36. McBride WJ, Li TK (1998) Animal models of alcoholism: neurobiology of high alcohol-drinking behavior in rodents. Crit Rev Neurobiol 12:339-369
37. McBride WJ, Chernet E, Dyr W, Lumeng L, Li TK (1993a) Densities of dopamine D2 receptors are reduced in CNS regions of alcohol-preferring P rats. Alcohol 10:387-390
38. McBride WJ, Murphy JM, Gatto GJ, Levy AD, Yoshimoto K, et al. (1993b) CNS mechanisms of alcohol self-administration. Alcohol Alcohol 2:463-467
39. Munafo MR, Matheson IJ, Flint J (2007) Association of the DRD2 gene Taq1A polymorphism and alcoholism: a meta-analysis of case-control studies and evidence of publication bias. Mol Psychiatry 12:454-461
40. Murphy JM, McBride WJ, Lumeng L, Li TK (1987) Contents of monoamines in forebrain regions of alcohol-preferring (P) and -nonpreferring (NP) lines of rats. Pharmacol Biochem Behav 26:389-392
41. Myers RD, Robinson DE (1999) Mmu and D2 receptor antisense oligonucleotides injected in nucleus accumbens suppress high alcohol intake in genetic drinking HEP rats. Alcohol 18:225-233
42. Neiswanger K, Hill SY, Kaplan BB (1995) Association and linkage studies of the TAQI A1 allele at the dopamine D2 receptor gene in samples of female and male alcoholics. Am J Med Genet 60:267-271
43. Noble EP (1996) Alcoholism and the dopaminergic system: a review. Addict Biol 1:333-348
44. Noble EP (2003) D2 dopamine receptor gene in psychiatric and neurologic disorders and its phenotypes. Am J Med Genet B Neuropsychiatr Genet 116:103-125
45. Noble EP, Blum K, Ritchie T, Montgomery A, Sheridan PJ (1991) Allelic association of the D2 dopamine receptor gene with receptor-binding characteristics in alcoholism. Arch Gen Psychiatry 48:648-654
46. Nowak KL, McBride WJ, Lumeng L, Li TK, Murphy JM (2000) Involvement of dopamine D2 autoreceptors in the ventral tegmental area on alcohol and saccharin intake of the alcohol-preferring P rat. Alcohol Clin Exp Res 24:476-483
47. Parsian A, Todd RD, Devor EJ, O'Malley KL, Suarez BK, et al. (1991) Alcoholism and alleles of the human D2 dopamine receptor locus. Studies of association and linkage. Arch Gen Psychiatry 48:655-663
48. Parsian A, Cloninger CR, Zhang ZH (2000) Functional variant in the DRD2 receptor promoter region and subtypes of alcoholism. Am J Med Genet 96:407-411
49. Pato CN, Macciardi F, Pato MT, Verga M, Kennedy JL (1993) Review of the putative association of dopamine D2 receptor and alcoholism: a meta-analysis. Am J Med Genet 48:78-82
50. Paxinos G, Franklin KBJ (2004) The mouse brain in stereotaxic coordinates. 2nd edn. Academic Press
51. Phillips TJ, Shen EH (1996) Neurochemical bases of locomotion and ethanol stimulant effects. Int Rev Neurobiol 39:243-282
52. Phillips TJ, Brown KJ, Burkhart-Kasch S, Wenger CD, Kelly MA, et al. (1998) Alcohol preference and sensitivity are markedly reduced in mice lacking dopamine D2 receptors. Nat Neurosci 1:610-615
53. Samson HH, Tolliver GA, Schwarz-Stevens K (1990) Oral ethanol self-administration: a behavioral pharmacological approach to CNS control mechanisms. Alcohol 7:187-191
54. Samson HH, Hodge CW, Tolliver GA, Haraguchi M (1993) Effect of dopamine agonists and antagonists on ethanol-reinforced behavior: the involvement of the nucleus accumbens. Brain Res Bull 30:133-141
55. Silvestre JS, O'Neill MF, Fernandez AG, Palacios JM (1996) Effects of a range of dopamine receptor agonists and antagonists on ethanol intake in the rat. Eur J Pharmacol 318:257-265
56. Stefanini E, Frau M, Garau MG, Garau B, Fadda F, et al. (1992) Alcohol-preferring rats have fewer dopamine D2 receptors in the limbic system. Alcohol Alcohol 27:127-130
57. Thanos PK, Taintor NB, Rivera SN, Umegaki H, Ikari H, et al. (2004) DRD2 gene transfer into the nucleus accumbens core of the alcohol preferring and nonpreferring rats attenuates alcohol drinking. Alcohol Clin Exp Res 28:720-728
58. Thanos PK, Rivera SN, Weaver K, Grandy DK, Rubinstein M, et al. (2005) Dopamine D2R DNA transfer in dopamine D2 receptor-deficient mice: effects on ethanol drinking. Life Sci 77:130-139
59. Tran AH, Tamura R, Uwano T, Kobayashi T, Katsuki M, et al. (2002) Altered accumbens neural response to prediction of reward associated with place in dopamine D2 receptor knockout mice. Proc Natl Acad Sci U S A 99:8986-8991
60. Volkow ND, Fowler JS, Gatley SJ, Logan J, Wang GJ, et al. (1996a) PET evaluation of the dopamine system of the human brain. J Nucl Med 37:1242-1256
61. Volkow ND, Wang GJ, Fowler JS, Logan J, Hitzemann R, et al. (1996b) Decreases in dopamine receptors but not in dopamine transporters in alcoholics. Alcohol Clin Exp Res 20:1594-1598
62. Volkow ND, Fowler JS, Wang GJ (1999a) Imaging studies on the role of dopamine in cocaine reinforcement and addiction in humans. J Psychopharmacol 13:337-345
63. Volkow ND, Wang GJ, Fowler JS, Logan J, Gatley SJ, et al. (1999b) Prediction of reinforcing responses to psychostimulants in humans by brain dopamine D2 receptor levels. Am J Psychiatry 156:1440-1443
64. Volkow ND, Wang GJ, Fowler JS, Thanos PP, Logan J, et al. (2002) Brain DA D2 receptors predict reinforcing effects of stimulants in humans: replication study. Synapse 46:79-82
65. Weiss F, Hurd YL, Ungerstedt U, Markou A, Plotsky PM, et al. (1992) Neurochemical correlates of cocaine and ethanol self-administration. Ann N Y Acad Sci 654:220-241
66. Witzmann FA, Li J, Strother WN, McBride WJ, Hunter L, Crabb DW, Lumeng L, Li T-K (2003) Innate differences in protein expression in the nucleus accumbens and hippocampus of inbred alcoholpreferring (iP) and -nonpreferring (iNP) rats. Proteomics 3:1335-1344
67. Xu K, Lichtermann D, Lipsky RH, Franke P, Liu X, et al. (2004) Association of specific haplotypes of D2 dopamine receptor gene with vulnerability to heroin dependence in 2 distinct populations. Arch Gen Psychiatry 61:597-606
68. Zhou FC, Zhang JK, Lumeng L, Li TK (1995) Mesolimbic dopamine system in alcohol-preferring rats. Alcohol 12:403-412