Structure-based characterization of canine-human chimeric uricases and its evolutionary implications

Biochimie

Volumn 94, Issue 6, 2012, Pages 1412-1420

  Zhang, Chun ^a   Fan, Kai ^b   Zhang, Weitao ^b   Zhu, Ruixin ^c   Zhang, Lujia ^a   Wei, Dongzhi ^a  

^a EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b Fagen Biomedical Inc   (China)

^c TONGJI UNIVERSITY   (China)

Author keywords

Chimeric construction; Hominoid uricase; Inactivation process; Multistep mutations; Primate evolution

Indexed keywords

URATE OXIDASE;

APE; ARTICLE; DOG; ENZYME ANALYSIS; ENZYME INACTIVATION; ENZYME STABILITY; ENZYME STRUCTURE; HUMAN; MOLECULAR EVOLUTION; MOLECULAR MODEL; NONHUMAN; NONSENSE MUTATION; NUCLEOTIDE SEQUENCE; PRIMATE; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANIMALS; BIOLOGICAL EVOLUTION; DOGS; HOMINIDAE; HUMANS; MUTANT CHIMERIC PROTEINS; MUTATION; PHYLOGENY; PRIMATES; SEQUENCE ALIGNMENT; URATE OXIDASE;

HOMINIDAE; HOMINOIDEA; HOMO; MAMMALIA; PRIMATES;

EID: 84860459187     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2012.03.016     Document Type: Article

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