Alzheimer's Aβ10-40 peptide binds and penetrates DMPC bilayer: An isobaric-isothermal replica exchange molecular dynamics study

Journal of Physical Chemistry B

Volumn 118, Issue 10, 2014, Pages 2638-2648

  Lockhart, Christopher ^a   Klimov, Dmitri K ^a  

^a GEORGE MASON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; HYDROPHOBICITY; LIPID BILAYERS; MONOMERS; PEPTIDES;

HELICAL CONFORMATION; HELICAL STRUCTURES; HYDROPHOBIC CLUSTERS; HYDROPHOBIC ENVIRONMENT; ISOBARIC-ISOTHERMAL; REPLICA EXCHANGE MOLECULAR DYNAMICS; STRUCTURAL TRANSITIONS; ZWITTERIONIC LIPIDS;

ISOTHERMS;

AMINO ACID; AMYLOID BETA PROTEIN; AMYLOID BETA-PROTEIN (10-40); DIMYRISTOYLPHOSPHATIDYLCHOLINE; IBUPROFEN; LIPID BILAYER; PEPTIDE FRAGMENT; PROTEIN BINDING; SOLUTION AND SOLUBILITY; SOLVENT; WATER;

CHEMICAL PHENOMENA; CHEMISTRY; LIPID BILAYER; MOLECULAR DYNAMICS; PROBABILITY; PROTEIN SECONDARY STRUCTURE; SOLUTION AND SOLUBILITY;

AMINO ACIDS; AMYLOID BETA-PEPTIDES; DIMYRISTOYLPHOSPHATIDYLCHOLINE; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; IBUPROFEN; LIPID BILAYERS; MOLECULAR DYNAMICS SIMULATION; PEPTIDE FRAGMENTS; PROBABILITY; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; SOLUTIONS; SOLVENTS; WATER;

EID: 84896292216     PISSN: 15206106     EISSN: 15205207     Source Type: Journal    
DOI: 10.1021/jp412153s     Document Type: Article

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