Emodin elicits cytotoxicity in human lung adenocarcinoma A549 cells through inducing apoptosis

Inflammopharmacology

Volumn 22, Issue 2, 2014, Pages 127-134

  Li, Wing Yan ^a   Ng, Yam Fung ^a   Zhang, Huan ^a   Guo, Zi Dong ^a   Guo, De Jian ^b   Kwan, Yiu Wa ^c   Leung, George Pak Heng ^d   Lee, Simon Ming Yuen ^e   Yu, Peter Hoi Fu ^a,b   Chan, Shun Wan ^a,b  

^a HONG KONG POLYTECHNIC UNIVERSITY   (Hong Kong)

^b State Key Laboratory of Chinese Medicine and Molecular Pharmacology   (China)

^c Prince of Wales Hospital   (Hong Kong)

^d UNIVERSITY OF HONG KONG   (Hong Kong)

^e China Macau University of Science and Technology Zhuhai MUST Science and Technology Research Institute   (Macao)

Author keywords

Cell cycle arrest; DNA fragmentation; Emodin; Growth inhibition

Indexed keywords

CYCLIN D1; EMODIN; FAS LIGAND; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; PROTEIN BAX; PROTEIN MCL 1;

APOPTOSIS; ARTICLE; CARCINOMA CELL; CELL GROWTH; CELL PROLIFERATION ASSAY; COLONY FORMATION; COLONY FORMING UNIT; COMET ASSAY; CONTROLLED STUDY; DNA FRAGMENTATION; DOWN REGULATION; DRUG CYTOTOXICITY; GENE EXPRESSION; GROWTH INHIBITION; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; LUNG ADENOCARCINOMA; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SINGLE STRANDED DNA BREAK; UPREGULATION;

ADENOCARCINOMA; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL PROLIFERATION; DNA BREAKS, SINGLE-STRANDED; DNA FRAGMENTATION; EMODIN; GENE EXPRESSION; HUMANS; LUNG NEOPLASMS;

EID: 84896077868     PISSN: 09254692     EISSN: 15685608     Source Type: Journal    
DOI: 10.1007/s10787-013-0186-4     Document Type: Article

References (38)

1. Ahn KS, Hahn BS, Kwack K et al (2006) Platycodin D-induced apoptosis through nuclear factor-kappaB activation in immortalized keratinocytes. Eur J Pharmacol 537:1-11
2. Akervall J, Bockmuhl U, Petersen I et al (2003) The gene ratios c-MYC: cyclin-dependent kinase (CDK)N2A and CCND1: CDKN2A correlate with poor prognosis in squamous cell carcinoma of the head and neck. Clin Cancer Res 9:1750-1755 (Pubitemid 36554600)
3. Basu S, Ghosh A, Hazra B (2005) Evaluation of the antibacterial activity of Ventilago madraspatana Gaertn., Rubia cordifolia Linn. and Lantana camara Linn.: isolation of emodin and physcion as active antibacterial agents. Phytother Res 19:888-894 (Pubitemid 41665959)
4. Cameron R, Feuer G (2001) The effect of drugs and toxins on the process of apoptosis. Drug Metab Drug Interact 18:1-32 (Pubitemid 32291032)
5. Chang GC, Hsu SL, Tsai JR et al (2004) Molecular mechanisms of ZD1839-induced G1-cell cycle arrest and apoptosis in human lung adenocarcinoma A549 cells. Biochem Pharmacol 68:1453-1464
6. Chen YC, Shen SC, Lee WR et al (2002) Emodin induces apoptosis in human promyeloleukemic HL-60 cells accompanied by activation of caspase 3 cascade but independent of reactive oxygen species production. Biochem Pharmacol 64:1713-1724
7. Choi HS, Cho MC, Lee HG et al (2010) Indole-3-carbinol induces apoptosis through p53 and activation of caspase-8 pathway in lung cancer A549 cells. Food Chem Toxicol 48:883-890
8. Hsu YL, Kuo PL, Liu CF et al (2004) Acacetin-induced cell cycle arrest and apoptosis in human non-small cell lung cancer A549 cells. Cancer Lett 212:53-60
9. Huang HC, Chu SH, Chao PD (1991a) Vasorelaxants from Chinese herbs, emodin and scoparin, possess immunosuppressive properties. Eur J Pharmacol 198:211-213
10. Huang HC, Lee CR, Chao PD et al (1991b) Vasorelaxant effect of emodin, an anthraquinone from a Chinese herb. Eur J Pharmacol 205:289-294
11. Huang Q, Shen HM, Ong CN (2004) Inhibitory effect of emodin on tumour invasion through suppression of activator protein-1 and nuclear factor-kappaB. Biochem Pharmacol 68:361-371 (Pubitemid 38757705)
12. Huang Z, Chen G, Shi P (2008) Emodin-induced apoptosis in human breast cancer BCap-37 cells through the mitochondrial signalling pathway. Arch Pharmacal Res 31:742-748
13. Ishitani R, Tajima H, Takata H et al (2003) Proapoptotic protein glyceraldehyde-3-phosphate dehydrogenase: a possible site of action of antiapoptotic drugs. Prog Neuropsychopharmacol Biol Psychiatry 27:291-301 (Pubitemid 36351496)
14. Jang BC, Paik JH, Jeong HY et al (2004) Leptomycin B-induced apoptosis is mediated through caspase activation and down-regulation of Mcl-1 and XIAP expression, but not through the generation of ROS in U937 leukemia cells. Biochem Pharmacol 68:263-274
15. Kim MS, Park MJ, Kim SJ et al (2005) Emodin suppresses hyaluronic acid-induced MMP-9 secretion and invasion of glioma cells. Int J Oncol 27:839-846
16. Klaude M, Eriksson S, Nygren J et al (1996) The comet assay: mechanisms and technical considerations. Mutat Res 363:89-96 (Pubitemid 26225011)
17. Lee HZ (2001) Effects and mechanisms of emodin on cell death in human lung squamous cell carcinoma. Br J Pharmacol 134:11-20
18. Lee HZ, Hsu SL, Liu MC et al (2001) Effects and mechanisms of aloe-emodin on cell death in human lung squamous cell carcinoma. Eur J Pharmacol 431:287-295
19. Lee EJ, Min HY, Chung HJ et al (2005) A novel adenosine analog, thio-Cl-IB-MECA, induces G0/G1 cell cycle arrest and apoptosis in human promyelocytic leukemia HL-60 cells. Biochem Pharmacol 70:918-924
20. Li HL, Chen HL, Li H et al (2005) Regulatory effects of emodin on NF-kappaB activation and inflammatory cytokine expression in RAW 264.7 macrophages. Int J Mol Med 16:41-47
21. Li WY, Chan SW, Guo DJ et al (2009) Water extract of Rheum officinale Baill induces apoptosis in human lung adenocarcinoma A549 and human breast cancer MCF-7 cell lines. J Ethnopharmacol 124:251-256
22. Li WY, Chan RY, Yu PH et al (2013) Emodin induces cytotoxic effect in human breast carcinoma MCF-7 cell through modulating the expression of apoptosis-related genes. Pharm Biol 51:1175-1181
23. Lin HI, Lee YJ, Chen BF et al (2005) Involvement of Bcl-2 family, cytochrome c and caspase 3 in induction of apoptosis by beauvericin in human non-small cell lung cancer cells. Cancer Lett 230:248-259
24. Liu T, Zhu E, Wang L et al (2005) Abnormal expression of Rb pathway-related proteins in salivary gland acinic cell carcinoma. Hum Pathol 36:962-970 (Pubitemid 41253381)
25. Miller DM, Thomas SD, Islam A et al (2012) c-Myc and cancer metabolism. Clin Cancer Res 18:5546-5553
26. Mogal A, Abdulkadir SA (2006) Effects of histone deacetylase inhibitor (HDACi); trichostatin-A (TSA) on the expression of housekeeping genes. Mol Cell Probes 20:81-86 (Pubitemid 43343719)
27. Pelengaris S, Khan M, Evan G (2002a) c-MYC: more than just a matter of life and death. Nat Rev Cancer 2:764-776 (Pubitemid 37328911)
28. Pelengaris S, Khan M, Evan GI (2002b) Suppression of Myc-induced apoptosis in beta cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression. 109:321-334
29. Petty WJ, Dragnev KH, Dmitrovsky E (2003) Cyclin D1 as a target for chemoprevention. Lung Cancer 41(Suppl 1):S155-S161 (Pubitemid 36819007)
30. Shieh DE, Chen YY, Yen MH et al (2004) Emodin-induced apoptosis through p53-dependent pathway in human hepatoma cells. Life Sci 74:2279-2290 (Pubitemid 38249548)
31. Siegel R, Naishadham D, Jemal A (2012) Cancer statistics, 2012. CA Cancer J Clin 62:10-29
32. Singh NP, McCoy MT, Tice RR et al (1988) A simple technique for quantitation of low levels of DNA damage in individual cells. Exp Cell Res 175:184-191
33. Srinivas G, Anto RJ, Srinivas P et al (2003) Emodin induces apoptosis of human cervical cancer cells through poly (ADP-ribose) polymerase cleavage and activation of caspase-9. Eur J Pharmacol 473:117-125 (Pubitemid 36929875)
34. Wang CF, Wu XD, Chen M et al (2007) Emodin induces apoptosis through caspase 3-dependent pathway in HK-2 cells. Toxicology 231:120-128 (Pubitemid 46283155)
35. Way TD, Kao MC, Lin JK (2005) Degradation of HER2/neu by apigenin induces apoptosis through cytochrome c release and caspase-3 activation in HER2/neu-overexpressing breast cancer cells. FEBS Lett 579:145-152
36. Wu SJ, Ng LT, Lin CC (2005) Cinnamaldehyde-induced apoptosis in human PLC/PRF/5 cells through activation of the proapoptotic Bcl-2 family proteins and MAPK pathway. Life Sci 77:938-951
37. Zhang CX, Huang KX (2006) Mechanism of apoptosis induced by a polysaccharide, from the loach Misgurnus anguillicaudatus (MAP) in human hepatocellular carcinoma cells. Toxicol Appl Pharmacol 210:236-245
38. Zhang HQ, Zhou CH, Wu YQ (2005) Effect of emodin on small intestinal peristalsis of mice and relevant mechanism. World J Gastroenterol 11:3147-3150 (Pubitemid 40790680)