메뉴 건너뛰기




Volumn 280, Issue 1767, 2013, Pages

Adaptive noise

Author keywords

Bet hedging; Evolution; Variation

Indexed keywords

BET-HEDGING; ERROR ANALYSIS; FITNESS; GENE EXPRESSION; GENETIC VARIATION; GENOTYPE; NOISE; PHENOTYPIC PLASTICITY;

EID: 84896059789     PISSN: 09628452     EISSN: 14712954     Source Type: Journal    
DOI: 10.1098/rspb.2013.1104     Document Type: Review
Times cited : (61)

References (53)
  • 1
    • 0017185026 scopus 로고
    • Non-genetic individuality: Chance in the single cell
    • (doi:10.1038/262467a0)
    • Spudich JL, Koshland DE. 1976 Non-genetic individuality: chance in the single cell. Nature 262, 467-471. (doi:10.1038/262467a0)
    • (1976) Nature , vol.262 , pp. 467-471
    • Spudich, J.L.1    Koshland, D.E.2
  • 2
    • 77956528790 scopus 로고    scopus 로고
    • Fundamental limits on the suppression of molecular fluctuations
    • (doi:10.1038/ nature09333)
    • Lestas I, Vinnicombe G, Paulsson J. 2010 Fundamental limits on the suppression of molecular fluctuations. Nature 467, 174-178. (doi:10.1038/ nature09333)
    • (2010) Nature , vol.467 , pp. 174-178
    • Lestas, I.1    Vinnicombe, G.2    Paulsson, J.3
  • 3
    • 84859641038 scopus 로고    scopus 로고
    • Using gene expression noise to understand gene regulation
    • (doi:10.1126/ science.1216379)
    • Munsky B, Neuert G, van Oudenaarden A. 2012 Using gene expression noise to understand gene regulation. Science 336, 183-187. (doi:10.1126/ science.1216379)
    • (2012) Science , vol.336 , pp. 183-187
    • Munsky, B.1    Neuert, G.2    van Oudenaarden, A.3
  • 4
    • 0037119587 scopus 로고    scopus 로고
    • Stochastic gene expression in a single cell
    • (doi:10.1126/science.1070919)
    • Elowitz MB, Levine AJ, Siggia ED, Swain PS. 2002 Stochastic gene expression in a single cell. Science 297, 1183-1186. (doi:10.1126/science.1070919)
    • (2002) Science , vol.297 , pp. 1183-1186
    • Elowitz, M.B.1    Levine, A.J.2    Siggia, E.D.3    Swain, P.S.4
  • 5
    • 33748058888 scopus 로고    scopus 로고
    • Bistability in bacteria
    • (doi:10.1111/j.1365-2958.2006.05249. x)
    • Dubnau D, Losick R. 2006 Bistability in bacteria. Mol. Microbiol. 61, 564-572. (doi:10.1111/j.1365-2958.2006.05249. x)
    • (2006) Mol. Microbiol. , vol.61 , pp. 564-572
    • Dubnau, D.1    Losick, R.2
  • 7
    • 84857437687 scopus 로고    scopus 로고
    • Cellular noise regulons underlie fluctuations in Saccharomyces cerevisiae
    • (doi:10.1016/j. molcel.2011.11.035)
    • Stewart-Ornstein J, Weissman JS, El-Samad H. 2012 Cellular noise regulons underlie fluctuations in Saccharomyces cerevisiae. Mol. Cell. 45, 483-493. (doi:10.1016/j. molcel.2011.11.035)
    • (2012) Mol. Cell. , vol.45 , pp. 483-493
    • Stewart-Ornstein, J.1    Weissman, J.S.2    El-Samad, H.3
  • 8
    • 53549123008 scopus 로고    scopus 로고
    • Nature, nurture, or chance: Stochastic gene expression and its consequences
    • (doi:10.1016/j. cell.2008.09.050)
    • Raj A, van Oudenaarden A. 2008 Nature, nurture, or chance: stochastic gene expression and its consequences. Cell 135, 216-226. (doi:10.1016/j. cell.2008.09.050)
    • (2008) Cell , vol.135 , pp. 216-226
    • Raj, A.1    van Oudenaarden, A.2
  • 9
    • 49549120841 scopus 로고    scopus 로고
    • The stochastic nature of biochemical networks
    • (doi:10.1016/j. copbio.2008.06.011)
    • Shahrezaei V, Swain PS. 2008 The stochastic nature of biochemical networks. Curr. Opin. Biotech. 19, 369-374. (doi:10.1016/j. copbio.2008.06.011)
    • (2008) Curr. Opin. Biotech. , vol.19 , pp. 369-374
    • Shahrezaei, V.1    Swain, P.S.2
  • 10
    • 2942718723 scopus 로고    scopus 로고
    • Control of stochasticity in eukaryotic gene expression
    • (doi:10.1126/science.1098641)
    • Raser JM, O'Shea EK. 2004 Control of stochasticity in eukaryotic gene expression. Science 304, 1811-1814. (doi:10.1126/science.1098641)
    • (2004) Science , vol.304 , pp. 1811-1814
    • Raser, J.M.1    O'Shea, E.K.2
  • 11
    • 70350344043 scopus 로고    scopus 로고
    • A single molecule view of gene expression
    • (doi:10.1016/j. tcb.2009.08.008)
    • Larson DR, Singer RH, Zenklusen D. 2009 A single molecule view of gene expression. Trends Cell Biol. 19, 630-637. (doi:10.1016/j. tcb.2009.08.008)
    • (2009) Trends Cell Biol. , vol.19 , pp. 630-637
    • Larson, D.R.1    Singer, R.H.2    Zenklusen, D.3
  • 12
    • 80054884922 scopus 로고    scopus 로고
    • Negative feedback through mRNA provides the best control of gene-expression noise
    • (doi:10.1109/ TNB.2011.2168826)
    • Singh A. 2011 Negative feedback through mRNA provides the best control of gene-expression noise. IEEE Trans. Nanobiosci. 10, 194-200. (doi:10.1109/ TNB.2011.2168826)
    • (2011) IEEE Trans. Nanobiosci. , vol.10 , pp. 194-200
    • Singh, A.1
  • 13
    • 16644373292 scopus 로고    scopus 로고
    • Noise minimization in eukaryotic gene expression
    • (doi:10.1371/journal. pbio.0020137)
    • Fraser HB, Hirsh AE, Giaever G, Kumm J, Eisen MB. 2004 Noise minimization in eukaryotic gene expression. PLoS Biol. 2, e137. (doi:10.1371/journal. pbio.0020137)
    • (2004) PLoS Biol. , vol.2
    • Fraser, H.B.1    Hirsh, A.E.2    Giaever, G.3    Kumm, J.4    Eisen, M.B.5
  • 15
    • 80053449076 scopus 로고    scopus 로고
    • Genomic analysis of QTLs and genes altering natural variation in stochastic noise
    • (doi:10.1371/ journal. pgen.1002295)
    • Jimenez-Gomez JM, Corwin JA, Joseph B, Maloof JN, Kliebenstein DJ. 2011 Genomic analysis of QTLs and genes altering natural variation in stochastic noise. PLoS Genet. 7, e10002295. (doi:10.1371/ journal. pgen.1002295)
    • (2011) PLoS Genet. , vol.7
    • Jimenez-Gomez, J.M.1    Corwin, J.A.2    Joseph, B.3    Maloof, J.N.4    Kliebenstein, D.J.5
  • 16
    • 84857480997 scopus 로고    scopus 로고
    • A genome-wide analysis of promoter-mediated phenotypic noise in Escherichia coli
    • (doi:10. 1371/journal. pgen.1002443)
    • Silander OK, Nikolic N, Zaslaver A, Bren A, Kikoin I, Alon U, Ackermann M. 2012 A genome-wide analysis of promoter-mediated phenotypic noise in Escherichia coli. PLoS Genet. 8, e1002443. (doi:10. 1371/journal. pgen.1002443)
    • (2012) PLoS Genet. , vol.8
    • Silander, O.K.1    Nikolic, N.2    Zaslaver, A.3    Bren, A.4    Kikoin, I.5    Alon, U.6    Ackermann, M.7
  • 17
    • 78649708844 scopus 로고    scopus 로고
    • Conflict between noise and plasticity in yeast
    • (doi:10.1371/ journal. pgen.1001185)
    • Lehner B. 2010 Conflict between noise and plasticity in yeast. PLoS Genet. 6, e1001185. (doi:10.1371/ journal. pgen.1001185)
    • (2010) PLoS Genet. , vol.6
    • Lehner, B.1
  • 18
    • 34249079154 scopus 로고    scopus 로고
    • Network motifs: Theory and experimental approaches
    • (doi:10.1038/nrg2102)
    • Alon U. 2007 Network motifs: theory and experimental approaches. Nat. Rev. Genet. 8, 450-461. (doi:10.1038/nrg2102)
    • (2007) Nat. Rev. Genet. , vol.8 , pp. 450-461
    • Alon, U.1
  • 21
    • 77955155615 scopus 로고    scopus 로고
    • Noise and robustness in prokaryotic regulatory networks
    • (doi:10.1146/annurev. micro.091208.073229)
    • Silva-Rocha R, de Lorenzo V. 2010 Noise and robustness in prokaryotic regulatory networks. Ann. Rev. Microbiol. 64, 257-275. (doi:10.1146/annurev. micro.091208.073229)
    • (2010) Ann. Rev. Microbiol. , vol.64 , pp. 257-275
    • Silva-Rocha, R.1    de Lorenzo, V.2
  • 22
    • 80054837496 scopus 로고    scopus 로고
    • Stochastic pulse regulation in bacterial stress response
    • (doi:10.1126/science.1208144)
    • Locke JCW, Young JW, Fontes M, Jimenez MJH, Elowitz MB. 2011 Stochastic pulse regulation in bacterial stress response. Science 334, 366-369. (doi:10.1126/science.1208144)
    • (2011) Science , vol.334 , pp. 366-369
    • Locke, J.C.W.1    Young, J.W.2    Fontes, M.3    Jimenez, M.J.H.4    Elowitz, M.B.5
  • 23
    • 70350336588 scopus 로고    scopus 로고
    • Architecture-dependent noise discriminates functionally analogous differentiation circuits
    • (doi:10.1016/j. cell. 2009.07.046)
    • Çaǧatay T, Turcotte M, Elowitz MB, Garci-Ojalvo J, Süel GM. 2009 Architecture-dependent noise discriminates functionally analogous differentiation circuits. Cell 139, 512-522. (doi:10.1016/j. cell. 2009.07.046)
    • (2009) Cell , vol.139 , pp. 512-522
    • Çaǧatay, T.1    Turcotte, M.2    Elowitz, M.B.3    Garci-Ojalvo, J.4    Süel, G.M.5
  • 24
    • 0033578424 scopus 로고    scopus 로고
    • Systematic changes in gene expression patterns following adaptive evolution in yeast
    • (doi:10.1073/ pnas.96.17.9721)
    • Ferea TL, Botstein D, Brown PO, Rosenzweig RF. 1999 Systematic changes in gene expression patterns following adaptive evolution in yeast. Proc. Natl Acad. Sci. USA 96, 9721-9726. (doi:10.1073/ pnas.96.17.9721)
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , pp. 9721-9726
    • Ferea, T.L.1    Botstein, D.2    Brown, P.O.3    Rosenzweig, R.F.4
  • 25
    • 34247487796 scopus 로고    scopus 로고
    • Genome-wide transcriptional plasticity underlies cellular adaptation to novel challenge
    • (doi:10.1038/ msb4100147)
    • Stern S, Dror T, Stolovicki E, Brenner N, Braun E. 2007 Genome-wide transcriptional plasticity underlies cellular adaptation to novel challenge. Mol. Syst. Biol. 3, 106. (doi:10.1038/ msb4100147)
    • (2007) Mol. Syst. Biol. , vol.3 , pp. 106
    • Stern, S.1    Dror, T.2    Stolovicki, E.3    Brenner, N.4    Braun, E.5
  • 26
    • 21044445510 scopus 로고    scopus 로고
    • Evolution of the environmental component of the phenotypic variance: Stabilizing selection in changing environments and the cost of homogeneity
    • (doi:10.1554/05-038)
    • Zhang X-S, Hill WG. 2005 Evolution of the environmental component of the phenotypic variance: stabilizing selection in changing environments and the cost of homogeneity. Evolution 59, 1237-1244. (doi:10.1554/05-038)
    • (2005) Evolution , vol.59 , pp. 1237-1244
    • Zhang, X.-S.1    Hill, W.G.2
  • 27
    • 84867330691 scopus 로고    scopus 로고
    • FTO genotype is associated with phenotpyic variability of body mass index
    • (doi:10.1038/nature11401)
    • Yang J et al. 2012 FTO genotype is associated with phenotpyic variability of body mass index. Nature 490, 267-272. (doi:10.1038/nature11401)
    • (2012) Nature , vol.490 , pp. 267-272
    • Yang, J.1
  • 28
    • 33847394655 scopus 로고    scopus 로고
    • MAPK-mediated bimodal gene expression and adaptive gradient sensing in yeast
    • (doi:10.1038/ nature05561)
    • Paliwal S, Iglesias PA, Campbell K, Hilioti Z, Groisman A, Levchenko A. 2007 MAPK-mediated bimodal gene expression and adaptive gradient sensing in yeast. Nature 446, 46-51. (doi:10.1038/ nature05561)
    • (2007) Nature , vol.446 , pp. 46-51
    • Paliwal, S.1    Iglesias, P.A.2    Campbell, K.3    Hilioti, Z.4    Groisman, A.5    Levchenko, A.6
  • 29
    • 42949131308 scopus 로고    scopus 로고
    • Selection to minimize noise in living systems and its implications for the evolution of gene expression
    • (doi:10. 1038/msb.2008.11)
    • Lehner B. 2008 Selection to minimize noise in living systems and its implications for the evolution of gene expression. Mol. Syst. Biol. 4, 170. (doi:10. 1038/msb.2008.11)
    • (2008) Mol. Syst. Biol. , vol.4 , pp. 170
    • Lehner, B.1
  • 30
    • 33745220278 scopus 로고    scopus 로고
    • Singlecell proteomic analysis of S. cerevisiae reveals the architecture of biological noise
    • (doi:10.1038/nature04785)
    • Newman JRS, Ghaemmaghami S, Ihmels J, Breslow DK, Noble M, DeRisi JL, Weissman JS. 2006 Singlecell proteomic analysis of S. cerevisiae reveals the architecture of biological noise. Nature, 441, 840-846. (doi:10.1038/nature04785)
    • (2006) Nature , vol.441 , pp. 840-846
    • Newman, J.R.S.1    Ghaemmaghami, S.2    Ihmels, J.3    Breslow, D.K.4    Noble, M.5    DeRisi, J.L.6    Weissman, J.S.7
  • 31
    • 34247513357 scopus 로고    scopus 로고
    • The evolutionary ecology of individual phenotypic plasticity in wild populations
    • (doi:10.1111/j.1420-9101.2007. 01300. x)
    • Nussey DH, Wilson AJ, Brommer JE. 2007 The evolutionary ecology of individual phenotypic plasticity in wild populations. J. Evol. Biol. 20, 831-844. (doi:10.1111/j.1420-9101.2007. 01300. x)
    • (2007) J. Evol. Biol. , vol.20 , pp. 831-844
    • Nussey, D.H.1    Wilson, A.J.2    Brommer, J.E.3
  • 32
    • 71449096836 scopus 로고    scopus 로고
    • Strategies for cellular decision-making
    • (doi:10. 1038/msb.2009.83)
    • Perkins TJ, Swain PS. 2009 Strategies for cellular decision-making. Mol. Syst. Biol. 5, 326. (doi:10. 1038/msb.2009.83)
    • (2009) Mol. Syst. Biol. , vol.5 , pp. 326
    • Perkins, T.J.1    Swain, P.S.2
  • 33
    • 34249850790 scopus 로고    scopus 로고
    • Noisy information processing through transcriptional regulation
    • (doi:10.1073/pnas.0608963104)
    • Libby E, Perkins TJ, Swain PS. 2007 Noisy information processing through transcriptional regulation. Proc. Natl Acad. Sci. USA 104, 7151-7156. (doi:10.1073/pnas.0608963104)
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 7151-7156
    • Libby, E.1    Perkins, T.J.2    Swain, P.S.3
  • 34
    • 79952638264 scopus 로고    scopus 로고
    • Cellular decision making and biological noise: From microbes to mammals
    • (doi:10. 1016/j. cell.2011.01.030)
    • Balazsi G, van Oudenaarden A, Collins JJ. 2011 Cellular decision making and biological noise: from microbes to mammals. Cell 144, 910-925. (doi:10. 1016/j. cell.2011.01.030)
    • (2011) Cell , vol.144 , pp. 910-925
    • Balazsi, G.1    van Oudenaarden, A.2    Collins, J.J.3
  • 35
    • 80054756690 scopus 로고    scopus 로고
    • Nontranscriptional regulatory processes shape transcriptional network dynamics
    • (doi:10.1038/nrmicro2667)
    • Ray JCJ, Tabor JJ, Igoshin OA. 2011 Nontranscriptional regulatory processes shape transcriptional network dynamics. Nat. Rev. Micro. 9, 817-828. (doi:10.1038/nrmicro2667)
    • (2011) Nat. Rev. Micro. , vol.9 , pp. 817-828
    • Ray, J.C.J.1    Tabor, J.J.2    Igoshin, O.A.3
  • 36
    • 18744361871 scopus 로고    scopus 로고
    • Enhancement of cellular memory by reducing stochastic transitions
    • (doi:10.1038/nature03524)
    • Acar M, Becskel A, van Oudenaarden A. 2005 Enhancement of cellular memory by reducing stochastic transitions. Nature 435, 228-232. (doi:10.1038/nature03524)
    • (2005) Nature , vol.435 , pp. 228-232
    • Acar, M.1    Becskel, A.2    van Oudenaarden, A.3
  • 37
    • 41749107942 scopus 로고    scopus 로고
    • Stochasticity and cell fate
    • (doi:10.1126/science.1147888)
    • Losick R, Desplan C. 2008 Stochasticity and cell fate. Science 320, 65068. (doi:10.1126/science.1147888)
    • (2008) Science , vol.320 , pp. 65068
    • Losick, R.1    Desplan, C.2
  • 38
    • 78049411785 scopus 로고    scopus 로고
    • Stochastic mechanisms of cell fate specification that yield random or robust outcomes
    • (doi:10.1146/annurev-cellbio-100109-104113)
    • Johnston RJ, Desplan C. 2010 Stochastic mechanisms of cell fate specification that yield random or robust outcomes. Annu. Rev. Cell Dev. Biol. 26, 689-719. (doi:10.1146/annurev-cellbio-100109-104113)
    • (2010) Annu. Rev. Cell Dev. Biol. , vol.26 , pp. 689-719
    • Johnston, R.J.1    Desplan, C.2
  • 39
    • 77249114260 scopus 로고    scopus 로고
    • Variability in gene expression underlies incomplete penetrance
    • (doi:10.1038/nature08781)
    • Raj A, Rifkin SA, Andersen E, van Oudenaarden A. 2010 Variability in gene expression underlies incomplete penetrance. Nature 463, 913-918. (doi:10.1038/nature08781)
    • (2010) Nature , vol.463 , pp. 913-918
    • Raj, A.1    Rifkin, S.A.2    Andersen, E.3    van Oudenaarden, A.4
  • 40
    • 84859581036 scopus 로고    scopus 로고
    • Geometry, epistasis, and developmental patterning
    • (doi:10.1073/pnas. 1201505109)
    • Corson F, Siggia ED. 2012 Geometry, epistasis, and developmental patterning. Proc. Natl Acad. Sci. USA 109, 5568-5575. (doi:10.1073/pnas. 1201505109)
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , pp. 5568-5575
    • Corson, F.1    Siggia, E.D.2
  • 41
    • 84855478341 scopus 로고    scopus 로고
    • Fitness trade-offs and environmentally induced mutation buffering in isogenic C. elegans
    • (doi:10.1126/science.1213491)
    • Casanueva MO, Burga A, Lehner B. 2012 Fitness trade-offs and environmentally induced mutation buffering in isogenic C. elegans. Science 335, 82-85. (doi:10.1126/science.1213491)
    • (2012) Science , vol.335 , pp. 82-85
    • Casanueva, M.O.1    Burga, A.2    Lehner, B.3
  • 42
    • 83055180178 scopus 로고    scopus 로고
    • Predicting mutation outcome from early stochastic variation in genetic interaction partners
    • (doi:10.1038/nature10665)
    • Burga A, Casanueva MO, Lehner B. 2011 Predicting mutation outcome from early stochastic variation in genetic interaction partners. Nature 480, 250-253. (doi:10.1038/nature10665)
    • (2011) Nature , vol.480 , pp. 250-253
    • Burga, A.1    Casanueva, M.O.2    Lehner, B.3
  • 43
    • 2942555282 scopus 로고    scopus 로고
    • Stochastic gene expression in fluctuating environments
    • (doi:10.1534/genetics.167. 1.523)
    • Thattai M, van Oudenaarden A. 2004 Stochastic gene expression in fluctuating environments. Genetics 167, 523-530. (doi:10.1534/genetics.167. 1.523)
    • (2004) Genetics , vol.167 , pp. 523-530
    • Thattai, M.1    van Oudenaarden, A.2
  • 44
    • 25444489027 scopus 로고    scopus 로고
    • Phenotypic diversity, population growth, and information in fluctuating environments
    • (doi:10. 1126/science.1114383)
    • Kussell E, Leibler S. 2005 Phenotypic diversity, population growth, and information in fluctuating environments. Science 309, 2075-2078. (doi:10. 1126/science.1114383)
    • (2005) Science , vol.309 , pp. 2075-2078
    • Kussell, E.1    Leibler, S.2
  • 47
    • 84874126703 scopus 로고    scopus 로고
    • Stabilization of cooperative virulence by the expression of an avirulent phenotype
    • (doi:10.1038/nature11913)
    • Diard M, Garcia V, Maier L, Remus-Emsermann MNP, Regoes RR, Ackermann M, Hardt W-D. 2013 Stabilization of cooperative virulence by the expression of an avirulent phenotype. Nature 494, 353-356. (doi:10.1038/nature11913)
    • (2013) Nature , vol.494 , pp. 353-356
    • Diard, M.1    Garcia, V.2    Maier, L.3    Remus-Emsermann, M.N.P.4    Regoes, R.R.5    Ackermann, M.6    Hardt, W.-D.7
  • 48
    • 41349119880 scopus 로고    scopus 로고
    • Stochastic switching as a survival strategy in fluctuating environments
    • (doi:10.1038/ng.110)
    • Acar M, Mettetal J, van Oudenaarden A. 2008 Stochastic switching as a survival strategy in fluctuating environments. Nat. Genet. 40, 471-475. (doi:10.1038/ng.110)
    • (2008) Nat. Genet. , vol.40 , pp. 471-475
    • Acar, M.1    Mettetal, J.2    van Oudenaarden, A.3
  • 49
    • 84861544417 scopus 로고    scopus 로고
    • Bet hedging in yeast by heterogeneous, age-correlated expression of a stress protectant
    • (doi:10.1371/journal. pbio.1001325)
    • Levy SF, Ziv N, Siegel ML. 2012 Bet hedging in yeast by heterogeneous, age-correlated expression of a stress protectant. PLoS Biol. 10, e1001325. (doi:10.1371/journal. pbio.1001325)
    • (2012) PLoS Biol. , vol.10
    • Levy, S.F.1    Ziv, N.2    Siegel, M.L.3
  • 50
    • 0016136872 scopus 로고
    • Natural selection for withingeneration variance in offspring number
    • Gillespie JH. 1974 Natural selection for withingeneration variance in offspring number. Genetics 76, 601-606.
    • (1974) Genetics , vol.76 , pp. 601-606
    • Gillespie, J.H.1
  • 51
    • 0001360887 scopus 로고
    • Natural selection for variances in offspring numbers: A new evolutionary principle
    • (doi:10.1086/283230)
    • Gillespie JH. 1977 Natural selection for variances in offspring numbers: a new evolutionary principle. Am. Nat. 111, 1010-1014. (doi:10.1086/283230)
    • (1977) Am. Nat. , vol.111 , pp. 1010-1014
    • Gillespie, J.H.1
  • 52
    • 79955386056 scopus 로고    scopus 로고
    • Modes of response to environmental change and the elusive empirical evidence for bet hedging
    • (doi:10.1098/rspb.2011.0176)
    • Simons A. 2011 Modes of response to environmental change and the elusive empirical evidence for bet hedging. Proc. R. Soc. B 278, 1601-1609. (doi:10.1098/rspb.2011.0176)
    • (2011) Proc. R. Soc. B , vol.278 , pp. 1601-1609
    • Simons, A.1
  • 53
    • 79951552049 scopus 로고    scopus 로고
    • Bet hedging or not? A guide to proper classification of microbial strategies
    • (doi:10.1002/ bies.201000127)
    • de Jong IG, Haccou P, Kuipers OP. 2011 Bet hedging or not? A guide to proper classification of microbial strategies. Bioessays 33, 215-223. (doi:10.1002/ bies.201000127)
    • (2011) Bioessays , vol.33 , pp. 215-223
    • de Jong, I.G.1    Haccou, P.2    Kuipers, O.P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.