Effect of melatonin on the functional recovery from experimental traumatic compression of the spinal cord

Brazilian Journal of Medical and Biological Research

Volumn 46, Issue 4, 2013, Pages 348-358

  Schiaveto de Souza, A ^a   da Silva, C A ^b   Defino, H L A ^b   Del Bel, E A ^b  

^a FEDERAL UNIVERSITY OF MATO GROSSO DO SUL   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Functional recovery; Melatonin; Spinal cord injury

Indexed keywords

MELATONIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; NEUROPROTECTIVE AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR; CONTROLLED STUDY; CORRELATION ANALYSIS; GRAY MATTER; HISTOCHEMISTRY; HISTOLOGY; LAMINECTOMY; LOCOMOTION; MALE; MICROPHOTOGRAPHY; MOBILIZATION; NONHUMAN; OPEN FIELD TEST; POSTOPERATIVE CARE; QUANTITATIVE ANALYSIS; RAT; SPINAL CORD COMPRESSION; SPINAL CORD INJURY; ANIMAL; CONVALESCENCE; DISEASE MODEL; DRUG EFFECTS; MOTOR ACTIVITY; PATHOLOGY; PHYSIOLOGY; TIME; WISTAR RAT;

ANIMALIA; RATTUS NORVEGICUS;

ANIMALS; DISEASE MODELS, ANIMAL; MALE; MELATONIN; MOTOR ACTIVITY; NEUROPROTECTIVE AGENTS; RATS; RATS, WISTAR; RECOVERY OF FUNCTION; SPINAL CORD COMPRESSION; TIME FACTORS;

EID: 84895931946     PISSN: 0100879X     EISSN: 1414431X     Source Type: Journal    
DOI: 10.1590/1414-431X20132322     Document Type: Article

References (40)

1. Mautes AE, Weinzierl MR, Donovan F, Noble LJ. Vascular events after spinal cord injury: contribution to secondary pathogenesis. Phys Ther 2000; 80: 673-687.
2. Christie SD, Comeau B, Myers T, Sadi D, Purdy M, Mendez I. Duration of lipid peroxidation after acute spinal cord injury in rats and the effect of methylprednisolone. Neurosurg Focus 2008; 25: E5, doi: 10.3171/FOC.2008.25.11.E5.
3. Kaptanoglu E, Tuncel M, Palaoglu S, Konan A, Demirpence E, Kilinc K. Comparison of the effects of melatonin and methylprednisolone in experimental spinal cord injury. J Neurosurg 2000; 93: 77-84, doi: 10.3171/jns.2000.93.1.0077.
4. Reiter RJ, Korkmaz A. Clinical aspects of melatonin. Saudi Med J 2008; 29: 1537-1547.
5. Reiter R, Tang L, Garcia JJ, Munoz-Hoyos A. Pharmacological actions of melatonin in oxygen radical pathophysiology. Life Sci 1997; 60: 2255-2271, doi: 10.1016/S0024-3205(97)00030-1.
6. Fujimoto T, Nakamura T, Ikeda T, Takagi K. Potent protective effects of melatonin on experimental spinal cord injury. Spine 2000; 25: 769-775, doi: 10.1097/00007632-200004010-00003.
7. Topsakal C, Kilic N, Ozveren F, Akdemir I, Kaplan M, Tiftikci M, et al. Effects of prostaglandin E1, melatonin, and oxytetracycline on lipid peroxidation, antioxidant defense system, paraoxonase (PON1) activities, and homocysteine levels in an animal model of spinal cord injury. Spine 2003; 28: 1643-1652.
8. Guizar-Sahagun G, Rodriguez-Balderas CA, Franco-Bourland RE, Martinez-Cruz A, Grijalva I, Ibarra A, et al. Lack of neuroprotection with pharmacological pretreatment in a paradigm for anticipated spinal cord lesions. Spinal Cord 2009; 47: 156-160, doi: 10.1038/sc.2008.85.
9. Dimar JR, Glassman SD, Raque GH, Zhang YP, Shields CB. The influence of spinal canal narrowing and timing of decompression on neurologic recovery after spinal cord contusion in a rat model. Spine 1999; 24: 1623-1633, doi: 10.1097/00007632-199908150-00002.
10. Giglio CA, Defino HL, da-Silva CA, de-Souza AS, Del Bel EA. Behavioral and physiological methods for early quantitative assessment of spinal cord injury and prognosis in rats. Braz J Med Biol Res 2006; 39: 1613-1623, doi: 10.1590/S0100-879X2006001200013.
11. Basso DM, Beattie MS, Bresnahan JC. A sensitive and reliable locomotor rating scale for open field testing in rats. J Neurotrauma 1995; 12: 1-21, doi: 10.1089/neu.1995.12.1.
12. Rivlin AS, Tator CH. Objective clinical assessment of motor function after experimental spinal cord injury in the rat. J Neurosurg 1977; 47: 577-581, doi: 10.3171/jns.1977.47.4.0577.
13. Paxinos G, Watson C. The rat brain in stereotaxic coordinates. Burlington: Academic Press; 2005.
14. Vincent SR, Kimura H. Histochemical mapping of nitric oxide synthase in the rat brain. Neuroscience 1992; 46: 755-784, doi: 10.1016/0306-4522(92)90184-4.
15. Rogerio F, de Souza QL, Teixeira SA, Oliveira AL, de Nucci G, Langone F. Neuroprotective action of melatonin on neonatal rat motoneurons after sciatic nerve transection. Brain Res 2002; 926: 33-41, doi: 10.1016/S0006-8993(01)03286-3.
16. Cheung RT. The utility of melatonin in reducing cerebral damage resulting from ischemia and reperfusion. J Pineal Res 2003; 34: 153-160, doi: 10.1034/j.1600-079X.2003.00034.x.
17. Reiter RJ. Oxidative damage in the central nervous system: protection by melatonin. Prog Neurobiol 1998; 56: 359-384, doi: 10.1016/S0301-0082(98)00052-5.
18. Kunkel-Bagden E, Dai HN, Bregman BS. Methods to assess the development and recovery of locomotor function after spinal cord injury in rats. Exp Neurol 1993; 119: 153-164, doi: 10.1006/exnr.1993.1017.
19. Muir GD, Webb AA. Mini-review: assessment of behavioural recovery following spinal cord injury in rats. Eur J Neurosci 2000; 12: 3079-3086, doi: 10.1046/j.1460-9568.2000.00205.x.
20. Ramon-Cueto A, Avila J. Two modes of microtubule-associated protein 1B phosphorylation are differentially regulated during peripheral nerve regeneration. Brain Res 1999; 815: 213-226, doi: 10.1016/S0006-8993(98)01092-0.
21. Metz GA, Merkler D, Dietz V, Schwab ME, Fouad K. Efficient testing of motor function in spinal cord injured rats. Brain Res 2000; 883: 165-177, doi: 10.1016/S0006-8993(00)02778-5.
22. Kerlinger F, Rokeach M. The factorial nature of the F and D scales. J Pers Soc Psychol 1966; 4: 391-399, doi: 10.1037/h0023731.
23. Scheff SW, Saucier DA, Cain ME. A statistical method for analyzing rating scale data: the BBB locomotor score. J Neurotrauma 2002; 19: 1251-1260, doi: 10.1089/08977150260338038.
24. Samantaray S, Sribnick EA, Das A, Knaryan VH, Matzelle DD, Yallapragada AV, et al. Melatonin attenuates calpain upregulation, axonal damage and neuronal death in spinal cord injury in rats. J Pineal Res 2008; 44: 348-357, doi: 10.1111/j.1600-079X.2007.00534.x.
25. Reiter RJ, Tan DX, Qi WB. Suppression of oxygen toxicity by melatonin. Zhongguo Yao Li Xue Bao 1998; 19: 575-581.
26. Reiter RJ, Tan DX, Osuna C, Gitto E. Actions of melatonin in the reduction of oxidative stress. A review. J Biomed Sci 2000; 7: 444-458, doi: 10.1007/BF02253360.
27. Lahiri DK, Ghosh C. Interactions between melatonin, reactive oxygen species, and nitric oxide. Ann N Y Acad Sci 1999; 893: 325-330, doi: 10.1111/j.1749-6632.1999.tb07847.x.
28. Teixeira A, Morfim MP, de Cordova CA, Charao CC, de Lima V, Creczynski-Pasa TB. Melatonin protects against pro-oxidant enzymes and reduces lipid peroxidation in distinct membranes induced by the hydroxyl and ascorbyl radicals and by peroxynitrite. J Pineal Res 2003; 35: 262-268, doi: 10.1034/j.1600-079X.2003.00085.x.
29. Pei Z, Ho HT, Cheung RT. Pre-treatment with melatonin reduces volume of cerebral infarction in a permanent middle cerebral artery occlusion stroke model in the rat. Neurosci Lett 2002; 318: 141-144, doi: 10.1016/S0304-3940(01)02503-4.
30. Pei Z, Fung PC, Cheung RT. Melatonin reduces nitric oxide level during ischemia but not blood-brain barrier breakdown during reperfusion in a rat middle cerebral artery occlusion stroke model. J Pineal Res 2003; 34: 110-118, doi: 10.1034/j.1600-079X.2003.00014.x.
31. Escames G, Guerrero JM, Reiter RJ, Garcia JJ, Munoz-Hoyos A, Ortiz GG, et al. Melatonin and vitamin E limit nitric oxide-induced lipid peroxidation in rat brain homogenates. Neurosci Lett 1997; 230: 147-150, doi: 10.1016/S0304-3940(97)00498-9.
32. Pagliaro P. Differential biological effects of products of nitric oxide (NO) synthase: it is not enough to say NO. Life Sci 2003; 73: 2137-2149, doi: 10.1016/S0024-3205(03)00593-9.
33. Amar AP, Levy ML. Pathogenesis and pharmacological strategies for mitigating secondary damage in acute spinal cord injury. Neurosurgery 1999; 44: 1027-1039, doi: 10.1097/00006123-199905000-00052.
34. Liu D, Ling X, Wen J, Liu J. The role of reactive nitrogen species in secondary spinal cord injury: formation of nitric oxide, peroxynitrite, and nitrated protein. J Neurochem 2000; 75: 2144-2154, doi: 10.1046/j.1471-4159.2000.0752144.x.
35. Kroncke KD, Fehsel K, Kolb-Bachofen V. Nitric oxide: cytotoxicity versus cytoprotection - how, why, when, and where? Nitric Oxide 1997; 1: 107-120, doi: 10.1006/niox.1997.0118.
36. Xu M, Ng YK, Leong SK. Neuroprotective and neurodestructive functions of nitric oxide after spinal cord hemisection. Exp Neurol 2000; 161: 472-480, doi: 10.1006/exnr.1999.7278.
37. Hu WH, Qiang WA, Li F, Liu N, Wang GQ, Wang HY, et al. Constitutive and inducible nitric oxide synthases after dynorphin-induced spinal cord injury. J Chem Neuroanat 2000; 17: 183-197, doi: 10.1016/S0891-0618(99)00039-3.
38. Diaz-Ruiz A, Ibarra A, Perez-Severiano F, Guizar-Sahagun G, Grijalva I, Rios C. Constitutive and inducible nitric oxide synthase activities after spinal cord contusion in rats. Neurosci Lett 2002; 319: 129-132, doi: 10.1016/S0304-3940(01)02540-X.
39. Nakahara S, Yone K, Setoguchi T, Yamaura I, Arishima Y, Yoshino S, et al. Changes in nitric oxide and expression of nitric oxide synthase in spinal cord after acute traumatic injury in rats. J Neurotrauma 2002; 19: 1467-1474, doi: 10.1089/089771502320914697.
40. Bracken MB, Shepard MJ, Holford TR, Leo-Summers L, Aldrich EF, Fazl M, et al. Methylprednisolone or tirilazad mesylate administration after acute spinal cord injury: 1-year follow up. Results of the third National Acute Spinal Cord Injury randomized controlled trial. J Neurosurg 1998; 89: 699-706, doi: 10.3171/jns.1998.89.5.0699.