Potent protective effects of melatonin on experimental spinal cord injury

Spine

Volumn 25, Issue 7, 2000, Pages 769-775

  Fujimoto, Toru ^a,b   Nakamura, Takafumi ^a   Ikeda, Takashi ^a   Takagi, Katsumasa ^a  

^a KUMAMOTO UNIV SCHOOL OF MEDICINE   (Japan)

^b Kicine ^*  (Japan)

Author keywords

Melatonin; Myeloperoxidase; Neutrophil; Spinal cord injury; TBARS

Indexed keywords

CHLORMETHINE; MELATONIN; MYELOPEROXIDASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; LAMINECTOMY; LEUKOPENIA; LIPID PEROXIDATION; LYMPHOCYTIC INFILTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL CORD INJURY;

ANIMALS; LEUKOPENIA; LIPID PEROXIDATION; LOCOMOTION; MALE; MECHLORETHAMINE; MELATONIN; PEROXIDASE; RATS; RATS, WISTAR; SPINAL CORD; SPINAL CORD INJURIES; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

EID: 0034000083     PISSN: 03622436     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007632-200004010-00003     Document Type: Article

References (28)

1. Agrawal SK, Fehlings MG. Role of NMDA and non-NMDA ionotropic glutamate receptors in traumatic spinal cord axonal injury. J Neurosci 1997;17: 1055-63.
2. Anderson DK, Hall ED. Pathophysiology of spinal cord trauma. Ann Emerg Med 1993;22:987-92.
3. Behrmann DL, Bresnahan JC, Beattie MS. Modeling of acute spinal cord injury in the rat: Neuroprotection and enhanced recovery with methylprednisolone, U-74006F and YM-14673. Exp Neurol 1994;126:61-75.
4. Bracken MB, Shepard MJ, Holford TR, et al. Methylprednisolone or tirilazad mesylate administration after acute spinal cord injury: 1-year follow up: Results of the third national acute spinal cord injury randomized controlled trial. J Neurosurg 1998;89:699-706.
5. Cassone VM, Chesworth MJ, Armstrong SM. Entrainment of rat circadian rhythms by daily injection of melatonin depends upon the hypothalamic suprachiasmatic nuclei. Physiol Behav 1986;36:1111-21.
6. De La Lastra CA, Cabeza J, Motilva V, Martin MJ. Melatonin protects against gastric ischemia-reperfusion injury in rats. J Pineal Res 1997;23:47-52.
7. Demopoulos HB, Flamm ES, Pietronigro DD, Seligman ML. The free radical pathology and the microcirculation in the major central nervous system disorders. Acta Physiol Scand Suppl 1980;492:91-119.
8. + ATPase activity, and tissue water content of spinal cord following experimental traumatic Injury. J Neurochem 1987;48:1809-16.
9. Fantone JC, Ward PA. Role of oxygen-derived free radicals and metabolites in leukocyte-dependent inflammatory reactions. Am J Pathol 1982;107:395-418.
10. Hamada Y, Ikata T, Katoh S, et al. Involvement of an intercellular adhesion molecule 1-dependent pathway in the pathogenesis of secondary changes after spinal cord injury in rats. J Neurochem 1996;66:1525-31.
11. Iwasa K, Ikata T, Fukuzawa K. Protective effect of vitamin E on spinal cord injury by compression and concurrent lipid peroxidation. Free Radic Biol Med 1989;6:599-606.
12. Kikugawa K, Kojima T, Yamaki S, Kosugi H. Interpretation of the thiobarbituric acid reactivity of rat liver and brain homogenates in the presence of ferric ion and ethylenediaminetetraacetic acid. Anal Biochem 1992;202:249-55.
13. Kunkel-Bagden E, Dai HN, Bregman, BS. Methods to assess the development and recovery of locomotor function after spinal cord injury in rats. Exp Neurol 1993;119:153-64.
14. Lamb RG, Harper CC, McKinney JS, Rzigalinski BA, Ellis EF. Alterations in phosphatidylcholine metabolism of stretch-injured cultured rat astrocytes. J Neurochem 1997;68:1904-10.
15. Liu D, Yang R, Yan X, Mcadoo DJ. Hydroxyl radicals generated in vivo kill neurons in the rat spinal cord: Electrophysiological, histological, and neurochemical results. J Neurochem 1994;62:37-44.
16. Means ED, Anderson DK. Neuronophagia by leukocytes in experimental spinal cord injury. J Neuropathol Exp Neurol 1983;42:707-19.
17. Melchiorri D, Reiter RJ, Attia AM, Hara M, Burgos A, Nistico G. Potent protective effect of melatonin on in vivo paraquat-induced oxidative damage in rats. Life Sci 1995;56:83-9.
18. Mesenge C. Margaill I, Verrecchia C, Allix M, Boulu RG, Plotkine M. Protective effect of melatonin in a model of traumatic brain injury in mice. J Pineal Res 1998;25:41-6.
19. Müller-Berghaus G, Eckhardt T. The role of granulocytes in the activation of intravascular coagulation and the precipitation of soluble fibrin by endotoxin. Blood 1975;45:631-41.
20. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979;95:351-8.
21. Pieri C, Marra M, Moroni F, Recchioni R, Marcheselli F. Melatonin: A peroxyl radical scavenger more effective than vitamin E. Life Sci 1994;55:271-6.
22. Reiter RJ, Tan DX, Poeggeler B, Menendez-Pelaez A, Chen LD, Saarela S. Melatonin as a free radical scavenger: Implications for aging and age-related diseases. Ann N Y Acad Sci 1994;719:1-12.
23. Rivlin AS, Tator CH. Objective clinical assessment of motor function after experimental spinal cord injury in the rat. J Neurosurg 1977;47:577-81.
24. Rubanyi GM. Vascular effects of oxygen-derived free radicals. Free Radic Biol Med 1988;4:107-20.
25. Sacco S, Aquilini L, Ghezzi P, Pinza M, Guglielmotti A. Mechanism of the inhibitory effect of melatonin on tumor necrosis factor production in vivo and in vitro. Eur J Pharmacol 1998;343:249-55.
26. Stokkan KA, Reiter RJ, Nonaka KO, Lerchl A, Yu BP, Vaughan MK. Food restriction retards aging of the pineal gland. Brain Res 1991;545:66-72.
27. Taoka Y, Okajima K. Spinal cord injury in the rat. Prog Neurobiol 1998;55: 1-18.
28. Tarlov IM, Klinger H. Spinal cord compression studies. AMA Arch Neurol Psychiatry 1954;71:271-90.