Women with high early pregnancy urinary iodine levels have an increased risk of hyperthyroid newborns: The population-based Generation R Study

Clinical Endocrinology

Volumn 80, Issue 4, 2014, Pages 598-606

  Medici, Marco ^a   Ghassabian, Akhgar ^a,b   Visser, Willy ^b   De Muinck Keizer Schrama, Sabine M P F ^b   Jaddoe, Vincent W V ^a,b   Visser, W Edward ^a   Hooijkaas, Herbert ^a   Hofman, Albert ^a   Steegers, Eric A P ^b   Bongers Schokking, Jacoba J ^b   Ross, H Alec ^c   Tiemeier, Henning ^a,b   Visser, Theo J ^a   De Rijke, Yolanda B ^a,b   Peeters, Robin P ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b SOPHIA CHILDREN S HOSPITAL   (Netherlands)

^c RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

IODINE; THYROID PEROXIDASE ANTIBODY; THYROTROPIN;

ADULT; ARTICLE; FEMALE; FIRST TRIMESTER PREGNANCY; FREE THYROXINE INDEX; HUMAN; HYPERTHYROIDISM; HYPOTHYROXINEMIA; MAJOR CLINICAL STUDY; NEWBORN; PRIORITY JOURNAL; THYROID DISEASE; THYROTROPIN BLOOD LEVEL; URINE LEVEL;

FEMALE; FETAL BLOOD; HUMANS; HYPERTHYROIDISM; INFANT, NEWBORN; INFANT, NEWBORN, DISEASES; IODIDES; IODINE; MOTHERS; PREGNANCY; THYROTROPIN; THYROXINE;

EID: 84895928534     PISSN: 03000664     EISSN: 13652265     Source Type: Journal    
DOI: 10.1111/cen.12321     Document Type: Article

References (37)

1. Andersson, M., de Benoist, B., &, Rogers, L., (2010) Epidemiology of iodine deficiency: salt iodisation and iodine status. Best Practice & Research Clinical Endocrinology & Metabolism, 24, 1-11.
2. Laurberg, P., Cerqueira, C., Ovesen, L., et al,. (2010) Iodine intake as a determinant of thyroid disorders in populations. Best Practice & Research Clinical Endocrinology & Metabolism, 24, 13-27.
3. Glinoer, D., (2007) The importance of iodine nutrition during pregnancy. Public Health Nutrition, 10, 1542-1546.
4. Yarrington, C.D., &, Pearce, E.N., (2011) Dietary iodine in pregnancy and postpartum. Clinical Obstetrics and Gynecology, 54, 459-470.
5. Zimmermann, M.B., (2007) The impact of iodised salt or iodine supplements on iodine status during pregnancy, lactation and infancy. Public Health Nutrition, 10, 1584-1595.
6. de Escobar, G.M., Obregon, M.J., &, del Rey, F.E., (2007) Iodine deficiency and brain development in the first half of pregnancy. Public Health Nutrition, 10, 1554-1570.
7. World Health Organization United Nations Children's Fund, International Council for Control of Iodine Deficiency Disorders (2007) Assessment of Iodine Deficiency Disorders and Monitoring Their Elimination, 3rd edn. WHO, Geneva.
8. Melse-Boonstra, A., &, Jaiswal, N., (2010) Iodine deficiency in pregnancy, infancy and childhood and its consequences for brain development. Best Practice & Research Clinical Endocrinology & Metabolism, 24, 29-38.
9. Pearce, E.N., (2012) Effects of iodine deficiency in pregnancy. Journal of Trace Elements in Medicine and Biology, 26, 131-133.
10. Pharoah, P.O., Buttfield, I.H., &, Hetzel, B.S., (1971) Neurological damage to the fetus resulting from severe iodine deficiency during pregnancy. Lancet, 1, 308-310.
11. Andersson, M., de Benoist, B., Delange, F., et al,. (2007) Prevention and control of iodine deficiency in pregnant and lactating women and in children less than 2-years-old: conclusions and recommendations of the Technical Consultation. Public Health Nutrition, 10, 1606-1611.
12. Delange, F., (2007) Iodine requirements during pregnancy, lactation and the neonatal period and indicators of optimal iodine nutrition. Public Health Nutrition, 10, 1571-1580; discussion 1581-1573.
13. Nishiyama, S., Mikeda, T., Okada, T., et al,. (2004) Transient hypothyroidism or persistent hyperthyrotropinemia in neonates born to mothers with excessive iodine intake. Thyroid, 14, 1077-1083.
14. Sang, Z., Wei, W., Zhao, N., et al,. (2012) Thyroid dysfunction during late gestation is associated with excessive iodine intake in pregnant women. Journal of Clinical Endocrinology and Metabolism, 97, E1363-E1369.
15. Jaddoe, V.W., van Duijn, C.M., van der Heijden, A.J., et al,. (2010) The Generation R Study: design and cohort update 2010. European Journal of Epidemiology, 25, 823-841.
16. Medici, M., de Rijke, Y.B., Peeters, R.P., et al,. (2012) Maternal early pregnancy and newborn thyroid hormone parameters: the Generation R study. Journal of Clinical Endocrinology and Metabolism, 97, 646-652.
17. Chanoine, J.P., Bourdoux, P., Vo Thi, N.B., et al,. (1987) Iodine contamination of urine samples by test strips. Clinical Chemistry, 33, 1935.
18. Pearce, E.N., Lazarus, J.H., Smyth, P.P., et al,. (2009) Urine test strips as a source of iodine contamination. Thyroid, 19, 919.
19. De Groot, L., Abalovich, M., Alexander, E.K., et al,. (2012) Management of thyroid dysfunction during pregnancy and postpartum: an Endocrine Society clinical practice guideline. Journal of Clinical Endocrinology and Metabolism, 97, 2543-2565.
20. Stagnaro-Green, A., Abalovich, M., Alexander, E., et al,. (2011) Guidelines of the American Thyroid association for the diagnosis and management of thyroid disease during pregnancy and postpartum. Thyroid, 21, 1081-1125.
21. Azizi, F., Hosseini, M.S., Amouzegar, A., et al,. (2011) Neonatal thyroid status in an area of iodine sufficiency. Journal of Endocrinological Investigation, 34, 197-200.
22. Polak, M., Legac, I., Vuillard, E., et al,. (2006) Congenital hyperthyroidism: the fetus as a patient. Hormone Research, 65, 235-242.
23. Polak, M., (1998) Hyperthyroidism in early infancy: pathogenesis, clinical features and diagnosis with a focus on neonatal hyperthyroidism. Thyroid, 8, 1171-1177.
24. Fuse, Y., Ohashi, T., Yamaguchi, S., et al,. (2011) Iodine status of pregnant and postpartum Japanese women: effect of iodine intake on maternal and neonatal thyroid function in an iodine-sufficient area. Journal of Clinical Endocrinology and Metabolism, 96, 3846-3854.
25. Markou, K., Georgopoulos, N., Kyriazopoulou, V., et al,. (2001) Iodine-Induced hypothyroidism. Thyroid, 11, 501-510.
26. Wolff, J., Chaikoff, I.L., Goldberg, R.C., et al,. (1949) The temporary nature of the inhibitory action of excess iodine on organic iodine synthesis in the normal thyroid. Endocrinology, 45, 504-513.
27. Eng, P.H., Cardona, G.R., Fang, S.L., et al,. (1999) Escape from the acute Wolff-Chaikoff effect is associated with a decrease in thyroid sodium/iodide symporter messenger ribonucleic acid and protein. Endocrinology, 140, 3404-3410.
28. Uyttersprot, N., Pelgrims, N., Carrasco, N., et al,. (1997) Moderate doses of iodide in vivo inhibit cell proliferation and the expression of thyroperoxidase and Na+/I- symporter mRNAs in dog thyroid. Molecular and Cellular Endocrinology, 131, 195-203.
29. Laurberg, P., Pedersen, K.M., Vestergaard, H., et al,. (1991) High incidence of multinodular toxic goitre in the elderly population in a low iodine intake area vs. high incidence of Graves' disease in the young in a high iodine intake area: comparative surveys of thyrotoxicosis epidemiology in East-Jutland Denmark and Iceland. Journal of Internal Medicine, 229, 415-420.
30. Chan, G.W., &, Mandel, S.J., (2007) Therapy insight: management of Graves' disease during pregnancy. Nature Clinical Practice Endocrinology & Metabolism, 3, 470-478.
31. Benhadi, N., Wiersinga, W.M., Reitsma, J.B., et al,. (2007) Ethnic differences in TSH but not in free T4 concentrations or TPO antibodies during pregnancy. Clinical Endocrinology, 66, 765-770.
32. Iijima, T., Tada, H., Hidaka, Y., et al,. (1997) Effects of autoantibodies on the course of pregnancy and fetal growth. Obstetrics & Gynecology, 90, 364-369.
33. Negro, R., Formoso, G., Mangieri, T., et al,. (2006) Levothyroxine treatment in euthyroid pregnant women with autoimmune thyroid disease: effects on obstetrical complications. Journal of Clinical Endocrinology and Metabolism, 91, 2587-2591.
34. König, F., Andersson, M., Hotz, K., et al,. (2011) Ten repeat collections for urinary iodine from spot samples or 24-hour samples are needed to reliably estimate individual iodine status in women. Journal of Nutrition, 141, 2049-2054.
35. Andersen, S., Karmisholt, J., Pedersen, K.M., et al,. (2008) Reliability of studies of iodine intake and recommendations for number of samples in groups and in individuals. British Journal of Nutrition, 99, 813-818.
36. Health Council of The Netherlands (2008) Towards Maintaining an Optimum Iodine Intake. Publication no. 2008/14. Health Council of The Netherlands, The Hague.
37. Wiersinga, W.M., Podoba, J., Srbecky, M., et al,. (2001) A survey of iodine intake and thyroid volume in Dutch schoolchildren: reference values in an iodine-sufficient area and the effect of puberty. European Journal of Endocrinology, 144, 595-603.