Iodine deficiency and brain development in the first half of pregnancy

Public Health Nutrition

Volumn 10, Issue 12 A, 2007, Pages 1554-1570

  De Escobar, Gabriella Morreale ^a   Obregón, María Jesús ^a   Del Rey, Francisco Escobar ^a  

^a INSTITUTO DE INVESTIGACIONES BIOMÉDICAS ALBERTO SOLS   (Spain)

Author keywords

Brain development; Foetus; Hypothyroxinemia; Iodine deficiency; Pregnancy; Thyroid hormone

Indexed keywords

IODINE; LIOTHYRONINE; THYROID HORMONE; THYROXINE;

BEHAVIOR DISORDER; BRAIN CORTEX; BRAIN DEVELOPMENT; CELL MIGRATION; CONFERENCE PAPER; FETUS DEVELOPMENT; GESTATIONAL AGE; HIPPOCAMPUS; HORMONE BINDING; HORMONE DEFICIENCY; HORMONE SYNTHESIS; HUMAN; HYPOTHYROXINEMIA; IODINE DEFICIENCY; LEARNING DISORDER; PREGNANCY; PRIORITY JOURNAL; RADIAL NERVE; RISK;

ADULT; ANIMALS; BRAIN; FEMALE; FETUS; GOITER; HUMANS; HYPOTHYROIDISM; IODINE; MATERNAL-FETAL EXCHANGE; PREGNANCY; PREGNANCY COMPLICATIONS; PREGNANCY TRIMESTER, FIRST; THYROID HORMONES;

ANIMALIA;

EID: 36849050817     PISSN: 13689800     EISSN: 14752727     Source Type: Journal    
DOI: 10.1017/S1368980007360928     Document Type: Conference Paper

References (107)

1. Jonsson U. Nutrition and the convention on the rights of the child. Food Policy 1996; 21: 41-55.
2. Hetzel BS, Chavadej J, Potter BJ. The brain in iodine deficiency. Neuropathology and Applied Neurobiology 1988; 14: 93-104.
3. Hetzel BS. Historical development of concepts of brain-thyroid relationships. In: Stanbury JB, ed. The Damaged Brain of Iodine Deficiency. Elmsford, New York: Cognizant Communication, 1994; 1-8.
4. Delange F. Iodine deficiency as a cause of brain damage. Postgraduate Medical Journal 2001; 77: 217-20.
5. Delange F, Lecomte P. Iodine supplementation: benefits outweigh risks. Drug Safety 2000; 22: 89-95.
6. Glinoer D, Delange F. The potential repercussions of maternal, fetal, and neonatal hypothyroxinemia on the progeny. Thyroid 2000; 10: 871-7.
7. Morreale de Escobar G, Obregón MJ, Calvo R, Pedraza PE, Escobar del Rey F. Iodine deficiency, the hidden scourge: the rat model of human neurological cretinism. In: Hendrich CH, ed. Neuroendocrinology. Trivandrum, India: Research Signpost and Scientific Information Guild, 1997; 55-70.
8. Morreale de Escobar G, Obregón MJ, Escobar del Rey F. Is neuropsychological development related to maternal hypothyroidism, or to maternal hypothyroxinemia? Journal of Clinical Endocrinology and Metabolism 2000; 85: 3975-87.
9. Morreale de Escobar G, Escobar del Rey F. Consequences of iodine deficiency for brain development. In: deVijlder J, Morreale de Escobar G, eds. The Thyroid and the Brain. Stuttgart: Schattauer Verlag, 2003; 33-56.
10. Morreale de Escobar G, Obregón MJ, Escobar del Rey F. Role of thyroid hormone during early brain development. European Journal of Endocrinology 2004; 151: U25-U37.
11. Choufoer JC, van Rhijn M, Querido A. Endemic goiter in Western New Guinea. II. Clinical picture, incidence and pathogenesis of endemic cretinism. Journal of Clinical Endocrinology and Metabolism 1965; 25: 385-402.
12. Pharoah POD, Ellis SM, Ekins RP, Williams ES. Maternal thyroid function, iodine deficiency and fetal development. Clinical Endocrinology (Oxford) 1976; 5: 159-66.
13. Pretell EA, Stanbury JB. Effect of chronic iodine deficiency on maternal and fetal thyroid hormone synthesis. In: Hetzel BS, Pharoah POD, eds. Endemic Cretinism. Papua New Guinea Institute of Medical Research Monograph Series, No 2. Goroka: Institute of Human Biology, 1971; 117-24.
14. Pretell EA, Cáceres A. Impairment of mental development by iodine deficiency and its correction. A retrospective view from studies in Peru. In: Stanbury JB, ed. The Damaged Brain of Iodine Deficiency. Elmsford, New York: Cognizant Communication, 1994; 187-92.
15. Pharoah POD, Buttfield IH, Hetzel BS. Neurological damage to the fetus resulting from severe iodine deficiency during pregnancy. Lancet 1971; 1: 308-11.
16. Xue-Yi C, Xin-Min J, Zhi-Jong D, Rakeman MA, Ming-Li Z, O'Donnell K, et al. Timing of vulnerability of the brain to iodine deficiency in endemic cretinism. New England Journal of Medicine 1994; 331: 1739-44.
17. Connolly KJ, Pharoah POD, Hetzel BS. Fetal iodine deficiency and motor performance during childhood. Lancet 1979; 1: 1149-51.
18. Pharoah POD, Connolly K, Hetzel B, Ekins R. Maternal thyroid function and motor competence in the child. Developmental Medicine and Child Neurology 1981; 23: 76-82.
19. Pharoah POD, Connolly KJ, Ekins RP, Harding AG. Maternal thyroid hormone levels in pregnancy and the subsequent cognitive and motor performance of the children. Clinical Endocrinology (Oxford) 1984; 21: 265-70.
20. Pharoah POD, Connolly KJ. Relationship between maternal thyroxine levels during pregnancy and memory function in childhood. Early Human Development 1991; 25: 43-51.
21. Bleichrodt N, Bjorn M. A metaanalysis of research on iodine and its relationship to cognitive development. In: Stanbury JB, ed. The Damaged Brain of Iodine Deficiency. Elmsford, New York: Cognizant Communication, 1994; 195-200.
22. Vitti P, Aghini-Lombardi F, Chiovato L, Ferretti G, Pinchera A. Neuropsychological assessment in humans living in mild to moderate iodine deficiency. In: DeVijlder J, Morreale de Escobar G, eds. The Thyroid and the Brain. Stuttgart: Schattauer Verlag, 2003; 57-63.
23. Vermiglio F, Lo Presti VP, Moleti M, Sidoti M, Tortorella G, Scaffidi G, et al. Attention deficit and hyperactivity disorders (ADHD) in the offspring of mothers exposed to iodine deficiency: a possible novel iodine deficiency disorder in developed countries? Journal of Clinical Endocrinology and Metabolism 2004; 89: 6054-60.
24. Contempré B, Jauniaux E, Calvo R, Jurkovic D, Campbell S, Morreale de Escobar G. Detection of thyroid hormones in human embryonic cavities during the first trimester of pregnancy. Journal of Clinical Endocrinology and Metabolism 1993; 77: 1719-22.
25. Calvo RM, Jauniaux E, Gulbis B, Asunción M, Gervy C, Contempré B, et al. Fetal tissues are exposed to biologically relevant free thyroxine concentrations during early phases of development. Possible consequences of maternal hypothyroxinemia. Journal of Clinical Endocrinology and Metabolism 2002; 87: 1768-77.
26. Anselmo J, Cao D, Karrison T, Weiss RE, Refetoff S. Fetal loss associated with excess thyroid hormone exposure. Journal of the American Medical Association 2004; 292: 691-5.
27. Thorpe-Beeston JG, Nicolaides KH, Felton CV, Butler J, McGregor AM. Maturation of the secretion of thyroid hormone and thyroid-stimulating hormone in the fetus. New England Journal of Medicine 1991; 324: 532-6.
28. Grasso S, Filetti S, Mazzon D, Pezzino V, Vigo R, Vigneri R. Thyroid-pituitary function in eight anencephalic infants. Acta Endocrinologica (Copenhagen) 1980; 93: 396-401.
29. Beck-Peccoz P, Cortelazzi D, Persani L, Papandreou MJ, Asteria C, Borgato S, et al. Maturation of pituitary-thyroid function in the anencephalic fetus. Acta Medica Austriaca 1992; 19(Suppl. 1): 72-6.
30. Morine M, Takeda T, Minekawa R, Sugiyama T, Wasada K, Mizutani T, et al. Antenatal diagnosis and treatment of a case of fetal goitrous hypothyroidism associated with high-output cardiac failure. Ultrasound in Obstetrics and Gynecology 2002; 19: 506-9.
31. Crisanti P, Omri B, Hughes EJ, Meduri G, Hery C, Clauser E, et al. The expression of thyrotropin receptor in the brain. Endocrinology 2001; 142: 812-22.
32. Saunier B, Pierre M, Jacquemin C, Courtin F. Evidence for cAMP-independent thyrotropin effects on astroglial cells. European Journal of Biochemistry 1993; 218: 1091-4.
33. Szkudlinski MW, Fremont V, Ronin C, Weintraub BD. Thyroid stimulating hormone and thyroid stimulating hormone receptor structure-function relationships. Physiological Reviews 2002; 82: 473-502.
34. Bernal J, Pekonen F. Ontogenesis of the nuclear 3,5,3′- triiodothyroxine receptor in the human fetal brain. Endocrinology 1984; 114: 677-9.
35. Ferreiro B, Bernal J, Goodyer CG, Branchard CL. Estimation of nuclear thyroid hormone receptor saturation in human fetal brain and lung during early gestation. Journal of Clinical Endocrinology and Metabolism 1988; 67: 853-6.
36. Iskaros J, Pickard M, Evans I, Sinha A, Hardiman P, Ekins R. Thyroid hormone receptor gene expression in first trimester human fetal brain. Journal of Clinical Endocrinology and Metabolism 2000; 85: 2620-3.
37. Lazar MA. Thyroid hormone receptors: multiple forms, multiple possibilities. Endocrine Reviews 1993; 14: 184-93.
38. Kester M-HA, Martinez de Mena R, Obregon MJ, Marinkovic D, Howatson A, Visser TH, et al. Iodothyronine levels in the human developing brain: major regulatory roles of iodothyronine deiodinases in different areas. Journal of Clinical Endocrinology and Metabolism 2004; 89: 3117-28.
39. Calvo R, Obregon MJ, Ruiz de Oña C, Escobar del Rey F, Morreale de Escobar G, et al. Congenital hypothyroidism, as studied in rats. Crucial role of maternal thyroxine but not of 3,5,3′-triiodothyronine in the protection of the fetal brain. Journal of Clinical Investigation 1990; 86: 889-99.
40. Glinoer D. The regulation of thyroid function in pregnancy: pathways of endocrine adaptation from physiology to pathology. Endocrine Reviews 1997; 18: 404-33.
41. Anselmo J, Kay T, Dennis S, Szmulewitz R, Refetoff S, Weiss RE. Resistance to thyroid hormone does not abrogate the transient thyrotoxicosis associated with gestation: report of a case. Journal of Clinical Endocrinology and Metabolism 2001; 86: 4273-5.
42. Wasco EC, Martinez E, Grant KS, StGermain DI, Galton VA. Determinants of iodothyronine deiodinase activities in rodent uterus. Endocrinology 2003; 144: 4253-61.
43. Glinoer D. Regulation of thyroid function during normal pregnancy: importance of the iodine nutrition status. Best Practice and Research in Clinical Endocrinology and Metabolism 2004; 18: 133-52.
44. Mandel SJ. Hypothyroidism and chronic autoimmune thyroiditis in the pregnant state: maternal aspects. Best Practice and Research in Clinical Endocrinology and Metabolism 2004; 18: 213-24.
45. Mandel SJ, Larsen PR, Seely EW, Brent GA. Increased need for thyroxine during pregnancy in women with primary hypothyroidism. New England Journal of Medicine 1990; 232: 91-6.
46. Alexander EK, Marqusee E, Lawrence J, Jarolim P, Fischer GA, Larsen PR. Timing and magnitude of increases in levothyroxine requirements during pregnancy in women with hypothyroidism. New England Journal of Medicine 2004; 351: 241-9.
47. Delange F. Optimal iodine nutrition during pregnancy, lactation and the neonatal period. International Journal of Endocrinology and Metabolism 2004; 2: 1-12.
48. de Santiago J, Pastor I, Escobar del Rey F, Morreale de Escobar G. Thyroid function in pregnant women from an area with mild (Grade I) iodine deficiency. Journal of Endocrinological Investigation 1999; 22(Suppl. 6, Abstract 126): 68.
49. Escobar del Rey F, Lavado Autric R, Vázquez JA, Morreale de Escobar G. Are all criteria defining degrees of iodine deficiency adequate to assess eradication of Iodine Deficiency Disdorders?. In: Sánchez-Franco F, Wass J, eds. IV European Congress of Endocrinology, 1998 . Sevilla, Spain: BioScientifica, 1998.
50. Barnett CA, Visser TJ, Williams F, van Toor H, Durán S, Presas MJ, et al. Inadequate iodine intake of 40% of pregnant women from a region in Scotland. In: 28th Annual meeting of the European Thyroid Association, 2002, Göteborg, Sweden. Journal of Endocrinological Investigation 2002; 25(Suppl. 7, Abstract P110): 90.
51. Escobar del Rey F, Sánchez-Vega J, Morreale de Escobar G. Informe sobre el estudio epidemiológico de la nutrición en yodo de mujeres embarazadas de Extremadura. Sent to Local Health Authorities 2004: unpublished.
52. Domínguez I, Reviriego S, Rojo-Martínez G, Valdés JM, Carrasco R, Coronas I, et al. Déficit de yodo y función tiroidea en una población de mujeres embarazadas sanas. Medicina Clínica (Barcelona) 2004; 122: 449-53.
53. Halmi NS, Spirtos BN. Analysis of the modifying effect of dietary iodine levels on the thyroidal response of hypophysectomized rats to thyrotropin. Endocrinology 1955; 56: 157-60.
54. Greer MA. Qualitative changes in the secretion of thyroid hormones induced by iodine deficiency. Endocrinology 1968; 83: 1193-8.
55. Arntzenius AB, Smit LJ, Schipper J, van der Heide D, Meinders AE. Inverse relation between iodine intake and thyroid blood flow: color Doppler flow imaging in euthyroid humans. Journal of Clinical Endocrinology and Metabolism 1991; 73: 1051-5.
56. Pisarev MA. Thyroid autoregulation. Journal of Endocrinological Investigation 1985; 8: 475-84.
57. Pharoah POD, Lawton NF, Ellis SM, Williams ES, Ekins RP. The role of triiodothyronine in the maintenance of euthyroidism in endemic goitre. Clinical Endocrinology (Oxford) 1973; 2: 193-9.
58. Vagenakis A, Koutras D, Burger A, Malamos B, Ingbar S. Studies of serum triiodothyronine, thyroxine and thyrotropin concentrations in endemic goiter in Greece. Journal of Clinical Endocrinology and Metabolism 1973; 37: 485-8.
59. Missler U, Gutekunst R, Wood WG. Thyroglobulin is a more sensitive indicator of iodine deficiency than thyrotropin: development and evaluation of dry blood spot assays for thyrotropin and thyroglobulin in iodine-deficient geographical areas. European Journal of Clinical Chemistry and Clinical Biochemistry 1994; 32: 137-43.
60. Dumont JE, Corvilain B, Contempré B. Endemic cretinism: the myxoedematous and neurological forms of the disease caused by severe iodine deficiency. In: Stanbury JB, ed. The Damaged Brain of Iodine Deficiency. Elmsford, New York: Cognizant Communication, 1994; 195-200.
61. Delange F, Bourdoux P, Ermans AM. Transient disorders of thyroid function and regulation in preterm infants. In: Delange F, Fisher DA, Malvoux P, eds. Pediatric Thyroidology. Basel: S Karger AG, 1985; 369-93.
62. World Health Organization. Assessment of Iodine Deficiency Disorders and Monitoring their Elimination, 2 ed. Geneva, Switzerland: Department of Nutrition, World Health Organization, 2001.
63. Yan YQ, Guan C, Leng L, LI JQ. Quantitative histology study on brain nervous cells of neurological endemic cretins. In: Delong GR, Robbins J, Condliffe PG, eds. Iodine and the Brain. New York: Plenum Publishing Corporation, 1989; 359.
64. Cruz M, Cavelos P, Uteras A, Malo L. Gina de tomografía axial computerizada. Quito, Ecuador, 1984.
65. Ma T, Lian ZC, R HE, DeLong GR. Magnetic resonance imaging of the brain and the neuromotor deficit in endemic cretinism. Annals of Neurology 1993; 34: 91-4.
66. DeLong GR, Tai M, Xue-ui C, Xin-Min J, Zhi-hong D, Rakeman MA, et al. The neuromotor deficit in endemic cretinism. In: Stanbury JB, ed. The Damaged Brain of Iodine Deficiency. Elmsford, NY: Cognizant Communication Co, 1994; 9-14.
67. Jia-Liu L, Zhong-Jie S, Zhon-Fu S, Jia-Xiu Z, Yu-Bin T, Bing-Zhong C. Influence of iodine deficiency on human fetal thyroid gland and brain. In: Delong GR, Robbins J, Condliffe PG, eds. Iodine and the Brain. New York: Plenum Publishing Corporation, 1989; 249-58.
68. Jia-Liu L, Zhong-Jie S, Yu-Bin T, Zhon-Fu S, Xi-tian L, Xiubao Y, et al. Morphologic study on cerebral cortex development in therapeutically aborted fetuses in an endemic goiter region in Guizhou. Chinese Medical Journal (English) 1984; 97: 67-72.
69. Jia-Liu L, Zhong-Jie S, Xu-mao C, Shang-an L, Fu-guang Z, Zhong-guo G, et al. Changes in thyroid, cerebral cortex and bones of therapeutically aborted fetuses from endemic goiter region supplied with iodized salt for 5 years. Chinese Medical Journal (English) 1988; 101: 133-6.
70. Potter BJ, Jones GB, Buckley RA, Belling GB, Mcintosh GH, Hetzel BS. Production of severe iodine deficiency in sheep using a prepared low-iodine diet. Australian Journal of Biological Sciences 1980; 33: 53-61.
71. Hetzel BS. Hormone nurturing of the developing brain: Sheep and Marmoset models. In: Stanbury JB, ed. The Damaged Brain of Iodine Deficiency. Elmsford, New York: Cognizant Communication, 1994; 123-30.
72. Potter BJ, Mano MT, Belling GB, Mcintosh GH, Hua C, Cragg BG, et al. Retarded fetal brain development resulting from severe dietary iodine deficiency in sheep. Neuropathology and Applied Neurobiology 1982; 8: 303-13.
73. McIntosh GH, Baghurst KI, Potter BJ, Hetzel BS. Foetal thyroidectomy and brain development in the sheep. Neuropathology and Applied Neurobiology 1979; 5: 363-76.
74. Potter BJ, Mano MT, Belling GB, Martin DM, Cragg BG, Chavadej J, et al. Restoration of brain growth in fetal sheep after iodized oil administration to pregnant iodine-deficient ewes. Journal of Neurological Sciences 1984; 66: 15-26.
75. Hetzel BS, Potter B. Iodine deficiency and the role of thyroid hormones in brain development. In: Dreosti IE, Smith RM, eds. Neurobiology of the Trace Elements. Totawa, NJ: Humana Press, 1983; 83-133.
76. Mano MT, Potter BJ, Belling GB, Hetzel BS. Low-iodine diet for the production of severe iodine deficiency in marmosets (Callithrix jacchus jacchus). British Journal of Nutrition 1985; 54: 367-73.
77. Mano MT, Potter BJ, Belling GB, Chavadej J, Hetzel BS. Fetal brain development in response to iodine deficiency in a primate model (Callithrix Jacchus Jacchus). Journal of Neurological Sciences 1987; 79: 287-300.
78. Morreale de Escobar G, Ruiz de Oña C, Obregon MJ, Escobar del Rey F. Models in fetal iodine deficiency. In: Delong GR, Robbins J, Condliffe PG, eds. Iodine and the Brain. New York: Plenum Publishing Corporation, 1989; 187-201.
79. Morreale de Escobar G, Obregõn MJ, Calvo R, Escobar del Rey F. Hormone nurturing of the developing brain: the rat model. In: Stanbury JB, ed. The Damaged Brain in Iodine Deficiency. Elmsford, New York: Cognizant Communication Co, 1994; 103-22.
80. Obregón MJ, Santisteban P, Rodriguez-Peña A, Pascual A, Cartagena P, Ruiz-Marcos A, et al. Cerebral hypothyroidism in rats with adult-onset iodine deficiency. Endocrinology 1984; 115: 614-24.
81. Chen ZP, Chen XX, Zhu XL, Dong L, Hu X, Zhao WD, et al. The iodine deficient rat. In: Medeiros-Neto G, Maciel RMB, Halpern A, eds. Iodine Deficiency Diseases and Congenital Hypothyroidism. Sao Paulo: Aché Press, 1986; 46-51.
82. Martinez-Galan JR, Pedraza P, Santacana M, Escobar del Rey F, Morreale de Escobar G, Ruiz Marcos A. Early effects of iodine deficiency on radial glial cells of the hippocampus of the rat fetus a model of neurological cretinism. Journal of Clinical Investigation 1997; 99: 2701-9.
83. McIntosh GH, Howard DA, Mano MT, Wellby ML, Hetzel BS. Iodine deficiency and brain development in the rat. Australian Journal of Biological Sciences 1981; 34: 427-33.
84. Li JQ, Wang X, Yan YQ, Wang KW, Qin DK, Xin ZF, et al. The effects on fetal brain development in the rat of a severely iodined deficient diet derived from an endemic area: observations on the first generation. Neuropathology and Applied Neurobiology 1986; 12: 261-76.
85. Lavado-Autric R, Ausó E, García-Velasco JV, Arufe MC, Escobar del Rey F, Berbel P, et al. Early maternal hypothyroxinemia alters histogenesis and cerebral cortex cytoarchitecture of the progeny. Journal of Clinical Investigation 2003; 111: 1073-82.
86. Zoeller RT. Transplacental thyroxine and fetal brain development. Journal of Clinical Investigation 2003; 111: 954-7.
87. Ausó E, Lavado-Autric R, Cuevas E, Escobar del Rey F, Morreale de Escobar G, Berbel P, et al. A moderate and transient deficiency of maternal thyroid function at the beginning of fetal neocorticogenesis alters neuronal migration. Endocrinology 2004; 145: 4037-47.
88. Bayer SA, Altman J. Neocortical Development. New York: Raven Press, 1991.
89. Forrest D. The developing brain and maternal thyroid hormone: finding the links. Endocrinology 2004; 149: 4034-6.
90. Dowling ALS, Zoeller RT. Thyroid hormone of maternal origin regulates the expression of RC3/neurogranin mRNA in the fetal rat brain. Brain Research Molecular Brain Research 2000; 82: 126-32.
91. Dowling ALS, Iannacone EA, Zoeller RT. Maternal hypothyroidism selectively affects the expression of neuroendocrine-specific protein A messenger ribonucleic acid in the proliferative zone of the fetal rat brain cortex. Endocrinology 2001; 142: 390-9.
92. Dowling ALS, Martz GU, Leonard JL, Zoeller RT. Acute changes in maternal thyroid hormone induce rapid and transient changes in gene expression in fetal rat brain. Journal of Neuroscience 2000; 20: 2255-65.
93. Vanderpas J, Thilly CH. Endemic neonatal, infantile and juvenile hypothyroidism in Ubangi, Northern Zaïre: clinical consequences and prevention. In: Stanbury JB, ed. The Damaged Brain of Iodine Deficiency. Elmsford, New York: Cognizant Communication, 1994; 209-24.
94. Contempré B, Morreale de Escobar G, Denef JF, Dumont JE, Many MC. Thiocyanate induces cell necrosis and and fibrosis in selenium- and Iodine-deficient rat thyroids: a potential expedrimental model for myxedematous endemic cretinism in central Africa. Endocrinology 2004; 145: 994-1002.
95. Pop V, Kuipens JL, van Baar AL, Verkerk G, van Son MM, de Vijlder JJ, et al. Low normal maternal free T4 concentrations during early pregnancy are associated with impaired psychomotor development in infancy. Clinical Endocrinology (Oxford) 1999; 50: 149-55.
96. Pop VJ, Brouwers EP, Vader HL, Vulsma T, van Baar AL, de Vijlder JJ. Maternal hypothyroxinaemia during early pregnancy and subsequent child development: a 3-year follow-up study. Clinical Endocrinology (Oxford) 2003; 59: 282-8.
97. Delange F, de Benoist B, Pretell E, Dunn JT. Iodine deficiency in the world: where do we stand at the turn of the century? Thyroid 2001; 11: 437-47.
98. Fisher DA, Hobel CJ, Garza RBS, Pierce CA. Thyroid function in the preterm fetus. Pediatrics 1970; 46: 208-16.
99. Hume R, Simpson J, Delahunty C, van Toor H, Wu SY, Williams FL, et al. Human fetal and cord serum thyroid hormones: developmental trends and interrelationships. Journal of Clinical Endocrinology and Metabolism 2004; 89: 4097-103.
100. Persani L, Borgato S, Romoli R, Asteria C, Pizzocaro A, Beck-Peccoz P. Changes in the degree of sialylation of carbohydrate chains modify the biological properties of circulating thyrotropin isoforms in various physiological and pathological states. Journal of Clinical Endocrinology and Metabolism 1998; 83: 2486-92.
101. Morreale de Escobar G, Obregón MJ, Escobar del Rey F. Maternal thyroid hormones early in pregnancy and fetal brain development. Best Practice & Research in Clinical Endocrinology and Metabolism 2004; 18: 225-48.
102. Heinrichs C, de Zegher F, Vansnick F, Vokaer A, Chistophe C, Frankenne F. Fetal hypopituitarism: perinatal endocrine and morphological studies in two cases. Acta Paediatrica 1994; 83: 448-51.
103. Perelman AH, Johnson RL, Clemons RD, Finberg HJ, Clewell WH, Trujillo L. Intrauterine diagnosis and treatment of fetal goitrous hypothyroidism. Journal of Clinical Endocrinology and Metabolism 1990; 71: 618-21.
104. Abuhamad AZ, Fisher DA, Worsof SL, Slomick RN, Pyle PG, Wu SY, et al. Antenatal diagnosis and treatment of fetal goitrous hypothyroidism: case report and review of the literature. Ultrasound in Obstetrics and Gynecology 1995; 6: 368-71.
105. Chan LY, Leung TN, Lau TK. Influences of perinatal factors on cord blood thyroid-stimulating hormone level. Acta Obstetricia et Gynecologica Scandinavica 2001; 80: 1014-8.
106. Choudbury N, Gorman KS. Subclinical prenatal iodine deficiency negatively affects infant development in Northern China. Journal of Nutrition 2003; 133: 3162-5.
107. Nohr SB, Laurberg P. Opposite variations in maternal and neonatal thyroid function induced by iodine supplementation during pregnancy. Journal of Clinical Endocrinology and Metabolism 2000; 85: 623-7.