Surface-stress sensors for rapid and ultrasensitive detection of active free drugs in human serum

Nature Nanotechnology

Volumn 9, Issue 3, 2014, Pages 225-232

  Ndieyira, Joseph W ^a,b   Kappeler, Natascha ^a   Logan, Stephen ^a   Cooper, Matthew A ^c   Abell, Chris ^d   Mckendry, Rachel A ^a   Aeppli, Gabriel ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b JOMO KENYATTA UNIVERSITY OF AGRICULTURE AND TECHNOLOGY   (Kenya)

^c UNIVERSITY OF QUEENSLAND   (Australia)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTICS; BODY FLUIDS; CYTOLOGY; LIGANDS; STRESS MEASUREMENT; SURFACE CHEMISTRY; SURFACE PROPERTIES;

EQUILIBRIUM THEORY; FOOD AND DRUG ADMINISTRATION; MECHANICAL RESPONSE; MECHANICAL SIGNALS; NANO-MECHANICAL CANTILEVER; QUANTITATIVE EXPERIMENTS; SURFACE STRESS SENSORS; ULTRASENSITIVE DETECTION;

DRUG DOSAGE;

ANTIBIOTIC AGENT; DRUG RECEPTOR; LIGAND; ORITAVANCIN; PROTEIN; SOLVENT; VANCOMYCIN;

ARTICLE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG EFFICACY; FOOD AND DRUG ADMINISTRATION; HUMAN; MOLECULAR MECHANICS; MOLECULAR SENSOR; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SERUM; SURFACE STRESS; THEORY;

ANTI-BACTERIAL AGENTS; BACTERIA; BIOMECHANICAL PHENOMENA; BIOSENSING TECHNIQUES; EQUIPMENT DESIGN; GLYCOPEPTIDES; HUMANS; LIGANDS; MODELS, BIOLOGICAL; NANOTECHNOLOGY; SOLVENTS; SURFACE PROPERTIES; VANCOMYCIN;

EID: 84895923902     PISSN: 17483387     EISSN: 17483395     Source Type: Journal    
DOI: 10.1038/nnano.2014.33     Document Type: Article

References (33)

1. Ghatkesar, M. K., Lang, H-P., Gerber, C., Hegner, M. & Braun, T. Comprehensive characterization of molecular interactions based on nanomechanics. PLoS ONE 3, 1-6 (2008
2. Dwyer, D. J. et al. Antibiotic-induced bacterial cell death exhibits physiological and biochemical hallmarks of apoptosis. Mol. Cell 46, 561-572 (2012
3. Kohanski, M. A., Dwyer, D. J., Wierzbowski, J., Cottarel, G. & Collins, J. J. Mistranslation of membrane proteins and two-component system activation trigger antibiotic-mediated cell death. Cell 135, 679-690 (2008
4. Zeitlinger, M. A. et al. Protein binding: Do we ever learn? Antimicrob. Agents Chemother. 55, 3067-3074 (2011
5. Bailey, E. M., Rybak, M. J. & Kaatz, G. W. Comparative effect of protein binding on the killing activities of teicoplanin and vancomycin. Antimicrob. Agents Chemother. 35, 1089-1092 (1991
6. Perkins, H. R. Specificity of combination between mucopeptide precursors and vancomycin or ristomycin. Biochem. J. 111, 195-205 (1969
7. Beauregard, D. A.,Williams, D. H., Gwynn, M. N. & Knowles, D. J. Dimerization and membrane anchors in extracellular targeting of vancomycin group antibiotics. Antimicrob. Agents Chemother. 39, 781-785 (1995
8. Lai, C-Y. et al. A mesoporous silica nanosphere-based carrier system with chemically removable CdS nanoparticle caps for stimuli-responsive controlled release of neurotransmitters and drug molecules. J. Am. Chem. Soc. 125, 4451-4459 (2003
9. Sieradzki, K. et al. The development of vancomycin resistance in a patient with methicillin-resistant Staphylococcus aureus infection. N. Engl. J. Med. 340, 517-523 (1999
10. McKay, G. A et al. Time-kill kinetics of oritavancin and comparator agents against Staphylococcus aureus, Enterococcus faecalis and Enterococcus faecium. J. Antimicrob. Chemother. 63, 1191-1199 (2009
11. Minamide, L. S. & Bamburg, J. R. Filter paper dye-binding assay for quantitative determination of protein without interference from reducing agents or detergents. Anal. Biochem. 190, 66-70 (1990
12. Lonnroth, P., Jansson, P. A. & Smith, U. A microdialysis method allowing characterization of intercellular water space in humans. Am. J. Physiol. 253, E228-E231 (1987
13. Nasir, M. S. & Jolley, M. E. Fluorescence polarization: An analytical tool for immunoassay and drug discovery. Combin. Chem. High Throughput Screen. 2, 177-190 (1999
14. Frostell-Karlsson, A. et al. Biosensor analysis of the interaction between immobilised human serum albumin and drug compounds for prediction of human serum albumin binding levels. J. Med. Chem. 43, 1986-1992 (2000
15. Ndieyira, J. W. et al. Nanomechanical detection of antibiotic-mucopeptide binding in a model for superbug drug resistance. Nature Nanotech. 3, 691-696 (2008
16. Arlett, J. L., Myers, E. B. & Roukes, M. L. Comparative advantages of mechanical biosensors. Nature Nanotech. 6, 203-215 (2011
17. Fritz, J. et al. Translating biomolecular recognition into nanomechanics. Science 288, 316-318 (2000
18. Shekhawat, G., Tark, S-H. & Dravid, V. P. MOSFET-embedded microcantilevers for measuring deflection in biomolecular sensors. Science 311, 1592-1595 (2006
19. Williams, D. H., Maguire, A. J., Tsuzuki, W. & Westwell, M. S. An analysis of the origins of a cooperative binding energy of dimerisation. Science 280, 711-714 (1998
20. Allen, N. E. & Nicas, T. I. Mechanism of action of oritavancin and related glycopeptide antibiotics. FEMS Microbiol. Rev. 93, 511-532 (2003
21. Sun, H., Maderazo, E. G. & Krusell, A. R. Serum protein-binding characteristics of vancomycin. Antimicrob. Agents Chemother. 37, 1132-1136 (1993
22. Arhin, F. F. et al. Effect of polysorbate 80 on oritavancin binding to plastic surfaces: Implications for susceptility testing. Antimicrob. Agents Chemother. 52, 1597-1603 (2008
23. Yung-Chi, C. & Prusoff, W. H. Relationship between the inhibition constant (K3) and the concentration of the inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction. Biochem. Pharmacol. 22, 3099-3108 (1973
24. Allen, N. E., LeTourneau, D. L. & Hobbs, J. N. Jr The role of hydrophobic side chains as determinants of antibacterial activity of semisynthetic glycopeptide antibiotics. J. Antibiot. 50, 677-684 (1997
25. Cooper, M. A., Fiorini, M. T., Abell, C. Williams, D. H. Binding of vancomycin group antibiotics to D-Alanine and D-lactate presenting self-Assembled monolayers. Bioorg. Med. Chem. 8, 2609-2616 (2000
26. Rao, J., Yan, L., Xu, B. & Whitesides, G. M. Using surface plasmon resonance to study the binding of vancomycin and its dimer to self-Assembled monolayers presenting D-Ala-D-Ala. J. Am. Chem. Soc. 121, 2629-2630 (1999
27. Cooper, M. A.,Williams, D. H. & Cho, Y. R. Surface plasmon resonance analysis of glycopeptide antibiotic activity at a model membrane surface. Chem. Commun. 17, 1625-1626 (1997
28. Mercier, R-C., Houlhan, H. H. & Rybak, J. M. Pharmacodynamic evaluation of a new glycopeptide, LY333328, and in vitro activity against Staphylococcus aureus and enterococcus faecium. Antimicrob. Agents Chemother. 41, 1307-1312 (1997
29. McKay, G. A., Beaulieu, S., Lehoux, D., Parr, J. R. T. & Moeck, G. Methods of treating bacterial infections using oritavancin. US patent 0035097 A1 (2012
30. Vuignier, K., Schappler, J., Veuthey, J-L., Carrupt, P-A. & Martel, S. Drug-protein binding: A critical review of analytical tools. Anal. Bioanal. Chem. 398, 53-66 (2010
31. Rotschafer, J. C. et al. Pharmacokinetics of vancomycin: Observations in 28 patients and dosage recommendations. Antimicrob. Agents Chemother. 22, 391-394 (1982
32. Bell, G. I. Models for the specific adhesion of cells to cells. Science 200, 618-627 (1978
33. Wu, Y. et al. Transforming binding affinities from three dimensions to two with application to cadherin clustering. Nature 475, 510-513 (2011