Sequence-specific DNA alkylation targeting for kras codon 13 mutation by pyrrole-imidazole polyamide seco-cbi conjugates

Chemistry - A European Journal

Volumn 20, Issue 5, 2014, Pages 1310-1317

  Taylor, Rhys Dylan ^a   Asamitsu, Sefan ^a   Takenaka, Tomohiro ^a   Yamamoto, Makoto ^a   Hashiya, Kaori ^a   Kawamoto, Yusuke ^a   Bando, Toshikazu ^a   Nagase, Hiroki ^b   Sugiyama, Hiroshi ^a,c,d  

^a KYOTO UNIVERSITY   (Japan)

^b CHIBA CANCER CENTER   (Japan)

^c KYOTO UNIVERSITY   (Japan)

^d JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

Adenine alkylation; Kras codon 13 mutation; PAGE analysis; Pyrrole imidazole polyamides; Sequence specificity

Indexed keywords

AROMATIC COMPOUNDS; DNA; ELECTROPHORESIS; ORGANIC POLYMERS; SYNTHESIS (CHEMICAL);

ALKYLATING ACTIVITY; GEL ELECTROPHORESIS; HAIRPIN CONFORMATION; KRAS CODON 13 MUTATION; PAGE ANALYSIS; PYRROLE-IMIDAZOLE POLYAMIDES; SEQUENCE SPECIFICITY; SOLID PHASE SYNTHESIS;

ALKYLATION;

1 METHYLIMIDAZOLE; 1 METHYLPYRROLE; 1-METHYLIMIDAZOLE; ALANINE; DNA; IMIDAZOLE DERIVATIVE; N-METHYLPYRROLE; NYLON; PYRROLE DERIVATIVE; RAS PROTEIN;

ADENINE ALKYLATION; ALKYLATION; ARTICLE; BASE PAIRING; CHEMICAL STRUCTURE; CHEMISTRY; CODON; GENETICS; HUMAN; KRAS CODON 13 MUTATION; METABOLISM; MUTATION; NUCLEOTIDE SEQUENCE; PAGE ANALYSIS; PYRROLE-IMIDAZOLE POLYAMIDES; SEQUENCE SPECIFICITY; SYNTHESIS;

ADENINE ALKYLATION; KRAS CODON 13 MUTATION; PAGE ANALYSIS; PYRROLE-IMIDAZOLE POLYAMIDES; SEQUENCE SPECIFICITY;

ALANINE; ALKYLATION; BASE PAIRING; BASE SEQUENCE; CODON; DNA; HUMANS; IMIDAZOLES; MODELS, MOLECULAR; MUTATION; NYLONS; PYRROLES; RAS PROTEINS;

EID: 84895923219     PISSN: 09476539     EISSN: 15213765     Source Type: Journal    
DOI: 10.1002/chem.201303295     Document Type: Article

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