Rationale, design, and methodology of the Women's Genome Health Study: A genome-wide association study of more than 25 000 initially healthy American women

Clinical Chemistry

Volumn 54, Issue 2, 2008, Pages 249-255

  Ridker, Paul M ^a,b   Chasman, Daniel I ^a,b   Zee, Robert Y L ^a,b   Parker, Alex ^c   Rose, Lynda ^a   Cook, Nancy R ^a,b   Buring, Julie E ^a,b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ALPHA TOCOPHEROL; BETA CAROTENE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; RETINOL;

ARTICLE; CARDIOVASCULAR DISEASE; DIABETES MELLITUS; GENE INTERACTION; HEALTH PROGRAM; MEDICAL RESEARCH; MEDICAL SOCIETY; NEOPLASM; OSTEOPOROSIS; SINGLE NUCLEOTIDE POLYMORPHISM; STROKE; THROMBOEMBOLISM; WOMEN'S HEALTH;

BIOLOGICAL MARKERS; BLOOD SPECIMEN COLLECTION; CONFIDENTIALITY; DATA INTERPRETATION, STATISTICAL; ENDPOINT DETERMINATION; EPIDEMIOLOGIC RESEARCH DESIGN; FEMALE; FOLLOW-UP STUDIES; GENOME, HUMAN; GENOTYPE; HUMANS; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; PROSPECTIVE STUDIES; UNITED STATES; WOMEN'S HEALTH;

EID: 39749089905     PISSN: 00099147     EISSN: None     Source Type: Journal    
DOI: 10.1373/clinchem.2007.099366     Document Type: Article

References (31)

1. Christensen K, Murray JC. What genome-wide association studies can do for medicine. N Engl J Med 2007;356:1094-7.
2. Lander ES. The new genomics: global views of biology. Science (Wash DC) 1996;274:536-9.
3. Hirschorn JN, Daly MJ. Genome-wide association studies for common disease and complex traits. Nature (Lond) Rev Genet 2005;6:95-108.
4. Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature (Lond) 2007;447:661-78.
5. Scott LJ, Mohlke KL, Bonnycastle LL, Willer CJ, Li Y, Duren WL, et al. A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science (Wash DC) 2007;316:1341-5.
6. Saxena R, Voight BF, Lyssenko V, Burtt NP, de Bakker PI, Chen H, et al. Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science (Wash DC) 2007;316:1331- 6.
7. Samani NJ, Erdmann J, Hall AS, Hengstenberg C, Mangino M, Mayer B, et al. Genome-wide association analysis of coronary artery disease. N Engl J Med 2007;357:443-53.
8. McPherson R, Pertsemlidis A, Kavaslar N, Stewart A, Roberts R, Cox DR, et al. A common allele on chromosome 9 associated with coronary heart disease. Science (Wash DC) 2007;316:1488-91.
9. Helgadottir A, Thorleifsson G, Manolescu A, Gretarsdottir S, Blondal T, Jonasdottir A, et al. A common variant on chromosome 9p21 affects the risk of myocardial infarction. Science (Wash DC) 2007;316:1491-3.
10. The International HapMap Consortium. A haplotype map of the human genome. Nature (Lond) 2005;437:1299-320.
11. Rexrode KM, Lee I-M, Cook NR, Hennekens CH, Buring JE. Baseline characteristics of participants in the Women's Health Study. J Womens Health Gend Based Med 2000;9:19-27.
12. Ridker PM, Cook NR, Lee I-M, Gordon D, Gaziano JM, Manson JE, et al. A randomized trial of low-dose aspirin in the primary prevention of cardiovascular disease in women. N Engl J Med 2005;352:1293-304.
13. Lee I-M, Cook NR, Gaziano JM, Gordon D, Ridker PM, Manson JE, et al. Vitamin E in the primary prevention of cardiovascular disease and cancer. The Women's Health Study: a randomized controlled trial. JAMA 2005;294:56-65.
14. Cook NR, Lee I-M, Gaziano JM, Gordon D, Ridker PM, Manson JE, et al. Low-dose aspirin in the primary prevention of cancer. The Women's Health Study: a randomized controlled trial. JAMA 2005;294:47-55.
15. Pradhan AD, Manson JE, Rifai N, Buring JE, Ridker PM. C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. JAMA 2001;286:327-34.
16. Sesso HD, Buring JE, Rifai N, Blake GJ, Gaziano JM, Ridker PM. C-reactive protein and the risk of developing hypertension. JAMA 2003;290:2945-51.
17. Kang JH, Cook N, Manson J, Buring JE, Grodstein F. Low-dose aspirin and cognitive function in the Women's Health Study cognitive cohort. BMJ 2007;12:334(7601):987. [e-pub 2007 Apr 27]
18. Pradhan AD, Shrivastava S, Cook NR, Rifai N, Creager MA, Ridker PM. Symptomatic peripheral arterial disease in women: Nontraditional biomarkers of elevated risk. Circulation 2007 (in press).
19. Ridker PM, Buring JE, Rifai N, Cook NR. Development and validation of improved algorithms for the assessment of global cardiovascular risk in women. The Reynolds Risk Score. JAMA 2007;297:611-9.
20. Ridker PM, Rifai N, Cook NR, Bradwin G, Buring JE. Non-HDL cholesterol, apolipoproteins A-I and B100, standard lipid measures, lipid ratios, and CRP as risk factors for cardiovascular disease in women. JAMA 2005;294:326-33.
21. Bansal S, Buring JE, Rifai M, Sacks FM, Ridker PM. Fasting compared with nonfasting triglycerides and risk of cardiovascular events in women. JAMA 2007;298:309-16.
22. Ridker PM, Rifai N, Rose L, Buring JE, Cook NR. Comparison of C-reactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events. N Engl J Med 2002;347:1557- 65.
23. Suk Danik J, Rifai N, Buring JE, Ridker PM. Lipoprotein (a), measured with an assay independent of apolipoprotein (a) isoform size, and risk of future cardiovascular events among initially healthy women. JAMA 2006;296:1363-70.
24. Zee RY, Mora S, Cheng S, Erlich HA, Lindpaintner K, Rifai N, et al. Homocysteine, 5,10-methylenetetrahydrofolate reductase 677C>T polymorphism, nutrient intake, and incident cardiovascular disease in 24,968 initially healthy women. Clin Chem 2007;53:845-51.
25. Mora S, Rifai N, Buring JE, Ridker PM. Additive value of immunoassay-measured fibrinogen and high-sensitivity C-reactive protein levels for predicting incident cardiovascular events. Circulation 2006;114:381-7.
26. Ridker PM, Hennekens CH, Buring JE, Rifai N. C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N Engl J Med 2000;342:836-43.
27. Gunderson KL, Steemers FJ, Ren H, Ng P, Zhou L, Tsan C, et al. Whole-genome genotyping. Methods Enzymol 2006;410:359-76.
28. Gunderson KL, Kuhn KM, Steemers FJ, Ng P, Murray SS, Shen R. Whole-genome genotyping of haplotype tag single nucleotide polymorphisms. Pharmacogenomics 2006;7:641-8.
29. Wang YSW, Barratt BJ, Clayton DG, Todd JA. Genome-wide association studies: theoretical and practical concerns. Nature (Lond) Rev Genetics 2005;6:109-18.
30. Balding DJ. A tutorial on statistical methods for population association studies. Nature (Lond) Rev Genetics 2006;7:781-91.
31. NCI-NHGRI Working Group on Replication in Association Studies. Replicating genotype-phenotype associations: what constitutes replication of a genotype-phenotype association, and how best can it be achieved? Nature (Lond) 2007;447:655-60.