Local Co-delivery of pancreatic islets and liposomal clodronate using injectable hydrogel to prevent acute immune reactions in a type 1 diabetes

Pharmaceutical Research

Volumn 31, Issue 9, 2014, Pages 2453-2462

  Haque, Muhammad R ^a   Lee, Dong Yun ^b   Ahn, Cheol Hee ^a   Jeong, Jee Heon ^c   Byun, Youngro ^a,d  

^a Seoul National University   (South Korea)

^b Hanyang University   (South Korea)

^c Yeungnam University   (South Korea)

^d Seoul National University   (South Korea)

Author keywords

injectable hydrogel; liposomal clodronate; local delivery; macrophage depletion; pancreatic islets

Indexed keywords

CLODRONIC ACID; COLLAGEN; DRUG COMBINATION; LAMININ; LIPOSOME; MATRIGEL; PROTEOGLYCAN;

ANIMAL; C57BL MOUSE; DIABETES MELLITUS, TYPE 1; DRUG COMBINATION; DRUG EFFECTS; IMMUNOLOGY; INFLAMMATION; INJECTION; MACROPHAGE; MALE; PANCREAS ISLET TRANSPLANTATION; PROCEDURES; SPRAGUE DAWLEY RAT;

ANIMALS; CLODRONIC ACID; COLLAGEN; DIABETES MELLITUS, TYPE 1; DRUG COMBINATIONS; INFLAMMATION; INJECTIONS; ISLETS OF LANGERHANS TRANSPLANTATION; LAMININ; LIPOSOMES; MACROPHAGES; MALE; MICE, INBRED C57BL; PROTEOGLYCANS; RATS, SPRAGUE-DAWLEY;

EID: 84895915125     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-014-1340-4     Document Type: Article

References (24)

1. Shapiro AM, Ricordi C, Hering BJ, Auchincloss H, Lindblad R, Robertson RP, et al. International trial of the Edmonton protocol for islet transplantation. N Engl J Med. 2006;355(13):1318-30.
2. Elander L, Engstrom L, Ruud J, Mackerlova L, Jakobsson PJ, Engblom D, et al. Inducible prostaglandin E2 synthesis interacts in a temporally supplementary sequence with constitutive prostaglandin-synthesizing enzymes in creating the hypothalamic-pituitary-adrenal axis response to immune challenge. J Neurosci Off J Soc Neurosci. 2009;29(5):1404-13.
3. Gibly RF, Graham JG, Luo X, Lowe Jr WL, Hering BJ, Shea LD. Advancing islet transplantation: from engraftment to the immune response. Diabetologia. 2011;54(10):2494-505.
4. Fox A, Koulmanda M, Mandel TE, van Rooijen N, Harrison LC. Evidence that macrophages are required for T-cell infiltration and rejection of fetal pig pancreas xenografts in nonobese diabetic mice. Transplantation. 1998;66(11):1407-16.
5. Karlsson-Parra A, Ridderstad A, Wallgren AC, Moller E, Ljunggren HG, Korsgren O. Xenograft rejection of porcine islet-like cell clusters in normal and natural killer cell-depleted mice. Transplantation. 1996;61(9):1313-20.
6. Shahaf G, Moser H, Ozeri E, Mizrahi M, Abecassis A, Lewis EC. Alpha-1-antitrypsin gene delivery reduces inflammation, increases T-regulatory cell population size and prevents islet allograft rejection. Mol Med. 2011;9-10:1000-11.
7. Frith JC, Monkkonen J, Blackburn GM, Russell RG, Rogers MJ. Clodronate and liposome-encapsulated clodronate are metabolized to a toxic ATP analog, adenosine 5-(beta, gamma-dichloromethylene) triphosphate, by mammalian cells in vitro. J Bone Miner Res Off J Am Soc Bone Miner Res. 1997;12(9):1358-67.
8. Mönkkönen H, Törmälehto S, Asunmaa K, Niemi R, Auriola S, Vepsäläinen J, Mönkkönen J. Cellular uptake and metabolism of clodronate and its derivatives in Caco-2 cells: a possible correlation with bisphosphonate-induced gastrointestinal side-effects. In: Eur J Pharm Sci. 2003. p. 23-29.
9. Jordan MB, Van Rooijen N, Izui S, Kappler J, Marrack P. Liposomal clodronate as a novel agent for treating autoimmune hemolytic anemia in a mouse model. In: Blood. 2003. p. 594-601.
10. Goto M, Groth CG, Nilsson B, Korsgren O. Intraportal pig islet xenotransplantation into athymic mice as an in vivo model for the study of the instant blood-mediated inflammatory reaction. Xenotransplantation. 2004;11(2):195-202.
11. Phelps EA, Headen DM, Taylor WR, Thulé PM, García AJ. Vasculogenic bio-synthetic hydrogel for enhancement of pancreatic islet engraftment and function in type 1 diabetes. In: Biomaterials. 2013. p. 4602-4611.
12. Liao SW, Rawson J, Omori K, Ishiyama K, Mozhdehi D, Oancea AR, Ito T, Guan Z, Mullen Y. Maintaining functional islets through encapsulation in an injectable saccharide-peptide hydrogel. In: Biomaterials; 2013. p. 3984-3991.
13. Yang K-C, Wu C-C, Lin F-H, Qi Z, Kuo T-F, Cheng Y-H, Chen M-P, Sumi S. Chitosan/gelatin hydrogel as immunoisolative matrix for injectable bioartificial pancreas. In: Xenotransplantation. 2008. p. 407-416.
14. Lanza RP, Jackson R, Sullivan A, Ringeling J, McGrath C, Kühtreiber W, Chick WL. Xenotransplantation of cells using biodegradable microcapsules. In: Transplantation. 1999. p. 1105-1111.
15. Sun AM, O'Shea GM, Goosen MF. Injectable microencapsulated islet cells as a bioartificial pancreas. In: Appl Biochem Biotechnol. 1984. p. 87-99.
16. Bottino R, Fernandez LA, Ricordi C, Lehmann R, Tsan MF, Oliver R, et al. Transplantation of allogeneic islets of Langerhans in the rat liver - effects of macrophage depletion of graft survival and microenvironment activation. Diabetes. 1998;47(3):316-23.
17. Omer A, Keegan M, Czismadia E, De Vos P, Van Rooijen N, Bonner-Weir S, et al. Macrophage depletion improves survival of porcine neonatal pancreatic cell clusters contained in alginate macrocapsules transplanted into rats. Xenotransplantation. 2003;10(3):240-51.
18. Slegers TP, van der Gaag R, van Rooijen N, van Rij G, Streilein JW. Effect of local macrophage depletion on cellular immunity and tolerance evoked by corneal allografts. Curr Eye Res. 2003;26(2):73-9.
19. Morris PJ. Xenotransplantation. Br Med Bull. 1999;55(2):446-59.
20. Soin B, Vial CM, Friend PJ. Xenotransplantation. Br J Surg. 2000;87(2):138-48.
21. Olack BJ, Jaramillo A, Benshoff ND, Kaleem Z, Swanson CJ, Lowell JA, et al. Rejection of porcine islet xenografts mediated by CD4+ T cells activated through the indirect antigen recognition pathway. Xenotransplantation. 2002;9(6):393-401.
22. Mirenda V, Golshayan D, Read J, Berton I, Warrens AN, Dorling A, et al. Achieving permanent survival of islet xenografts by independent manipulation of direct and indirect T-cell responses. Diabetes. 2005;54(4):1048-55.
23. Tian M, Lv Y, Zhai C, Zhu H, Yu L, Wang B. Alternative immunomodulatory strategies for xenotransplantation: CD80/CD86-CTLA4 pathway-modified immature dendritic cells promote xenograft survival. PLoS ONE. 2013;8(7):e69640.
24. Wu G, Korsgren O, Zhang J, Song Z, van Rooijen N, Tibell A. Pig islet xenograft rejection is markedly delayed in macrophage-depleted mice: a study in streptozotocin diabetic animals. Xenotransplantation. 2000;7(3):214-20.