Dendritic cells of myeloid lineage: The masterminds behind acute allograft rejection

Current Opinion in Organ Transplantation

Volumn 19, Issue 1, 2014, Pages 20-27

  Morelli, Adrian E ^a  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

dendritic cells; organ transplant; transplant rejection

Indexed keywords

EID: 84895907043     PISSN: 10872418     EISSN: 15317013     Source Type: Journal    
DOI: 10.1097/MOT.0000000000000039     Document Type: Review

References (74)

1. Merad M, Collin M, Bromberg J. Dendritic cell homeostasis and trafficking in transplantation. Trends Immunol 2007; 28:353-359.
2. Dominguez PM, Ardavin C. Differentiation and function of mouse monocytederived dendritic cells in steady state and inflammation. Immunol Rev 2010; 234:90-104.
3. Steptoe RJ, Patel RK, Subbotin VM, Thomson AW. Comparative analysis of dendritic cell density and total number in commonly transplanted organs: morphometric estimation in normal mice. Transpl Immunol 2000; 8:49-56.
4. Rosin DL, Okusa MD. Dangers within: DAMP responses to damage and cell death in kidney disease. J Am Soc Nephrol 2011; 22:416-425.
5. Alegre ML, Goldstein DR, Chong AS. Toll-like receptor signaling in transplantation. Curr Opin Organ Transplant 2008; 13:358-365.
6. Chong AS, Alegre ML. The impact of infection and tissue damage in solidorgan transplantation. Nat Rev Immunol 2012; 12:459-471.
7. Goldstein DR, Tesar BM, Akira S, Lakkis FG. Critical role of the Toll-like receptor signal adaptor protein MyD88 in acute allograft rejection. J Clin Invest 2003; 111:1571-1578.
8. Walker WE, Nasr IW, Camirand G, et al. Absence of innate MyD88 signaling promotes inducible allograft acceptance. J Immunol 2006; 177:5307-5316.
9. Tesar BM, Zhang J, Li Q, Goldstein DR. TH1 immune responses to fully MHC mismatched allografts are diminished in the absence of MyD88, a Toll-like receptor signal adaptor protein. Am J Transplant 2004; 4:1429-1439.
10. McKay D, Shigeoka A, Rubinstein M, et al. Simultaneous deletion of MyD88 and Trif delays major histocompatibility and minor antigen mismatch allograft rejection. Eur J Immunol 2006; 36:1994-2002.
11. Shen H, Song Y, Colangelo CM, et al. Haptoglobin activates innate immunity to enhance acute transplant rejection in mice. J Clin Invest 2012; 122:383- 387.
12. Kruger B, Krick S, Dhillon N, et al. Donor Toll-like receptor 4 contributes to ischemia and reperfusion injury following human kidney transplantation. Proc Natl Acad Sci U S A 2009; 106:3390-3395.
13. Tsung A, Sahai R, Tanaka H, et al. The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion. J Exp Med 2005; 201:1135-1143.
14. Huang Y, Yin H, Han J, et al. Extracellular HMGB1 functions as an innate immune-mediator implicated in murine cardiac allograft acute rejection. Am J Transplant 2007; 7:799-808.
15. Apetoh L, Ghiringhelli F, Tesniere A, et al. Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy. Nat Med 2007; 13:1050-1059.
16. Tsung A, Zheng N, Jeyabalan G, et al. Increasing numbers of hepatic dendritic cells promote HMGB1-mediated ischemia-reperfusion injury. J Leukoc Biol 2007; 81:119-128.
17. Moser B, Szabolcs MJ, Ankersmit HJ, et al. Blockade of RAGE suppresses alloimmune reactions in vitro and delays allograft rejection in murine heart transplantation. Am J Transplant 2007; 7:293-302.
18. Zhang M, Ueki S, Kimura S, et al. Roles of dendritic cells in murine hepatic warm and liver transplantation-induced cold ischemia/reperfusion injury. Hepatology 2013; 57:1585-1596.
19. Yoshida O, Kimura S, Jackson EK, et al. CD39 expression by hepatic myeloid dendritic cells attenuates inflammation in liver transplant ischemia-reperfusion injury. Hepatology 2013; doi: 10.1002/hep.26593. [Epub ahead of print]
20. Dong X, Swaminathan S, Bachman LA, et al. Resident dendritic cells are the predominant TNF-secreting cell in early renal ischemia-reperfusion injury. Kidney Int 2007; 71:619-628.
21. Li K, Fazekasova H, Wang N, et al. Expression of complement components, receptors and regulators by human dendritic cells. Mol Immunol 2011; 48:1121-1127.
22. Peng Q, Li K, Wang N, et al. Dendritic cell function in allostimulation is modulated by C5aR signaling. J Immunol 2009; 183:6058-6068.
23. Peng Q, Li K, Anderson K, et al. Local production and activation of complement up-regulates the allostimulatory function of dendritic cells through C3a- C3aR interaction. Blood 2008; 111:2452-2461.
24. Cravedi P, Leventhal J, Lakhani P, et al. Immune cell-derived C3a and C5a costimulate human T cell alloimmunity. Am J Transplant 2013; 13:2530- 2539.
25. Kreisel D, Sugimoto S, Zhu J, et al. Emergency granulopoiesis promotes neutrophil-dendritic cell encounters that prevent mouse lung allograft acceptance. Blood 2011; 118:6172-6182.
26. Jungraithmayr W, Codarri L, Bouchaud G, et al. Cytokine complex-expanded natural killer cells improve allogeneic lung transplant function via depletion of donor dendritic cells. Am J Respir Crit Care Med 2013; 187:1349- 1359.
27. Hanvesakul R, Kubal C, Moore J, et al. KIR and HLA-C interactions promote differential dendritic cell maturation and is a major determinant of graft failure following kidney transplantation. PLoS One 2011; 6:e23631.
28. Miyawaki S, Nakamura Y, Suzuka H, et al. A new mutation, aly, that induces a generalized lack of lymph nodes accompanied by immunodeficiency in mice. Eur J Immunol 1994; 24:429-434.
29. Lakkis FG, Arakelov A, Konieczny BT, Inoue Y. Immunologic 'ignorance' of vascularized organ transplants in the absence of secondary lymphoid tissue. Nat Med 2000; 6:686-688.
30. Larsen CP, Morris PJ, Austyn JM. Migration of dendritic leukocytes from cardiac allografts into host spleens. A novel pathway for initiation of rejection. J Exp Med 1990; 171:307-314.
31. Celli S, Albert ML, Bousso P. Visualizing the innate and adaptive immune responses underlying allograft rejection by two-photon microscopy. Nat Med 2011; 17:744-749.
32. Obhrai JS, Oberbarnscheidt M, Zhang N, et al. Langerhans cells are not required for efficient skin graft rejection. J Invest Dermatol 2008; 128:1950- 1955.
33. Ueta H, Shi C, Miyanari N, et al. Systemic transmigration of allosensitizing donor dendritic cells to host secondary lymphoid organs after rat liver transplantation. Hepatology 2008; 47:1352-1362.
34. Yu B, Ueta H, Kitazawa Y, et al. Two immunogenic passenger dendritic cell subsets in the rat liver have distinct trafficking patterns and radiosensitivities. Hepatology 2012; 56:1532-1545.
35. Fiorina P, Jurewicz M, Tanaka K, et al. Characterization of donor dendritic cells and enhancement of dendritic cell efflux with CC-chemokine ligand 21: a novel strategy to prolong islet allograft survival. Diabetes 2007; 56:912- 920.
36. Soos TJ, Sims TN, Barisoni L, et al. CX3CR1interstitial dendritic cells form a contiguous network throughout the entire kidney. Kidney Int 2006; 70:591- 596.
37. Woltman AM, de Fijter JW, Zuidwijk K, et al. Quantification of dendritic cell subsets in human renal tissue under normal and pathological conditions. Kidney Int 2007; 71:1001-1008.
38. Lechler RI, Batchelor Jr. Restoration of immunogenicity to passenger celldepleted kidney allografts by the addition of donor strain dendritic cells. J Exp Med 1982; 155:31-41.
39. Kuffova L, Netukova M, Duncan L, et al. Cross presentation of antigen on MHC class II via the draining lymph node after corneal transplantation in mice. J Immunol 2008; 180:1353-1361.
40. Wang J, Dong Y, Sun JZ, et al. Donor lymphoid organs are a major site of alloreactive T-cell priming following intestinal transplantation. Am J Transplant 2006; 6:2563-2571.
41. Gelman AE, Li W, Richardson SB, et al. Cutting edge: acute lung allograft rejection is independent of secondary lymphoid organs. J Immunol 2009; 182:3969-3973.
42. Chalasani G, Dai Z, Konieczny BT, et al. Recall and propagation of allospecific memory T cells independent of secondary lymphoid organs. Proc Natl Acad Sci U S A 2002; 99:6175-6180.
43. Lee RS, Grusby MJ, Glimcher LH, et al. Indirect recognition by helper cells can induce donor-specific cytotoxic T lymphocytes in vivo. J Exp Med 1994; 179:865-872.
44. Ridge JP, Di Rosa F, Matzinger P. A conditioned dendritic cell can be a temporal bridge between a CD4 T-helper and a T-killer cell. Nature 1998; 393:474-478.
45. Bennett SR, Carbone FR, Karamalis F, et al. Help for cytotoxic-T-cell responses is mediated by CD40 signalling. Nature 1998; 393:478-480.
46. Schoenberger SP, Toes RE, van der Voort EI, et al. T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions. Nature 1998; 393:480-483.
47. Smyth LA, Afzali B, Tsang J, et al. Intercellular transfer of MHC and immunological molecules: molecular mechanisms and biological significance. Am J Transplant 2007; 7:1442-1449.
48. Smyth LA, Hervouet C, Hayday T, et al. Acquisition of MHC:peptide complexes by dendritic cells contributes to the generation of antiviral CD8 T cell immunity in vivo. J Immunol 2012; 189:2274-2282.
49. Riond J, Elhmouzi J, Hudrisier D, Gairin JE. Capture of membrane components via trogocytosis occurs in vivo during both dendritic cells and target cells encounter by CD8 T cells. Scand J Immunol 2007; 66:441- 450.
50. Zhang QJ, Li XL, Wang D, et al. Trogocytosis of MHC-I/peptide complexes derived from tumors and infected cells enhances dendritic cell cross-priming and promotes adaptive T cell responses. PLoS One 2008; 3:e3097.
51. Harshyne LA, Watkins SC, Gambotto A, Barratt-Boyes SM. Dendritic cells acquire antigens from live cells for cross-presentation to CTL. J Immunol 2001; 166:3717-3723.
52. Montecalvo A, Larregina AT, Shufesky WJ, et al. Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes. Blood 2012; 119:756-766.
53. Montecalvo A, Shufesky WJ, Stolz DB, et al. Exosomes as a short-range mechanism to spread alloantigen between dendritic cells during T cell allorecognition. J Immunol 2008; 180:3081-3090.
54. Herrera OB, Golshayan D, Tibbott R, et al. A novel pathway of alloantigen presentation by dendritic cells. J Immunol 2004; 173:4828-4837.
55. Brown K, Sacks SH, Wong W. Coexpression of donor peptide/recipient MHC complex and intact donor MHC: evidence for a link between the direct and indirect pathways. Am J Transplant 2011; 11:826-831.
56. Sivaganesh S, Harper SJ, Conlon TM, et al. Copresentation of intact and processed MHC alloantigen by recipient dendritic cells enables delivery of linked help to alloreactive CD8 T cells by indirect-pathway CD4 T cells. J Immunol 2013; 190:5829-5838.
57. Ueno T, Tanaka K, Jurewicz M, et al. Divergent role of donor dendritic cells in rejection versus tolerance of allografts. J Am Soc Nephrol 2009; 20:535- 544.
58. Yu G, Xu X, Vu MD, et al. NK cells promote transplant tolerance by killing donor antigen-presenting cells. J Exp Med 2006; 203:1851-1858.
59. Laffont S, Coudert JD, Garidou L, et al. CD8 T-cell-mediated killing of donor dendritic cells prevents alloreactive T helper type-2 responses in vivo. Blood 2006; 108:2257-2264.
60. Laffont S, Seillet C, Ortaldo J, et al. Natural killer cells recruited into lymph nodes inhibit alloreactive T-cell activation through perforin-mediated killing of donor allogeneic dendritic cells. Blood 2008; 112:661-671.
61. Garrod KR, Liu FC, Forrest LE, et al. NK cell patrolling and elimination of donor-derived dendritic cells favor indirect alloreactivity. J Immunol 2010; 184:2329-2336.
62. Mandelbrot DA, Furukawa Y, McAdam AJ, et al. Expression of B7 molecules in recipient, not donor, mice determines the survival of cardiac allografts. J Immunol 1999; 163:3753-3757.
63. Chen Y, Demir Y, Valujskikh A, Heeger PS. The male minor transplantation antigen preferentially activates recipient CD4 T cells through the indirect presentation pathway in vivo. J Immunol 2003; 171:6510-6518.
64. Brennan TV, Jaigirdar A, Hoang V, et al. Preferential priming of alloreactive T cells with indirect reactivity. Am J Transplant 2009; 9:709-718.
65. Divito SJ, Wang Z, Shufesky WJ, et al. Endogenous dendritic cells mediate the effects of intravenously injected therapeutic immunosuppressive dendritic cells in transplantation. Blood 2010; 116:2694-2705.
66. Wang Z, Divito SJ, Shufesky WJ, et al. Dendritic cell therapies in transplantation revisited: deletion of recipient DCs deters the effect of therapeutic DCs. Am J Transplant 2012; 12:1398-1408.
67. Smyth LA, Ratnasothy K, Moreau A, et al. Tolerogenic donor-derived dendritic cells risk sensitization in vivo owing to processing and presentation by recipient APCs. J Immunol 2013; 190:4848-4860.
68. de Kort H, Crul C, van der Wal AM, et al. Accelerated antibody-mediated graft loss of rodent pancreatic islets after pretreatment with dexamethasonetreated immature donor dendritic cells. Transplantation 2012; 94:903- 910.
69. Saiki T, Ezaki T, Ogawa M, Matsuno K. Trafficking of host- and donor-derived dendritic cells in rat cardiac transplantation: allosensitization in the spleen and hepatic nodes. Transplantation 2001; 71:1806-1815.
70. Ochando JC, Homma C, Yang Y, et al. Alloantigen-presenting plasmacytoid dendritic cells mediate tolerance to vascularized grafts. Nat Immunol 2006; 7:652-662.
71. Walch JM, Zeng Q, Li Q, et al. Cognate antigen directs CD8 T cell migration to vascularized transplants. J Clin Invest 2013; 123:2663- 2671.
72. Kofler S, Petrakopoulou P, Grimm C, et al. Graft-infiltrating dendritic cells and coronary endothelial dysfunction after human heart transplantation. J Heart Lung Transplant 2008; 27:387-393.
73. Loverre A, Capobianco C, Stallone G, et al. Ischemia-reperfusion injuryinduced abnormal dendritic cell traffic in the transplanted kidney with delayed graft function. Kidney Int 2007; 72:994-1003.
74. Zuidwijk K, de Fijter JW, Mallat MJ, et al. Increased influx of myeloid dendritic cells during acute rejection is associated with interstitial fibrosis and tubular atrophy and predicts poor outcome. Kidney Int 2012; 81:64-75.