Induction of atrial fibrillation by neutrophils critically depends on CD11b/CD18 integrins

PLoS ONE

Volumn 9, Issue 2, 2014, Pages

  Friedrichs, Kai ^a   Adam, Matti ^b   Remane, Lisa ^a   Mollenhauer, Martin ^a   Rudolph, Volker ^a   Rudolph, Tanja K ^a   Andrié, René P ^c   Stöckigt, Florian ^c   Schrickel, Jan W ^c   Ravekes, Thorben ^a   Deuschl, Florian ^b   Nickenig, Georg ^c   Willems, Stephan ^b   Baldus, Stephan ^a   Klinke, Anna ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

^b UNIVERSITY HEART CENTER HAMBURG   (Germany)

^c UNIVERSITY HOSPITAL BONN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN II; CD11B ANTIGEN; CD18 ANTIGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIOVASCULAR INFLAMMATION; COMPARATIVE STUDY; CONTROLLED STUDY; CORRELATIONAL STUDY; DISEASE PREDISPOSITION; ELECTRIC CONDUCTIVITY; HEART ATRIUM FIBRILLATION; HEART ATRIUM REMODELING; HEART ELECTROPHYSIOLOGY; HEART MUSCLE FIBROSIS; IMMUNOHISTOCHEMISTRY; LEUKOCYTE ACTIVATION; MALE; MOLECULAR PATHOLOGY; MOUSE; NEUTROPHIL; NEUTROPHIL CHEMOTAXIS; NONHUMAN;

ANALYSIS OF VARIANCE; ANGIOTENSIN II; ANIMALS; ANTIGENS, CD11B; ANTIGENS, CD18; ATRIAL FIBRILLATION; ELECTROPHYSIOLOGIC TECHNIQUES, CARDIAC; FLUORESCENT ANTIBODY TECHNIQUE; HEART ATRIA; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEUTROPHILS;

EID: 84895883056     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0089307     Document Type: Article

References (49)

1. Kannel WB, Abbott RD, Savage DD, McNamara PM (1982) Epidemiologic features of chronic atrial fibrillation: the Framingham study. N Engl J Med 306: 1018-1022. (Pubitemid 12155370)
2. Stewart S, Hart CL, Hole DJ, McMurray JJ (2002) A population-based study of the long-term risks associated with atrial fibrillation: 20-year follow-up of the Renfrew/Paisley study. Am J Med 113: 359-364. (Pubitemid 35223606)
3. Kirchhof P, Auricchio A, Bax J, Crijns H, Camm J, et al (2007) Outcome parameters for trials in atrial fibrillation: executive summary. Eur Heart J 28: 2803-2817.
4. Camm AJ, Kirchhof P, Lip GY, Schotten U, Savelieva I, et al (2010) Guidelines for the management of atrial fibrillation: the Task Force for the Management of Atrial Fibrillation of the European Society of Cardiology (ESC). Europace 12: 1360-1420.
5. Weerasooriya R, Khairy P, Litalien J, Macle L, Hocini M, et al (2011) Catheter ablation for atrial fibrillation: are results maintained at 5 years of follow-up? J Am Coll Cardiol 57: 160-166.
6. Ouyang F, Tilz R, Chun J, Schmidt B, Wissner E, et al (2010) Long-term results of catheter ablation in paroxysmal atrial fibrillation: lessons from a 5-year follow-up. Circulation 122: 2368-2377.
7. Goudis CA, Kallergis EM, Vardas PE (2012) Extracellular matrix alterations in the atria: insights into the mechanisms and perpetuation of atrial fibrillation. Europace 14: 623-630.
8. Friedrichs K, Klinke A, Baldus S (2011) Inflammatory pathways underlying atrial fibrillation. Trends Mol Med 17: 556-563.
9. Friedrichs K, Baldus S, Klinke A (2012) Fibrosis in Atrial Fibrillation - Role of Reactive Species and MPO. Front Physiol 3: 214.
10. Spodick DH (1976) Arrhythmias during acute pericarditis. A prospective study of 100 consecutive cases. JAMA 235: 39-41.
11. Frustaci A, Chimenti C, Bellocci F, Morgante E, Russo MA, et al (1997) Histological substrate of atrial biopsies in patients with lone atrial fibrillation. Circulation 96: 1180-1184. (Pubitemid 27344221)
12. Aviles RJ, Martin DO, Apperson-Hansen C, Houghtaling PL, Rautaharju P, et al (2003) Inflammation as a risk factor for atrial fibrillation. Circulation 108: 3006-3010. (Pubitemid 37553570)
13. Conway DS, Buggins P, Hughes E, Lip GY (2004) Prognostic significance of raised plasma levels of interleukin-6 and C-reactive protein in atrial fibrillation. Am Heart J 148: 462-466. (Pubitemid 39265119)
14. Dernellis J, Panaretou M (2004) Relationship between C-reactive protein concentrations during glucocorticoid therapy and recurrent atrial fibrillation. Eur Heart J 25: 1100-1107. (Pubitemid 38842447)
15. Henningsen KM, Therkelsen SK, Bruunsgaard H, Krabbe KS, Pedersen BK, et al (2009) Prognostic impact of hs-CRP and IL-6 in patients with persistent atrial fibrillation treated with electrical cardioversion. Scand J Clin Lab Invest 69: 425-432.
16. Leftheriotis DI, Fountoulaki KT, Flevari PG, Parissis JT, Panou FK, et al (2009) The predictive value of inflammatory and oxidative markers following the successful cardioversion of persistent lone atrial fibrillation. Int J Cardiol 135: 361-369.
17. Letsas KP, Weber R, Bürkle G, Mihas CC, Minners J, et al (2009) Pre-ablative predictors of atrial fibrillation recurrence following pulmonary vein isolation: the potential role of inflammation. Europace 11: 158-163.
18. Marcus GM, Smith LM, Ordovas K, Scheinman MM, Kim AM, et al (2010) Intracardiac and extracardiac markers of inflammation during atrial fibrillation. Heart Rhythm 7: 149-154.
19. Psychari SN, Apostolou TS, Sinos L, Hamodraka E, Liakos G, et al (2005) Relation of elevated C-reactive protein and interleukin-6 levels to left atrial size and duration of episodes in patients with atrial fibrillation. Am J Cardiol 95: 764-767. (Pubitemid 40340139)
20. Schnabel RB, Larson MG, Yamamoto JF, Sullivan LM, Pencina MJ, et al (2010) Relations of biomarkers of distinct pathophysiological pathways and atrial fibrillation incidence in the community. Circulation 121: 200-207.
21. Smith JG, Newton-Cheh C, Almgren P, Struck J, Morgenthaler NG, et al (2010) Assessment of conventional cardiovascular risk factors and multiple biomarkers for the prediction of incident heart failure and atrial fibrillation. J Am Coll Cardiol 56: 1712-1719.
22. Bruins P, te Velthuis H, Yazdanbakhsh AP, Jansen PG, van Hardevelt FW, et al (1997) Activation of the complement system during and after cardiopulmonary bypass surgery: postsurgery activation involves C-reactive protein and is associated with postoperative arrhythmia. Circulation 96: 3542-3548. (Pubitemid 27513431)
23. Ramlawi B, Otu H, Mieno S, Boodhwani M, Sodha NR, et al (2007) Oxidative stress and atrial fibrillation after cardiac surgery: a case-control study. Ann Thorac Surg 84: 1166-72; discussion 1172-3.
24. Lamm G, Auer J, Weber T, Berent R, Ng C, et al (2006) Postoperative white blood cell count predicts atrial fibrillation after cardiac surgery. J Cardiothorac Vasc Anesth 20: 51-56. (Pubitemid 43182777)
25. Rudolph V, Andrié RP, Rudolph TK, Friedrichs K, Klinke A, et al (2010) Myeloperoxidase acts as a profibrotic mediator of atrial fibrillation. Nat Med 16: 470-474.
26. Okumura Y, Watanabe I, Nakai T, Ohkubo K, Kofune T, et al (2011) Impact of biomarkers of inflammation and extracellular matrix turnover on the outcome of atrial fibrillation ablation: importance of matrix metalloproteinase-2 as a predictor of atrial fibrillation recurrence. J Cardiovasc Electrophysiol 22: 987-993.
27. Ding ZM, Babensee JE, Simon SI, Lu H, Perrard JL, et al (1999) Relative contribution of LFA-1 and Mac-1 to neutrophil adhesion and migration. J Immunol 163: 5029-5038. (Pubitemid 29501271)
28. Harris ES, McIntyre TM, Prescott SM, Zimmerman GA (2000) The leukocyte integrins. J Biol Chem 275: 23409-23412. (Pubitemid 30624617)
29. Mocsai A, Ligeti E, Lowell CA, Berton G (1999) Adhesion-dependent degranulation of neutrophils requires the Src family kinases Fgr and Hck. J Immunol 162: 1120-1126. (Pubitemid 29035443)
30. Murdoch C, Finn A (2000) Chemokine receptors and their role in inflammation and infectious diseases. Blood 95: 3032-3043. (Pubitemid 30321151)
31. Hughes BJ, Hollers JC, Crockett-Torabi E, Smith CW (1992) Recruitment of CD11b/CD18 to the neutrophil surface and adherence-dependent cell locomotion. J Clin Invest 90: 1687-1696.
32. Ross GD (2002) Role of the lectin domain of Mac-1/CR3 (CD11b/CD18) in regulating intercellular adhesion. Immunol Res 25: 219-227.
33. Zhou MJ, Brown EJ (1994) CR3 (Mac-1, alpha M beta 2, CD11b/CD18) and Fc gamma RIII cooperate in generation of a neutrophil respiratory burst: requirement for Fc gamma RIII and tyrosine phosphorylation. J Cell Biol 125: 1407-1416.
34. Lau D, Mollnau H, Eiserich JP, Freeman BA, Daiber A, et al (2005) Myeloperoxidase mediates neutrophil activation by association with CD11b/CD18 integrins. Proc Natl Acad Sci U S A 102: 431-436. (Pubitemid 40116784)
35. Jerke U, Rolle S, Purfürst B, Luft FC, Nauseef WM, et al (2013) β2 integrin-mediated cell-cell contact transfers active myeloperoxidase from neutrophils to endothelial cells. J Biol Chem 288: 12910-12919.
36. Coxon A, Rieu P, Barkalow FJ, Askari S, Sharpe AH, et al (1996) A novel role for the beta 2 integrin CD11b/CD18 in neutrophil apoptosis: a homeostatic mechanism in inflammation. Immunity 5: 653-666. (Pubitemid 27062073)
37. Schrickel JW, Brixius K, Herr C, Clemen CS, Sasse P, et al (2007) Enhanced heterogeneity of myocardial conduction and severe cardiac electrical instability in annexin A7-deficient mice. Cardiovasc Res 76: 257-268. (Pubitemid 350198597)
38. Sah VP, Minamisawa S, Tam SP, Wu TH, Dorn GW, et al (1999) Cardiac-specific overexpression of RhoA results in sinus and atrioventricular nodal dysfunction and contractile failure. J Clin Invest 103: 1627-1634. (Pubitemid 29534356)
39. Soriano SG, Coxon A, Wang YF, Frosch MP, Lipton SA, et al (1999) Mice deficient in Mac-1 (CD11b/CD18) are less susceptible to cerebral ischemia/reperfusion injury. Stroke 30: 134-139. (Pubitemid 29029454)
40. Gao XP, Liu Q, Broman M, Predescu D, Frey RS, et al (2005) Inactivation of CD11b in a mouse transgenic model protects against sepsis-induced lung PMN infiltration and vascular injury. Physiol Genomics 21: 230-242. (Pubitemid 40898483)
41. Walzog B, Schuppan D, Heimpel C, Hafezi-Moghadam A, Gaehtgens P, et al (1995) The leukocyte integrin Mac-1 (CD11b/CD18) contributes to binding of human granulocytes to collagen. Exp Cell Res 218: 28-38.
42. Reil JC, Hohl M, Oberhofer M, Kazakov A, Kaestner L, et al (2010) Cardiac Rac1 overexpression in mice creates a substrate for atrial arrhythmias characterized by structural remodelling. Cardiovasc Res 87: 485-493.
43. Sovari AA, Morita N, Karagueuzian HS (2008) Apocynin: a potent NADPH oxidase inhibitor for the management of atrial fibrillation. Redox Rep 13: 242-245.
44. Novo G, Guttilla D, Fazio G, Cooper D, Novo S (2008) The role of the renin-angiotensin system in atrial fibrillation and the therapeutic effects of ACE-Is and ARBS. Br J Clin Pharmacol 66: 345-351.
45. Bapat A, Nguyen TP, Lee JH, Sovari AA, Fishbein MC, et al (2012) Enhanced sensitivity of aged fibrotic hearts to angiotensin II- and hypokalemia-induced early afterdepolarization-mediated ventricular arrhythmias. Am J Physiol Heart Circ Physiol 302: H2331-H2340.
46. Masson S, Aleksova A, Favero C, Staszewsky L, Bernardinangeli M, et al (2010) Predicting atrial fibrillation recurrence with circulating inflammatory markers in patients in sinus rhythm at high risk for atrial fibrillation: data from the GISSI atrial fibrillation trial. Heart 96: 1909-1914.
47. Disertori M, Latini R, Barlera S, Franzosi MG, Staszewsky L, et al (2009) Valsartan for prevention of recurrent atrial fibrillation. N Engl J Med 360: 1606-1617.
48. Khatib R, Joseph P, Briel M, Yusuf S, Healey J (2013) Blockade of the renin-angiotensin-aldosterone system (RAAS) for primary prevention of non-valvular atrial fibrillation: a systematic review and meta analysis of randomized controlled trials. Int J Cardiol 165: 17-24.
49. Huang G, Xu JB, Liu JX, He Y, Nie XL, et al (2011) Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers decrease the incidence of atrial fibrillation: a meta-analysis. Eur J Clin Invest 41: 719-733.