Altered systemic cortisol metabolism in bipolar disorder and schizophrenia spectrum disorders

Journal of Psychiatric Research

Volumn 52, Issue 1, 2014, Pages 57-62

  Steen, Nils Eiel ^a,b,c   Methlie, Paal ^d,e   Lorentzen, Steinar ^a,b   Dieset, Ingrid ^a,b   Aas, Monica ^a,b   Nerhus, Mari ^a,b   Haram, Marit ^a,b   Agartz, Ingrid ^a,b,f   Melle, Ingrid ^a,b   Berg, Jens P ^a,b   Andreassen, Ole A ^a,b  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

^b UNIVERSITY OF OSLO   (Norway)

^c VESTRE VIKEN HOSPITAL TRUST   (Norway)

^d UNIVERSITY OF BERGEN   (Norway)

^e HAUKELAND UNIVERSITY HOSPITAL   (Norway)

^f DIAKONHJEMMET HOSPITAL   (Norway)

Author keywords

11 Hydroxysteroid dehydrogenase; 5 reductase; 5 reductase; Hypothalamic pituitary adrenal axis; Psychosis; Severe mental disorders

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; CORTISONE; HYDROCORTISONE; MOOD STABILIZER; NEUROLEPTIC AGENT; STEROID 5ALPHA REDUCTASE; STEROID 5BETA REDUCTASE; ALLOTETRAHYDROCORTISOL; TETRAHYDROCORTISOL; TETRAHYDROCORTISONE;

ADULT; AGED; ARTICLE; BIPOLAR DISORDER; BIPOLAR I DISORDER; BIPOLAR II DISORDER; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; HORMONE METABOLISM; HUMAN; HYDROCORTISONE URINE LEVEL; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; LABORATORY TEST; MAJOR CLINICAL STUDY; MALE; MENTAL PATIENT; METABOLITE; MIDDLE AGED; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN ANALYSIS; SCHIZOAFFECTIVE PSYCHOSIS; SCHIZOPHRENIA; SCHIZOPHRENIFORM DISORDER; URINALYSIS; YOUNG ADULT; ADOLESCENT; ANALOGS AND DERIVATIVES; ANALYSIS OF VARIANCE; METABOLISM; PSYCHOLOGICAL RATING SCALE;

ADOLESCENT; ADULT; ANALYSIS OF VARIANCE; BIPOLAR DISORDER; FEMALE; HUMANS; HYDROCORTISONE; MALE; MIDDLE AGED; PSYCHIATRIC STATUS RATING SCALES; SCHIZOPHRENIA; TETRAHYDROCORTISOL; TETRAHYDROCORTISONE; YOUNG ADULT;

EID: 84895867799     PISSN: 00223956     EISSN: 18791379     Source Type: Journal    
DOI: 10.1016/j.jpsychires.2014.01.017     Document Type: Article

References (36)

1. Aas M., Dazzan P., Mondelli V., Toulopoulou T., Reichenberg A., Di F.M., et al. Abnormal cortisol awakening response predicts worse cognitive function in patients with first-episode psychosis. Psychol Med 2011, 41:463-476.
2. Addington D., Addington J., Schissel B. Adepression rating scale for schizophrenics. Schizophr Res 1990, 3:247-251.
3. American Psychiatric Association Diagnostic and statistical manual of mental disorders 2000, American Psychiatric Association, Washington, DC. 4th ed, Text Revision.
4. Bao A.M., Swaab D.F. Corticotropin-releasing hormone and arginine vasopressin in depression focus on the human postmortem hypothalamus. Vitam Horm 2010, 82:339-365.
5. Brown E.S. Effects of glucocorticoids on mood, memory, and the hippocampus. Treatment and preventive therapy. Ann N Y Acad Sci 2009, 1179:41-55.
6. Corcoran C., Walker E., Huot R., Mittal V., Tessner K., Kestler L., et al. The stress cascade and schizophrenia: etiology and onset. Schizophr Bull 2003, 29:671-692.
7. Craddock N., O'Donovan M.C., Owen M.J. Psychosis genetics: modeling the relationship between schizophrenia, bipolar disorder, and mixed (or "schizoaffective") psychoses. Schizophr Bull 2009, 35:482-490.
8. Daban C., Vieta E., Mackin P., Young A.H. Hypothalamic-pituitary-adrenal axis and bipolar disorder. Psychiatr Clin North Am 2005, 28:469-480.
9. de Kloet E.R., Joels M., Holsboer F. Stress and the brain: from adaptation to disease. Nat Rev Neurosci 2005, 6:463-475.
10. First M.B., Spitzer R.L., Gibbon M., Williams J.B.W. Structured Clinical Interview for DSM-IV Axis I disorders: Patient Edition (SCID-P), version 2 1995, Biometrics Research, New York State Psychiatric Institute, New York.
11. Herman J.P., Ostrander M.M., Mueller N.K., Figueiredo H. Limbic system mechanisms of stress regulation: hypothalamo-pituitary-adrenocortical axis. Prog Neuropsychopharmacol Biol Psychiatry 2005, 29:1201-1213.
12. Holsboer F., Ising M. Central CRH system in depression and anxiety-evidence from clinical studies with CRH1 receptor antagonists. Eur J Pharmacol 2008, 583:350-357.
13. Hugin-Flores M.E., Steimer T., Aubert M.L., Schulz P. Mineralo- and glucocorticoid receptor mrnas are differently regulated by corticosterone in the rat hippocampus and anterior pituitary. Neuroendocrinology 2004, 79:174-184.
14. Jansen L.M., Gispen-de Wied C.C., Kahn R.S. Selective impairments in the stress response in schizophrenic patients. Psychopharmacol Berl 2000, 149:319-325.
15. Jerjes W.K., Cleare A.J., Peters T.J., Taylor N.F. Circadian rhythm of urinary steroid metabolites. Ann Clin Biochem 2006, 43:287-294.
16. Kay S.R., Fiszbein A., Opler L.A. The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull 1987, 13:261-276.
17. Lichtenstein P., Yip B.H., Bjork C., Pawitan Y., Cannon T.D., Sullivan P.F., et al. Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study. Lancet 2009, 373:234-239.
18. Paterson J.M., Holmes M.C., Kenyon C.J., Carter R., Mullins J.J., Seckl J.R. Liver-selective transgene rescue of hypothalamic-pituitary-adrenal axis dysfunction in 11beta-hydroxysteroid dehydrogenase type 1-deficient mice. Endocrinology 2007, 148:961-966.
19. Poor V., Juricskay S., Gati A., Osvath P., Tenyi T. Urinary steroid metabolites and 11beta-hydroxysteroid dehydrogenase activity in patients with unipolar recurrent major depression. JAffect Disord 2004, 81:55-59.
20. Raven P.W., Taylor N.F. Evidence for independent modulation of human 11-HSD and 5 alpha/5 beta reductase activities. Endocr Res 1996, 22:811-815.
21. Raven P.W., Taylor N.F. 11Beta-HSD and 17beta-HSD as biological markers of depression: sex differences and correlation with symptom severity. Endocr Res 1998, 24:659-662.
22. Romer B., Lewicka S., Kopf D., Lederbogen F., Hamann B., Gilles M., et al. Cortisol metabolism in depressed patients and healthy controls. Neuroendocrinology 2009, 90:301-306.
23. Rush A.J., Gullion C.M., Basco M.R., Jarrett R.B., Trivedi M.H. The Inventory of Depressive Symptomatology (IDS): psychometric properties. Psychol Med 1996, 26:477-486.
24. Steen N.E., Lorentzen S., Barrett E.A., Lagerberg T.V., Hope S., Larsson S., et al. Sex-specific cortisol levels in bipolar disorder and schizophrenia during mental challenge-relationship to clinical characteristics and medication. Prog Neuropsychopharmacol Biol Psychiatry 2011, 35:1100-1107.
25. Steen N.E., Methlie P., Lorentzen S., Hope S., Barrett E.A., Larsson S., et al. Increased systemic cortisol metabolism in patients with schizophrenia and bipolar disorder: a mechanism for increased stress vulnerability?. JClin Psychiatry 2011, 72:1515-1521.
26. Steen N.E., Tesli M., Kahler A.K., Methlie P., Hope S., Barrett E.A., et al. SRD5A2 is associated with increased cortisol metabolism in schizophrenia spectrum disorders. Prog Neuropsychopharmacol Biol Psychiatry 2010, 34:1500-1506.
27. Tomlinson J.W., Finney J., Hughes B.A., Hughes S.V., Stewart P.M. Reduced glucocorticoid production rate, decreased 5alpha-reductase activity, and adipose tissue insulin sensitization after weight loss. Diabetes 2008, 57:1536-1543.
28. Tomlinson J.W., Stewart P.M. Cortisol metabolism and the role of 11beta-hydroxysteroid dehydrogenase. Best Pract Res Clin Endocrinol Metab 2001, 15:61-78.
29. Ulick S., Tedde R., Wang J.Z. Defective ring A reduction of cortisol as the major metabolic error in the syndrome of apparent mineralocorticoid excess. JClin Endocrinol Metab 1992, 74:593-599.
30. van Venrooij J.A., Fluitman S.B., Lijmer J.G., Kavelaars A., Heijnen C.J., Westenberg H.G., et al. Impaired neuroendocrine and immune response to acute stress in medication-naive patients with a first episode of psychosis. Schizophr Bull 2012, 38:272-279.
31. van Winkel R., Stefanis N.C., Myin-Germeys I. Psychosocial stress and psychosis. A review of the neurobiological mechanisms and the evidence for gene-stress interaction. Schizophr Bull 2008, 34:1095-1105.
32. Walker E., Mittal V., Tessner K. Stress and the hypothalamic pituitary adrenal axis in the developmental course of schizophrenia. Annu Rev Clin Psychol 2008, 4:189-216.
33. Watson S., Gallagher P., Ritchie J.C., Ferrier I.N., Young A.H. Hypothalamic-pituitary-adrenal axis function in patients with bipolar disorder. Br J Psychiatry 2004, 184:496-502.
34. Weber B., Lewicka S., Deuschle M., Colla M., Vecsei P., Heuser I. Increased diurnal plasma concentrations of cortisone in depressed patients. JClin Endocrinol Metab 2000, 85:1133-1136.
35. Yi S.S., Hwang I.K., Shin J.H., Choi J.H., Lee C.H., Kim I.Y., et al. Regulatory mechanism of hypothalamo-pituitary-adrenal (HPA) axis and neuronal changes after adrenalectomy in type 2 diabetes. JChem Neuroanat 2010, 40:130-139.
36. Young R.C., Biggs J.T., Ziegler V.E., Meyer D.A. Arating scale for mania: reliability, validity and sensitivity. Br J Psychiatry 1978, 133:429-435.