Cortisol metabolism in depressed patients and healthy controls

Neuroendocrinology

Volumn 90, Issue 3, 2009, Pages 301-306

  Römer, Benedikt ^a   Lewicka, Sabina ^b   Kopf, Daniel ^a   Lederbogen, Florian ^a   Hamann, Bettina ^a   Gilles, Maria ^a   Schilling, Claudia ^a   Onken, Vera ^a   Frankhauser, Pascal ^a   Deuschle, Michael ^a  

^a CENTRAL INSTITUTE OF MENTAL HEALTH   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Antidepressant treatment; Cortisol metabolism; Depression; Hypercortisolemia; Steroids

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; GLUCOCORTICOID; HYDROCORTISONE; MIRTAZAPINE; STEROID 5ALPHA REDUCTASE; STEROID 5BETA REDUCTASE; TETRAHYDROCORTISOL; TETRAHYDROCORTISONE; VENLAFAXINE;

ADULT; AGED; ARTICLE; CHRONIC STRESS; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORTICOSTEROID METABOLISM; ENZYME ACTIVITY; FEMALE; HUMAN; HYPERCORTISOLISM; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; MAJOR DEPRESSION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; URINE LEVEL;

ADULT; AGED; AGED, 80 AND OVER; ANTIDEPRESSIVE AGENTS, SECOND-GENERATION; ANTIDEPRESSIVE AGENTS, TRICYCLIC; CORTISONE; CYCLOHEXANOLS; DEPRESSIVE DISORDER, MAJOR; FEMALE; HUMANS; HYDROCORTISONE; MIANSERIN; MIDDLE AGED; TETRAHYDROCORTISOL; TETRAHYDROCORTISONE; YOUNG ADULT;

EID: 70350324896     PISSN: 00283835     EISSN: None     Source Type: Journal    
DOI: 10.1159/000235904     Document Type: Article

References (29)

1. Gold PW, Chrousos GP: Organization of the stress system and its dysregulation in melancholic and atypical depression: high vs low CRH/NE states. Mol Psychiatry 2002; 7: 254-275.
2. Deuschle M, Schweiger U, Standhardt H, Weber B, Heuser I: Corticosteroid-binding globulin is not decreased in depressed patients. Psychoneuroendocrinology 1996; 21: 645-649.
3. Heuser I, Yassouridis A, Holsboer F: The combined dexamethasone/CRH test: a refined laboratory test for psychiatric disorders. J Psychiatr Res 1994; 28: 341-356.
4. Weber-Hamann B, Kopf D, Lederbogen F, Gilles M, Heuser I, Colla M, Deuschle M: Activity of the hypothalamus-pituitary-adrenal system and oral glucose tolerance in depressed patients. Neuroendocrinology 2005; 81: 200-204.
5. Weber-Hamann B, Hentschel F, Kniest A, Deuschle M, Colla M, Lederbogen F, Heuser I: Hypercortisolemic depression is associated with increased intra-abdominal fat. Psychosom Med 2002; 64: 274-277.
6. Weber-Hamann B, Werner M, Hentschel F, Bindeballe N, Lederbogen F, Deuschle M, Heuser I: Metabolic changes in elderly patients with major depression: evidence for increased accumulation of visceral fat at follow- up. Psychoneuroendocrinology 2006; 31: 347-354.
7. Draper N, Stewart PM: 11 - -Hydroxysteroid dehydrogenase and the pre-receptor regulation of corticosteroid hormone action. J Endocrinol 2005; 186: 251-271.
8. Walker BR, Andrew R: Tissue production of cortisol by 11 - -hydroxysteroid dehydrogenase type 1 and metabolic disease. Ann NY Acad Sci 2006; 1083: 165-184.
9. Quinkler M, Stewart PM: Hypertension and the cortisol-cortisone shuttle. J Clin Endocrinol Metab 2003; 88: 2384-2392.
10. Carlstedt-Duke J, Gustafsson JA, Gustafsson SA, Wrange O: Interactions of corticosterone, 5 - -dihydrocorticosterone and dexamethasone with proteins in rat-liver cytosol. Eur J Biochem 1977; 73: 231-238.
11. McInnes KJ, Kenyon CJ, Chapman KE, Livingstone DE, Macdonald LJ, Walker BR, Andrew R: 5 - -Reduced glucocorticoids, novel endogenous activators of the glucocorticoid receptor. J Biol Chem 2004; 279: 22908-22912.
12. Weber B, Schweiger U, Deuschle M, Heuser I: Major depression and impaired glucose tolerance. Exp Clin Endocrinol Diabetes 2000; 108: 187-190.
13. Raven PW, Taylor NF: 11 -HSD and 17 - HSD as biological markers of depression: sex differences and correlation with symptom severity. Endocr Res 1998; 24: 659-662.
14. Poór V, Juricskay S, Gáti A, Osváth P, Tényi T: Urinary steroid metabolites and 11 -hydroxysteroid dehydrogenase activity in patients with unipolar recurrent major depression. J Affect Disord 2004; 81: 55-59.
15. Poór V, Bufa A, Bíró I, Telegdy E, Tényi T, Gáti A, Osváth P, Wilhelm F, Juricskay S: Urinary steroid measurements in some endocrine and psychiatric diseases. Curr Med Chem 2005; 12: 1339-1342.
16. Deuschle M, Luppa P, Gilles M, Hamann B, Heuser I: Antidepressant treatment and dehydroepiandrosterone sulfate: different effects of amitriptyline and paroxetine. Neuropsychobiology 2004; 50: 252-256.
17. Uhart M, Chong RY, Oswald L, Lin PI, Wand GS: Gender differences in hypothalamic-pituitary- adrenal (HPA) axis reactivity. Psychoneuroendocrinology 2006; 31: 642-652.
18. Will H, Aderjan R, Winkler T, Penke B, Vecsei P: Radioimmunoassays of tetrahydrocortisone and tetrahydrocortisol in human urine. Acta Endocrinol (Copenh) 1977; 86: 369-379.
19. Maser-Gluth C, Reincke M, Allolio B, Schulze E: Metabolism of glucocorticoids and mineralocorticoids in patients with adrenal incidentalomas. Eur J Clin Invest 2000; 30(suppl 3):83-86.
20. Palermo M, Shackleton CH, Mantero F, Stewart PM: Urinary free cortisone and the assessment of 11 beta-hydroxysteroid dehydrogenase activity in man. Clin Endocrinol (Oxf) 1996; 45: 605-611.
21. Weber B, Lewicka S, Deuschle M, Colla M, Vecsei P, Heuser I: Increased diurnal plasma concentrations of cortisone in depressed patients. J Clin Endocrinol Metab 2000; 85: 1133-1136.
22. Wenk EJ, Hernandez MR, Weinstein BI, Gordon GG, Dunn MW, Southren AL: Glucocorticoid receptor binding in bovine lens. Invest Ophthalmol Vis Sci 1982; 22: 599-605.
23. Agis-Balboa RC, Pinna G, Pibiri F, Kadriu B, Costa E, Guidotti A: Down-regulation of neurosteroid biosynthesis in corticolimbic circuits mediates social isolation-induced behavior in mice. Proc Natl Acad Sci USA 2007; 104: 18736-18741.
24. Rahimi-Ardabili B, Pourandarjani R, Habibollahi P, Mualeki A: Finasteride induced depression: a prospective study. BMC Clin Pharmacol 2006; 6: 7.
25. Beckley EH, Finn DA: Inhibition of progesterone metabolism mimics the effect of progesterone withdrawal on forced swim test immobility. Pharmacol Biochem Behav 2007; 87: 412-419.
26. Pinna G, Costa E, Guidotti A: Fluoxetine and norfluoxetine stereospecifically and selectively increase brain neurosteroid content at doses that are inactive on 5-HT reuptake. Psychopharmacology (Berl) 2006; 186: 362-372.
27. Rutledge T, Hogan BE: A quantitative review of prospective evidence linking psychological factors with hypertension development. Psychosom Med 2002; 64: 758-766.
28. Wedekind D, Preiss B, Cohrs S, Ruether E, Huether G, Adler L: Relationship between nocturnal urinary cortisol excretion and symptom severity in subgroups of patients with depressive episodes. Neuropsychobiology 2007; 56: 119-122.
29. Doering S, Wedekind D, Pilz J, Bandelow B, Adler L, Huether G: Cortisol in night-urine: introduction of a research method in psychoneuroendocrinology (in German). Z Psychosom Med Psychother 2001; 47: 42-57.