Impaired neuroendocrine and immune response to acute stress in medication-naive patients with a first episode of psychosis

Schizophrenia Bulletin

Volumn 38, Issue 2, 2012, Pages 272-279

  Van Venrooij, Janine A E M ^a   Fluitman, Sjoerd B A H A ^a   Lijmer, Jeroen G ^a   Kavelaars, Annemieke ^b   Heijnen, Cobi J ^b   Westenberg, Herman G M ^a   Kahn, René S ^a   Gispen De Wied, Christine C ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

autonomic nervous system; first episode psychosis; immune; neuroendocrine; schizophrenia; stress

Indexed keywords

ACUTE STRESS; ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ENDOPHENOTYPE; HUMAN; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; IMMUNE RESPONSE; MALE; NEUROENDOCRINE SYSTEM; PRIORITY JOURNAL; PSYCHOSIS;

ADOLESCENT; ADRENOCORTICOTROPIC HORMONE; ADULT; AUTONOMIC NERVOUS SYSTEM; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; EPINEPHRINE; HEART RATE; HUMANS; HYDROCORTISONE; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; IMMUNE SYSTEM; KILLER CELLS, NATURAL; MALE; NOREPINEPHRINE; PITUITARY-ADRENAL SYSTEM; PSYCHOTIC DISORDERS; SCHIZOPHRENIA; STRESS, PSYCHOLOGICAL;

EID: 84857548498     PISSN: 05867614     EISSN: 17451701     Source Type: Journal    
DOI: 10.1093/schbul/sbq062     Document Type: Article

References (72)

1. Zubin J, Spring B. Vulnerability-a new view of schizophrenia. J Abnorm Psychol. 1977;86:103-126.
2. Norman RM, Malla AK. Stressful life events and schizophrenia. I: a review of the research. Br J Psychiatry. 1993;162:161-166.
3. Nuechterlein KH, Dawson ME, Ventura J, et al. The vulnerability/stress model of schizophrenic relapse: a longitudinal study. Acta Psychiatr Scand Suppl. 1994;382:58-64.
4. Shevlin M, Houston JE, Dorahy MJ, Adamson G. Cumulative traumas and psychosis: an analysis of the national comorbidity survey and the British Psychiatric Morbidity Survey. Schizophr Bull. 2008;34:193-199.
5. Norman RM, Malla AK. A prospective study of daily stressors and symptomatology in schizophrenic patients. Soc Psychiatry Psychiatr Epidemiol. 1994;29:244-249.
6. Marcelis M, Navarro-Mateu F, Murray R, Selten JP, van OJ. Urbanization and psychosis: a study of 1942-1978 birth cohorts in The Netherlands. Psychol Med. 1998;28:871-879.
7. Butzlaff RL, Hooley JM. Expressed emotion and psychiatric relapse: a meta-analysis. Arch Gen Psychiatry. 1998;55:547-552.
8. van Winkel WR, Stefanis NC, Myin-Germeys I. Psychosocial stress and psychosis. A review of the neurobiological mechanisms and the evidence for gene-stress interaction. Schizophr Bull. 2008;34:1095-1105.
9. Myin-Germeys I, van OJ. Stress-reactivity in psychosis: evidence for an affective pathway to psychosis. Clin Psychol Rev. 2007;27:409-424.
10. Ader R, Cohen N. Conditioning of the immune response. Neth J Med. 1991;39:263-273.
11. Sheridan JF, Dobbs C, Brown D, Zwilling B. Psychoneuroimmunology: stress effects on pathogenesis and immunity during infection. Clin Microbiol Rev. 1994;7:200-212.
12. Benschop RJ, Godaert GL, Geenen R, et al. Relationships between cardiovascular and immunological changes in an experimental stress model. Psychol Med. 1995;25:323-327.
13. Marsland AL, Herbert TB, Muldoon MF, et al. Lymphocyte subset redistribution during acute laboratory stress in young adults: mediating effects of hemoconcentration. Health Psychol. 1997;16:341-348.
14. Breznitz S, Ben Zur H, Berzon Y, et al. Experimental induction and termination of acute psychological stress in human volunteers: effects on immunological, neuroendocrine, cardiovascular, and psychological parameters. Brain Behav Immun. 1998;12:34-52.
15. Isowa T, Ohira H, Murashima S. Immune, endocrine and cardiovascular responses to controllable and uncontrollable acute stress. Biol Psychol. 2006;71:202-213.
16. Atanackovic D, Schnee B, Schuch G, et al. Acute psychological stress alerts the adaptive immune response: stress-induced mobilization of effector T cells. J Neuroimmunol. 2006;176:141-152.
17. Zahn TP, Carpenter WT, Jr., McGlashan TH. Autonomic nervous system activity in acute schizophrenia: II. Relationships to short-term prognosis and clinical state. Arch Gen Psychiatry. 1981;38:260-266.
18. Jansen LM, Gispen-de Wied CC, Kahn RS. Selective impairments in the stress response in schizophrenic patients. Psychopharmacology (Berl). 2000;149:319-325.
19. Zahn TP, Pickar D, van Kammen DP. Neuroleptic effects on autonomic activity in schizophrenia: between-group and within-subject paradigms and comparisons with controls. Schizophr Bull. 2001;27:503-515.
20. Mujica-Parodi LR, Yeragani V, Malaspina D. Nonlinear complexity and spectral analyses of heart rate variability in medicated and unmedicated patients with schizophrenia. Neuropsychobiology. 2005;51:10-15.
21. Castro MN, Vigo DE, Weidema H, et al. Heart rate variability response to mental arithmetic stress in patients with schizophrenia: autonomic response to stress in schizophrenia. Schizophr Res. 2008;99:294-303.
22. Fujibayashi M, Matsumoto T, Kishida I, et al. Autonomic nervous system activity and psychiatric severity in schizophrenia. Psychiatry Clin Neurosci. 2009;63:538-545.
23. Rao ML, Strebel B, Halaris A, et al. Circadian rhythm of vital signs, norepinephrine, epinephrine, thyroid hormones, and cortisol in schizophrenia. Psychiatry Res. 1995;57:21-39.
24. Breier A, Buchanan RW. The effects of metabolic stress on plasma progesterone in healthy volunteers and schizophrenic patients. Life Sci. 1992;51:1527-1534.
25. Phillips LJ, McGorry PD, Garner B, et al. Stress, the hippocampus and the hypothalamic-pituitary-adrenal axis: implications for the development of psychotic disorders. Aust N Z J Psychiatry. 2006;40:725-741.
26. Goldsmith CA, Rogers DP. The case for autoimmunity in the etiology of schizophrenia. Pharmacotherapy. 2008;28:730-741.
27. Muller N, Schwarz MJ. A psychoneuroimmunological perspective to Emil Kraepelins dichotomy: schizophrenia and major depression as inflammatory CNS disorders. Eur Arch Psychiatry Clin Neurosci. 2008;258(suppl 2):97-106.
28. Sperner-Unterweger B, Whitworth A, Kemmler G, et al. T-cell subsets in schizophrenia: a comparison between drugnaive first episode patients and chronic schizophrenic patients. Schizophr Res. 1999;38:61-70.
29. Yovel G, Sirota P, Mazeh D, Shakhar G, Rosenne E, Ben Eliyahu S. Higher natural killer cell activity in schizophrenic patients: the impact of serum factors, medication, and smoking. Brain Behav Immun. 2000;14:153-169.
30. Jones AL, Mowry BJ, Pender MP, Greer JM. Immune dysregulation and self-reactivity in schizophrenia: do some cases of schizophrenia have an autoimmune basis? Immunol Cell Biol. 2005;83:9-17.
31. Strous RD, Shoenfeld Y. Schizophrenia, autoimmunity and immune system dysregulation: a comprehensive model updated and revisited. J Autoimmun. 2006;27:71-80.
32. Rogers DP, Goldsmith CA. Treatment of schizophrenia in the 21st century: beyond the neurotransmitter hypothesis. Expert Rev Neurother. 2009;9:47-54.
33. Rothermundt M, Arolt V, Bayer TA. Review of immunological and immunopathological findings in schizophrenia. Brain Behav Immun. 2001;15:319-339.
34. Bernstein AS. Orienting response research in schizophrenia: where we have come and where we might go. Schizophr Bull. 1987;13:623-641.
35. Jansen LM, Gispen-de Wied CC, Gademan PJ, De Jonge RC, van der Linden JA, Kahn RS. Blunted cortisol response to a psychosocial stressor in schizophrenia. Schizophr Res. 1998;33:87-94.
36. Brenner K, Liu A, Laplante DP, et al. Cortisol response to a psychosocial stressor in schizophrenia: blunted, delayed, or normal? Psychoneuroendocrinology. 2009;34:859-868.
37. Albus M, Ackenheil M, Engel RR, Muller F. Situational reactivity of autonomic functions in schizophrenic patients. Psychiatry Res. 1982;6:361-370.
38. Kudoh A, Kudo T, Ishihara H, Matsuki A. Depressed pituitary-adrenal response to surgical stress in chronic schizophrenic patients. Neuropsychobiology. 1997;36:112-116.
39. Kudoh A, Ishihara H, Matsuki A. Pituitary-adrenal and parasympathetic function in chronic schizophrenic patients with postoperative ileus or hypotension. Neuropsychobiology. 1999;39:125-130.
40. Kudoh A, Sakai T, Ishihara H, Matsuki A. Plasma cytokine response to surgical stress in schizophrenic patients. Clin Exp Immunol. 2001;125:89-93.
41. Breier A, Wolkowitz OM, Doran AR, Bellar S, Pickar D. Neurobiological effects of lumbar puncture stress in psychiatric patients and healthy volunteers. Psychiatry Res. 1988;25:187-194.
42. Marcelis M, Cavalier E, Gielen J, Delespaul P, van OJ. Abnormal response to metabolic stress in schizophrenia: marker of vulnerability or acquired sensitization? Psychol Med. 2004;34:1103-1111.
43. Breier AAE. Bennett award paper. Experimental approaches to human stress research: assessment of neurobiological mechanisms of stress in volunteers and psychiatric patients. Biol Psychiatry. 1989;26:438-462.
44. Kathol RG, Gehris TL, Carroll BT, et al. Blunted ACTH response to hypoglycemic stress in depressed patients but not in patients with schizophrenia. J Psychiatr Res. 1992;26:103-116.
45. Elman I, Adler CM, Malhotra AK, Bir C, Pickar D, Breier A. Effect of acute metabolic stress on pituitary-adrenal axis activation in patients with schizophrenia. Am J Psychiatry. 1998;155:979-981.
46. Hatzimanolis J, Lykouras L, Markianos M, Oulis P. Neurochemical variables in schizophrenic patients during switching from neuroleptics to clozapine. Prog Neuropsychopharmacol Biol Psychiatry. 1998;22:1077-1085.
47. Haack M, Hinze-Selch D, Fenzel T, et al. Plasma levels of cytokines and soluble cytokine receptors in psychiatric patients upon hospital admission: effects of confounding factors and diagnosis. J Psychiatr Res. 1999;33:407-418.
48. Zhang XY, Zhou DF, Cao LY, Wu GY, Shen YC. Cortisol and cytokines in chronic and treatment-resistant patients with schizophrenia: association with psychopathology and response to antipsychotics. Neuropsychopharmacology. 2005;30:1532-1538.
49. Walker E, Mittal V, Tessner K. Stress and the hypothalamic pituitary adrenal axis in the developmental course of schizophrenia. Annu Rev Clin Psychol. 2008;4:189-216.
50. Zhang XY, Zhou DF, Qi LY, et al. Superoxide dismutase and cytokines in chronic patients with schizophrenia: association with psychopathology and response to antipsychotics. Psychopharmacology (Berl). 2009;204:177-184.
51. Andreasen NC, Flaum M, Arndt S. The Comprehensive Assessment of Symptoms and History (CASH). An instrument for assessing diagnosis and psychopathology. Arch Gen Psychiatry. 1992;49:615-623.
52. Kay SR, Fiszbein A, Opler LA. The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull. 1987;13:261-276.
53. Endicott J, Spitzer RL. A diagnostic interview: the schedule for affective disorders and schizophrenia. Arch Gen Psychiatry. 1978;35:837-844.
54. Kirschbaum C, Pirke KM, Hellhammer DH. The 'Trier Social Stress Test'-a tool for investigating psychobiological stress responses in a laboratory setting. Neuropsychobiology. 1993;28:76-81.
55. Jansen LM, Gispen-de Wied CC, Wiegant VM, Westenberg HG, Lahuis BE, van Engeland H. Autonomic and neuroendocrine responses to a psychosocial stressor in adults with autistic spectrum disorder. J Autism Dev Disord. 2006;36:891-899.
56. Cohen S, Kamarck T, Mermelstein R. A global measure of perceived stress. J Health Soc Behav. 1983;24:385-396.
57. van de Ploeg HM. Zelfbeoordelingsvragenlijst Handleiding: Addendum. Lisse, the Netherlands: Swerts & Zeitlinger; 1981.
58. Kavelaars A, van der PG, Bakker JM, et al. Altered immune function in human newborns after prenatal administration of betamethasone: enhanced natural killer cell activity and decreased T cell proliferation in cord blood. Pediatr Res. 1999;45:306-312.
59. Schindler L, Leroux M, Beck J, Moises HW, Kirchner H. Studies of cellular immunity, serum interferon titers, and natural killer cell activity in schizophrenic patients. Acta Psychiatr Scand. 1986;73:651-657.
60. McDaniel JS, Jewart RD, Eccard MB, et al. Natural killer cell activity in schizophrenia and schizoaffective disorder: a pilot study. Schizophr Res. 1992;8:125-128.
61. Mizruchin A, Gold I, Krasnov I, Livshitz G, Shahin R, Kook AI. Comparison of the effects of dopaminergic and serotonergic activity in the CNS on the activity of the immune system. J Neuroimmunol. 1999;101:201-204.
62. Abdeljaber MH, Nair MP, Schork MA, Schwartz SA. Depressed natural killer cell activity in schizophrenic patients. Immunol Invest. 1994;23:259-268.
63. Sasaki T, Nanko S, Fukuda R, Kawate T, Kunugi H, Kazamatsuri H. Changes of immunological functions after acute exacerbation in schizophrenia. Biol Psychiatry. 1994;35:173-178.
64. Benschop RJ, Rodriguez-Feuerhahn M, Schedlowski M. Catecholamine-induced leukocytosis: early observations, current research, and future directions. Brain Behav Immun. 1996;10:77-91.
65. Benschop RJ, Schedlowski M, Wienecke H, Jacobs R, Schmidt RE. Adrenergic control of natural killer cell circulation and adhesion. Brain Behav Immun. 1997;11:321-332.
66. Myin-Germeys I, van OJ, Schwartz JE, Stone AA, Delespaul PA. Emotional reactivity to daily life stress in psychosis. Arch Gen Psychiatry. 2001;58:1137-1144.
67. Brunelin J, d'Amato T, van OJ, Cochet A, Suaud-Chagny MF, Saoud M. Effects of acute metabolic stress on the dopaminergic and pituitary-adrenal axis activity in patients with schizophrenia, their unaffected siblings and controls. Schizophr Res. 2008;100:206-211.
68. Castro MN, Vigo DE, Chu EM, et al. Heart rate variability response to mental arithmetic stress is abnormal in firstdegree relatives of individuals with schizophrenia. Schizophr Res. 2009;109:134-140.
69. Kavelaars A, Kuis W, Knook L, Sinnema G, Heijnen CJ. Disturbed neuroendocrine-immune interactions in chronic fatigue syndrome. J Clin Endocrinol Metab. 2000;85:692-696.
70. Kirschbaum C, Wust S, Strasburger CJ. 'Normal' cigarette smoking increases free cortisol in habitual smokers. Life Sci. 1992;50:435-442.
71. Tsuda A, Steptoe A, West R, Fieldman G, Kirschbaum C. Cigarette smoking and psychophysiological stress responsiveness: effects of recent smoking and temporary abstinence. Psychopharmacology (Berl). 1996;126:226-233.
72. Zeidel A, Beilin B, Yardeni I, Mayburd E, Smirnov G, Bessler H. Immune response in asymptomatic smokers. Acta Anaesthesiol Scand. 2002;46:959-964.