Decitabine induces delayed reactive oxygen species (ROS) accumulation in leukemia cells and induces the expression of ROS generating enzymes

Clinical Cancer Research

Volumn 20, Issue 5, 2014, Pages 1249-1258

  Fandy, Tamer E ^a   Jiemjit, Anchalee ^b   Thakar, Manjusha ^b   Rhoden, Paulette ^a   Suarez, Lauren ^b   Gore, Steven D ^b  

^a ALBANY COLLEGE OF PHARMACY AND HEALTH SCIENCES   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; CASPASE; CELL NUCLEUS DNA; DEOXYCYTIDINE KINASE; PROTEIN P53; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; SCAVENGER;

APOPTOSIS; ARTICLE; CELL CYCLE; CELL CYCLE ARREST; CELL DIFFERENTIATION; CELL SURVIVAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA DAMAGE; DNA METHYLATION; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG MECHANISM; DRUG SENSITIVITY; DRUG TARGETING; FLOW CYTOMETRY; GENE EXPRESSION; GENETIC ANALYSIS; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; INTRACELLULAR SIGNALING; LEUKEMIA CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN METABOLISM; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SOLID TUMOR; TUMOR CELL; UPREGULATION; WESTERN BLOTTING;

ANTIMETABOLITES, ANTINEOPLASTIC; ANTIOXIDANTS; APOPTOSIS; AZACITIDINE; CASPASES; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; DRUG RESISTANCE, NEOPLASM; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, LEUKEMIC; GENE KNOCKDOWN TECHNIQUES; HUMANS; LEUKEMIA; MATRIX METALLOPROTEINASES; OXIDATION-REDUCTION; REACTIVE OXYGEN SPECIES; TRANSCRIPTIONAL ACTIVATION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84895793456     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-13-1453     Document Type: Article

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