Genotoxicity and mitochondrial damage in human lymphocytic cells chronically exposed to 3'-azido-2',3'-dideoxytbymidine

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 390, Issue 3, 1997, Pages 223-231

  Agarwal, Ram P ^a   Olivero, Ofelia A ^b  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Mitochondrial DNA; Mitochondrium; Nucleoside analog

Indexed keywords

LACTIC ACID; MITOCHONDRIAL DNA; RNA DIRECTED DNA POLYMERASE; ZIDOVUDINE;

ARTICLE; CELL CULTURE; CHROMOSOME ABERRATION; CONTROLLED STUDY; CYTOTOXICITY; DNA DETERMINATION; DRUG METABOLISM; ELECTRON MICROSCOPY; GENOTOXICITY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; LYMPHOCYTE; PRIORITY JOURNAL; RADIOIMMUNOASSAY;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; MAMMALIA;

EID: 0030994880     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1383-5718(97)00014-4     Document Type: Article

References (36)

1. Yarchoan, R. and S. Broder (1987) Preliminary results on the use of dideoxynucleosides in the therapy of AIDS, in: R.M. Chanock, R.A. Lerner, F. Brown and H.S. Ginsberg (Eds.), Vaccine 87, Cold Spring Harbor Press, New York, pp. 214-224.
2. P.A. Furman, J.A. Fyfe, M.H. St Clair, K. Weinhold, J.L. Rideout, G.A. Freeman, S.N. Lehrman, D.P. Bolognesi, S. Broder, H. Mitsuya, D.A. Barry, Phosphorylation of 3′-azido-3′-deoxythymidine and selective interaction of the 5′-triphosphate with human immunodeficiency virus reverse transcriptase, Proc. Natl. Acad. Sci. USA 83 (1986) 8333-8337.
3. Y.C. Cheng, G.E. Dutschman, K.F. Bastow, M.G. Sarngadharan, R.Y.C. Ting, Human immunodeficiency virus reverse transcriptase. General properties and its interactions with nucleoside triphosphate analogs, J. Biol. Chem. 262 (1987) 2187-2189.
4. M.A. Vazquez-Padua, M.C. Starnes, Y.C. Cheng, Incorporation of 3′-azido-3′-deoxythymidine into cellular DNA and its removal in a human leukemic cell line, Cancer Commun. 2 (1990) 55-62.
5. V.I. Avramis, W. Markson, R.L. Jackson, E. Gomperts, Biochemical pharmacology of zidovudine in human T-lymphoblastoid cells (CEM), Aids 3 (1989) 417-422.
6. J.P. Sommadossi, R. Carlisle, Z. Zhou, Cellular pharmacology of 3′-azido-3′-deoxythymidine with evidence of incorporation into DNA of human bone marrow cells, Mol. Pharmacol. 36 (1989) 9-14.
7. O.A. Olivero, F.A. Beland, M.C. Poirier, Immunofluorescent localization and quantitation of 3′-azido-2′,3′-dideoxythymidine (AZT) incorporated into chromosomal DNA of human, hamster and mouse cell lines, Int. J. Oncol. 4 (1994) 49-54.
8. O.A. Olivero, M.C. Poirier, Preferential incorporation of 3′-azido-2′,3′-dideoxythymidine (AZT) into telomeric DNA and Z-DNA-containing regions of chinese hamster ovary cells, Mol. Carcinog. 8 (1993) 81-88.
9. D.E. Gomez, A. Kassim, O.A. Olivero, Preferential incorporation of 3′-Azido-2′,3′-dideoxythymidine (AZT) in telomeric sequences of CHO cells, Int. J. Oncol. 7 (1995) 1057-1060.
10. R.P. Agarwal, 3′-Azido-2′,3′-dideoxythymidine induces thymidine kinase activity in vitro, Int. J. Purine Pyrimidine Res. 2 (1991) 1-3.
11. 9-AZT cells, Cell. Pharmacol. 1 (1994) 121-125.
12. R.P. Agarwal, A.M. Mian, Thymidine and zidovudine metabolism in chronically zidovudine-exposed cells in vitro, Biochem. Pharmacol. 42 (1991) 905-911.
13. D.J. Medina, C.H. Tsai, G.D. Hsiung, Y.C. Cheng, Comparison of mitochondrial morphology, mitochondrial DNA content, and cell viability in cultured cells treated with three anti-human immunodeficiency virus dideoxynucleosides, Antimicrob. Agents Chemother. 38 (1994) 1824-1828.
14. C.H. Tsai, S.L. Doong, D.G. Johns, J.S. Driscoll, Y.C. Cheng, Effect of anti-HIV 2′-beta-fluoro-2′,3′-dideoxynucleoside analogs on the cellular content of mitochondrial DNA and on lactate production, Biochem. Pharmacol. 48 (1994) 1477-1481.
15. C.H. Chen, M. Vazquez-Padua, Y.C. Cheng, Effect of anti-human immunodeficiency virus nucleoside analogs on mitochondrial DNA and its implication for delayed toxicity, Mol. Pharmacol. 39 (1991) 625-628.
16. S.A. Keilbaugh, W.H. Prusoff, M.V. Simpson, The PC12 cell as a model for studies of the mechanism of induction of peripheral neuropathy by anti-HIV-1 dideoxynucleoside analogs, Biochem. Pharmacol. 42 (1991) 5-8.
17. J.L. Martin, C.E. Brown, N. Matthews-Davis, J.E. Reardon, Effects of antiviral nucleoside analogs on human DNA polymerases and mitochondrial DNA synthesis, Antimicrob. Agents Chemother. 38 (1995) 2743-2749.
18. M.C. Dalakas, I. Illa, G.H. Pezeshkpour, J.P. Laukaitis, B. Cohen, J.L. Griffin, Mitochondrial myopathy caused by long-term zidovudine therapy, New Engl. J. Med. 322 (1990) 1098-1105.
19. C. Mhiri, M. Baudrimont, G. Bonne, C. Geny, F. Degoul, C. Marsac, E. Roullet, R. Gherardi, Zidovudine myopathy: a distinctive disorder associated with mitochondrial dysfunction, Ann. Neurol. 29 (1991) 606-614.
20. Flamm, W.G., M.L. Birnstiel and P.M.B. Walker (1967) Preparation and fractionation and isolation of single strands of DNA by ultracentrifugation in fixed-angle rotors, in: G.D. Birnie and S.M. Fox (Eds.), Subcellular Components: Preparation and Fractionation, Butterworths, London, pp. 126-154.
21. C.W. Greider, Telomeres, telomerase and senescence, Bioessays 12 (1990) 363-369.
22. Coolidge, B.J. and R.M. Howard (1979) Animal Histology Procedures, U.S. Dept. of Health, Education and Welfare, Bethesda, MD.
23. M.C. Dalakas, M.E. Leon-Monzon, I. Bernardini, W.A. Gahl, C.A. Jay, Zidovudine-induced mitochondrial myopathy is associated with muscle carnitine deficiency and lipid storage, Ann. Neurol. 35 (1994) 482-487.
24. E.L. White, W.B. Parker, L.J. Macy, S.C. Shaddix, G. McCaleb, J.A. Secrist, R. Vince, W.M. Shannon, Comparison of the effect of Carbovir, AZT, and dideoxynucleoside triphosphates on the activity of human immunodeficiency virus reverse transcriptase and selected human polymerases, Biochem. Biophys. Res. Commun. 161 (1989) 393-398.
25. P. Huang, D. Farquhar, W. Plunkett, Selective action of 3′-azido-3′-deoxythymidine 5′-triphosphate on viral reverse transcriptases and human DNA polymerases, J. Biol. Chem. 265 (1990) 11914-11918.
26. W. Nickel, S. Austermann, G. Bialek, F. Grosse, Interactions of azidothymidine triphosphate with the cellular DNA polymerases alpha, delta, and epsilon and with DNA primase, J. Biol. Chem. 267 (1992) 848-854.
27. E.H. Blackburn, Telomeres: structure and synthesis, J. Biol. Chem. 265 (1990) 5919-5921.
28. D. Shippen-Lentz, E.H. Blackburn, Functional evidence for an RNA template in telomerase, Science 247 (1990) 546-552.
29. M.D. Phillips, B. Nascimbeni, R.R. Tice, M.D. Shelby, Induction of micronuclei in mouse bone marrow cells: an evaluation of nucleoside analogues used in the treatment of AIDS, Environ. Mol. Mutagen. 18 (1991) 168-183.
30. M. Gonzalez Cid, I. Larripa, Genotoxic activity of azidothymidine (AZT) in in vitro systems, Mutation Res. 321 (1994) 113-118.
31. G.H. Pezeshkpour, I. Illa, M.C. Dalakas, Ultrastructural characteristics and DNA immunocytochemistry in human immunodeficiency virus and zidovudine-associated myopathies, Hum. Pathol. 22 (1991) 1281-1288.
32. B.S. Peters, J. Winer, D.N. Landon, A. Stotter, A.J. Pinching, Mitochondrial myopathy associated with chronic zidovudine therapy in AIDS, Q. J. Med. 86 (1993) 5-15.
33. M.C. Semino-Mora, M.E. Leon-Monzon, M.C. Dalakas, Effect of L-carnitine on the zidovudine-induced destruction of human myotubes. Part I: L-carnitine prevents the myotoxicity of AZT in vitro, Lab. Invest. 71 (1994) 102-112.
34. M.D. Shelby, The cytogenetic effects of AZT, Environ. Mol. Mutagen. 24 (1994) 148-151.
35. C.H. Chen, Y.C. Cheng, Delayed cytotoxicity and selective loss of mitochondrial DNA in cells treated with the anti-human immunodeficiency virus compound 2′,3′-dideoxycytidine, J. Biol. Chem. 264 (1989) 11934-11937.
36. W.B. Parker, Y.C. Cheng, Mitochondrial toxicity of antiviral nucleoside analogs, J. NIH Res. 6 (1994) 57-61.