Antioxidant activity contributes to flavonol cardioprotection during reperfusion of rat hearts

Free Radical Biology and Medicine

Volumn 51, Issue 7, 2011, Pages 1437-1444

  Qin, Cheng Xue ^a,b   Williams, Spencer J ^b   Woodman, Owen L ^c  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c RMIT UNIVERSITY   (Australia)

Author keywords

Antioxidant; Cardioprotection; Flavonol; Free radicals; Heart; Ischemia reperfusion

Indexed keywords

3',4' DIHYDROXYFLAVONOL; 3',4' DIHYDROXYFLAVONOL 6 SUCIINAMIC ACID; 4' HYDROXY 3' METHOXYFLAVONOL; ENDOTHELIAL NITRIC OXIDE SYNTHASE; FLAVONOL; LACTATE DEHYDROGENASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; DRUG EFFECT; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART PROTECTION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY;

ANIMALS; ANTIOXIDANTS; CALCIUM; CARDIOTONIC AGENTS; FLAVONOLS; INFUSIONS, INTRA-ARTERIAL; MALE; MYOCARDIAL CONTRACTION; MYOCARDIAL ISCHEMIA; MYOCARDIUM; NITRIC OXIDE SYNTHASE TYPE III; ORGAN CULTURE TECHNIQUES; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION; REPERFUSION INJURY; VENTRICULAR FUNCTION, LEFT;

RATTUS;

EID: 80052266047     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2011.07.003     Document Type: Article

References (24)

1. S.R.J. Maxwell, and G.Y.H. Lip Reperfusion injury: a review of the pathophysiology, clinical manifestations and therapeutic options Int. J. Cardiol. 58 1997 95 117 (Pubitemid 27064668)
2. A.L. Moens, M.J. Claeys, J.P. Timmermans, and C.J. Vrints Myocardial ischemia/reperfusion-injury, a clinical view on a complex pathophysiological process Int. J. Cardiol. 100 2005 179 190
3. J.L. Park, and B.R. Lucchesi Mechanisms of myocardial reperfusion injury Ann. Thorac. Surg. 68 1999 1905 1912
4. C. Qin, S. Yap, and O.L. Woodman Antioxidants in the prevention of myocardial ischemia/reperfusion injury Expert Rev. Clin. Pharmacol. 2 2009 673 695
5. D.L. Carden, and D.N. Granger Pathophysiology of ischaemia-reperfusion injury J. Pathol. 190 2000 255 266 (Pubitemid 30141372)
6. S. Verma, P.W.M. Fedak, R.D. Weisel, J. Butany, V. Rao, A. Maitland, R.K. Li, B. Dhillon, and T.M. Yau Fundamentals of reperfusion injury for the clinical cardiologist Circulation 105 2002 2332 2336 (Pubitemid 34556381)
7. S. Wang, G.J. Dusting, C.N. May, and O.L. Woodman 3′,4′- Dihydroxyflavonol reduces infarct size and injury associated with myocardial ischaemia and reperfusion in sheep Br. J. Pharmacol. 142 2004 443 452 (Pubitemid 38869857)
8. S. Wang, G.J. Dusting, O.L. Woodman, and C.N. May Selective vasodilator and chronotropic actions of 3′,4′-dihydroxyflavonol in conscious sheep Eur. J. Pharmacol. 491 2004 43 51 (Pubitemid 38501774)
9. S. Wang, K. Fei, Y. Xu, L. Wang, and Y. Chen Dihydroxyflavonol reduces post-infarction left ventricular remodeling by preventing myocyte apoptosis in the non-infarcted zone in goats Chin. Med. J. 122 2009 61 67
10. S.J. Williams, C.J. Thomas, M. Boujaoude, C.T. Gannon, S.D. Zanatta, B. Jarrott, C.N. May, and O.L. Woodman Water soluble flavonol prodrugs that protect against ischaemia-reperfusion injury in rat hindlimb and sheep heart MedChemComm 2 2011 321 324
11. C.X. Qin, X. Chen, R.A. Hughes, S.J. Williams, and O.L. Woodman Understanding the cardioprotective effects of flavonols: discovery of relaxant flavonols without antioxidant activity J. Med. Chem. 51 2008 1874 1884 (Pubitemid 351438869)
12. S. Yap, K.J. Loft, O.L. Woodman, and S.J. Williams Discovery of water-soluble antioxidant flavonols without vasorelaxant activity ChemMedChem 3 2008 1572 1579
13. S.S. Goh, O.L. Woodman, S. Pepe, A.H. Cao, C. Qin, and R.H. Ritchie The red wine antioxidant resveratrol prevents cardiomyocyte injury following ischemia-reperfusion via multiple sites and mechanisms Antioxid. Redox Signal. 9 2007 101 113 (Pubitemid 44901876)
14. M.O. Jeroudi, C.J. Hartley, and R. Bolli Myocardial reperfusion injury-role of oxygen radicals and potential therapy with antioxidants Am. J. Cardiol. 73 1994 B2 B7 (Pubitemid 124007804)
15. H. Narita, T. Nagao, M. Sato, H. Nakajima, and A. Kiyomoto Ischemia-reperfusion induced elevation of diastolic tension in the isolated guinea pig heart and the effects of calcium antagonists Jpn. Heart J. 24 1983 277 288 (Pubitemid 13133148)
16. R.R. Giraldez, A. Panda, Y. Xia, S.P. Sanders, and J.L. Zweier Decreased nitric-oxide synthase activity causes impaired endothelium-dependent relaxation in the postischemic heart J. Biol. Chem. 272 1997 21420 21426 (Pubitemid 27374012)
17. J.M. McCord Oxygen-derived free radicals in postischemic tissue injury N. Engl. J. Med. 312 1985 159 163 (Pubitemid 15192863)
18. C.G. Sobey, R.A. Dalipram, G.J. Dusting, and O.L. Woodman Impaired endothelium-dependent relaxation of dog coronary arteries after myocardial ischemia and reperfusion-prevention by amlodipine, propranolol and allopurinol Br. J. Pharmacol. 105 1992 557 562
19. H. Lum, D.A. Barr, J.R. Shaffer, R.J. Gordon, A.M. Ezrin, and A.B. Malik Reoxygenation of endothelial cells increases permeability by oxidant-dependent mechanisms Circ. Res. 70 1992 991 998
20. F.M. Sheridan, I.M. Dauber, I.F. McMurtry, E.J. Lesnefsky, and L.D. Horwitz Role of leukocytes in coronary vascular endothelial injury due to ischemia and reperfusion Circ. Res. 69 1991 1566 1574
21. C.M. Arroyo, A.J. Carmichael, B. Bouscarel, J.H. Liang, and W.B. Weglicki Endothelial cells as a source of oxygen-free radicals-an ESR study Free Radic. Res. Commun. 9 1990 287 296 (Pubitemid 20376782)
22. N. Cotelle, J.L. Bernier, J.P. Catteau, J. Pommery, J.C. Wallet, and E.M. Gaydou Antioxidant properties of hydroxy-flavones Free Radic. Biol. Med. 20 1996 35 43 (Pubitemid 26018504)
23. D. Bandyopadhyay, A. Chattopadhyay, G. Ghosh, and A.G. Datta Oxidative stress-induced ischemic heart disease: protection by antioxidants Curr. Med. Chem. 11 2004 369 387 (Pubitemid 38240213)
24. B. Halliwell Mechanisms involved in the generation of free radicals Pathol. Biol. 44 1996 6 13 (Pubitemid 26088472)