Dihydroxyflavonol reduces post-infarction left ventricular remodeling by preventing myocyte apoptosis in the non-infarcted zone in goats

Chinese Medical Journal

Volumn 122, Issue 1, 2009, Pages 61-67

  Wang, Sheng ^a   Fei, Ke ^a   Xu, Ya Wei ^a   Wang, Liang Xu ^a   Chen, Yan Qin ^a  

^a TONGJI UNIVERSITY   (China)

Author keywords

Apoptosis; Flavonoids; Heart failure; Myocardial infarction; Remodeling

Indexed keywords

3',4' DIHYDROXYFLAVONOL; CASPASE 3; CYTOCHROME C; FAS ANTIGEN; FLAVONOID; PROTEIN BAX; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; ECHOCARDIOGRAPHY; FEMALE; GOAT; HEART INFARCTION; HEART INFARCTION SIZE; HEART LEFT VENTRICLE DP-DT; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE ENDDIASTOLIC VOLUME; HEART LEFT VENTRICLE FUNCTION; HEART LEFT VENTRICLE MASS; HEART LEFT VENTRICLE PRESSURE; HEART VENTRICLE REMODELING; MALE; MUSCLE CELL; NICK END LABELING; NONHUMAN; PROTEIN EXPRESSION; REPERFUSION INJURY; RISK REDUCTION;

ANIMALS; ANTIGENS, CD95; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CYTOCHROMES C; ECHOCARDIOGRAPHY; FEMALE; FLAVONOLS; GOATS; IN SITU NICK-END LABELING; MALE; MYOCARDIAL INFARCTION; MYOCYTES, CARDIAC; RANDOM ALLOCATION; VENTRICULAR REMODELING;

EID: 60649101644     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: 10.3760/cma.j.issn.0366-6999.2009.01.012     Document Type: Article

References (23)

1. Mudd JO, Kass DA. Reversing chronic remodeling in heart failure. Expert Rev Cardiovasc Ther 2007; 5: 585-598.
2. Whelan RS, Mani K, Kitsis RN. Nipping at cardiac remodeling. J Clin Invest 2007; 117: 2751-2753.
3. Hilfiker-Kleiner D, Landmesser U, Drexler H. Molecular mechanisms in heart failure focus on cardiac hypertrophy, inflammation, angiogenesis, and apoptosis. J Am Coll Cardiol 2006; 48: A56-A66.
4. Narula J, Haider N, Arbustini E, Chandrashekhar Y. Mechanisms of disease: apoptosis in heart failure-seeing hope in death. Nat Clin Pract Cardiovasc Med 2006; 3: 681-688.
5. Mani K. Programmed cell death in cardiac myocytes: strategies to maximize post-ischemic salvage. Heart Fail Rev 2008; 13: 193-209.
6. Burda S, Oleszek W. Antioxidant and antiradical activities of flavonoids. J Agric Food Chem 2001; 49: 2774-2779.
7. Pietta PG. Flavonoids as antioxidants. J Nat Prod 2000; 63: 1035-1042.
8. Wang S, Dusting GJ, May CN, Woodman OL. 3′,4′-Dihydroxyflavonol reduces infarct size and injury associated with myocardial ischaemia and reperfusion in sheep. Br J Pharmacol 2004; 142: 443-452.
9. Wang S, May CN, Woodman OL, Dusting GJ. 3′, 4′-Dihydroxyflavonol prevents the loss of eNOS expression and attenuates lethal reperfusion injury during experimental myocardial infarction. Eur Heart J 2004; 25 Suppl: P1151.
10. Takimoto E, Kass DA. Role of oxidative stress in cardiac hypertrophy and remodeling. Hypertension 2007; 49: 241-248.
11. Sun Y. Oxidative stress and cardiac repair/remodeling following infarction. Am J Med Sci 2007; 334: 197-205.
12. Maejima Y, Adachi S, Morikawa K, Ito H, Isobe M. Nitric oxide inhibits myocardial apoptosis by preventing caspase-3 activity via S-nitrosylation. J Mol Cell Cardiol 2005; 38: 163-174.
13. Yeh CH, Chen TP, Lee CH, Wu YC, Lin YM, Lin PJ. Cardioplegia-induced cardiac arrest under cardiopulmonary bypass decreased nitric oxide production which induced cardiomyocytic apoptosis via nuclear factor kappa B activation. Shock 2007; 27: 422-428.
14. Cerqueira MD, Weissman NJ, Dilsizian V, Jacobs AK, Kaul S, Laskey WK, et al. Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart: a statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association. Circulation 2002; 105: 539-542.
15. Gottdiener JS, Bednarz J, Devereux R, Gardin J, Klein A, Manning WJ, et al. American Society of Echocardiography recommendations for use of echocardiography in clinical trials. J Am Soc Echocardiogr 2004; 17: 1086-1119.
16. Abbate A, Bussani R, Amin MS, Vetrovec GW, Baldi A. Acute myocardial infarction and heart failure: role of apoptosis. Int J Biochem Cell Biol 2006; 38: 1834-1840.
17. Ling H, Lou Y, Wu H, Lou H. Total flavones from Elsholtzia blanda reduce infarct size and improve heart function during acute myocardial infarction by inhibiting myocardial apoptosis in canines. Acta Cardiol 2005; 60: 295-301.
18. Ji ES, Yue H, Wu YM, He RR. Effects of phytoestrogen genistein on myocardial ischemia/reperfusion injury and apoptosis in rabbits. Acta Pharmacol Sin 2004; 25: 306-312.
19. Takemura G, Fujiwara H. Morphological aspects of apoptosis in heart diseases. J Cell Mol Med 2006; 10: 56-75.
20. Kang PM, Izumo S. Apoptosis in heart: basic mechanisms and implications in cardiovascular diseases. Trends Mol Med 2003; 9: 177-182.
21. Sirker A, Zhang M, Murdoch C, Shah AM. Involvement of NADPH oxidases in cardiac remodeling and heart failure. Am J Nephrol 2007; 27: 649-660.
22. Looi YH, Grieve DJ, Siva A, Walker SJ, Anilkumar N, Cave AC, et al. Involvement of Nox2 NADPH oxidase in adverse cardiac remodeling after myocardial infarction. Hypertension 2008; 51: 319-325.
23. Jiang F, Guo N, Dusting GJ. Modulation of nicotinamide adenine dinucleotide phosphate oxidase expression and function by 3′,4′-dihydroxyflavonol in phagocytic and vascular cells. J Pharmacol Exp Ther 2008; 324: 261-269.