Bisphosphonate prodrugs: Synthesis and biological evaluation in HuH7 hepatocarcinoma cells

European Journal of Medicinal Chemistry

Volumn 77, Issue , 2014, Pages 56-64

  Monteil, Maelle ^a   Migianu Griffoni, Evelyne ^a   Sainte Catherine, Odile ^a   Di Benedetto, Mélanie ^a   Lecouvey, Marc ^a  

^a UNIVERSITÉ PARIS 13   (France)

Author keywords

Bisphosphonates; Hepatocarcinoma; Phosphodiesterase inhibitor (IBMX); Prodrugs

Indexed keywords

BISPHOSPHONIC ACID DERIVATIVE; ISOBUTYLMETHYLXANTHINE; PHOSPHODIESTERASE; PHOSPHODIESTERASE INHIBITOR; PRODRUG; ZOLEDRONIC ACID; ANTINEOPLASTIC AGENT;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; BIOLOGICAL ACTIVITY; CELL DEATH; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CELL VIABILITY; COMPARATIVE STUDY; DRUG SCREENING; DRUG SYNTHESIS; HUH7 HEPATOCARCINOMA CELL; HUMAN; HUMAN CELL; HYDROLYSIS; IC 50; ISOMERIZATION; LIVER CELL CARCINOMA; ONE POT SYNTHESIS; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; TUMOR CELL LINE; CELL MOTION; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CELL SURVIVAL; DIPHOSPHONATES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MOLECULAR STRUCTURE; PRODRUGS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84895788424     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.02.054     Document Type: Article

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