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Volumn 42, Issue 3, 2000, Pages 175-195

Administration routes and delivery systems of bisphosphonates for the treatment of bone resorption

Author keywords

Administration routes; Bisphosphonates; Bone resorption; Delivery systems

Indexed keywords

BONE; CALCIFICATION (BIOCHEMISTRY); DRUG PRODUCTS;

EID: 0034739243     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-409X(00)00061-2     Document Type: Article
Times cited : (219)

References (119)
  • 1
    • 0031036965 scopus 로고    scopus 로고
    • Bisphosphonates: Preclinical aspects and use in osteoporosis
    • Fleisch H. Bisphosphonates: preclinical aspects and use in osteoporosis. Ann. Med. 29:1997;55-62.
    • (1997) Ann. Med. , vol.29 , pp. 55-62
    • Fleisch, H.1
  • 3
    • 0030483389 scopus 로고    scopus 로고
    • Bisphosphonate therapy in metastatic breast cancer
    • Blomqvist C., Elomaa I. Bisphosphonate therapy in metastatic breast cancer. Acta Oncol. 35:(Suppl. 5):1996;81-83.
    • (1996) Acta Oncol. , vol.35 , pp. 81-83
    • Blomqvist, C.1    Elomaa, I.2
  • 5
    • 0031059787 scopus 로고    scopus 로고
    • The management of Paget′s disease of bone
    • Delmas P.D., Meunier P.J. The management of Paget′s disease of bone. N. Engl. J. Med. 336:1997;558-566.
    • (1997) N. Engl. J. Med. , vol.336 , pp. 558-566
    • Delmas, P.D.1    Meunier, P.J.2
  • 6
    • 0030512278 scopus 로고    scopus 로고
    • Rationale for the use of bisphosphonates in breast cancer
    • Kanis J.A. Rationale for the use of bisphosphonates in breast cancer. Acta Oncol. 35:(Suppl. 5):1996;61-67.
    • (1996) Acta Oncol. , vol.35 , pp. 61-67
    • Kanis, J.A.1
  • 7
    • 0030497544 scopus 로고    scopus 로고
    • Bisphosphonate therapy in multiple myeloma
    • Laakso M., Jantunen E. Bisphosphonate therapy in multiple myeloma. Acta Oncol. 35:(Suppl. 5):1996;55-56.
    • (1996) Acta Oncol. , vol.35 , pp. 55-56
    • Laakso, M.1    Jantunen, E.2
  • 8
    • 0031034009 scopus 로고    scopus 로고
    • Bisphosphonate therapy
    • Licata A.A. Bisphosphonate therapy. Am. J. Med. Sci. 313:1997;17-22.
    • (1997) Am. J. Med. Sci. , vol.313 , pp. 17-22
    • Licata, A.A.1
  • 9
    • 0030457851 scopus 로고    scopus 로고
    • Alendronate treatment for osteoporosis: A review of the clinical evidence
    • Selby P. Alendronate treatment for osteoporosis: a review of the clinical evidence. Osteoporos. Int. 6:1996;419-426.
    • (1996) Osteoporos. Int. , vol.6 , pp. 419-426
    • Selby, P.1
  • 11
    • 0029961805 scopus 로고    scopus 로고
    • Current and future nonhormonal approaches to the treatment of osteoporosis
    • Bilezikian J.P. Current and future nonhormonal approaches to the treatment of osteoporosis. Int. J. Fertil. 41:1996;148-155.
    • (1996) Int. J. Fertil. , vol.41 , pp. 148-155
    • Bilezikian, J.P.1
  • 12
    • 0030023323 scopus 로고    scopus 로고
    • Bisphosphonates and the treatment of bone disease in the elderly
    • Johansen A., Stone M., Rawlinson F. Bisphosphonates and the treatment of bone disease in the elderly. Drugs Aging. 8:1996;113-126.
    • (1996) Drugs Aging , vol.8 , pp. 113-126
    • Johansen, A.1    Stone, M.2    Rawlinson, F.3
  • 13
    • 0029872576 scopus 로고    scopus 로고
    • Comparative clinical pharmacology and therapeutic use of bisphosphonates in metabolic bone diseases
    • Rosen C.J., Kessenich C.R. Comparative clinical pharmacology and therapeutic use of bisphosphonates in metabolic bone diseases. Drugs. 51:1996;537-551.
    • (1996) Drugs , vol.51 , pp. 537-551
    • Rosen, C.J.1    Kessenich, C.R.2
  • 14
    • 0014759515 scopus 로고
    • The inhibitory effect of phosphonates on the formation of calcium phosphate crystals in vitro and on aortic and kidney calcification in vivo
    • Fleisch H.A., Russell R.G.G., Bisaz S., Muhlbauer R.C., Williams D.A. The inhibitory effect of phosphonates on the formation of calcium phosphate crystals in vitro and on aortic and kidney calcification in vivo. Eur. J. Clin. Invest. 1:1970;12-18.
    • (1970) Eur. J. Clin. Invest. , vol.1 , pp. 12-18
    • Fleisch, H.A.1    Russell, R.G.G.2    Bisaz, S.3    Muhlbauer, R.C.4    Williams, D.A.5
  • 15
    • 0014684364 scopus 로고
    • Diphosphonates inhibit formation of calcium phosphate crystals in vitro and pathological calcification in vivo
    • Francis M.D., Russell R.G., Fleisch H. Diphosphonates inhibit formation of calcium phosphate crystals in vitro and pathological calcification in vivo. Science. 165:1969;1264-1266.
    • (1969) Science , vol.165 , pp. 1264-1266
    • Francis, M.D.1    Russell, R.G.2    Fleisch, H.3
  • 16
    • 0014463723 scopus 로고
    • The inhibition of calcium hydroxypatite crystal growth by polyphosphonates and polyphosphates
    • Francis M.D. The inhibition of calcium hydroxypatite crystal growth by polyphosphonates and polyphosphates. Calcif. Tissue Res. 3:1969;151-162.
    • (1969) Calcif. Tissue Res. , vol.3 , pp. 151-162
    • Francis, M.D.1
  • 17
    • 0015759128 scopus 로고
    • The influence of multidentate organic phosphonates on the crystal growth of hydroxyapatite
    • Meyer J.L., Nancollas G.H. The influence of multidentate organic phosphonates on the crystal growth of hydroxyapatite. Calcif. Tissue Res. 13:1973;295-303.
    • (1973) Calcif. Tissue Res. , vol.13 , pp. 295-303
    • Meyer, J.L.1    Nancollas, G.H.2
  • 19
    • 0014684354 scopus 로고
    • Diphosphonates inhibit hydroxyapatite dissolution in vitro and bone resorption in tissue culture and in vivo
    • Fleisch H., Russell R.G.G., Francis M.D. Diphosphonates inhibit hydroxyapatite dissolution in vitro and bone resorption in tissue culture and in vivo. Science. 165:1969;1262-1264.
    • (1969) Science , vol.165 , pp. 1262-1264
    • Fleisch, H.1    Russell, R.G.G.2    Francis, M.D.3
  • 21
    • 0027193759 scopus 로고
    • Bisphosphonates act on rat resorption through the mediation of osteoblasts
    • Sahni M., Guenther H.L., Fleisch H., Collin P., Martin T.J. Bisphosphonates act on rat resorption through the mediation of osteoblasts. J. Clin. Invest. 91:1993;2004-2011.
    • (1993) J. Clin. Invest. , vol.91 , pp. 2004-2011
    • Sahni, M.1    Guenther, H.L.2    Fleisch, H.3    Collin, P.4    Martin, T.J.5
  • 23
    • 0026318521 scopus 로고
    • Bisphosphonates. Pharmacology and use in the treatment of tumour-induced hypercalcaemic and metastatic bone disease
    • Fleisch H. Bisphosphonates. Pharmacology and use in the treatment of tumour-induced hypercalcaemic and metastatic bone disease. Drugs. 42:1991;919-944.
    • (1991) Drugs , vol.42 , pp. 919-944
    • Fleisch, H.1
  • 24
    • 0029886359 scopus 로고    scopus 로고
    • Bisphosphonates: A review of their pharmacokinetic properties
    • Lin J.H. Bisphosphonates: A review of their pharmacokinetic properties. Bone. 18:1996;75-85.
    • (1996) Bone , vol.18 , pp. 75-85
    • Lin, J.H.1
  • 25
    • 0026690327 scopus 로고
    • Effects of dose, sex, and age on the disposition of alendronate, a potent antiosteolytic bisphosphonate, in rats
    • Lin J.H., Chen I., Duggan D.E. Effects of dose, sex, and age on the disposition of alendronate, a potent antiosteolytic bisphosphonate, in rats. Drug Metab. Dispos. 20:(4):1992;473-478.
    • (1992) Drug Metab. Dispos. , vol.20 , Issue.4 , pp. 473-478
    • Lin, J.H.1    Chen, I.2    Duggan, D.E.3
  • 26
    • 0026077161 scopus 로고
    • Physiological disposition of alendronate, a potent anti-osteolytic biphosphonate, in laboratory animals
    • Lin J.H., Duggan D.E., Chen I.W., Ellsworth R.L. Physiological disposition of alendronate, a potent anti-osteolytic biphosphonate, in laboratory animals. Drug Metab. Dispos. 19:1991;926-932.
    • (1991) Drug Metab. Dispos. , vol.19 , pp. 926-932
    • Lin, J.H.1    Duggan, D.E.2    Chen, I.W.3    Ellsworth, R.L.4
  • 27
    • 0026694920 scopus 로고
    • Retention of etidronate in human, dog and rat
    • Kasting G.B., Francis M.D. Retention of etidronate in human, dog and rat. J. Bone Miner. Res. 7:1992;513-522.
    • (1992) J. Bone Miner. Res. , vol.7 , pp. 513-522
    • Kasting, G.B.1    Francis, M.D.2
  • 29
    • 0025144285 scopus 로고
    • The tissue distribution of clodronate (dichloromethylene bisphosphonate) in mice. The effects of vehicle and the route of administration
    • Monkkonen J., Ylitalo P. The tissue distribution of clodronate (dichloromethylene bisphosphonate) in mice. The effects of vehicle and the route of administration. Eur. J. Drug. Metab. Pharmacokinet. 15:1990;239-243.
    • (1990) Eur. J. Drug. Metab. Pharmacokinet. , vol.15 , pp. 239-243
    • Monkkonen, J.1    Ylitalo, P.2
  • 30
    • 0023176427 scopus 로고
    • Pharmacokinetics of the osteotropic diphosphonate 3-amino-1-hydroxypropane-1,1-diphosphonic acid in mammals
    • Wingen F., Schmahl D. Pharmacokinetics of the osteotropic diphosphonate 3-amino-1-hydroxypropane-1,1-diphosphonic acid in mammals. Arzneim.-Forsch. 37:1987;1037-1042.
    • (1987) Arzneim.-Forsch. , vol.37 , pp. 1037-1042
    • Wingen, F.1    Schmahl, D.2
  • 31
    • 0025164063 scopus 로고
    • Comparison of the distribution of three bisphosphonates in mice
    • Monkkonen J., Koponen H.M., Ylitalo P. Comparison of the distribution of three bisphosphonates in mice. Pharmacol. Toxicol. 66:1990;294-298.
    • (1990) Pharmacol. Toxicol. , vol.66 , pp. 294-298
    • Monkkonen, J.1    Koponen, H.M.2    Ylitalo, P.3
  • 32
    • 0026064309 scopus 로고
    • Pamidronate. A review of its pharmacological properties and therapeutic efficacy in resortive bone disease
    • Fitton A., McTavish D. Pamidronate. A review of its pharmacological properties and therapeutic efficacy in resortive bone disease. Drugs. 41:1991;289-318.
    • (1991) Drugs , vol.41 , pp. 289-318
    • Fitton, A.1    McTavish, D.2
  • 33
    • 0015325498 scopus 로고
    • Metabolism of disodium ethane-1-hydroxy-1,1-diphosphonate (disodium etidronate) in the rat, rabbit, dog and monkey
    • Michael W.R., King W.R., Wakim J.M. Metabolism of disodium ethane-1-hydroxy-1,1-diphosphonate (disodium etidronate) in the rat, rabbit, dog and monkey. Toxicol. Appl. Pharmacol. 21:1972;503-515.
    • (1972) Toxicol. Appl. Pharmacol. , vol.21 , pp. 503-515
    • Michael, W.R.1    King, W.R.2    Wakim, J.M.3
  • 35
  • 36
    • 0028285203 scopus 로고
    • Clodronate. A review of its pharmacological properties and therapeutic efficacy in resorptive bone disease
    • Plosker G.L., Goa K.L. Clodronate. A review of its pharmacological properties and therapeutic efficacy in resorptive bone disease. Drugs. 47:1994;945-982.
    • (1994) Drugs , vol.47 , pp. 945-982
    • Plosker, G.L.1    Goa, K.L.2
  • 37
    • 0015612725 scopus 로고
    • Intestinal absorption of disodium ethane-1-hydroxy-1,1-diphosphonate (disodium etidronate) using a deconvolution technique
    • Recker R.R., Saville P.D. Intestinal absorption of disodium ethane-1-hydroxy-1,1-diphosphonate (disodium etidronate) using a deconvolution techniQC Toxicol. Appl. Pharmacol. 24:1973;580-589.
    • (1973) Toxicol. Appl. Pharmacol. , vol.24 , pp. 580-589
    • Recker, R.R.1    Saville, P.D.2
  • 38
    • 0027377181 scopus 로고
    • Pharmacokinetic evaluation of pamidronate after oral administration: A study on dose proportionality, absolute bioavailability, and effect of repeated administration
    • Hyldstrup L., Flesch G., Hauffe S.A. Pharmacokinetic evaluation of pamidronate after oral administration: A study on dose proportionality, absolute bioavailability, and effect of repeated administration. Calcif. Tissue int. 53:1993;297-300.
    • (1993) Calcif. Tissue Int. , vol.53 , pp. 297-300
    • Hyldstrup, L.1    Flesch, G.2    Hauffe, S.A.3
  • 40
    • 0028580533 scopus 로고
    • On the absorption of alendronate in rats
    • Lin J.H., Chen I.-W., Deluna F.A. On the absorption of alendronate in rats. J. Pharm. Sci. 83:1994;1741-1746.
    • (1994) J. Pharm. Sci. , vol.83 , pp. 1741-1746
    • Lin, J.H.1    Chen, I.-W.2    Deluna, F.A.3
  • 46
    • 0027364293 scopus 로고
    • Importance of the paracellullar pathway for the transport of a new bisphosphonate using the human caco-2 monolayers model
    • Boulenc X., Marti E., Joyeux H., Roques C., Berger Y., Fabre G. Importance of the paracellullar pathway for the transport of a new bisphosphonate using the human caco-2 monolayers model. Biochem. Pharmacol. 46:1993;1591-1600.
    • (1993) Biochem. Pharmacol. , vol.46 , pp. 1591-1600
    • Boulenc, X.1    Marti, E.2    Joyeux, H.3    Roques, C.4    Berger, Y.5    Fabre, G.6
  • 47
    • 0022410089 scopus 로고
    • The gastrointestinal absorption of drugs in man: A review of current concepts and methods of investigation
    • Hirtz J. The gastrointestinal absorption of drugs in man: a review of current concepts and methods of investigation. Br. J. Clin. Pharmacol. 19:(Suppl. 2):1985;77s-83s.
    • (1985) Br. J. Clin. Pharmacol. , vol.19 , pp. 77s-83s
    • Hirtz, J.1
  • 49
    • 0026345116 scopus 로고
    • Sodium EDTA enhances intestinal absorption of two bisphosphonates
    • Janner M., Muhlbauer R.C., Fleisch H. Sodium EDTA enhances intestinal absorption of two bisphosphonates. Calcif. Tissue Int. 49:1991;280-283.
    • (1991) Calcif. Tissue Int. , vol.49 , pp. 280-283
    • Janner, M.1    Muhlbauer, R.C.2    Fleisch, H.3
  • 50
    • 33947293707 scopus 로고
    • Polynuclear complex formation in solutions of calcium ion and ethane-1-hydroxy-1,1-diphosphonic acid. I. Complexometric and pH titrations
    • Grabenstetter R.J., Cilley W.A. Polynuclear complex formation in solutions of calcium ion and ethane-1-hydroxy-1,1-diphosphonic acid. I. Complexometric and pH titrations. J. Phys. Chem. 75:1971;676-683.
    • (1971) J. Phys. Chem. , vol.75 , pp. 676-683
    • Grabenstetter, R.J.1    Cilley, W.A.2
  • 51
    • 0021129391 scopus 로고
    • Calcium and 1-hydroxyethylidene-1,1-bisphosphonic acid: Polynuclear complex formation in the physiological range of pH
    • Lamson M.L., Fox J.M., Higuchi W.I. Calcium and 1-hydroxyethylidene-1,1-bisphosphonic acid: Polynuclear complex formation in the physiological range of pH. Int. J. Pharm. 21:1984;143-154.
    • (1984) Int. J. Pharm. , vol.21 , pp. 143-154
    • Lamson, M.L.1    Fox, J.M.2    Higuchi, W.I.3
  • 52
    • 85054199355 scopus 로고
    • Chemical, biochemical, and medicinal properties of the diphosphonates
    • R.L. Hildebrand. Boca Raton: CRC Press
    • Francis M.D., Martodam R.R. Chemical, biochemical, and medicinal properties of the diphosphonates. Hildebrand R.L. The Role of Phosphonates in Living Systems. 1983;55-96 CRC Press, Boca Raton.
    • (1983) The Role of Phosphonates in Living Systems , pp. 55-96
    • Francis, M.D.1    Martodam, R.R.2
  • 53
    • 0026644809 scopus 로고
    • Oral tiludronate: Pharmacological properties and potential usefulness in Paget′s disease of bone and osteoporosis
    • Reginster J.Y.L. Oral tiludronate: pharmacological properties and potential usefulness in Paget′s disease of bone and osteoporosis. Bone. 13:1992;351-354.
    • (1992) Bone , vol.13 , pp. 351-354
    • Reginster, J.Y.L.1
  • 54
    • 0028106491 scopus 로고
    • The therapeutic use of bisphosphonates
    • Compston J.E. The therapeutic use of bisphosphonates. Br. Med. J. 309:1994;711-715.
    • (1994) Br. Med. J. , vol.309 , pp. 711-715
    • Compston, J.E.1
  • 55
    • 0002774122 scopus 로고    scopus 로고
    • Bisphosphonates pharmacology and use in the treatment of osteoporosis
    • New York: Academic Press
    • Papapoulos S.E. Bisphosphonates pharmacology and use in the treatment of osteoporosis. Osteoporosis. 1996;1209-1234 Academic Press, New York.
    • (1996) Osteoporosis , pp. 1209-1234
    • Papapoulos, S.E.1
  • 57
    • 0024341006 scopus 로고
    • 3-Amino-1-hydroxypropylidene-1,1-diphosphonate (APD): A novel enhancer of rectal cefoxitin absorption in rats
    • van Hoogdalem E.J., Wackwitz A.T., de Boer A.G., Breimer D.D. 3-Amino-1-hydroxypropylidene-1,1-diphosphonate (APD): a novel enhancer of rectal cefoxitin absorption in rats. J. Pharm. Pharmacol. 41:1989;339-341.
    • (1989) J. Pharm. Pharmacol. , vol.41 , pp. 339-341
    • Van Hoogdalem, E.J.1    Wackwitz, A.T.2    De Boer, A.G.3    Breimer, D.D.4
  • 58
    • 0342358176 scopus 로고    scopus 로고
    • Mode of administration - dependent pharmacokinetics of bisphosphonates and bioavailability determination
    • Hoffman A., Stepensky D., Ezra A., Breuer E., Golomb G. Mode of administration - dependent pharmacokinetics of bisphosphonates and bioavailability determination. Eur. J. Pharm. Sci. 8:1999;24.
    • (1999) Eur. J. Pharm. Sci. , vol.8 , pp. 24
    • Hoffman, A.1    Stepensky, D.2    Ezra, A.3    Breuer, E.4    Golomb, G.5
  • 59
    • 0017716715 scopus 로고
    • Appearance of a gastric ulcer during diphosphonate therapy in a woman with CRST syndrome
    • Saunders R.L. Jr. Appearance of a gastric ulcer during diphosphonate therapy in a woman with CRST syndrome. South. Med. J. 70:1977;1327-1329.
    • (1977) South. Med. J. , vol.70 , pp. 1327-1329
    • Saunders, R.L.1
  • 60
    • 0025103376 scopus 로고
    • Reduction in calcium excretion in women with breast cancer and bone metastases using the oral bisphosphonate pamidronate
    • Dodwell D.J., Howell A., Ford J. Reduction in calcium excretion in women with breast cancer and bone metastases using the oral bisphosphonate pamidronate. Br. J. Cancer. 61:1990;123-125.
    • (1990) Br. J. Cancer , vol.61 , pp. 123-125
    • Dodwell, D.J.1    Howell, A.2    Ford, J.3
  • 61
    • 0023520871 scopus 로고
    • Paget′s disease of bone: Early and late responses to three different modes of treatment with aminohydroxypropylidene bisphosphonate (APD)
    • Harinck H.I., Papapoulos S.E., Blanksma H.J., Moolenaar A.J., Vermeij P., Bijvoet O.L. Paget′s disease of bone: early and late responses to three different modes of treatment with aminohydroxypropylidene bisphosphonate (APD). Br. Med. J. Clin. Res. Ed. 295:1987;1301-1305.
    • (1987) Br. Med. J. Clin. Res. Ed. , vol.295 , pp. 1301-1305
    • Harinck, H.I.1    Papapoulos, S.E.2    Blanksma, H.J.3    Moolenaar, A.J.4    Vermeij, P.5    Bijvoet, O.L.6
  • 63
    • 0020503148 scopus 로고
    • Effect of dosage form and formulation factors on the adherence of drugs to the esophagus
    • Marvola M., Rajaniemi M., Marttila E., Vahervuo K., Sothmann A. Effect of dosage form and formulation factors on the adherence of drugs to the esophagus. J. Pharm. Sci. 72:1983;1034-1036.
    • (1983) J. Pharm. Sci. , vol.72 , pp. 1034-1036
    • Marvola, M.1    Rajaniemi, M.2    Marttila, E.3    Vahervuo, K.4    Sothmann, A.5
  • 64
    • 0031671019 scopus 로고    scopus 로고
    • Esophageal irritation due to alendronate sodium tablets
    • Peter C.P., Handt L.K., Smith S.M. Esophageal irritation due to alendronate sodium tablets. Dig. Dis. Sci. 43:1998;1998-2002.
    • (1998) Dig. Dis. Sci. , vol.43 , pp. 1998-2002
    • Peter, C.P.1    Handt, L.K.2    Smith, S.M.3
  • 65
    • 0029926353 scopus 로고    scopus 로고
    • Adverse Effects of bisphosphonates
    • Adami S., Zamberlan N. Adverse Effects of bisphosphonates. Drug Safety. 14:1996;159-170.
    • (1996) Drug Safety , vol.14 , pp. 159-170
    • Adami, S.1    Zamberlan, N.2
  • 67
    • 0007715313 scopus 로고    scopus 로고
    • Gastric damage with nitrogen-containing bisphosphonates (N-BPs) does not correlate with antiresorptive potency
    • Blank M., Gibson G., Dierckman T., Myers W., Phipps R., Smith P. Gastric damage with nitrogen-containing bisphosphonates (N-BPs) does not correlate with antiresorptive potency. Bone. 22:1998;46S.
    • (1998) Bone , vol.22 , pp. 46S
    • Blank, M.1    Gibson, G.2    Dierckman, T.3    Myers, W.4    Phipps, R.5    Smith, P.6
  • 68
    • 0032946138 scopus 로고    scopus 로고
    • The effects of nitrogen-containing bisphosphonates on human epithelial(Caco-2) cells, an in vitro model for intestinal epithelium
    • Twiss I.M., den Hartigh J., Ramp-Koopmanschap W., Vermeij P. The effects of nitrogen-containing bisphosphonates on human epithelial(Caco-2) cells, an in vitro model for intestinal epithelium. J. Bone Miner. Res. 14:1999;784-791.
    • (1999) J. Bone Miner. Res. , vol.14 , pp. 784-791
    • Twiss, I.M.1    Den Hartigh, J.2    Ramp-Koopmanschap, W.3    Vermeij, P.4
  • 70
    • 0026542421 scopus 로고
    • Bisacylphosphonates inhibit hydroxyapatite formation and dissolution in vitro and dystrophic calcification in vivo
    • Golomb G., Schlossman A., Saadeh H., Levi M., Van Gelder J.M., Breuer E. Bisacylphosphonates inhibit hydroxyapatite formation and dissolution in vitro and dystrophic calcification in vivo. Pharm. Res. 9:1992;143-148.
    • (1992) Pharm. Res. , vol.9 , pp. 143-148
    • Golomb, G.1    Schlossman, A.2    Saadeh, H.3    Levi, M.4    Van Gelder, J.M.5    Breuer, E.6
  • 71
    • 0024213835 scopus 로고
    • Biological and clinical assessment of a new bisphosphonate, (chloro-4 phenyl) thiomethylene bisphosphonate, in the treatment of Paget′s disease of bone
    • Reginster J.Y., Jeugmans-Huynen A.M., Albert A., Denis D., Deroisy R., Lecart M.P., Fontaine M.A., Collette J., Franchimont P. Biological and clinical assessment of a new bisphosphonate, (chloro-4 phenyl) thiomethylene bisphosphonate, in the treatment of Paget′s disease of bone. Bone. 9:1988;349-354.
    • (1988) Bone , vol.9 , pp. 349-354
    • Reginster, J.Y.1    Jeugmans-Huynen, A.M.2    Albert, A.3    Denis, D.4    Deroisy, R.5    Lecart, M.P.6    Fontaine, M.A.7    Collette, J.8    Franchimont, P.9
  • 72
    • 84908811305 scopus 로고
    • Short-term therapy of Paget′s disease of bone by increasing doses of a new bisphosphonate:4-chloro thiomethylene bisphosphonate
    • Lecart M.P., Reginster J.Y., Deroisy R., Denis D., Sarlet N., Franchimont P. Short-term therapy of Paget′s disease of bone by increasing doses of a new bisphosphonate:4-chloro thiomethylene bisphosphonate. Calcif. Tissue Int. 44:(Suppl. 1):1989;N29.
    • (1989) Calcif. Tissue Int. , vol.44 , pp. 29
    • Lecart, M.P.1    Reginster, J.Y.2    Deroisy, R.3    Denis, D.4    Sarlet, N.5    Franchimont, P.6
  • 73
  • 74
  • 76
    • 0028119643 scopus 로고
    • Long-term effects of a treatment course with oral alendronate of postmenopausal osteoporosis
    • Rossini M., Gatti D., Zamberlan N., Braga V., Dorizzi R., Adami S. Long-term effects of a treatment course with oral alendronate of postmenopausal osteoporosis. J. Bone Miner. Res. 9:1994;1833-1837.
    • (1994) J. Bone Miner. Res. , vol.9 , pp. 1833-1837
    • Rossini, M.1    Gatti, D.2    Zamberlan, N.3    Braga, V.4    Dorizzi, R.5    Adami, S.6
  • 80
    • 0342358164 scopus 로고
    • Alendronate prevents or reverses bone loss at the spine and hip in recently menopausal women
    • McClung M.R., Yates A.G. Alendronate prevents or reverses bone loss at the spine and hip in recently menopausal women. J. Bone Miner. Res. 8:1993;S141.
    • (1993) J. Bone Miner. Res. , vol.8 , pp. 141
    • McClung, M.R.1    Yates, A.G.2
  • 82
    • 0028200995 scopus 로고
    • Effects of two oral doses of alendronate in the treatment of Paget′s disease of bone
    • Adami S., Mian M., Gatti P., Rossini M., Zamberlan N., Bertoldo F., Cascio V.L. Effects of two oral doses of alendronate in the treatment of Paget′s disease of bone. Bone. 15:1994;415-417.
    • (1994) Bone , vol.15 , pp. 415-417
    • Adami, S.1    Mian, M.2    Gatti, P.3    Rossini, M.4    Zamberlan, N.5    Bertoldo, F.6    Cascio, V.L.7
  • 83
    • 0021868671 scopus 로고
    • Dose-dependent effect of calcium and magnesium etidronate on salicylic acid absorption in the rat
    • Shrewsbury R.P., Wurster D.E., Dittert L.W. Dose-dependent effect of calcium and magnesium etidronate on salicylic acid absorption in the rat. J. Pharm. Pharmacol. 37:1985;440-442.
    • (1985) J. Pharm. Pharmacol. , vol.37 , pp. 440-442
    • Shrewsbury, R.P.1    Wurster, D.E.2    Dittert, L.W.3
  • 84
    • 3242835402 scopus 로고    scopus 로고
    • Preparation and identification of tetraamide esters of methylene and (dichloromethylene)bisphosphonates
    • Vepsalainen J., Vainiotalo P., Nupponen H., Pohjala E. Preparation and identification of tetraamide esters of methylene and (dichloromethylene)bisphosphonates. Acta Chem. Scand. 51:1997;932-937.
    • (1997) Acta Chem. Scand. , vol.51 , pp. 932-937
    • Vepsalainen, J.1    Vainiotalo, P.2    Nupponen, H.3    Pohjala, E.4
  • 86
    • 0342547008 scopus 로고    scopus 로고
    • Strategies for the selective synthesis of monosubstituted (dicloromethylene)bisphosphonte esters
    • Ahlmark M.J., Vepsalainen J. Strategies for the selective synthesis of monosubstituted (dicloromethylene)bisphosphonte esters. Tetrahedron. 53:1997;16153-16160.
    • (1997) Tetrahedron , vol.53 , pp. 16153-16160
    • Ahlmark, M.J.1    Vepsalainen, J.2
  • 87
    • 0344731435 scopus 로고    scopus 로고
    • Bisphosphonate prodrugs: Synthesis and in vitro evaluation of novel clodronic acid dianhydrides as bioreversible prodrugs of clodronate
    • Ahlmark M., Vepsalainen J., Taipale H., Niemi R., Jarvinen T. Bisphosphonate prodrugs: synthesis and in vitro evaluation of novel clodronic acid dianhydrides as bioreversible prodrugs of clodronate. J. Med. Chem. 42:1999;1473-1476.
    • (1999) J. Med. Chem. , vol.42 , pp. 1473-1476
    • Ahlmark, M.1    Vepsalainen, J.2    Taipale, H.3    Niemi, R.4    Jarvinen, T.5
  • 88
    • 0022578756 scopus 로고
    • Concentration and pH dependency of alpha-methyldopa absorption in rat intestine
    • Amidon G.L., Merfeld A.E., Dressman J.B. Concentration and pH dependency of alpha-methyldopa absorption in rat intestine. J. Pharm. Pharmacol. 38:1986;363-368.
    • (1986) J. Pharm. Pharmacol. , vol.38 , pp. 363-368
    • Amidon, G.L.1    Merfeld, A.E.2    Dressman, J.B.3
  • 89
    • 0022654329 scopus 로고
    • The effect of size and shape of tablets on their esophageal transit
    • Channer K.S., Virjee J.P. The effect of size and shape of tablets on their esophageal transit. J. Clin. Pharmacol. 26:1986;141-146.
    • (1986) J. Clin. Pharmacol. , vol.26 , pp. 141-146
    • Channer, K.S.1    Virjee, J.P.2
  • 90
    • 0025668535 scopus 로고
    • Mechanism of L-alpha-methyldopa transport through a monolayer of polarized human intestinal epithelial cells (Caco-2)
    • Hu M., Borchardt R.T. Mechanism of L-alpha-methyldopa transport through a monolayer of polarized human intestinal epithelial cells (Caco-2). Pharm. Res. 7:1990;1313-1319.
    • (1990) Pharm. Res. , vol.7 , pp. 1313-1319
    • Hu, M.1    Borchardt, R.T.2
  • 92
    • 0024987425 scopus 로고
    • Sodium and pH dependent carrier-mediated transport of antibiotic, fosfomycin, in the rat intestinal brush-border membrane
    • Ishizawa T., Tsuji A., Tamai I., Terasaki T., Hosoi K., Fukatsu S. Sodium and pH dependent carrier-mediated transport of antibiotic, fosfomycin, in the rat intestinal brush-border membrane. J. Pharmacobiol. Dyn. 13:1990;292-300.
    • (1990) J. Pharmacobiol. Dyn. , vol.13 , pp. 292-300
    • Ishizawa, T.1    Tsuji, A.2    Tamai, I.3    Terasaki, T.4    Hosoi, K.5    Fukatsu, S.6
  • 93
    • 0024499995 scopus 로고
    • + and pH dependent transport of foscarnet via the phosphate carrier system across intestinal brush-border membrane
    • + and pH dependent transport of foscarnet via the phosphate carrier system across intestinal brush-border membrane. Biochem. Pharmacol. 38:1989;1019-1022.
    • (1989) Biochem. Pharmacol. , vol.38 , pp. 1019-1022
    • Tsuji, A.1    Tamai, I.2
  • 94
    • 0019793945 scopus 로고
    • Intestinal absorption mechanism of amphoteric β-lactam antibiotics II: Michaelis-Menten kinetics of cyclacillin absorption and its pharmacokinetic analysis in rats
    • Tsuji A., Nakashima E., Kagami I., Yamana T. Intestinal absorption mechanism of amphoteric β-lactam antibiotics II: Michaelis-Menten kinetics of cyclacillin absorption and its pharmacokinetic analysis in rats. J. Pharm. Sci. 70:1981;772-777.
    • (1981) J. Pharm. Sci. , vol.70 , pp. 772-777
    • Tsuji, A.1    Nakashima, E.2    Kagami, I.3    Yamana, T.4
  • 95
    • 0025106137 scopus 로고
    • Interaction of renin inhibitors with the intestinal uptake system for oligopeptides and β-lactam antibiotics
    • Kramer W., Girbig F., Gutjahr U., Kleemann H.W., Leipe I., Urbach H., Wagner A. Interaction of renin inhibitors with the intestinal uptake system for oligopeptides and β-lactam antibiotics. Biochim. Biophys. Acta. 1027:1990;25-30.
    • (1990) Biochim. Biophys. Acta , vol.1027 , pp. 25-30
    • Kramer, W.1    Girbig, F.2    Gutjahr, U.3    Kleemann, H.W.4    Leipe, I.5    Urbach, H.6    Wagner, A.7
  • 96
    • 0029013867 scopus 로고
    • Molecular mechanisms for the relative binding affinity to the intestinal peptide carrier. Comparison of three ACE inhibitors: Enalapril, enalaprilat, and lisinopril
    • Swaan P.W., Stehouwer M.F.C., Tukker J.J. Molecular mechanisms for the relative binding affinity to the intestinal peptide carrier. Comparison of three ACE inhibitors: enalapril, enalaprilat, and lisinopril. Biochim. Biophys. Acta. 1236:1995;31-38.
    • (1995) Biochim. Biophys. Acta , vol.1236 , pp. 31-38
    • Swaan, P.W.1    Stehouwer, M.F.C.2    Tukker, J.J.3
  • 97
    • 0024891564 scopus 로고
    • Passive and carrier-mediated intestinal absorption components of two angiotensin-converting enzyme (ACE) inhibitor prodrugs in rats: Enalapril and fosinopril
    • Friedman D.I., Amidon G.L. Passive and carrier-mediated intestinal absorption components of two angiotensin-converting enzyme (ACE) inhibitor prodrugs in rats: enalapril and fosinopril. Pharm. Res. 6:1989;1043-1047.
    • (1989) Pharm. Res. , vol.6 , pp. 1043-1047
    • Friedman, D.I.1    Amidon, G.L.2
  • 98
    • 0024505073 scopus 로고
    • Use of the peptide carrier system to improve the intestinal absorption of L-α-methyldopa: Carrier kinetics, intestinal permeabilities, and in vitro hydrolysis of dipeptidyl derivatives of L-α-methyldopa
    • Hu M., Subramanian P., Mosberg H.I., Amidon G.L. Use of the peptide carrier system to improve the intestinal absorption of L-α-methyldopa: carrier kinetics, intestinal permeabilities, and in vitro hydrolysis of dipeptidyl derivatives of L-α-methyldopa. Pharm. Res. 6:1989;66-70.
    • (1989) Pharm. Res. , vol.6 , pp. 66-70
    • Hu, M.1    Subramanian, P.2    Mosberg, H.I.3    Amidon, G.L.4
  • 99
    • 0032546467 scopus 로고    scopus 로고
    • Valacyclovir: A substrate for the intestinal and renal peptide transporters PEPT1 and PEPT2
    • Ganapathy M.E., Huang W., Wang H., Ganapathy V. Valacyclovir: A substrate for the intestinal and renal peptide transporters PEPT1 and PEPT2. Biochem. Biophys. Res. Commun. 246:1998;470-475.
    • (1998) Biochem. Biophys. Res. Commun. , vol.246 , pp. 470-475
    • Ganapathy, M.E.1    Huang, W.2    Wang, H.3    Ganapathy, V.4
  • 103
    • 0002871904 scopus 로고
    • The evaluation of bisphosphonates as potential drugs for the treatment of calcium-related disorders
    • A. Ornoy. Boca Raton, FL: CRC Press
    • Van Gelder J.M., Golomb G. The evaluation of bisphosphonates as potential drugs for the treatment of calcium-related disorders. Ornoy A. Animal Models For Human Related Calcium Metabolic Disorders. 1995;181-205 CRC Press, Boca Raton, FL.
    • (1995) Animal Models for Human Related Calcium Metabolic Disorders , pp. 181-205
    • Van Gelder, J.M.1    Golomb, G.2
  • 105
    • 0027175547 scopus 로고
    • Intranasal delivery of the bisphosphonate alendronate in the rat and dog
    • Sutton S.C., Engle K., Fix J.A. Intranasal delivery of the bisphosphonate alendronate in the rat and dog. Pharm. Res. 10:1993;924-926.
    • (1993) Pharm. Res. , vol.10 , pp. 924-926
    • Sutton, S.C.1    Engle, K.2    Fix, J.A.3
  • 106
    • 0029760056 scopus 로고    scopus 로고
    • Nasal delivery. The use of animal models to predict performance in man
    • Illum L. Nasal delivery. The use of animal models to predict performance in man. J. Drug Target. 3:1996;427-442.
    • (1996) J. Drug Target. , vol.3 , pp. 427-442
    • Illum, L.1
  • 107
    • 0026000375 scopus 로고
    • Pharmacokinetics of clodronate after single intravenous, intramuscular and subcutaneous injections in rats
    • Lauren L., Osterman T., Karhi T. Pharmacokinetics of clodronate after single intravenous, intramuscular and subcutaneous injections in rats. Pharmacol. Toxicol. 69:1991;365-368.
    • (1991) Pharmacol. Toxicol. , vol.69 , pp. 365-368
    • Lauren, L.1    Osterman, T.2    Karhi, T.3
  • 108
    • 0032910349 scopus 로고    scopus 로고
    • Intramuscular clodronate therapy in postmenopausal osteoporosis
    • Rossini M., Gatti D., Gerardi D., Zamberlan N., Braga V., Adami S. Intramuscular clodronate therapy in postmenopausal osteoporosis. Bone. 24:1999;125-129.
    • (1999) Bone , vol.24 , pp. 125-129
    • Rossini, M.1    Gatti, D.2    Gerardi, D.3    Zamberlan, N.4    Braga, V.5    Adami, S.6
  • 109
    • 0030850538 scopus 로고    scopus 로고
    • Subcutaneous clodronate: A study evaluating efficacy in hypercalcemia of malignancy and local toxicity
    • Walker P., Watanabe S., Lawlor P., Hanson J., Pereira J., Bruera E. Subcutaneous clodronate: a study evaluating efficacy in hypercalcemia of malignancy and local toxicity. Ann. Oncol. 8:1997;915-916.
    • (1997) Ann. Oncol. , vol.8 , pp. 915-916
    • Walker, P.1    Watanabe, S.2    Lawlor, P.3    Hanson, J.4    Pereira, J.5    Bruera, E.6
  • 110
    • 0030747547 scopus 로고    scopus 로고
    • Preparation and evaluation of chitosan microspheres containing bisphosphonates
    • Patashnik S., Rabinovich L., Golomb G. Preparation and evaluation of chitosan microspheres containing bisphosphonates. J. Drug Target. 4:(6):1997;371-380.
    • (1997) J. Drug Target. , vol.4 , Issue.6 , pp. 371-380
    • Patashnik, S.1    Rabinovich, L.2    Golomb, G.3
  • 111
    • 0029940367 scopus 로고    scopus 로고
    • Arthroplasty implant biomaterial particle associated macrophages differentiate into lacunar bone resorbing cells
    • Pandey R., Quinn J., Joyner C., Murray D.W., Triffitt J.T., Athanasou N.A. Arthroplasty implant biomaterial particle associated macrophages differentiate into lacunar bone resorbing cells. Ann. Rheum. Dis. 55:1996;388-395.
    • (1996) Ann. Rheum. Dis. , vol.55 , pp. 388-395
    • Pandey, R.1    Quinn, J.2    Joyner, C.3    Murray, D.W.4    Triffitt, J.T.5    Athanasou, N.A.6
  • 112
    • 0031732534 scopus 로고    scopus 로고
    • Bisphosphonates in bone cement inhibit PMMA particle induced bone resorption
    • Sabokbar A., Fujikawa Y., Murray D.W., Athanasou N.A. Bisphosphonates in bone cement inhibit PMMA particle induced bone resorption. Ann. Rheum. Dis. 57:1998;614-618.
    • (1998) Ann. Rheum. Dis. , vol.57 , pp. 614-618
    • Sabokbar, A.1    Fujikawa, Y.2    Murray, D.W.3    Athanasou, N.A.4
  • 113
    • 0029590793 scopus 로고
    • Osteotropic drug delivery system (ODDS) based on bisphosphonic prodrug. I. synthesis and in vivo characterization of osteotropic carboxyfluorescein
    • Fujisaki J., Tokunaga Y., Takahashi T., Hirose T., Shimojo F., Kagayama A., Hata T. Osteotropic drug delivery system (ODDS) based on bisphosphonic prodrug. I. synthesis and in vivo characterization of osteotropic carboxyfluorescein. J. Drug Target. 3:1995;273-282.
    • (1995) J. Drug Target. , vol.3 , pp. 273-282
    • Fujisaki, J.1    Tokunaga, Y.2    Takahashi, T.3    Hirose, T.4    Shimojo, F.5    Kagayama, A.6    Hata, T.7
  • 114
    • 0029812942 scopus 로고    scopus 로고
    • Physicochemical characterization of bisphosphonic carboxyfluorescein for osteotropic drug delivery
    • Fujisaki J., Tokunaga Y., Takahashi T., Murata S., Fhimojo F., Hata T. Physicochemical characterization of bisphosphonic carboxyfluorescein for osteotropic drug delivery. J. Pharm. Pharmacol. 48:1996;798-800.
    • (1996) J. Pharm. Pharmacol. , vol.48 , pp. 798-800
    • Fujisaki, J.1    Tokunaga, Y.2    Takahashi, T.3    Murata, S.4    Fhimojo, F.5    Hata, T.6
  • 115
    • 0029800986 scopus 로고    scopus 로고
    • Osteotropic drug delivery system (ODDS) based on bisphosphonic prodrug. III. Pharmacokinetics and targeting characteristics of osteotropic carboxyfluorescein
    • Fujisaki J., Tokunaga Y., Sawamoto T., Takahashi T., Kimura S., Shimojo F., Hata T. Osteotropic drug delivery system (ODDS) based on bisphosphonic prodrug. III. Pharmacokinetics and targeting characteristics of osteotropic carboxyfluorescein. J. Drug Target. 4:1996;117-123.
    • (1996) J. Drug Target. , vol.4 , pp. 117-123
    • Fujisaki, J.1    Tokunaga, Y.2    Sawamoto, T.3    Takahashi, T.4    Kimura, S.5    Shimojo, F.6    Hata, T.7
  • 116
    • 0031945527 scopus 로고    scopus 로고
    • Osteotropic drug delivery system (ODDS) based on bisphosphonic prodrug. IV. Effects of osteotropic estradiol on bone mineral density and uterine weight in ovariectomized rats
    • Fujisaki J., Tokunaga Y., Takahashi T., Kimura S., Shimojo F., Hata T. Osteotropic drug delivery system (ODDS) based on bisphosphonic prodrug. IV. Effects of osteotropic estradiol on bone mineral density and uterine weight in ovariectomized rats. J. Drug Target. 5:1997;129-138.
    • (1997) J. Drug Target. , vol.5 , pp. 129-138
    • Fujisaki, J.1    Tokunaga, Y.2    Takahashi, T.3    Kimura, S.4    Shimojo, F.5    Hata, T.6
  • 117
    • 0024997302 scopus 로고
    • 17 Beta-estradiol and continuous norethisterone: A unique treatment for established osteoporosis in elderly women
    • Christiansen C., Riis B.J. 17 Beta-estradiol and continuous norethisterone: a unique treatment for established osteoporosis in elderly women. J. Clin. Endocrinol. Metab. 71:1990;836-841.
    • (1990) J. Clin. Endocrinol. Metab. , vol.71 , pp. 836-841
    • Christiansen, C.1    Riis, B.J.2
  • 118
    • 0025339574 scopus 로고
    • Estrogen treatment of patients with established postmenopausal osteoporosis
    • Lindsay R., Tohme J.F. Estrogen treatment of patients with established postmenopausal osteoporosis. Obstet. Gynecol. 76:1990;290-295.
    • (1990) Obstet. Gynecol. , vol.76 , pp. 290-295
    • Lindsay, R.1    Tohme, J.F.2
  • 119
    • 0026758261 scopus 로고
    • Structural specificity of mucosal cell transport and metabolism of peptide drugs: Implication for oral peptide drug delivery
    • Bai J.P.F., Amidon G.L. Structural specificity of mucosal cell transport and metabolism of peptide drugs: implication for oral peptide drug delivery. Pharm. Res. 9:1992;969-978.
    • (1992) Pharm. Res. , vol.9 , pp. 969-978
    • Bai, J.P.F.1    Amidon, G.L.2


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