Simultaneous assessment of uptake and metabolism in rat hepatocytes: A comprehensive mechanistic model

Journal of Pharmacology and Experimental Therapeutics

Volumn 341, Issue 1, 2012, Pages 2-15

  Ménochet, Karelle ^a   Kenworthy, Kathryn E ^b   Houston, J Brian ^a   Galetin, Aleksandra ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BOSENTAN; PITAVASTATIN; PRAVASTATIN; REPAGLINIDE; ROSUVASTATIN; TELMISARTAN; VALSARTAN;

ACTIVE TRANSPORT; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL LEVEL; COMPARTMENT MODEL; CONTROLLED STUDY; DIFFUSION; DRUG CLEARANCE; DRUG METABOLISM; DRUG UPTAKE; IN VITRO STUDY; INCUBATION TIME; LIMIT OF QUANTITATION; LIPOPHILICITY; LIVER CELL; NONHUMAN; PASSIVE DIFFUSION; PRIORITY JOURNAL; RAT; STEADY STATE; TRANSPORT KINETICS;

ANIMALS; BINDING SITES; BIOLOGICAL TRANSPORT, ACTIVE; CELLS, CULTURED; DIFFUSION; HEPATOCYTES; INTRACELLULAR FLUID; MODELS, BIOLOGICAL; PHARMACEUTICAL PREPARATIONS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84858673980     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.111.187112     Document Type: Article

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