Inhibiting 11β-hydroxysteroid dehydrogenase type 1 prevents stress effects on hippocampal synaptic plasticity and impairs contextual fear conditioning

Neuropharmacology

Volumn 81, Issue , 2014, Pages 231-236

  Sarabdjitsingh, R Angela ^a   Zhou, Ming ^b   Yau, Joyce L W ^c,d   Webster, Scott P ^c,d   Walker, Brian R ^c,d   Seckl, Jonathan R ^c,d   Joëls, Marian ^a   Krugers, Harm J ^b  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

^d UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Corticosterone; Fear conditioning; Long term potentiation; Memory; Stress

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 1; CENTRAL NERVOUS SYSTEM AGENTS; GLUCOCORTICOID; OXIDOREDUCTASE INHIBITOR; PSYCHOTROPIC AGENT; UE 2316; UNCLASSIFIED DRUG; CORTICOSTERONE; ENZYME INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASSOCIATION; BRAIN DISEASE; CONDITIONING; CONTROLLED STUDY; DRUG EFFECT; ENZYME INHIBITION; FEAR; HIPPOCAMPUS; LONG TERM POTENTIATION; MALE; MENTAL DISEASE; MENTAL STRESS; MOUSE; NERVE CELL PLASTICITY; NEUROMODULATION; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; SINGLE DRUG DOSE; STEROID METABOLISM; TREATMENT RESPONSE; ANALYSIS OF VARIANCE; ANIMAL; AUDITORY STIMULATION; BLOOD; C57BL MOUSE; COMPLICATION; DISEASE MODEL; DRUG EFFECTS; IN VITRO STUDY; LEARNING DISORDERS; METABOLISM; PHYSIOLOGY;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1; ACOUSTIC STIMULATION; ANALYSIS OF VARIANCE; ANIMALS; CONDITIONING (PSYCHOLOGY); CORTICOSTERONE; CUES; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; FEAR; HIPPOCAMPUS; IN VITRO TECHNIQUES; LEARNING DISORDERS; LONG-TERM POTENTIATION; MALE; MICE; MICE, INBRED C57BL; NEURONAL PLASTICITY; STRESS, PSYCHOLOGICAL;

EID: 84895769825     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2014.01.042     Document Type: Article

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