Novel anti-inflammatory function of NSC95397 by the suppression of multiple kinases

Biochemical Pharmacology

Volumn 88, Issue 2, 2014, Pages 201-215

  Yang, Yanyan ^a   Yang, Woo Seok ^a   Yu, Tao ^a   Yi, Young Su ^a   Park, Jae Gwang ^a   Jeong, Deok ^a   Kim, Ji Hye ^a   Oh, Jeong Su ^a   Yoon, Keejung ^a   Kim, Jong Hoon ^b   Cho, Jae Youl ^a  

^a Sungkyunkwan University   (South Korea)

^b Chonbuk National University   (South Korea)

Author keywords

AKT; Anti inflammatory effects; IKK ; Inflammatory mediators; Multiple kinases; NSC95397

Indexed keywords

1,4 NAPHTHOQUINONE DERIVATIVE; 2,3 BIS [(2 HYDROXYETHYL)THIO] 1,4 NAPHTHOQUINONE; 3 (4 METHYLPHENYLSULFONYL) 2 PROPENENITRILE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; ANTIINFLAMMATORY AGENT; BETA INTERFERON; CYCLOOXYGENASE 2; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; I KAPPA B KINASE ALPHA; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERFERON REGULATORY FACTOR 3; LUCIFERASE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE KINASE 7; MITOGEN ACTIVATED PROTEIN KINASE P38; MYELOID DIFFERENTIATION FACTOR 88; NITRIC OXIDE; NSC 95397; PHOSPHOTRANSFERASE; PROSTAGLANDIN E2; PROTEIN KINASE B; PROTEIN TYROSINE PHOSPHATASE INHIBITOR; STRESS ACTIVATED PROTEIN KINASE; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR ADAPTOR MOLECULE 1; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL STRAIN HEK293; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; DRUG TARGETING; ENZYME ASSAY; ENZYME REPRESSION; FRACTIONATION; GENE EXPRESSION; GENE OVEREXPRESSION; IMMUNOBLOTTING; IMMUNOPRECIPITATION; INFLAMMATION; LUCIFERASE ASSAY; MALE; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PRIORITY JOURNAL;

AKT; ANTI-INFLAMMATORY EFFECTS; IKKΑ/Β; INFLAMMATORY MEDIATORS; MULTIPLE KINASES; NSC95397;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CDC25 PHOSPHATASES; CELL LINE; CELL SURVIVAL; MALE; MICE; MICE, INBRED C57BL; NAPHTHOQUINONES; PROTEIN-SERINE-THREONINE KINASES;

EID: 84895559429     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2014.01.022     Document Type: Article

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