Two distinct classes of novel pyrazolinecarboxamides as potent cannabinoid CB1 receptor agonists

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 17, 2010, Pages 4992-4998

  Lange, Jos H M ^a   Attali, Amos ^a   Van Der Neut, Martina A W ^a   Wals, Henri C ^a   Mulder, Arie ^a   Zilaout, Hicham ^a   Duursma, Ate ^a   Van Aken, Hans H M ^a   Van Vliet, Bernard J ^a  

^a Chemical Design and Synthesis Unit   (Netherlands)

Author keywords

Agonist; Cannabinoid; CB1 receptor; CNS plasma ratio; EAE assay; Multiple sclerosis; Pyrazoline; SAR

Indexed keywords

CANNABINOID 1 RECEPTOR; CANNABINOID 1 RECEPTOR AGONIST; CANNABINOID 2 RECEPTOR; NABILONE; PYRAZOLINECARBOXAMIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG SYNTHESIS; MALE; MULTIPLE SCLEROSIS; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

PYRAZOLES; RECEPTOR, CANNABINOID, CB1;

RODENTIA;

EID: 77955713688     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.07.056     Document Type: Article

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