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Volumn 39, Issue 2, 2014, Pages 118-135

Non-vitamin K antagonist oral anticoagulants in cardiovascular disease management: Evidence and unanswered questions

Author keywords

apixaban; dabigatran; rivaroxaban; thromboembolic disorders

Indexed keywords

APIXABAN; DABIGATRAN ETEXILATE; RIVAROXABAN; WARFARIN;

EID: 84895541979     PISSN: 02694727     EISSN: 13652710     Source Type: Journal    
DOI: 10.1111/jcpt.12122     Document Type: Review
Times cited : (30)

References (82)
  • 1
    • 0026580091 scopus 로고
    • Pulmonary embolism thrombolysis: A clarion call for international collaboration
    • Goldhaber SZ,. Pulmonary embolism thrombolysis: a clarion call for international collaboration. J Am Coll Cardiol, 1992; 19: 246-247.
    • (1992) J Am Coll Cardiol , vol.19 , pp. 246-247
    • Goldhaber, S.Z.1
  • 2
    • 34248664839 scopus 로고    scopus 로고
    • ACC/AHA/ESC 2006 guidelines for the management of patients with atrial fibrillation. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines
    • (Writing Committee to Revise the 2001 Guidelines for the Management of Patients with Atrial Fibrillation): Developed in collaboration with the European Heart Rhythm Association and the Heart Rhythm Society
    • Fuster V, Rydén LE, Cannom DS, et al,. ACC/AHA/ESC 2006 guidelines for the management of patients with atrial fibrillation. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Revise the 2001 Guidelines for the Management of Patients With Atrial Fibrillation): developed in collaboration with the European Heart Rhythm Association and the Heart Rhythm Society. Circulation, 2006; 114: e257-e354.
    • (2006) Circulation , vol.114
    • Fuster, V.1    Rydén, L.E.2    Cannom, D.S.3
  • 3
    • 84855353573 scopus 로고    scopus 로고
    • Heart disease and stroke statistics - 2012 update: A report from the American Heart Association
    • Roger VL, Go AS, Lloyd-Jones DM, et al,. Heart disease and stroke statistics-2012 update: a report from the American Heart Association. Circulation, 2012; 125: e2-e220.
    • (2012) Circulation , vol.125
    • Roger, V.L.1    Go, A.S.2    Lloyd-Jones, D.M.3
  • 4
    • 84856784474 scopus 로고    scopus 로고
    • Oral anticoagulant therapy: Antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians evidence-based clinical practice guidelines
    • Ageno W, Gallus AS, Wittkowsky A, Crowther M, Hylek EM, Palareti G, Oral anticoagulant therapy: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest, 2012; 141: e44S-e88S.
    • (2012) Chest , vol.141
    • Ageno, W.1    Gallus, A.S.2    Wittkowsky, A.3    Crowther, M.4    Hylek, E.M.5    Palareti, G.6
  • 5
    • 84856745317 scopus 로고    scopus 로고
    • Antithrombotic therapy for atrial fibrillation: Antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians evidence-based clinical practice guidelines
    • You JJ, Singer DE, Howard PA, et al,. Antithrombotic therapy for atrial fibrillation: Antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest, 2012; 141: e531S-e575S.
    • (2012) Chest , vol.141
    • You, J.J.1    Singer, D.E.2    Howard, P.A.3
  • 6
    • 79951853372 scopus 로고    scopus 로고
    • Boehringer Ingelheim International GmbH (accessed 5 November 2013)
    • Boehringer Ingelheim International GmbH. Pradaxa® (dabigatran etexilate) Summary of Product Characteristics. 2013. Available at: http://www.ema.europa.eu/docs/en-GB/document-library/EPAR-Product-Information/ human/000829/WC500041059.pdf (accessed 5 November 2013).
    • (2013) Pradaxa® (Dabigatran Etexilate) Summary of Product Characteristics
  • 7
    • 84892586035 scopus 로고    scopus 로고
    • Boehringer Ingelheim Pharmaceuticals Inc (accessed 23 October 2013)
    • Boehringer Ingelheim Pharmaceuticals Inc. Pradaxa® (dabigatran etexilate) Prescribing Information. 2013. Available at: http://www.accessdata. fda.gov/drugsatfda-docs/label/2013/022512s017lbl.pdf (accessed 23 October 2013).
    • (2013) Pradaxa® (Dabigatran Etexilate) Prescribing Information
  • 8
    • 84895527639 scopus 로고    scopus 로고
    • Boehringer Ingelheim Canada Ltd (accessed 11 November 2013)
    • Boehringer Ingelheim Canada Ltd. Pradax™ (dabigatran etexilate mesilate) Product Monograph. 2013. Available at: http://www.boehringer- ingelheim.ca/content/dam/internet/opu/ca-EN/documents/humanhealth/ product-monograph/Pradax-pm.pdf (accessed 11 November 2013).
    • (2013) Pradax™ (Dabigatran Etexilate Mesilate) Product Monograph
  • 9
    • 79952995005 scopus 로고    scopus 로고
    • Bayer Pharma AG. (accessed 1 November 2013)
    • Bayer Pharma AG. Xarelto® (rivaroxaban) Summary of Product Characteristics. 2013. Available at: http://www.ema.europa.eu/docs/en-GB/ document-library/EPAR-Product-Information/human/000944/WC500057108.pdf (accessed 1 November 2013).
    • (2013) Xarelto® (Rivaroxaban) Summary of Product Characteristics
  • 10
    • 84880942033 scopus 로고    scopus 로고
    • Janssen Pharmaceuticals Inc. (accessed 23 July 2013)
    • Janssen Pharmaceuticals Inc. Xarelto® (rivaroxaban) Prescribing Information. 2013. Available at: http://www.accessdata.fda.gov/drugsatfda-docs/ label/2013/022406s004lbl.pdf (accessed 23 July 2013).
    • (2013) Xarelto® (Rivaroxaban) Prescribing Information
  • 11
    • 84895508944 scopus 로고    scopus 로고
    • Bayer Inc. (accessed 18 December 2013)
    • Bayer Inc. Product Monograph (Canada). 2013. Available at: http://www.bayer.ca/files/XARELTO-PM-ENG-28AUG2013-164839.pdf?# (accessed 18 December 2013).
    • (2013) Product Monograph (Canada)
  • 12
    • 84894061381 scopus 로고    scopus 로고
    • Bristol-Myers Squibb (accessed 22 October 2013)
    • Bristol-Myers Squibb, Pfizer EEIG. Eliquis® (apixaban) Summary of Product Characteristics. 2013. Available at: http://www.ema.europa.eu/docs/en- GB/document-library/EPAR-Product-Information/human/002148/WC500107728.pdf (accessed 22 October 2013).
    • (2013) Pfizer EEIG. Eliquis® (Apixaban) Summary of Product Characteristics
  • 13
    • 84876222056 scopus 로고    scopus 로고
    • Bristol-Myers Squibb Company, Pfizer Inc. (accessed 23 October 2013)
    • Bristol-Myers Squibb Company, Pfizer Inc. Eliquis® (apixaban) Prescribing Information. 2012. Available at: http://www.accessdata.fda.gov/ drugsatfda-docs/label/2012/202155s000lbl.pdf (accessed 23 October 2013).
    • (2012) Eliquis® (Apixaban) Prescribing Information
  • 14
    • 84886777861 scopus 로고    scopus 로고
    • Bristol-Myers Squibb Canada Inc, Pfizer Canada Inc. (accessed 11 November 2013)
    • Bristol-Myers Squibb Canada Inc, Pfizer Canada Inc. Eliquis (apixaban) Product Monograph. 2012. Available at: http://www.bmscanada.ca/static/products/ en/pm-pdf/ELIQUIS-EN-PM.pdf (accessed 11 November 2013).
    • (2012) Eliquis (Apixaban) Product Monograph
  • 17
    • 0037171819 scopus 로고    scopus 로고
    • Structure-based design of novel potent nonpeptide thrombin inhibitors
    • Hauel NH, Nar H, Priepke H, Ries U, Stassen JM, Wienen W,. Structure-based design of novel potent nonpeptide thrombin inhibitors. J Med Chem, 2002; 45: 1757-1766.
    • (2002) J Med Chem , vol.45 , pp. 1757-1766
    • Hauel, N.H.1    Nar, H.2    Priepke, H.3    Ries, U.4    Stassen, J.M.5    Wienen, W.6
  • 18
  • 19
    • 42149172523 scopus 로고    scopus 로고
    • Apixaban, an oral, direct and highly selective Factor Xa inhibitor: In vitro, antithrombotic and antihemostatic studies
    • Wong PC, Crain EJ, Xin B, et al,. Apixaban, an oral, direct and highly selective Factor Xa inhibitor: in vitro, antithrombotic and antihemostatic studies. J Thromb Haemost, 2008; 6: 820-829.
    • (2008) J Thromb Haemost , vol.6 , pp. 820-829
    • Wong, P.C.1    Crain, E.J.2    Xin, B.3
  • 20
    • 80052351015 scopus 로고    scopus 로고
    • Preclinical discovery of apixaban, a direct and orally bioavailable factor Xa inhibitor
    • Wong PC, Pinto DJ, Zhang D,. Preclinical discovery of apixaban, a direct and orally bioavailable factor Xa inhibitor. J Thromb Thrombolysis, 2011; 31: 478-492.
    • (2011) J Thromb Thrombolysis , vol.31 , pp. 478-492
    • Wong, P.C.1    Pinto, D.J.2    Zhang, D.3
  • 21
    • 38749131205 scopus 로고    scopus 로고
    • The metabolism and disposition of the oral direct thrombin inhibitor, dabigatran, in humans
    • Blech S, Ebner T, Ludwig-Schwellinger E, Stangier J, Roth W,. The metabolism and disposition of the oral direct thrombin inhibitor, dabigatran, in humans. Drug Metab Dispos, 2008; 36: 386-399.
    • (2008) Drug Metab Dispos , vol.36 , pp. 386-399
    • Blech, S.1    Ebner, T.2    Ludwig-Schwellinger, E.3    Stangier, J.4    Roth, W.5
  • 22
    • 25844525489 scopus 로고    scopus 로고
    • Safety, pharmacodynamics, and pharmacokinetics of single doses of BAY 59-7939, an oral, direct Factor Xa inhibitor
    • Kubitza D, Becka M, Voith B, Zuehlsdorf M, Wensing G,. Safety, pharmacodynamics, and pharmacokinetics of single doses of BAY 59-7939, an oral, direct Factor Xa inhibitor. Clin Pharmacol Ther, 2005; 78: 412-421.
    • (2005) Clin Pharmacol Ther , vol.78 , pp. 412-421
    • Kubitza, D.1    Becka, M.2    Voith, B.3    Zuehlsdorf, M.4    Wensing, G.5
  • 23
    • 66449099711 scopus 로고    scopus 로고
    • Metabolism and excretion of rivaroxaban, an oral, direct Factor Xa inhibitor, in rats, dogs and humans
    • Weinz C, Schwarz T, Kubitza D, Mueck W, Lang D,. Metabolism and excretion of rivaroxaban, an oral, direct Factor Xa inhibitor, in rats, dogs and humans. Drug Metab Dispos, 2009; 37: 1056-1064.
    • (2009) Drug Metab Dispos , vol.37 , pp. 1056-1064
    • Weinz, C.1    Schwarz, T.2    Kubitza, D.3    Mueck, W.4    Lang, D.5
  • 24
    • 58149458160 scopus 로고    scopus 로고
    • Apixaban metabolism and pharmacokinetics after oral administration to humans
    • Raghavan N, Frost CE, Yu Z, et al,. Apixaban metabolism and pharmacokinetics after oral administration to humans. Drug Metab Dispos, 2009; 37: 74-81.
    • (2009) Drug Metab Dispos , vol.37 , pp. 74-81
    • Raghavan, N.1    Frost, C.E.2    Yu, Z.3
  • 25
    • 67349275592 scopus 로고    scopus 로고
    • For estimating creatinine clearance measuring muscle mass gives better results than those based on demographics
    • Rule AD, Bailey KR, Schwartz GL, Khosla S, Lieske JC, Melton LJ III,. For estimating creatinine clearance measuring muscle mass gives better results than those based on demographics. Kidney Int, 2009; 75: 1071-1078.
    • (2009) Kidney Int , vol.75 , pp. 1071-1078
    • Rule, A.D.1    Bailey, K.R.2    Schwartz, G.L.3    Khosla, S.4    Lieske, J.C.5    Melton III, L.J.6
  • 26
    • 84856675273 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics in Japanese and Caucasian subjects after oral administration of dabigatran etexilate
    • Härtter S, Yamamura N, Stangier J, Reilly PA, Clemens A,. Pharmacokinetics and pharmacodynamics in Japanese and Caucasian subjects after oral administration of dabigatran etexilate. Thromb Haemost, 2012; 107: 260-269.
    • (2012) Thromb Haemost , vol.107 , pp. 260-269
    • Härtter, S.1    Yamamura, N.2    Stangier, J.3    Reilly, P.A.4    Clemens, A.5
  • 27
    • 57449098437 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of dabigatran etexilate, an oral direct thrombin inhibitor, are not affected by moderate hepatic impairment
    • Stangier J, Stahle H, Rathgen K, Roth W, Shakeri-Nejad K,. Pharmacokinetics and pharmacodynamics of dabigatran etexilate, an oral direct thrombin inhibitor, are not affected by moderate hepatic impairment. J Clin Pharmacol, 2008; 48: 1411-1419.
    • (2008) J Clin Pharmacol , vol.48 , pp. 1411-1419
    • Stangier, J.1    Stahle, H.2    Rathgen, K.3    Roth, W.4    Shakeri-Nejad, K.5
  • 28
    • 77949421739 scopus 로고    scopus 로고
    • Influence of renal impairment on the pharmacokinetics and pharmacodynamics of oral dabigatran etexilate: An open-label, parallel-group, single-centre study
    • Stangier J, Rathgen K, Stahle H, Mazur D,. Influence of renal impairment on the pharmacokinetics and pharmacodynamics of oral dabigatran etexilate: an open-label, parallel-group, single-centre study. Clin Pharmacokinet, 2010; 49: 259-268.
    • (2010) Clin Pharmacokinet , vol.49 , pp. 259-268
    • Stangier, J.1    Rathgen, K.2    Stahle, H.3    Mazur, D.4
  • 29
    • 29144518504 scopus 로고    scopus 로고
    • Safety, pharmacodynamics, and pharmacokinetics of BAY 59-7939 - An oral, direct Factor Xa inhibitor - After multiple dosing in healthy male subjects
    • Kubitza D, Becka M, Wensing G, Voith B, Zuehlsdorf M,. Safety, pharmacodynamics, and pharmacokinetics of BAY 59-7939-an oral, direct Factor Xa inhibitor-after multiple dosing in healthy male subjects. Eur J Clin Pharmacol, 2005; 61: 873-880.
    • (2005) Eur J Clin Pharmacol , vol.61 , pp. 873-880
    • Kubitza, D.1    Becka, M.2    Wensing, G.3    Voith, B.4    Zuehlsdorf, M.5
  • 30
    • 42949123582 scopus 로고    scopus 로고
    • Population pharmacokinetics and pharmacodynamics of rivaroxaban - An oral, direct Factor Xa inhibitor - In patients undergoing major orthopaedic surgery
    • Mueck W, Eriksson BI, Bauer KA, et al,. Population pharmacokinetics and pharmacodynamics of rivaroxaban-an oral, direct Factor Xa inhibitor-in patients undergoing major orthopaedic surgery. Clin Pharmacokinet, 2008; 47: 203-216.
    • (2008) Clin Pharmacokinet , vol.47 , pp. 203-216
    • Mueck, W.1    Eriksson, B.I.2    Bauer, K.A.3
  • 31
    • 55549139511 scopus 로고    scopus 로고
    • Dose-escalation study of the pharmacokinetics and pharmacodynamics of rivaroxaban in healthy elderly subjects
    • Kubitza D, Becka M, Roth A, Mueck W,. Dose-escalation study of the pharmacokinetics and pharmacodynamics of rivaroxaban in healthy elderly subjects. Curr Med Res Opin, 2008; 24: 2757-2765.
    • (2008) Curr Med Res Opin , vol.24 , pp. 2757-2765
    • Kubitza, D.1    Becka, M.2    Roth, A.3    Mueck, W.4
  • 32
    • 84877846026 scopus 로고    scopus 로고
    • The influence of age and gender on the pharmacokinetics and pharmacodynamics of rivaroxaban - An oral, direct Factor Xa inhibitor
    • Kubitza D, Becka M, Roth A, Mueck W,. The influence of age and gender on the pharmacokinetics and pharmacodynamics of rivaroxaban-an oral, direct Factor Xa inhibitor. J Clin Pharmacol, 2013; 53: 249-255.
    • (2013) J Clin Pharmacol , vol.53 , pp. 249-255
    • Kubitza, D.1    Becka, M.2    Roth, A.3    Mueck, W.4
  • 33
    • 74249121331 scopus 로고    scopus 로고
    • Safety, pharmacokinetics and pharmacodynamics of single doses of rivaroxaban - An oral, direct Factor Xa inhibitor - In elderly Chinese subjects
    • Jiang J, Hu Y, Zhang J, et al,. Safety, pharmacokinetics and pharmacodynamics of single doses of rivaroxaban-an oral, direct Factor Xa inhibitor-in elderly Chinese subjects. Thromb Haemost, 2010; 103: 234-241.
    • (2010) Thromb Haemost , vol.103 , pp. 234-241
    • Jiang, J.1    Hu, Y.2    Zhang, J.3
  • 34
    • 33846448135 scopus 로고    scopus 로고
    • Body weight has limited influence on the safety, tolerability, pharmacokinetics, or pharmacodynamics of rivaroxaban (BAY 59-7939) in healthy subjects
    • Kubitza D, Becka M, Zuehlsdorf M, Mueck W,. Body weight has limited influence on the safety, tolerability, pharmacokinetics, or pharmacodynamics of rivaroxaban (BAY 59-7939) in healthy subjects. J Clin Pharmacol, 2007; 47: 218-226.
    • (2007) J Clin Pharmacol , vol.47 , pp. 218-226
    • Kubitza, D.1    Becka, M.2    Zuehlsdorf, M.3    Mueck, W.4
  • 35
    • 84879486549 scopus 로고    scopus 로고
    • Effect of hepatic impairment on the pharmacokinetics and pharmacodynamics of a single dose of rivaroxaban - An oral, direct Factor Xa inhibitor
    • Kubitza D, Roth A, Becka M, et al,. Effect of hepatic impairment on the pharmacokinetics and pharmacodynamics of a single dose of rivaroxaban-an oral, direct Factor Xa inhibitor. Br J Clin Pharmacol, 2013; 76: 89-98.
    • (2013) Br J Clin Pharmacol , vol.76 , pp. 89-98
    • Kubitza, D.1    Roth, A.2    Becka, M.3
  • 36
    • 67650932119 scopus 로고    scopus 로고
    • Safety, pharmacokinetics and pharmacodynamics of single/multiple doses of the oral, direct Factor Xa inhibitor rivaroxaban in healthy Chinese subjects
    • Zhao X, Sun P, Zhou Y, et al,. Safety, pharmacokinetics and pharmacodynamics of single/multiple doses of the oral, direct Factor Xa inhibitor rivaroxaban in healthy Chinese subjects. Br J Clin Pharmacol, 2009; 68: 77-88.
    • (2009) Br J Clin Pharmacol , vol.68 , pp. 77-88
    • Zhao, X.1    Sun, P.2    Zhou, Y.3
  • 37
    • 84874615039 scopus 로고    scopus 로고
    • Model-based dose selection for phase III rivaroxaban study in Japanese patients with non-valvular atrial fibrillation
    • Tanigawa T, Kaneko M, Hashizume K, et al,. Model-based dose selection for phase III rivaroxaban study in Japanese patients with non-valvular atrial fibrillation. Drug Metab Pharmacokinet, 2013; 28: 59-70.
    • (2013) Drug Metab Pharmacokinet , vol.28 , pp. 59-70
    • Tanigawa, T.1    Kaneko, M.2    Hashizume, K.3
  • 38
    • 78649289929 scopus 로고    scopus 로고
    • Effects of renal impairment on the pharmacokinetics, pharmacodynamics and safety of rivaroxaban, an oral, direct Factor Xa inhibitor
    • Kubitza D, Becka M, Mueck W, et al,. Effects of renal impairment on the pharmacokinetics, pharmacodynamics and safety of rivaroxaban, an oral, direct Factor Xa inhibitor. Br J Clin Pharmacol, 2010; 70: 703-712.
    • (2010) Br J Clin Pharmacol , vol.70 , pp. 703-712
    • Kubitza, D.1    Becka, M.2    Mueck, W.3
  • 39
    • 34250166525 scopus 로고    scopus 로고
    • Population model of the pharmacokinetics and pharmacodynamics of rivaroxaban - An oral, direct Factor Xa inhibitor - In healthy subjects
    • Mueck W, Becka M, Kubitza D, Voith B, Zuehlsdorf M,. Population model of the pharmacokinetics and pharmacodynamics of rivaroxaban-an oral, direct Factor Xa inhibitor-in healthy subjects. Int J Clin Pharmacol Ther, 2007; 45: 335-344.
    • (2007) Int J Clin Pharmacol Ther , vol.45 , pp. 335-344
    • Mueck, W.1    Becka, M.2    Kubitza, D.3    Voith, B.4    Zuehlsdorf, M.5
  • 40
    • 33645779998 scopus 로고    scopus 로고
    • Effect of food, an antacid, and the H2 antagonist ranitidine on the absorption of BAY 59-7939 (rivaroxaban), an oral, direct Factor Xa inhibitor, in healthy subjects
    • Kubitza D, Becka M, Zuehlsdorf M, Mueck W,. Effect of food, an antacid, and the H2 antagonist ranitidine on the absorption of BAY 59-7939 (rivaroxaban), an oral, direct Factor Xa inhibitor, in healthy subjects. J Clin Pharmacol, 2006; 46: 549-558.
    • (2006) J Clin Pharmacol , vol.46 , pp. 549-558
    • Kubitza, D.1    Becka, M.2    Zuehlsdorf, M.3    Mueck, W.4
  • 41
    • 84880237573 scopus 로고    scopus 로고
    • The effect of food on the absorption and pharmacokinetics of rivaroxaban
    • Stampfuss J, Kubitza D, Becka M, Mueck W,. The effect of food on the absorption and pharmacokinetics of rivaroxaban. Int J Clin Pharmacol Ther, 2013; 51: 549-561.
    • (2013) Int J Clin Pharmacol Ther , vol.51 , pp. 549-561
    • Stampfuss, J.1    Kubitza, D.2    Becka, M.3    Mueck, W.4
  • 42
    • 84878921385 scopus 로고    scopus 로고
    • Effect of extremes of body weight on the pharmacokinetics, pharmacodynamics, safety and tolerability of apixaban in healthy subjects
    • Upreti VV, Wang J, Barrett YC, et al,. Effect of extremes of body weight on the pharmacokinetics, pharmacodynamics, safety and tolerability of apixaban in healthy subjects. Br J Clin Pharmacol, 2013; 76: 908-916.
    • (2013) Br J Clin Pharmacol , vol.76 , pp. 908-916
    • Upreti, V.V.1    Wang, J.2    Barrett, Y.C.3
  • 43
    • 84872260247 scopus 로고    scopus 로고
    • Apixaban, an oral, direct Factor Xa inhibitor: Single-dose safety, pharmacokinetics, pharmacodynamics and food effect in healthy subjects
    • Frost C, Wang J, Nepal S, et al,. Apixaban, an oral, direct Factor Xa inhibitor: single-dose safety, pharmacokinetics, pharmacodynamics and food effect in healthy subjects. Br J Clin Pharmacol, 2013; 75: 476-487.
    • (2013) Br J Clin Pharmacol , vol.75 , pp. 476-487
    • Frost, C.1    Wang, J.2    Nepal, S.3
  • 44
    • 34548031359 scopus 로고    scopus 로고
    • The pharmacokinetics, pharmacodynamics and tolerability of dabigatran etexilate, a new oral direct thrombin inhibitor, in healthy male subjects
    • Stangier J, Rathgen K, Stahle H, Gansser D, Roth W,. The pharmacokinetics, pharmacodynamics and tolerability of dabigatran etexilate, a new oral direct thrombin inhibitor, in healthy male subjects. Br J Clin Pharmacol, 2007; 64: 292-303.
    • (2007) Br J Clin Pharmacol , vol.64 , pp. 292-303
    • Stangier, J.1    Rathgen, K.2    Stahle, H.3    Gansser, D.4    Roth, W.5
  • 45
    • 37149005153 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of the direct oral thrombin inhibitor dabigatran in healthy elderly subjects
    • Stangier J, Stähle H, Rathgen K, Fuhr R,. Pharmacokinetics and pharmacodynamics of the direct oral thrombin inhibitor dabigatran in healthy elderly subjects. Clin Pharmacokinet, 2008; 47: 47-59.
    • (2008) Clin Pharmacokinet , vol.47 , pp. 47-59
    • Stangier, J.1    Stähle, H.2    Rathgen, K.3    Fuhr, R.4
  • 46
    • 84856593171 scopus 로고    scopus 로고
    • Using the HEMOCLOT direct thrombin inhibitor assay to determine plasma concentrations of dabigatran
    • Stangier J, Feuring M,. Using the HEMOCLOT direct thrombin inhibitor assay to determine plasma concentrations of dabigatran. Blood Coagul Fibrinolysis, 2012; 23: 138-143.
    • (2012) Blood Coagul Fibrinolysis , vol.23 , pp. 138-143
    • Stangier, J.1    Feuring, M.2
  • 47
    • 77952044405 scopus 로고    scopus 로고
    • Assessment of laboratory assays to measure rivaroxaban - An oral, direct Factor Xa inhibitor
    • Samama MM, Martinoli JL, Le Flem L, et al,. Assessment of laboratory assays to measure rivaroxaban-an oral, direct Factor Xa inhibitor. Thromb Haemost, 2010; 103: 815-825.
    • (2010) Thromb Haemost , vol.103 , pp. 815-825
    • Samama, M.M.1    Martinoli, J.L.2    Le Flem, L.3
  • 49
    • 84863679656 scopus 로고    scopus 로고
    • Accurate determination of rivaroxaban levels requires different calibrator sets but not addition of antithrombin
    • Mani H, Rohde G, Stratmann G, et al,. Accurate determination of rivaroxaban levels requires different calibrator sets but not addition of antithrombin. Thromb Haemost, 2012; 108: 191-198.
    • (2012) Thromb Haemost , vol.108 , pp. 191-198
    • Mani, H.1    Rohde, G.2    Stratmann, G.3
  • 50
    • 84856632988 scopus 로고    scopus 로고
    • Evaluation of the anti-Factor Xa chromogenic assay for the measurement of rivaroxaban plasma concentrations using calibrators and controls
    • Samama MM, Contant G, Spiro TE, et al,. Evaluation of the anti-Factor Xa chromogenic assay for the measurement of rivaroxaban plasma concentrations using calibrators and controls. Thromb Haemost, 2012; 107: 379-387.
    • (2012) Thromb Haemost , vol.107 , pp. 379-387
    • Samama, M.M.1    Contant, G.2    Spiro, T.E.3
  • 51
    • 84877114222 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic effects of comedication of clopidogrel and dabigatran etexilate in healthy male volunteers
    • Hartter S, Sennewald R, Schepers C, Baumann S, Fritsch H, Friedman J,. Pharmacokinetic and pharmacodynamic effects of comedication of clopidogrel and dabigatran etexilate in healthy male volunteers. Eur J Clin Pharmacol, 2013; 69: 327-339.
    • (2013) Eur J Clin Pharmacol , vol.69 , pp. 327-339
    • Hartter, S.1    Sennewald, R.2    Schepers, C.3    Baumann, S.4    Fritsch, H.5    Friedman, J.6
  • 52
    • 84875071896 scopus 로고    scopus 로고
    • Oral bioavailability of dabigatran etexilate (Pradaxa®) after co-medication with verapamil in healthy subjects
    • Hartter S, Sennewald R, Nehmiz G, Reilly P,. Oral bioavailability of dabigatran etexilate (Pradaxa®) after co-medication with verapamil in healthy subjects. Br J Clin Pharmacol, 2013; 75: 1053-1062.
    • (2013) Br J Clin Pharmacol , vol.75 , pp. 1053-1062
    • Hartter, S.1    Sennewald, R.2    Nehmiz, G.3    Reilly, P.4
  • 53
    • 84864808150 scopus 로고    scopus 로고
    • Decrease in the oral bioavailability of dabigatran etexilate after co-medication with rifampicin
    • Härtter S, Koenen-Bergmann M, Sharma A, et al,. Decrease in the oral bioavailability of dabigatran etexilate after co-medication with rifampicin. Br J Clin Pharmacol, 2012; 74: 490-500.
    • (2012) Br J Clin Pharmacol , vol.74 , pp. 490-500
    • Härtter, S.1    Koenen-Bergmann, M.2    Sharma, A.3
  • 54
    • 66449087353 scopus 로고    scopus 로고
    • In vitro metabolism of rivaroxaban - An oral, direct Factor Xa inhibitor - In liver microsomes and hepatocytes of rat, dog and man
    • Lang D, Freudenberger C, Weinz C,. In vitro metabolism of rivaroxaban-an oral, direct Factor Xa inhibitor-in liver microsomes and hepatocytes of rat, dog and man. Drug Metab Dispos, 2009; 37: 1046-1055.
    • (2009) Drug Metab Dispos , vol.37 , pp. 1046-1055
    • Lang, D.1    Freudenberger, C.2    Weinz, C.3
  • 55
    • 84877289110 scopus 로고    scopus 로고
    • Co-administration of rivaroxaban with drugs that share its elimination pathways: Pharmacokinetic effects in healthy subjects
    • Mueck W, Kubitza D, Becka M,. Co-administration of rivaroxaban with drugs that share its elimination pathways: pharmacokinetic effects in healthy subjects. Br J Clin Pharmacol, 2013; 76: 455-466.
    • (2013) Br J Clin Pharmacol , vol.76 , pp. 455-466
    • Mueck, W.1    Kubitza, D.2    Becka, M.3
  • 56
    • 84880594628 scopus 로고    scopus 로고
    • Absence of clinically relevant interactions between rivaroxaban - An oral, direct Factor Xa inhibitor - And digoxin or atorvastatin in healthy subjects
    • Kubitza D, Becka M, Roth A, Mueck W,. Absence of clinically relevant interactions between rivaroxaban-an oral, direct Factor Xa inhibitor-and digoxin or atorvastatin in healthy subjects. J Int Med Res, 2012; 40: 1688-1707.
    • (2012) J Int Med Res , vol.40 , pp. 1688-1707
    • Kubitza, D.1    Becka, M.2    Roth, A.3    Mueck, W.4
  • 57
    • 33947205635 scopus 로고    scopus 로고
    • Rivaroxaban (BAY 59-7939) - An oral, direct Factor Xa inhibitor - Has no clinically relevant interaction with naproxen
    • Kubitza D, Becka M, Mueck W, Zuehlsdorf M,. Rivaroxaban (BAY 59-7939)-an oral, direct Factor Xa inhibitor-has no clinically relevant interaction with naproxen. Br J Clin Pharmacol, 2007; 63: 469-476.
    • (2007) Br J Clin Pharmacol , vol.63 , pp. 469-476
    • Kubitza, D.1    Becka, M.2    Mueck, W.3    Zuehlsdorf, M.4
  • 58
    • 84859032875 scopus 로고    scopus 로고
    • Effect of co-administration of rivaroxaban and clopidogrel on bleeding time, pharmacodynamics and pharmacokinetics: A phase i study
    • Kubitza D, Becka M, Mueck W, Schwers S,. Effect of co-administration of rivaroxaban and clopidogrel on bleeding time, pharmacodynamics and pharmacokinetics: a phase I study. Pharmaceuticals (Basel), 2012; 5: 279-296.
    • (2012) Pharmaceuticals (Basel) , vol.5 , pp. 279-296
    • Kubitza, D.1    Becka, M.2    Mueck, W.3    Schwers, S.4
  • 59
    • 33747068794 scopus 로고    scopus 로고
    • Safety, tolerability, pharmacodynamics, and pharmacokinetics of rivaroxaban - An oral, direct Factor Xa inhibitor - Are not affected by aspirin
    • Kubitza D, Becka M, Mueck W, Zuehlsdorf M,. Safety, tolerability, pharmacodynamics, and pharmacokinetics of rivaroxaban-an oral, direct Factor Xa inhibitor-are not affected by aspirin. J Clin Pharmacol, 2006; 46: 981-990.
    • (2006) J Clin Pharmacol , vol.46 , pp. 981-990
    • Kubitza, D.1    Becka, M.2    Mueck, W.3    Zuehlsdorf, M.4
  • 60
    • 84892032701 scopus 로고    scopus 로고
    • Investigation of pharmacodynamic and pharmacokinetic interactions between rivaroxaban and enoxaparin in healthy male subjects
    • Kubitza D, Becka M, Schwers S, Voith B,. Investigation of pharmacodynamic and pharmacokinetic interactions between rivaroxaban and enoxaparin in healthy male subjects. Clin Pharmacol Drug Dev, 2013; 2: 270-277.
    • (2013) Clin Pharmacol Drug Dev , vol.2 , pp. 270-277
    • Kubitza, D.1    Becka, M.2    Schwers, S.3    Voith, B.4
  • 61
    • 84876996914 scopus 로고    scopus 로고
    • Effect of famotidine on the pharmacokinetics of apixaban, an oral direct Factor Xa inhibitor
    • Upreti VV, Song Y, Wang J, et al,. Effect of famotidine on the pharmacokinetics of apixaban, an oral direct Factor Xa inhibitor. Clin Pharmacol, 2013; 5: 59-66.
    • (2013) Clin Pharmacol , vol.5 , pp. 59-66
    • Upreti, V.V.1    Song, Y.2    Wang, J.3
  • 62
    • 70349306707 scopus 로고    scopus 로고
    • Dabigatran versus warfarin in patients with atrial fibrillation
    • Connolly SJ, Ezekowitz MD, Yusuf S, et al,. Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med, 2009; 361: 1139-1151.
    • (2009) N Engl J Med , vol.361 , pp. 1139-1151
    • Connolly, S.J.1    Ezekowitz, M.D.2    Yusuf, S.3
  • 63
    • 80052592404 scopus 로고    scopus 로고
    • Rivaroxaban versus warfarin in nonvalvular atrial fibrillation
    • Patel MR, Mahaffey KW, Garg J, et al,. Rivaroxaban versus warfarin in nonvalvular atrial fibrillation. N Engl J Med, 2011; 365: 883-891.
    • (2011) N Engl J Med , vol.365 , pp. 883-891
    • Patel, M.R.1    Mahaffey, K.W.2    Garg, J.3
  • 64
    • 80052825103 scopus 로고    scopus 로고
    • Apixaban versus warfarin in patients with atrial fibrillation
    • Granger CB, Alexander JH, McMurray JJ, et al,. Apixaban versus warfarin in patients with atrial fibrillation. N Engl J Med, 2011; 365: 981-992.
    • (2011) N Engl J Med , vol.365 , pp. 981-992
    • Granger, C.B.1    Alexander, J.H.2    McMurray, J.J.3
  • 65
    • 79952301326 scopus 로고    scopus 로고
    • Apixaban in patients with atrial fibrillation
    • Connolly SJ, Eikelboom J, Joyner C, et al,. Apixaban in patients with atrial fibrillation. N Engl J Med, 2011; 364: 806-817.
    • (2011) N Engl J Med , vol.364 , pp. 806-817
    • Connolly, S.J.1    Eikelboom, J.2    Joyner, C.3
  • 66
    • 84880370076 scopus 로고    scopus 로고
    • The long-term multicenter observational study of dabigatran treatment in patients with atrial fibrillation (RELY-ABLE) study
    • Connolly SJ, Wallentin L, Ezekowitz MD, et al,. The long-term multicenter observational study of dabigatran treatment in patients with atrial fibrillation (RELY-ABLE) study. Circulation, 2013; 128: 237-243.
    • (2013) Circulation , vol.128 , pp. 237-243
    • Connolly, S.J.1    Wallentin, L.2    Ezekowitz, M.D.3
  • 67
    • 84864379749 scopus 로고    scopus 로고
    • Rivaroxaban vs warfarin in Japanese patients with atrial fibrillation - The J-ROCKET AF study
    • Hori M, Matsumoto M, Tanahashi N, et al,. Rivaroxaban vs. warfarin in Japanese patients with atrial fibrillation-the J-ROCKET AF study. Circ J, 2012; 76: 2104-2111.
    • (2012) Circ J , vol.76 , pp. 2104-2111
    • Hori, M.1    Matsumoto, M.2    Tanahashi, N.3
  • 68
    • 84862907587 scopus 로고    scopus 로고
    • Rivaroxaban in patients with a recent acute coronary syndrome
    • Mega JL, Braunwald E, Wiviott SD, et al,. Rivaroxaban in patients with a recent acute coronary syndrome. N Engl J Med, 2012; 366: 9-19.
    • (2012) N Engl J Med , vol.366 , pp. 9-19
    • Mega, J.L.1    Braunwald, E.2    Wiviott, S.D.3
  • 69
    • 80052162121 scopus 로고    scopus 로고
    • Apixaban with antiplatelet therapy after acute coronary syndrome
    • Alexander JH, Lopes RD, James S, et al,. Apixaban with antiplatelet therapy after acute coronary syndrome. N Engl J Med, 2011; 365: 699-708.
    • (2011) N Engl J Med , vol.365 , pp. 699-708
    • Alexander, J.H.1    Lopes, R.D.2    James, S.3
  • 70
    • 78349242482 scopus 로고    scopus 로고
    • Regional anaesthesia and antithrombotic agents: Recommendations of the European Society of Anaesthesiology
    • Gogarten W, Vandermeulen E, Van Aken H, Kozek S, Llau JV, Samama CM,. Regional anaesthesia and antithrombotic agents: recommendations of the European Society of Anaesthesiology. Eur J Anaesthesiol, 2010; 27: 999-1015.
    • (2010) Eur J Anaesthesiol , vol.27 , pp. 999-1015
    • Gogarten, W.1    Vandermeulen, E.2    Van Aken, H.3    Kozek, S.4    Llau, J.V.5    Samama, C.M.6
  • 71
    • 82955195818 scopus 로고    scopus 로고
    • Surgery and invasive procedures in patients on long-term treatment with direct oral anticoagulants: Thrombin or Factor-Xa inhibitors. Recommendations of the Working Group on Perioperative Haemostasis and the French Study Group on Thrombosis and Haemostasis
    • Sié P, Samama CM, Godier A, et al,. Surgery and invasive procedures in patients on long-term treatment with direct oral anticoagulants: thrombin or Factor-Xa inhibitors. Recommendations of the Working Group on Perioperative Haemostasis and the French Study Group on Thrombosis and Haemostasis. Arch Cardiovasc Dis, 2011; 104: 669-676.
    • (2011) Arch Cardiovasc Dis , vol.104 , pp. 669-676
    • Sié, P.1    Samama, C.M.2    Godier, A.3
  • 72
    • 84859385808 scopus 로고    scopus 로고
    • Oral rivaroxaban for the treatment of symptomatic pulmonary embolism
    • The EINSTEIN-PE Investigators.
    • The EINSTEIN-PE Investigators. Oral rivaroxaban for the treatment of symptomatic pulmonary embolism. N Engl J Med, 2012; 366: 1287-1297.
    • (2012) N Engl J Med , vol.366 , pp. 1287-1297
  • 73
    • 79954534386 scopus 로고    scopus 로고
    • Laboratory assessment of new anticoagulants
    • Samama MM, Guinet C,. Laboratory assessment of new anticoagulants. Clin Chem Lab Med, 2011; 49: 761-772.
    • (2011) Clin Chem Lab Med , vol.49 , pp. 761-772
    • Samama, M.M.1    Guinet, C.2
  • 74
    • 33751275469 scopus 로고    scopus 로고
    • Hemostatic effect of activated factor VII without promotion of thrombus growth in melagatran-anticoagulated primates
    • Gruber A, Carlsson S, Kotze HF, Marzec U, Sarich TC, Hanson SR,. Hemostatic effect of activated factor VII without promotion of thrombus growth in melagatran-anticoagulated primates. Thromb Res, 2007; 119: 121-127.
    • (2007) Thromb Res , vol.119 , pp. 121-127
    • Gruber, A.1    Carlsson, S.2    Kotze, H.F.3    Marzec, U.4    Sarich, T.C.5    Hanson, S.R.6
  • 75
    • 84655176578 scopus 로고    scopus 로고
    • Evaluation of prothrombin complex concentrate and recombinant activated Factor VII to reverse rivaroxaban in a rabbit model
    • Godier A, Miclot A, Le Bonniec B, et al,. Evaluation of prothrombin complex concentrate and recombinant activated Factor VII to reverse rivaroxaban in a rabbit model. Anesthesiology, 2012; 116: 94-102.
    • (2012) Anesthesiology , vol.116 , pp. 94-102
    • Godier, A.1    Miclot, A.2    Le Bonniec, B.3
  • 76
    • 84865773023 scopus 로고    scopus 로고
    • Reversal of dabigatran anticoagulation by prothrombin complex concentrate (Beriplex P/N) in a rabbit model
    • Pragst I, Zeitler SH, Doerr B, et al,. Reversal of dabigatran anticoagulation by prothrombin complex concentrate (Beriplex P/N) in a rabbit model. J Thromb Haemost, 2012; 10: 1841-1848.
    • (2012) J Thromb Haemost , vol.10 , pp. 1841-1848
    • Pragst, I.1    Zeitler, S.H.2    Doerr, B.3
  • 77
    • 80053571188 scopus 로고    scopus 로고
    • Reversal of rivaroxaban and dabigatran by prothrombin complex concentrate: A randomized, placebo-controlled, crossover study in healthy subjects
    • Eerenberg ES, Kamphuisen PW, Sijpkens MK, Meijers JC, Buller HR, Levi M,. Reversal of rivaroxaban and dabigatran by prothrombin complex concentrate: a randomized, placebo-controlled, crossover study in healthy subjects. Circulation, 2011; 124: 1573-1579.
    • (2011) Circulation , vol.124 , pp. 1573-1579
    • Eerenberg, E.S.1    Kamphuisen, P.W.2    Sijpkens, M.K.3    Meijers, J.C.4    Buller, H.R.5    Levi, M.6
  • 78
    • 84864370719 scopus 로고    scopus 로고
    • Effect of non-specific reversal agents on anticoagulant activity of dabigatran and rivaroxaban. A randomised crossover ex vivo study in healthy volunteers
    • Marlu R, Hodaj E, Paris A, Albaladejo P, Crackowski JL, Pernod G,. Effect of non-specific reversal agents on anticoagulant activity of dabigatran and rivaroxaban. A randomised crossover ex vivo study in healthy volunteers. Thromb Haemost, 2012; 108: 217-224.
    • (2012) Thromb Haemost , vol.108 , pp. 217-224
    • Marlu, R.1    Hodaj, E.2    Paris, A.3    Albaladejo, P.4    Crackowski, J.L.5    Pernod, G.6
  • 79
    • 84870924316 scopus 로고    scopus 로고
    • Emergency management of bleeding associated with old and new oral anticoagulants
    • Peacock WF, Gearhart MM, Mills RM,. Emergency management of bleeding associated with old and new oral anticoagulants. Clin Cardiol, 2012; 35: 730-737.
    • (2012) Clin Cardiol , vol.35 , pp. 730-737
    • Peacock, W.F.1    Gearhart, M.M.2    Mills, R.M.3
  • 80
    • 84878460192 scopus 로고    scopus 로고
    • A specific antidote for reversal of anticoagulation by direct and indirect inhibitors of coagulation Factor Xa
    • Lu G, DeGuzman FR, Hollenbach SJ, et al,. A specific antidote for reversal of anticoagulation by direct and indirect inhibitors of coagulation Factor Xa. Nat Med, 2013; 19: 446-451.
    • (2013) Nat Med , vol.19 , pp. 446-451
    • Lu, G.1    Deguzman, F.R.2    Hollenbach, S.J.3
  • 81
    • 84879548455 scopus 로고    scopus 로고
    • A specific antidote for dabigatran: Functional and structural characterization
    • Schiele F, van Ryn J, Canada K, et al,. A specific antidote for dabigatran: functional and structural characterization. Blood, 2013; 121: 3554-3562.
    • (2013) Blood , vol.121 , pp. 3554-3562
    • Schiele, F.1    Van Ryn, J.2    Canada, K.3
  • 82
    • 41949116970 scopus 로고    scopus 로고
    • Clinical pharmacokinetics and pharmacodynamics of the oral direct thrombin inhibitor dabigatran etexilate
    • Stangier J,. Clinical pharmacokinetics and pharmacodynamics of the oral direct thrombin inhibitor dabigatran etexilate. Clin Pharmacokinet, 2008; 47: 285-295.
    • (2008) Clin Pharmacokinet , vol.47 , pp. 285-295
    • Stangier, J.1


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