Effect of extremes of body weight on the pharmacokinetics, pharmacodynamics, safety and tolerability of apixaban in healthy subjects

British Journal of Clinical Pharmacology

Volumn 76, Issue 6, 2013, Pages 908-916

  Upreti, Vijay V ^a   Wang, Jessie ^a   Barrett, Yu Chen ^a   Byon, Wonkyung ^b   Boyd, Rebecca A ^b   Pursley, Janice ^a   Lacreta, Frank P ^a   Frost, Charles E ^a  

^a BRISTOL MYERS SQUIBB   (United States)

^b PFIZER INC   (United States)

Author keywords

anticoagulation; apixaban; body weight; factor Xa inhibitor; pharmacodynamics; pharmacokinetics

Indexed keywords

APIXABAN; BLOOD CLOTTING FACTOR 10A;

ADULT; AREA UNDER THE CURVE; ARTICLE; BLEEDING; BODY WEIGHT; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG HALF LIFE; DRUG INDUCED HEADACHE; DRUG SAFETY; DRUG TOLERABILITY; EPISTAXIS; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; KIDNEY CLEARANCE; LIMIT OF QUANTITATION; MALE; MAXIMUM PLASMA CONCENTRATION; NAUSEA; NORMAL HUMAN; PRIORITY JOURNAL; SINGLE DRUG DOSE; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION; UPPER ABDOMINAL PAIN; URINALYSIS; VITAL SIGN;

ANTICOAGULATION; APIXABAN; BODY WEIGHT; FACTOR XA INHIBITOR; PHARMACODYNAMICS; PHARMACOKINETICS;

ADMINISTRATION, ORAL; ADOLESCENT; ADULT; ANTICOAGULANTS; AREA UNDER CURVE; BODY MASS INDEX; DOSE-RESPONSE RELATIONSHIP, DRUG; FACTOR XA; FEMALE; HEALTHY VOLUNTEERS; HUMANS; IDEAL BODY WEIGHT; MALE; MIDDLE AGED; OVERWEIGHT; PYRAZOLES; PYRIDONES; THINNESS; THROMBOSIS; YOUNG ADULT;

EID: 84878921385     PISSN: 03065251     EISSN: 13652125     Source Type: Journal    
DOI: 10.1111/bcp.12114     Document Type: Article

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