-
1
-
-
24944536065
-
Discovery of the novel antithrombotic agent 5-chloro-N-([(5S)-2-oxo-3-[4- (3-oxomorpholin-4-yl) phenyl]-1,3-oxazolidin-5-yl]methyl)thiophene-2-carboxamide (BAY 59-7939): An oral, direct Factor Xa inhibitor
-
Roehrig S, Straub A, Pohlmann J, et al. Discovery of the novel antithrombotic agent 5-chloro-N-([(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl) phenyl]-1,3-oxazolidin-5-yl]methyl)thiophene-2-carboxamide (BAY 59-7939): an oral, direct Factor Xa inhibitor. J Med Chem. 2005;48:5900-5908.
-
(2005)
J Med Chem
, vol.48
, pp. 5900-5908
-
-
Roehrig, S.1
Straub, A.2
Pohlmann, J.3
-
2
-
-
33748779231
-
Effect of BAY 59-7939 a novel, oral, direct Factor Xa inhibitor on clot-bound Factor Xa activity in vitro
-
Abstract P1104
-
Depasse F, Busson J, Mnich J, et al. Effect of BAY 59-7939 a novel, oral, direct Factor Xa inhibitor on clot-bound Factor Xa activity in vitro. J Thromb Haemost. 2005;3(Suppl 1). Abstract P1104.
-
(2005)
J Thromb Haemost
, vol.3
, Issue.SUPPL. 1
-
-
Depasse, F.1
Busson, J.2
Mnich, J.3
-
3
-
-
22844442726
-
In vitro and in vivo studies of the novel antithrombotic agent BAY 59-7939 an oral, direct Factor Xa inhibitor
-
Perzborn E, Strassburger J, Wilmen A, et al. In vitro and in vivo studies of the novel antithrombotic agent BAY 59-7939 an oral, direct Factor Xa inhibitor. J Thromb Haemost. 2005;3:514-521.
-
(2005)
J Thromb Haemost
, vol.3
, pp. 514-521
-
-
Perzborn, E.1
Strassburger, J.2
Wilmen, A.3
-
4
-
-
78650301534
-
-
Xarelto® Summary of Product Characteristics Accessed February 15, 2010
-
Bayer Schering Pharma. Xarelto® Summary of Product Characteristics. 2009. Available at: www.xarelto.com/html/downloads/Xarelto-Summary-of- Product-Characteristics-May2009.pdf Accessed February 15, 2010.
-
(2009)
Bayer Schering Pharma
-
-
-
5
-
-
34250166525
-
Population model of the pharmacokinetics and pharmacodynamics of rivaroxaban an oral, direct Factor Xa inhibitor in healthy subjects
-
Mueck W, Becka M, Kubitza D, et al. Population model of the pharmacokinetics and pharmacodynamics of rivaroxaban an oral, direct Factor Xa inhibitor in healthy subjects. Int J Clin Pharmacol Ther. 2007;45:335-344.
-
(2007)
Int J Clin Pharmacol Ther
, vol.45
, pp. 335-344
-
-
Mueck, W.1
Becka, M.2
Kubitza, D.3
-
6
-
-
42949123582
-
Population pharmacokinetics and pharmacodynamics of rivaroxaban an oral, direct factor Xa inhibitor in patients undergoing major orthopaedic surgery
-
Mueck W, Eriksson BI, Bauer KA, et al. Population pharmacokinetics and pharmacodynamics of rivaroxaban an oral, direct factor Xa inhibitor in patients undergoing major orthopaedic surgery. Clin Pharmacokinet. 2008;47:203-216.
-
(2008)
Clin Pharmacokinet
, vol.47
, pp. 203-216
-
-
Mueck, W.1
Eriksson, B.I.2
Bauer, K.A.3
-
8
-
-
33748590510
-
Emerging anticoagulants for the treatment of venous thromboembolism
-
Weitz JI. Emerging anticoagulants for the treatment of venous thromboembolism. Thromb Haemost. 2006;96:274-284.
-
(2006)
Thromb Haemost
, vol.96
, pp. 274-284
-
-
Weitz, J.I.1
-
9
-
-
34548031359
-
The pharmacokinetics, pharmacodynamics and tolerability of dabigatran etexilate, a new oral direct thrombin inhibitor, in healthy male subjects
-
Stangier J, Rathgen K, Stahle H, et al. The pharmacokinetics, pharmacodynamics and tolerability of dabigatran etexilate, a new oral direct thrombin inhibitor, in healthy male subjects. Br J Clin Pharmacol. 2007;64:292-303.
-
(2007)
Br J Clin Pharmacol
, vol.64
, pp. 292-303
-
-
Stangier, J.1
Rathgen, K.2
Stahle, H.3
-
10
-
-
57449094606
-
Comparative pharmacodynamics and pharmacokinetics of oral direct thrombin and factor Xa inhibitors in development
-
Eriksson BI, Quinlan DJ, Weitz JI. Comparative pharmacodynamics and pharmacokinetics of oral direct thrombin and factor Xa inhibitors in development. Clin Pharmacokinet. 2009;48:1-22.
-
(2009)
Clin Pharmacokinet
, vol.48
, pp. 1-22
-
-
Eriksson, B.I.1
Quinlan, D.J.2
Weitz, J.I.3
-
11
-
-
58149401862
-
Apixaban, an oral direct Factor Xa inhibitor: Awaiting the verdict
-
Carreiro J, Ansell J. Apixaban, an oral direct Factor Xa inhibitor: awaiting the verdict. Expert Opin Investig Drugs. 2008;17:1937-1945.
-
(2008)
Expert Opin Investig Drugs
, vol.17
, pp. 1937-1945
-
-
Carreiro, J.1
Ansell, J.2
-
12
-
-
42149159619
-
Apixaban, an oral direct Factor Xa inhibitor: Single-dose safety, pharmacokinetics and pharmacodynamics in healthy volunteers
-
Abstract P-M-665
-
Frost C, Yu Z, Nepal S, et al. Apixaban, an oral direct Factor Xa inhibitor: single-dose safety, pharmacokinetics and pharmacodynamics in healthy volunteers. J Thromb Haemost. 2007;5(Suppl 1). Abstract P-M-665.
-
(2007)
J Thromb Haemost
, vol.5
, Issue.SUPPL. 1
-
-
Frost, C.1
Yu, Z.2
Nepal, S.3
-
13
-
-
78650301810
-
Effects of the novel, oral, direct Factor Xa inhibitor rivaroxaban on coagulation assays
-
Abstract 3028
-
Samama MM, Le Flem L, Guinet C, et al. Effects of the novel, oral, direct Factor Xa inhibitor rivaroxaban on coagulation assays. Blood. 2008;112: Abstract 3028.
-
(2008)
Blood
, vol.112
-
-
Samama, M.M.1
Le Flem, L.2
Guinet, C.3
-
16
-
-
34347359499
-
How to interpret and pursue an abnormal prothrombin time, activated partial thromboplastin time, and bleeding time in adults
-
Kamal AH, Tefferi A, Pruthi RK. How to interpret and pursue an abnormal prothrombin time, activated partial thromboplastin time, and bleeding time in adults. Mayo Clin Proc. 2007;82:864-873.
-
(2007)
Mayo Clin Proc
, vol.82
, pp. 864-873
-
-
Kamal, A.H.1
Tefferi, A.2
Pruthi, R.K.3
-
17
-
-
0014752852
-
Standardization of laboratory tests for controlling anticoagulant therapy
-
Zucker S, Cathey MH, Sox PJ, et al. Standardization of laboratory tests for controlling anticoagulant therapy. Am J Clin Pathol. 1970;53:348-354.
-
(1970)
Am J Clin Pathol
, vol.53
, pp. 348-354
-
-
Zucker, S.1
Cathey, M.H.2
Sox, P.J.3
-
18
-
-
9444290325
-
International normalized ratios (INR): The first 20 years
-
Poller L. International normalized ratios (INR): the first 20 years. J Thromb Haemost. 2004;2:849-860.
-
(2004)
J Thromb Haemost
, vol.2
, pp. 849-860
-
-
Poller, L.1
-
19
-
-
45949103309
-
Pharmacology and management of the vitamin K antagonists: American College of Chest Physicians evidence-based clinical practice guidelines
-
8th Edition
-
Ansell J, Hirsh J, Hylek E, et al. Pharmacology and management of the vitamin K antagonists: American College of Chest Physicians evidence-based clinical practice guidelines (8th Edition). Chest. 2008;133: 160S-198S.
-
(2008)
Chest
, vol.133
-
-
Ansell, J.1
Hirsh, J.2
Hylek, E.3
-
20
-
-
51349095537
-
Population pharmacokinetics and pharmacodynamics of once- and twice-daily rivaroxaban for the prevention of venous thromboembolism in patients undergoing total hip replacement
-
Mueck W, Borris LC, Dahl OE, et al. Population pharmacokinetics and pharmacodynamics of once- and twice-daily rivaroxaban for the prevention of venous thromboembolism in patients undergoing total hip replacement. Thromb Haemost. 2008;100:453-461.
-
(2008)
Thromb Haemost
, vol.100
, pp. 453-461
-
-
Mueck, W.1
Borris, L.C.2
Dahl, O.E.3
-
21
-
-
42649097261
-
ReleVance of clotting tests in liver disease
-
Thachil J. ReleVance of clotting tests in liver disease. Postgrad Med J. 2008;84:177-181.
-
(2008)
Postgrad Med J
, vol.84
, pp. 177-181
-
-
Thachil, J.1
-
22
-
-
0031030245
-
Haemostatic abnormalities in lung cancer: Prognostic implications
-
Buccheri G, Ferrigno D, Ginardi C, et al. Haemostatic abnormalities in lung cancer: prognostic implications. Eur J Cancer. 1997;33:50-55.
-
(1997)
Eur J Cancer
, vol.33
, pp. 50-55
-
-
Buccheri, G.1
Ferrigno, D.2
Ginardi, C.3
-
23
-
-
0034930680
-
Increased warfarin sensitivity as an early manifestation of occult prostate cancer with chronic disseminated intravascular coagulation
-
Munter G, Hershko C. Increased warfarin sensitivity as an early manifestation of occult prostate cancer with chronic disseminated intravascular coagulation. Acta Haematol. 2001;105:97-99.
-
(2001)
Acta Haematol
, vol.105
, pp. 97-99
-
-
Munter, G.1
Hershko, C.2
-
24
-
-
49749150983
-
Delta neutrophil index in automated immature granulocyte counts for assessing disease severity of patients with sepsis
-
Nahm CH, Choi JW, Lee J. Delta neutrophil index in automated immature granulocyte counts for assessing disease severity of patients with sepsis. Ann Clin Lab Sci. 2008;38:241-246.
-
(2008)
Ann Clin Lab Sci
, vol.38
, pp. 241-246
-
-
Nahm, C.H.1
Choi, J.W.2
Lee, J.3
-
26
-
-
0034306569
-
Hirudin determination in plasma can be strongly influenced by the prothrombin level
-
Lindhoff-Last E, Piechottka GP, Rabe F, et al. Hirudin determination in plasma can be strongly influenced by the prothrombin level. Thromb Res. 2000;100:55-60.
-
(2000)
Thromb Res
, vol.100
, pp. 55-60
-
-
Lindhoff-Last, E.1
Piechottka, G.P.2
Rabe, F.3
-
27
-
-
25844525489
-
Safety, pharmacodynamics, and pharmacokinetics of single doses of BAY 59-7939, an oral, direct factor Xa inhibitor
-
Kubitza D, Becka M, Voith B, et al. Safety, pharmacodynamics, and pharmacokinetics of single doses of BAY 59-7939, an oral, direct factor Xa inhibitor. Clin Pharmacol Ther. 2005;78:412-421.
-
(2005)
Clin Pharmacol Ther
, vol.78
, pp. 412-421
-
-
Kubitza, D.1
Becka, M.2
Voith, B.3
-
28
-
-
29144518504
-
Safety, pharmacodynamics, and pharmacokinetics of BAY 59-7939 an oral, direct Factor Xa inhibitor after multiple dosing in healthy male subjects
-
Kubitza D, Becka M, Wensing G, et al. Safety, pharmacodynamics, and pharmacokinetics of BAY 59-7939 an oral, direct Factor Xa inhibitor after multiple dosing in healthy male subjects. Eur J Clin Pharmacol. 2005;61:873-880.
-
(2005)
Eur J Clin Pharmacol
, vol.61
, pp. 873-880
-
-
Kubitza, D.1
Becka, M.2
Wensing, G.3
-
29
-
-
78650279356
-
Evaluation of rivaroxaban calibrators and controls and the prothrombin time for measuring rivaroxaban plasma concentrations
-
Abstract P17-21
-
Samama M, Martinoli JL, Perzborn E, et al. Evaluation of rivaroxaban calibrators and controls and the prothrombin time for measuring rivaroxaban plasma concentrations. Haemostaseologie. 2010;30:A114: Abstract P17-21.
-
(2010)
Haemostaseologie
, vol.30
-
-
Samama, M.1
Martinoli, J.L.2
Perzborn, E.3
-
30
-
-
77949915096
-
Effects of rivaroxaban, a novel, oral direct Factor Xa inhibitor, on coagulation assays
-
Samama MM, Flem LL, Guinet C, et al. Effects of rivaroxaban, a novel, oral direct Factor Xa inhibitor, on coagulation assays. Br J Haematol. 2009;145(Suppl 1):35-36.
-
(2009)
Br J Haematol
, vol.145
, Issue.SUPPL. 1
, pp. 35-36
-
-
Samama, M.M.1
Flem, L.L.2
Guinet, C.3
-
31
-
-
77955981378
-
Thromboplastin composition affects the sensitivity of prothrombin time (PT) clotting tests to direct Factor Xa inhibitors
-
Abstract 928
-
Smith SA, Morrissey JH. Thromboplastin composition affects the sensitivity of prothrombin time (PT) clotting tests to direct Factor Xa inhibitors. Blood. 2007;110:Abstract 928.
-
(2007)
Blood
, vol.110
-
-
Smith, S.A.1
Morrissey, J.H.2
-
33
-
-
6344254762
-
Anti-Xa and anti-IIa drugs alter international normalized ratio measurements: Potential problems in the monitoring of oral anticoagulants
-
Tobu M, Iqbal O, Hoppensteadt D, et al. Anti-Xa and anti-IIa drugs alter international normalized ratio measurements: potential problems in the monitoring of oral anticoagulants. Clin Appl Thromb Hemost. 2004;10: 301-309.
-
(2004)
Clin Appl Thromb Hemost
, vol.10
, pp. 301-309
-
-
Tobu, M.1
Iqbal, O.2
Hoppensteadt, D.3
-
34
-
-
0020456713
-
An alternative extrinsic pathway of human blood coagulation
-
Marlar RA, Kleiss AJ, Griffin JH. An alternative extrinsic pathway of human blood coagulation. Blood. 1982;60:1353-1358.
-
(1982)
Blood
, vol.60
, pp. 1353-1358
-
-
Marlar, R.A.1
Kleiss, A.J.2
Griffin, J.H.3
-
35
-
-
77952044405
-
Assessment of laboratory assays to measure rivaroxaban an oral, direct factor Xa inhibitor
-
Samama MM, Martinoli JL, Leflem L, et al. Assessment of laboratory assays to measure rivaroxaban an oral, direct factor Xa inhibitor. Thromb Haemost. 2010;103:815-825.
-
(2010)
Thromb Haemost
, vol.103
, pp. 815-825
-
-
Samama, M.M.1
Martinoli, J.L.2
Leflem, L.3
-
37
-
-
33750599861
-
Effect of fondaparinux on coagulation assays: Results of College of American Pathologists proficiency testing
-
Smogorzewska A, Brandt JT, Chandler WL, et al. Effect of fondaparinux on coagulation assays: results of College of American Pathologists proficiency testing. Arch Pathol Lab Med. 2006;130:1605-1611.
-
(2006)
Arch Pathol Lab Med
, vol.130
, pp. 1605-1611
-
-
Smogorzewska, A.1
Brandt, J.T.2
Chandler, W.L.3
-
38
-
-
78650263004
-
Effects of rivaroxaban, a novel, oral, direct Factor Xa inhibitor, on coagulation assays
-
Samama MM, Le Flem L, Guinet C, et al. Effects of rivaroxaban, a novel, oral, direct Factor Xa inhibitor, on coagulation assays. J Thromb Haemost. 2009;7:693.
-
(2009)
J Thromb Haemost
, vol.7
, pp. 693
-
-
Samama, M.M.1
Le Flem, L.2
Guinet, C.3
-
39
-
-
78650273901
-
Effect of the novel, oral, direct Factor Xa inhibitor rivaroxaban on coagulation assays
-
Abstract 0439
-
Samama MM, Le Flem L, Guinet C, et al. Effect of the novel, oral, direct Factor Xa inhibitor rivaroxaban on coagulation assays. Haematologica. 2009;94:Abstract 0439.
-
(2009)
Haematologica
, vol.94
-
-
Samama, M.M.1
Le Flem, L.2
Guinet, C.3
-
40
-
-
55549103684
-
Monitoring direct FXa-inhibitors and fondaparinux by prothrombinase- induced clotting time (PiCT): Relation to FXa-activity and influence of assay modifications
-
Harder S, Parisius J, Picard-Willems B. Monitoring direct FXa-inhibitors and fondaparinux by prothrombinase-induced clotting time (PiCT): relation to FXa-activity and influence of assay modifications. Thromb Res. 2008;123:396-403.
-
(2008)
Thromb Res
, vol.123
, pp. 396-403
-
-
Harder, S.1
Parisius, J.2
Picard-Willems, B.3
-
41
-
-
34247474025
-
Monitoring effects of direct FXa-inhibitors with a new one-step prothrombinase-induced clotting time (PiCT) assay: Comparative in vitro investigation with heparin, enoxaparin, fondaparinux and DX 9065a
-
Graff J, Picard-Willems B, Harder S. Monitoring effects of direct FXa-inhibitors with a new one-step prothrombinase-induced clotting time (PiCT) assay: comparative in vitro investigation with heparin, enoxaparin, fondaparinux and DX 9065a. Int J Clin Pharmacol Ther. 2007;45: 237-243.
-
(2007)
Int J Clin Pharmacol Ther
, vol.45
, pp. 237-243
-
-
Graff, J.1
Picard-Willems, B.2
Harder, S.3
-
42
-
-
35448932027
-
Effects of the oral, direct Factor Xa inhibitor rivaroxaban on platelet-induced thrombin generation and prothrombinase activity
-
Graff J, von Hentig N, Misselwitz F, et al. Effects of the oral, direct Factor Xa inhibitor rivaroxaban on platelet-induced thrombin generation and prothrombinase activity. J Clin Pharmacol. 2007;47:1398-1407.
-
(2007)
J Clin Pharmacol
, vol.47
, pp. 1398-1407
-
-
Graff, J.1
Von Hentig, N.2
Misselwitz, F.3
-
43
-
-
58149084459
-
Standardization and clinical utility of thrombin-generation assays
-
Berntorp E, Salvagno GL. Standardization and clinical utility of thrombin-generation assays. Semin Thromb Hemost. 2008;34:670-682.
-
(2008)
Semin Thromb Hemost
, vol.34
, pp. 670-682
-
-
Berntorp, E.1
Salvagno, G.L.2
-
44
-
-
50049135947
-
Thrombin generation testing in routine clinical practice are we there yet?
-
Van Veen JJ, Gatt A, Makris M. Thrombin generation testing in routine clinical practice: are we there yet? Br J Haematol. 2008;142:889-903.
-
(2008)
Br J Haematol
, vol.142
, pp. 889-903
-
-
Van Veen, J.J.1
Gatt, A.2
Makris, M.3
-
45
-
-
34147147085
-
In vitro inhibition of thrombin generation, after tissue factor pathway activation, by the oral, direct Factor Xa inhibitor rivaroxaban
-
Gerotziafas GT, Elalamy I, Depasse F, et al. In vitro inhibition of thrombin generation, after tissue factor pathway activation, by the oral, direct Factor Xa inhibitor rivaroxaban. J Thromb Haemost. 2007;5:886-888.
-
(2007)
J Thromb Haemost
, vol.5
, pp. 886-888
-
-
Gerotziafas, G.T.1
Elalamy, I.2
Depasse, F.3
-
46
-
-
33748140686
-
Development and clinical evaluation of two chromogenic substrate methods for monitoring fondaparinux sodium
-
Klaeffling C, Piechottka G, Daemgen-von Brevern G, et al. Development and clinical evaluation of two chromogenic substrate methods for monitoring fondaparinux sodium. Ther Drug Monit. 2006;28:375-381.
-
(2006)
Ther Drug Monit
, vol.28
, pp. 375-381
-
-
Klaeffling, C.1
Piechottka, G.2
Daemgen-Von Brevern, G.3
-
47
-
-
77958005924
-
Assessment of Factor Xa chromogenic assays for measuring the pharmacodynamics of rivaroxaban an oral, direct Factor Xa inhibitor
-
Abstract PP-MO-185
-
Perzborn E, Harwardt M, Samama M. Assessment of Factor Xa chromogenic assays for measuring the pharmacodynamics of rivaroxaban an oral, direct Factor Xa inhibitor. J Thromb Haemost. 2009;7(Suppl 2):379. Abstract PP-MO-185.
-
(2009)
J Thromb Haemost
, vol.7
, Issue.SUPPL. 2
, pp. 379
-
-
Perzborn, E.1
Harwardt, M.2
Samama, M.3
-
48
-
-
78650271219
-
Monitoring of rivaroxaban: Suitability of a well-established chromogenic anti-Factor Xa assay
-
Abstract PP-MO-162
-
Karst A, Bakowski-Enzian B, Perzborn E. Monitoring of rivaroxaban: suitability of a well-established chromogenic anti-Factor Xa assay. J Thromb Haemost. 2009;7(Suppl 2):372. Abstract PP-MO-162.
-
(2009)
J Thromb Haemost
, vol.7
, Issue.SUPPL. 2
, pp. 372
-
-
Karst, A.1
Bakowski-Enzian, B.2
Perzborn, E.3
-
49
-
-
78650257030
-
Suitability of chromogenic anti-FXa methods to measure rivaroxaban in human plasma
-
Abstract PP-WE-199
-
Samama MM, Le Flem L, Guinet C, et al. Suitability of chromogenic anti-FXa methods to measure rivaroxaban in human plasma. J Thromb Haemost. 2009;7(Suppl 2):693. Abstract PP-WE-199.
-
(2009)
J Thromb Haemost
, vol.7
, Issue.SUPPL. 2
, pp. 693
-
-
Samama, M.M.1
Le Flem, L.2
Guinet, C.3
-
50
-
-
78650258905
-
Specific and rapid measurement of rivaroxaban in plasma using a new, dedicated chromogenic assay
-
Abstract P01-17
-
Samama M, Amiral J, Guinet C, et al. Specific and rapid measurement of rivaroxaban in plasma using a new, dedicated chromogenic assay. Haemostaseologie. 2010;30:A37:Abstract P01-17.
-
(2010)
Haemostaseologie
, vol.30
-
-
Samama, M.1
Amiral, J.2
Guinet, C.3
-
52
-
-
49849103069
-
Determination of rivaroxaban a novel, oral, direct Factor Xa inhibitor in human plasma by high-performance liquid chromatogra-phy-tandem mass spectrometry
-
Rohde G. Determination of rivaroxaban a novel, oral, direct Factor Xa inhibitor in human plasma by high-performance liquid chromatogra-phy-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2008;872:43-50.
-
(2008)
J Chromatogr B Analyt Technol Biomed Life Sci
, vol.872
, pp. 43-50
-
-
Rohde, G.1
|