Cigarette smoke activates the proto-oncogene c-Src to promote airway inflammation and lung tissue destruction

American Journal of Respiratory Cell and Molecular Biology

Volumn 50, Issue 3, 2014, Pages 559-570

  Geraghty, Patrick ^a   Hardigan, Andrew ^a   Foronjy, Robert F ^a  

^a ST LUKE S ROOSEVELT HOSPITAL CENTER   (United States)

Author keywords

Cell signaling; Epithelial; Inflammation; Kinase; Phosphorylation

Indexed keywords

CATHEPSIN K; CIGARETTE SMOKE; EPIDERMAL GROWTH FACTOR RECEPTOR; GELATINASE B; INTERLEUKIN 17; MACROPHAGE ELASTASE; MITOGEN ACTIVATED PROTEIN KINASE; MONOCYTE CHEMOTACTIC PROTEIN 1; PROTEIN KINASE C ALPHA; SARACATINIB; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONTROLLED STUDY; GENE ACTIVATION; GENE ACTIVITY; HUMAN; HUMAN CELL; LUNG ALVEOLUS MACROPHAGE; LUNG INJURY; MOUSE; NONHUMAN; ONCOGENE SRC; PATHOGENESIS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RESPIRATORY TRACT INFLAMMATION; SIGNAL TRANSDUCTION;

ANIMALS; CASE-CONTROL STUDIES; CELLS, CULTURED; CYTOKINES; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; EPITHELIAL CELLS; HUMANS; INFLAMMATION MEDIATORS; LUNG; MACROPHAGES; MICE; MICE, INBRED C57BL; MITOGEN-ACTIVATED PROTEIN KINASES; MONOCYTES; NEUTROPHILS; PHOSPHORYLATION; PNEUMONIA; PROTEIN KINASE C-ALPHA; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-RAF; PROTO-ONCOGENE PROTEINS PP60(C-SRC); PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RECEPTOR, EPIDERMAL GROWTH FACTOR; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SMOKE; SMOKING; TIME FACTORS; TRANSFECTION;

EID: 84895540993     PISSN: 10441549     EISSN: 15354989     Source Type: Journal    
DOI: 10.1165/rcmb.2013-0258OC     Document Type: Article

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