Simvastatin induces osteogenic differentiation in human amniotic fluid mesenchymal stem cells (AFMSC)

Fundamental and Clinical Pharmacology

Volumn 28, Issue 2, 2014, Pages 211-216

  de Lara Janz, Felipe ^a,b   Favero, Giovani Marino ^c   Bohatch, Milton Sérgio ^c   Aguiar Debes, Adrianade ^d   Bydlowski, Sergio Paulo ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b Universidade Bandeirante de Sao Paulo   (Brazil)

^c STATE UNIVERSITY OF PONTA GROSSA   (Brazil)

^d FUNDAÇÃO PRÓ SANGUE HEMOCENTRO DE SÃO PAULO   (Brazil)

Author keywords

Amniotic stem cell; Osteogenic differentiation; Simvastatin

Indexed keywords

ALIZARIN RED S; OSTEOCALCIN; OSTEOPONTIN; SIMVASTATIN;

AMNION FLUID; ARTICLE; BONE DEVELOPMENT; CALCIFICATION; CELL DIFFERENTIATION; CELL STRUCTURE; CONTROLLED STUDY; DRUG EFFECT; GENE EXPRESSION; HUMAN; HUMAN CELL; MESENCHYMAL STEM CELL; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION;

AMNIOTIC STEM CELL; OSTEOGENIC DIFFERENTIATION; SIMVASTATIN;

AMNIOTIC FLUID; CALCIUM; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; CELLS, CULTURED; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MESENCHYMAL STROMAL CELLS; OSTEOCALCIN; OSTEOPONTIN; SIMVASTATIN;

EID: 84895538073     PISSN: 07673981     EISSN: 14728206     Source Type: Journal    
DOI: 10.1111/fcp.12006     Document Type: Article

References (23)

1. Siegel N., Rosner M., Hanneder M., Freilinger A., Hengstschlager M. Human amniotic fluid stem cells: a new perspective. Amino Acids (2008) 35 291-293.
2. Delo D.M., De Coppi P., Bartsch G. Jr, Atala A. Amniotic fluid and placental stem cells. Methods Enzymol. (2006) 419 426-438.
3. De Coppi P., Bartsch G. Jr, Siddiqui M.M. et al. Isolation of amniotic stem cell lines with potential for therapy. Nat. Biotechnol. (2007) 25 100-106.
4. Cremer M., Schachner M., Cremer T., Schmidt W., Voigtlander T. Demonstration of astrocytes in cultured amniotic fluid cells of three cases with neural-tube defect. Hum. Genet. (1981) 56 365-370.
5. In 't Anker P.S., Scherjon S.A., Kleijburg-van der Keur C. et al. Amniotic fluid as a novel source of mesenchymal stem cells for therapeutic transplantation. Blood (2003) 102 1548-1549.
6. Kim J., Lee Y., Kim H. et al. Human amniotic fluid-derived stem cells have characteristics of multipotent stem cells. Cell Prolif. (2007) 40 75-90.
7. Peister A., Deutsch E.R., Kolambkar Y., Hutmacher D.W., Guldberg R. Amniotic Fluid Stem Cells Produce Robust Mineral Deposits on Biodegradable Scaffolds. Tissue Eng. Part A, (2009) 15 3129-3138.
8. Prusa A.R., Marton E., Rosner M. et al. Neurogenic cells in human amniotic fluid. Am. J. Obstet. Gynecol. (2004) 191 309-314.
9. Tsai M.S., Lee J.L., Chang Y.J., Hwang S.M. Isolation of human multipotent mesenchymal stem cells from second-trimester amniotic fluid using a novel two-stage culture protocol. Hum. Reprod. (2004) 19 1450-1456.
10. Qiao L.J., Kang K.L., Heo J.S. Simvastatin promotes osteogenic differentiation of mouse embryonic stem cells via canonical Wnt/β-catenin signaling. Mol. Cells (2011) 32 437-444.
11. Pagkalos J., Cha J.M., Kang Y., Heliotis M., Tsiridis E., Mantalaris A. Simvastatin induces osteogenic differentiation of murine embryonic stem cells. J. Bone Miner. Res. (2010) 25 2470-2478.
12. Lee S.Y., Min K.S., Choi G.W. et al. Effects of simvastain and enamel matrix derivative on Portland cement with bismuth oxide-induced growth and odontoblastic differentiation in human dental pulp cells. J Endod. (2012) 38 405-410.
13. Baek K.H., Lee W.Y., Oh K.W. et al. The effect of simvastatin on the proliferation and differentiation of human bone marrow stromal cells. J. Korean Med. Sci. (2005) 20 438-444.
14. Mundy G., Garrett R., Harris S. et al. Stimulation of bone formation in vitro and in rodents by statins. Science (1999) 286 1946-1949.
15. Garrett I.R., Mundy G.R. The role of statins as potential targets for bone formation. Arthritis Res. (2002) 4 237-240.
16. Prusa A.R., Marton E., Rosner M., Bernaschek G., Hengstschlager M. Oct-4-expressing cells in human amniotic fluid: a new source for stem cell research? Hum. Reprod. (2003) 18 1489-1493.
17. Lanza R., Gearhart J., Hogan B., Thomson J.A., Melton D. Essentials of stem cell Biology, 1st edn, Elsevier Science & Tecnology Books, San Diego, CA, 2006.
18. Polgar K., Adany R., Abel G., Kappelmayer J., Muszbek L., Papp Z. Characterization of rapidly adhering amniotic fluid cells by combined immunofluorescence and phagocytosis assays. Am. J. Hum. Genet. (1989) 45 786-792.
19. Cho C.K., Shan S.J., Winsor E.J., Diamandis E.P. Proteomics analysis of human amniotic fluid. Mol. Cell. Proteomics (2007) 6 1406-1415.
20. Jaiswal N., Haynesworth S.E., Caplan A.I., Bruder S.P. Osteogenic differentiation of purified, culture-expanded human mesenchymal stem cells in vitro. J. Cell. Biochem. (1997) 64 295-312.
21. Mareschi K., Biasin E., Piacibello W., Aglietta M., Madon E., Fagioli F. Isolation of human mesenchymal stem cells: bone marrow versus umbilical cord blood. Haematologica (2001) 86 1099-1100.
22. Wexler S.A., Donaldson C., Denning-Kendall P., Rice C., Bradley B., Hows J.M. Adult bone marrow is a rich source of human mesenchymal 'stem' cells but umbilical cord and mobilized adult blood are not. Br. J. Haematol. (2003) 121 368-374.
23. Xiao Y., Peperzak V., van Rijn L., Borst J., de Bruijn J.D. Dexamethasone treatment during the expansion phase maintains stemness of bone marrow mesenchymal stem cells. J Tissue Eng Regen Med. (2010) 4 374-386.