Endothelin receptor type B agonist, IRL-1620, prevents beta amyloid (Aβ) induced oxidative stress and cognitive impairment in normal and diabetic rats

Pharmacology Biochemistry and Behavior

Volumn 120, Issue , 2014, Pages 65-72

  Briyal, Seema ^a   Shepard, Cortney ^b   Gulati, Anil ^a  

^a MIDWESTERN UNIVERSITY   (United States)

^b MIDWESTERN UNIVERSITY   (United States)

Author keywords

Alzheimer's disease; Beta amyloid; Cognitive impairment; Endothelin; Oxidative stress

Indexed keywords

AMYLOID BETA PROTEIN[1-40]; GLUTATHIONE; MALONALDEHYDE; N (2,6 DIMETHYLPIPERIDINOCARBONYL) 4 METHYLLEUCYL DEXTRO (1 METHOXYCARBONYLTRYPTOPHANYL) DEXTRO NORLEUCINE; SODIUM CHLORIDE; STREPTOZOCIN; SUCCINYLENDOTHELIN 1 [8-21][9 GLUTAMIC ACID 11,15 ALANINE]; SUPEROXIDE DISMUTASE; AMYLOID BETA PROTEIN; ANTIOXIDANT; ENDOTHELIN; ENDOTHELIN B RECEPTOR; PEPTIDE FRAGMENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; CEREBROVASCULAR ACCIDENT; COGNITIVE DEFECT; CONTROLLED STUDY; DIABETES MELLITUS; DRUG EFFECT; LATERAL BRAIN VENTRICLE; LIPID PEROXIDATION; MALE; MORRIS WATER MAZE TEST; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; SPATIAL MEMORY; TREATMENT DURATION; AGONISTS; ANIMAL; ANTAGONISTS AND INHIBITORS; COGNITION DISORDERS; DRUG EFFECTS; EXPERIMENTAL DIABETES MELLITUS; MAZE TEST; METABOLISM; NON INSULIN DEPENDENT DIABETES MELLITUS; PSYCHOLOGY; SPRAGUE DAWLEY RAT; TOXICITY;

AMYLOID BETA-PEPTIDES; ANIMALS; ANTIOXIDANTS; COGNITION DISORDERS; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 2; ENDOTHELINS; LIPID PEROXIDATION; MALE; MAZE LEARNING; OXIDATIVE STRESS; PEPTIDE FRAGMENTS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, ENDOTHELIN B;

EID: 84895512179     PISSN: 00913057     EISSN: 18735177     Source Type: Journal    
DOI: 10.1016/j.pbb.2014.02.008     Document Type: Article

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