Repeated administration of ETB receptor agonist, IRL-1620, produces tachyphylaxis only to its hypotensive effect

Pharmacological Research

Volumn 60, Issue 5, 2009, Pages 402-410

  Leonard, Mary G ^a   Gulati, Anil ^a  

^a MIDWESTERN UNIVERSITY   (United States)

Author keywords

Blood flow; Endothelin (ET); IRL 1620; Mean arterial pressure; Tachyphylaxis

Indexed keywords

ENDOTHELIN A RECEPTOR AGONIST; ENDOTHELIN B RECEPTOR AGONIST; SUCCINYLENDOTHELIN 1 [8-21][9 GLUTAMIC ACID 11,15 ALANINE]; URETHAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE REGULATION; BRAIN BLOOD FLOW; CARDIOVASCULAR EFFECT; CLINICAL TRIAL; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG SELECTIVITY; HEART RATE; HUMAN; KIDNEY BLOOD FLOW; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PRIORITY JOURNAL; RAT; REPEATED DRUG DOSE; TACHYPHYLAXIS;

ANIMALS; ANTINEOPLASTIC AGENTS; BLOOD CIRCULATION; BLOOD PRESSURE; CEREBROVASCULAR CIRCULATION; ENDOTHELINS; HEART RATE; HYPOTENSION; MALE; PEPTIDE FRAGMENTS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, ENDOTHELIN B; RENAL CIRCULATION; TACHYPHYLAXIS;

EID: 69549110528     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2009.07.015     Document Type: Article

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