The fusion protein of CTP-HBcAg18-27-Tapasin mediates the apoptosis of CD8+ T cells and CD8+ T cell response in HLA-A2 transgenic mice

Hepatitis Monthly

Volumn 14, Issue 2, 2014, Pages

  Tang, Yu Yan ^a   Tang, Zheng Hao ^a   Zhang, Yi ^a   Zhuo, Meng ^a   Zang, Guo Qing ^a   Chen, Xiao Hua ^a   Yu, Yong Sheng ^a  

^a SHANGHAI JIAO TONG UNIVERSITY AFFILIATED SIXTH PEOPLE S HOSPITAL   (China)

Author keywords

Cytotoxic; Mice; PI3K Akt; T Lymphocytes; Tapasin; Transgenic

Indexed keywords

ACTIN; ALPHA INTERFERON; CTP HBCAG18 27 PROTEIN; CTP HBCAG18 27 TAPASIN; CYTOKINE; HBCAG18 27 PROTEIN; HBCAG18 27 TAPASIN; HLA A2 ANTIGEN; HYBRID PROTEIN; INTERLEUKIN 2; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; TAPASIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CD8+ T LYMPHOCYTE; CELL ISOLATION; CELL PROLIFERATION; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; IMMUNIZATION; MOUSE; NONHUMAN; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SPLEEN; SPLEEN CELL; TRANSGENIC MOUSE; UPREGULATION; WESTERN BLOTTING;

EID: 84895505125     PISSN: 1735143X     EISSN: 17353408     Source Type: Journal    
DOI: 10.5812/hepatmon.16161     Document Type: Article

References (31)

1. Ganem D, Prince AM. Hepatitis B virus infection--natural history and clinical consequences. N Engl J Med.2004;350(11):1118-29. [DOI] [PubMed]
2. Nebbia G, Peppa D, Maini MK. Hepatitis B infection: current concepts and future challenges. QJM.2012;105(2):109-13. [DOI] [PubMed]
3. Blackburn SD, Shin H, Haining WN, Zou T, Workman CJ, Polley A, Et al. Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection. Nat Immunol. 2009;10(1):29-37. [DOI] [PubMed]
4. Klenerman P, Hill A. T cells and viral persistence: lessons from diverse infections. Nat Immunol. 2005;6(9):873-9. [DOI] [PubMed]
5. Ou R, Zhang M, Huang L, Moskophidis D. Control of virus-specific CD8+ T-cell exhaustion and immune-mediated pathology by E3 ubiquitin ligase Cbl-b during chronic viral infection. J Virol. 2008;82(7):3353-68. [DOI] [PubMed]
6. Grayson JM, Weant AE, Holbrook BC, Hildeman D. Role of Bim in regulating CD8+ T-cell responses during chronic viral infection. J Virol. 2006;80(17):8627-38. [DOI] [PubMed]
7. Tinoco R, Alcalde V, Yang Y, Sauer K, Zuniga EI. Cell-intrinsic transforming growth factor-beta signaling mediates virus-specific CD8+ T cell deletion and viral persistence in vivo. Immunity. 2009;31(1):145-57. [DOI] [PubMed]
8. Wang X, Yan W, Lu Y, Chen T, Sun Y, Qin X, Et al. CD4-CD8-T cells contribute to the persistence of viral hepatitis by striking a delicate balance in immune modulation. Cell Immunol. 2012;280(1):76-84. [DOI] [PubMed]
9. Akbar SM, Chen S, Al-Mahtab M, Abe M, Hiasa Y, Onji M. Strong and multi-antigen specific immunity by hepatitis B core antigen (HBcAg)-based vaccines in a murine model of chronic hepatitis B: HBcAg is a candidate for a therapeutic vaccine against hepatitis B virus. Antiviral Res. 2012;96(1):59-64. [DOI] [PubMed]
10. Chen W, Shi M, Shi F, Mao Y, Tang Z, Zhang B, Et al. HBcAg-pulsed dendritic cell vaccine induces Th1 polarization and production of hepatitis B virus-specific cytotoxic T lymphocytes. Hepatol Res. 2009;39(4):355-65. [DOI] [PubMed]
11. Nanjundappa RH, Wang R, Xie Y, Umeshappa CS, Xiang J. Novel CD8+ T cell-based vaccine stimulates Gp120-specific CTL responses leading to therapeutic and long-term immunity in transgenic HLA-A2 mice. Vaccine.2012;30(24):3519-25. [DOI] [PubMed]
12. Purcell AW, Elliott T. Molecular machinations of the MHC-I peptide loading complex. Curr Opin Immunol.2008;20(1):75-81. [DOI] [PubMed]
13. Thirdborough SM, Roddick JS, Radcliffe JN, Howarth M, Stevenson FK, Elliott T. Tapasin shapes immunodominance hierarchies according to the kinetic stability of peptide-MHC class I complexes. Eur J Immunol. 2008;38(2):364-9. [DOI] [PubMed]
14. Boulanger DS, Oliveira R, Ayers L, Prior SH, James E, Williams AP, Et al. Absence of tapasin alters immunodominance against a lymphocytic choriomeningitis virus polytope. J Immunol. 2010;184(1):73-83. [DOI] [PubMed]
15. Chen X, Lai J, Pan Q, Tang Z, Yu Y, Zang G. The delivery of HBcAg via Tat-PTD enhances specific immune response and inhibits Hepatitis B virus replication in transgenic mice. Vaccine. 2010;28(23):3913-9. [DOI] [PubMed]
16. Chen X, Liu H, Tang Z, Yu Y, Zang G. The modification of Tapasin enhances cytotoxic T lymphocyte activity of intracellularly delivered CTL epitopes via cytoplasmic transduction peptide. Acta Biochim Biophys Sin (Shanghai).2013;45(3):203-12. [DOI] [PubMed]
17. Krachler AM, Woolery AR, Orth K. Manipulation of kinase signaling by bacterial pathogens. J Cell Biol.2011;195(7):1083-92. [DOI] [PubMed]
18. Sullivan JA, Kim EH, Plisch EH, Suresh M. FOXO3 regulates the CD8 T cell response to a chronic viral infection. J Virol. 2012;86(17):9025-34. [DOI] [PubMed]
19. Cai N, Dai SD, Liu NN, Liu LM, Zhao N, Chen L. PI3K/AKT/mTOR signaling pathway inhibitors in proliferation of retinal pigment epithelial cells. Int J Ophthalmol. 2012;5(6):675-80. [DOI] [PubMed]
20. Surviladze Z, Sterk RT, DeHaro SA, Ozbun MA. Cellular entry of human papillomavirus type 16 involves activation of the phosphatidylinositol 3-kinase/Akt/mTOR pathway and inhibition of autophagy. J Virol. 2013;87(5):2508-17. [DOI] [PubMed]
21. Harriague J, Bismuth G. Imaging antigen-induced PI3K activation in T cells. Nat Immunol. 2002;3(11):1090-6. [DOI] [PubMed]
22. Rubinstein MP, Lind NA, Purton JF, Filippou P, Best JA, McGhee PA, Et al. IL-7 and IL-15 differentially regulate CD8+ T-cell subsets during contraction of the immune response. Blood. 2008;112(9):3704-12. [DOI] [PubMed]
23. Virgin HW, Wherry EJ, Ahmed R. Redefining chronic viral infection. Cell. 2009;138(1):30-50. [DOI] [PubMed]
24. Stoop JN, van der Molen RG, Baan CC, van der Laan LJ, Kuipers EJ, Kusters JG, Et al. Regulatory T cells contribute to the impaired immune response in patients with chronic hepatitis B virus infection. Hepatology.2005;41(4):771-8. [DOI] [PubMed]
25. Woltman AM, Op den Brouw ML, Biesta PJ, Shi CC, Janssen HL. Hepatitis B virus lacks immune activating capacity, but actively inhibits plasmacytoid dendritic cell function. PLoS One. 2011;6(1):Eee15324 [DOI] [PubMed]
26. Tsai SL, Sheen IS, Chien RN, Chu CM, Huang HC, Chuang YL, Et al. Activation of Th1 immunity is a common immune mechanism for the successful treatment of hepatitis B and C: tetramer assay and therapeutic implications. J Biomed Sci. 2003;10(1):120-35. [DOI] [PubMed]
27. Chen M, Bouvier M. Analysis of interactions in a tapasin/class I complex provides a mechanism for peptide selection. EMBO J. 2007;26(6):1681-90. [DOI] [PubMed]
28. Chen HZ, Wu CP, Chao YC, Liu CY. Membrane penetrating peptides greatly enhance baculovirus transduction efficiency into mammalian cells. Biochem Biophys Res Commun. 2011;405(2):297-302. [DOI] [PubMed]
29. Kim D, Jeon C, Kim JH, Kim MS, Yoon CH, Choi IS, Et al. Cytoplasmic transduction peptide (CTP): new approach for the delivery of biomolecules into cytoplasm in vitro and in vivo. Exp Cell Res. 2006;312(8):1277-88. [DOI] [PubMed]
30. Kimura Y, Yashiroda H, Kudo T, Koitabashi S, Murata S, Kakizuka A, Et al. An inhibitor of a deubiquitinating enzyme regulates ubiquitin homeostasis. Cell. 2009;137(3):549-59. [DOI] [PubMed]
31. Fabre S, Carrette F, Chen J, Lang V, Semichon M, Denoyelle C, Et al. FOXO1 regulates L-Selectin and a network of human T cell homing molecules downstream of phosphatidylinositol 3-kinase. J Immunol. 2008;181(5):2980-9. [PubMed]