Structural basis of resistance to anti-cytochrome bc1 complex inhibitors: Implication for drug improvement

Current Pharmaceutical Design

Volumn 20, Issue 5, 2014, Pages 704-724

  Esser, Lothar ^a   Yu, Chang An ^b   Xia, Di ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b OKLAHOMA STATE UNIVERSITY   (United States)

Author keywords

Complex; Crystal structure; Inhibitors; Mechanism of inhibition; Resistance

Indexed keywords

IRON SULFUR PROTEIN; OXAZOLIDINE DERIVATIVE; OXIDOREDUCTASE INHIBITOR; PROTEIN; QUINONE DERIVATIVE; STIGMATELLIN; UBIQUINOL CYTOCHROME C REDUCTASE; UBIQUINOL CYTOCHROME C REDUCTASE INHIBITOR; UNCLASSIFIED DRUG;

BINDING SITE; CONFORMATIONAL TRANSITION; DRUG BINDING; DRUG RESISTANCE; ELECTRON TRANSPORT; HYDROGEN BOND; MUTATION; OXIDATION; PRIORITY JOURNAL; PROTEIN TARGETING; PROTON TRANSPORT; REDUCTION; REVIEW;

ANIMALS; BINDING SITES; DRUG DESIGN; DRUG RESISTANCE; ELECTRON TRANSPORT; ELECTRON TRANSPORT COMPLEX III; ENZYME INHIBITORS; HUMANS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; OXIDATIVE COUPLING; PROTON-MOTIVE FORCE;

EID: 84895190679     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/138161282005140214163327     Document Type: Review

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